LOCUS       NM_172621               5870 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus chloride intracellular channel 5 (Clic5), mRNA.
ACCESSION   NM_172621
VERSION     NM_172621.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5870)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5870)
  AUTHORS   Qi,J., Tan,F., Zhang,L., Zhou,Y., Zhang,Z., Sun,Q., Li,N., Fang,Y.,
            Chen,X., Wu,Y., Zhong,G. and Chai,R.
  TITLE     Critical role of TPRN rings in the stereocilia for hearing
  JOURNAL   Mol Ther 32 (1), 204-217 (2024)
   PUBMED   37952086
  REMARK    Erratum:[Mol Ther. 2025 Jan 8;33(1):419-420. doi:
            10.1016/j.ymthe.2024.12.004.. PMID: 39672160]
REFERENCE   3  (bases 1 to 5870)
  AUTHORS   Ebeid,M., Barnas,K., Zhang,H., Yaghmour,A., Noreikaite,G. and
            Bjork,B.C.
  TITLE     PRDM16 expression and function in mammalian cochlear development
  JOURNAL   Dev Dyn 251 (10), 1666-1683 (2022)
   PUBMED   35451126
REFERENCE   4  (bases 1 to 5870)
  AUTHORS   Li,J., Liu,C. and Zhao,B.
  TITLE     N-Terminus of GRXCR2 Interacts With CLIC5 and Is Essential for
            Auditory Perception
  JOURNAL   Front Cell Dev Biol 9, 671364 (2021)
   PUBMED   34026762
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5870)
  AUTHORS   Ashokkumar,D., Zhang,Q., Much,C., Bledau,A.S., Naumann,R.,
            Alexopoulou,D., Dahl,A., Goveas,N., Fu,J., Anastassiadis,K.,
            Stewart,A.F. and Kranz,A.
  TITLE     MLL4 is required after implantation, whereas MLL3 becomes essential
            during late gestation
  JOURNAL   Development 147 (12) (2020)
   PUBMED   32439762
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5870)
  AUTHORS   Bradford,E.M., Miller,M.L., Prasad,V., Nieman,M.L., Gawenis,L.R.,
            Berryman,M., Lorenz,J.N., Tso,P. and Shull,G.E.
  TITLE     CLIC5 mutant mice are resