LOCUS       NM_172469               3743 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus chloride intracellular channel 6 (Clic6), mRNA.
ACCESSION   NM_172469 XM_359207
VERSION     NM_172469.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3743)
  AUTHORS   Loyo-Celis,V., Patel,D., Sanghvi,S., Kaur,K., Ponnalagu,D.,
            Zheng,Y., Bindra,S., Bhachu,H.R., Deschenes,I., Gururaja Rao,S. and
            Singh,H.
  TITLE     Biophysical characterization of chloride intracellular channel 6
            (CLIC6)
  JOURNAL   J Biol Chem 299 (11), 105349 (2023)
   PUBMED   37838179
  REMARK    GeneRIF: Biophysical characterization of chloride intracellular
            channel 6 (CLIC6).
REFERENCE   2  (bases 1 to 3743)
  AUTHORS   Ebeid,M., Barnas,K., Zhang,H., Yaghmour,A., Noreikaite,G. and
            Bjork,B.C.
  TITLE     PRDM16 expression and function in mammalian cochlear development
  JOURNAL   Dev Dyn 251 (10), 1666-1683 (2022)
   PUBMED   35451126
REFERENCE   3  (bases 1 to 3743)
  AUTHORS   Decourtye,L., McCallum-Loudeac,J.A., Zellhuber-McMillan,S.,
            Young,E., Sircombe,K.J. and Wilson,M.J.
  TITLE     Characterization of a novel Lbx1 mouse loss of function strain
  JOURNAL   Differentiation 123, 30-41 (2022)
   PUBMED   34906895
REFERENCE   4  (bases 1 to 3743)
  AUTHORS   Billingsley,C.N., Allen,J.R., Baumann,D.D., Deitz,S.L.,
            Blazek,J.D., Newbauer,A., Darrah,A., Long,B.C., Young,B.,
            Clement,M., Doerge,R.W. and Roper,R.J.
  TITLE     Non-trisomic homeobox gene expression during craniofacial
            development in the Ts65Dn mouse model of Down syndrome
  JOURNAL   Am J Med Genet A 161A (8), 1866-1874 (2013)
   PUBMED   23843306
REFERENCE   5  (bases 1 to 3743)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3743)
  AUTHORS   Sousa-Nunes,R., Rana,A.A., Kettleborough,R., Brickman,J.M.,
            Clements,M., Forrest,A., Grimmond,S., Avner,P., Smith,J.C.,
            Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Characterizing embryonic gene expression patterns in the mouse
            using nonredundant sequence-based selection
  JOURNAL   Genome Res 13 (12), 2609-2620 (2003)
   PUBMED   14613977
REFERENCE   7  (bases 1 to 3743)
  AUTHORS   Friedli,M., Guipponi,M., Bertrand,S., Bertrand,D.,
            Neerman-Arbez,M., Scott,H.S., Antonarakis,S.E. and Reymond,A.
  TITLE     Identification of a novel member of the CLIC family, CLIC6, mapping
            to 21q22.12
  JOURNAL   Gene 320, 31-40 (2003)
   PUBMED   14597386
REFERENCE   8  (bases 1 to 3743)
  AUTHORS   Griffon,N., Jeanneteau,F., Prieur,F., Diaz,J. and Sokoloff,P.
  TITLE     CLIC6, a member of the intracellular chloride channel family,
            interacts with dopamine D(2)-like receptors
  JOURNAL   Brain Res Mol Brain Res 117 (1), 47-57 (2003)
   PUBMED   14499480
REFERENCE   9  (bases 1 to 3743)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   10 (bases 1 to 3743)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC174448.2.
            
            On May 1, 2007 this sequence version replaced NM_172469.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077599.1, BC075706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1411              AC174448.2         44623-46033         c
            1412-1521           AC174448.2         16011-16120         c
            1522-1647           AC174448.2         15359-15484         c
            1648-1754           AC174448.2         14205-14311         c
            1755-1936           AC174448.2         13243-13424         c
            1937-3743           AC174448.2         2939-4745           c
FEATURES             Location/Qualifiers
     source          1..3743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.64 cM"
     gene            1..3743
                     /gene="Clic6"
                     /gene_synonym="5730466J16Rik; CLIC1L"
                     /note="chloride intracellular channel 6"
                     /db_xref="GeneID:209195"
                     /db_xref="MGI:MGI:2146607"
     exon            1..1411
                     /gene="Clic6"
                     /gene_synonym="5730466J16Rik; CLIC1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2098
                     /gene="Clic6"
                     /gene_synonym="5730466J16Rik; CLIC1L"
                     /note="glutaredoxin-like oxidoreductase CLIC6"
                     /codon_start=1
                     /product="chloride intracellular channel protein 6"
                     /protein_id="NP_766057.1"
                     /db_xref="CCDS:CCDS28338.1"
                     /db_xref="GeneID:209195"
                     /db_xref="MGI:MGI:2146607"
                     /translation="MAEATEPKEVAPGSQGQPEGATIEGPGEPGAADLEGREASEEAA
                     EAPRDLGAGVEARASGKEEGGCGQDEGTGGAQAQDPRTGPEAETPGASGAPGEAEAAE
                     RDPEGAIPQGAEEAPSAQQVQGMSSGLDSQGEAPEVPGDSRREPEDPTASEAGEEAES
                     GQEAQGGGALGLQINPEVQGLAGDNMDTEAPAGGPLGSESEPQGGGESSPQPQDEAIE
                     IVTTEIGGNESGELAGASAADAAGEGETLGKDGSEEAASEDARVDAHENGDQGKLQEE
                     TGEEEARPEPELKGPCEGAIQEKPPDGSLDGEEAKSTEHEEESQAELSNHLAEEPSVQ
                     GGEELGRVNGRRENGPALEEGDPGQEHDITLFVKAGYDGESIGNCPFSQRLFMILWLK
                     GVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLVPPRYPK
                     LGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIYEKNLLRALKKLDSYLNSPLPDEID
                     ADSSEDVTVSQRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLN
                     NAYARDEFTNTCPADREIEHAYSDAAKRMK"
     exon            1412..1521
                     /gene="Clic6"
                     /gene_synonym="5730466J16Rik; CLIC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1647
                     /gene="Clic6"
                     /gene_synonym="5730466J16Rik; CLIC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1754
                     /gene="Clic6"
                     /gene_synonym="5730466J16Rik; CLIC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1936
                     /gene="Clic6"
                     /gene_synonym="5730466J16Rik; CLIC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..3743
                     /gene="Clic6"
                     /gene_synonym="5730466J16Rik; CLIC1L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgagaccgc agggaaccag cccatctctt ccaaagactt caagaggcaa gctgagttct
       61 ttagccccac accctggcct gcacagaagg attggggtcc gggcgcgaat ttaggagaaa
      121 caggaactct tgaggaagaa cccaaagacc ttaagacagg gaaaagggac atagagtctt
      181 ggggccctct agattttgca tcaagcgaaa ccttcgcttc tagaaccgcg agtggggtgt
      241 cctcccggag ggggcacgtc agcccctgcc cctcaccctg agcagcgtcg aggaagggtg
      301 ttttaccatg gctgaggcca cggagcccaa ggaggtcgct ccaggttccc aggggcaacc
      361 cgaaggtgcg acaatcgagg gaccaggaga gccaggagct gcggacctgg aggggcggga
      421 agcgagcgag gaagctgcag aggcacctag ggacctgggg gcgggcgtag aggccagggc
      481 ctcggggaag gaggaaggag gctgtgggca ggacgaggga actgggggag cgcaggcgca
      541 ggacccgcgc accggccctg aggccgagac gccgggcgcc agcggagctc caggtgaagc
      601 ggaggctgcg gagcgcgacc ccgagggcgc gatcccgcag ggagcggagg aggcgccaag
      661 cgcccagcag gtgcagggga tgagctctgg gttagactct cagggtgagg cccccgaggt
      721 ccctggggac tctcgccggg agcccgagga ccccacggcc tcagaggcag gggaagaggc
      781 agaatctggt caggaagcgc agggaggcgg cgcgctaggg ttgcagatca acccagaagt
      841 ccagggactt gcaggggaca acatggacac agaggcaccc gcaggagggc cacttgggtc
      901 ggagagtgag ccccagggtg gaggggaaag cagccctcag ccccaggatg aggcgattga
      961 gattgtaacc acagagatcg gagggaacga gtccggggag ctggcgggcg cttcggccgc
     1021 agacgccgcg ggggaagggg agaccctggg gaaagacggg tccgaggaag cagcttccga
     1081 ggatgcgaga gtagatgctc atgagaatgg ggaccagggc aagctccagg aggagaccgg
     1141 ggaggaagaa gcgaggccag aacccgagtt gaagggaccc tgcgaggggg ccatccaaga
     1201 gaagcccccc gacggcagcc ttgatggaga ggaggccaaa tccaccgaac acgaggagga
     1261 atcccaggca gagctcagca accacttagc tgaggagccc agcgtccagg gtggagaaga
     1321 gttggggcga gtgaacggcc gcagggagaa tggcccagca ttggaggagg gggatccggg
     1381 acaggagcac gacatcaccc tcttcgtcaa ggctggttat gacggcgaga gcatcggaaa
     1441 ctgcccattt tcacagcgtc tctttatgat cctctggcta aagggtgtta tattcaatgt
     1501 gacaacggtg gacctaaaac ggaagcctgc agaccttcag aacctggctc ctgggacgaa
     1561 ccctcctttc atgacttttg atggtgaagt caagacagat gtgaataaaa ttgaggagtt
     1621 cttagaggag aagttagttc ccccgaggta ccctaagctg ggaactcagc accctgagtc
     1681 caactcagcg ggaaatgatg tttttgccaa attctcagca tttattaaaa acaccaagaa
     1741 ggatgcaaat gagatttatg aaaagaacct actacgggcc ctgaagaagc tggacagtta
     1801 cttaaacagc ccgctgccag acgaaatcga tgccgacagt tcagaggatg tcactgtttc
     1861 acaaaggaag tttctggatg gggatgagct cacactggct gactgtaacc tcttacccaa
     1921 gctccatatc attaagattg tcgccaagaa atatagagat tttgagtttc cttctgaaat
     1981 gaccggcatt tggaggtact tgaacaacgc ttacgcccgg gatgagttca ctaacacgtg
     2041 tccggccgac cgggagattg aacacgcata ttccgatgca gcgaaaagga tgaagtgaca
     2101 ctggcttgca gcagatgagt gggcgggcct tccaggagag ccctctgttt cttccctgaa
     2161 acagctcttt tgcgaaatag cgctgactct ctaaatgcca ccataggatg cggggccttg
     2221 agatttgtct actcattcct cctacactaa tttatatctt tgagattcag ttctctggta
     2281 atccatgttt agggcgatag tgttttgtag cttgtttcag ggcaaacagg ctttgactta
     2341 agttcttggc attttaaaga ggttagtctt tttttttttt ttgatagttt tcataatcac
     2401 ctggcttgtt tttctcttct caagtatcag tttaaaatgg agatgctgtt ttatacttat
     2461 agaatacttt agaacagtat tagagggtat gaagaagaaa ttttttaaaa tcacctaaaa
     2521 ttctatatat tttctgatga caatttgatg aatgtttcca gaatcggtca atctttcatg
     2581 tatgcctgtg ctcatgcgtg cacatacatc acatataatt tcattcattt gtggaatggc
     2641 atttgtgtaa gaaagcaatg aagggatctc ctggttcctt aaaggttatc acagaagact
     2701 taaaacaaag gatttagccc tgctgagcca cacaggggct tggagagcct cttgcagaac
     2761 caagggacag caggacctag gataatggga ccagggtatc ttgcttctgc tttaaggatg
     2821 ttgttgctct gagcccaggt gtggaggaga gggttccccg tgcctttggg tctactcctt
     2881 ttctggaacc cattgttctc actcccccag agggactgtg ctttcctggg gactcttcct
     2941 gtcagctctg gcttggagac tctccctgcc ttatatcaca gtgtaaacct acaagtcctg
     3001 ctcatgtcag tgcttcagtg aagatggtgt acccgaggct agctcattca cgtcttcttt
     3061 ctatctcatt gctgttcttt ctgtgtcaac ctgaggcgaa gcaggaaaac tgaattccag
     3121 atgaaaatcc agaaagtccc actcttaagc ttttctggaa aatggtcctt tcctgagaag
     3181 ttgaggagtt tctggtgtgc ttgtggcatt ccctccatca ttcttggggc cacccttggt
     3241 catagtgagg cctgttccag cctaaccatg aatgaggaaa tgtgagcttg caagctctgc
     3301 aaggcttgtc ccttcaccac cacacaccct acaggaaaca tctcttgtac acttggctag
     3361 agcgctgggc tctggaacct cgtgcttcat aggcacttgg gtgagggtac cagtaagacc
     3421 ccgagattag gtgaaaaaat atctcgaaag gaaacaaagt ccaatatggt ggccactaca
     3481 ttttcttgtt tcttggaagc tgtggcttca gtccaatagt ctatttcttt gtcactcaaa
     3541 gaaggttttc agggtcgtgt ctagcctgtc ccaccctgct ccacatcact ctgcacctct
     3601 gtaggagtca ccttgttaag ctcttgtgac attcaaactt ggtaaatgag ttgatggttg
     3661 ggagtttagt tttgttaatt ttgttctttt agatattaaa atgatcacaa gcggtgtgcc
     3721 ttacaaatta aacattctca atc
//
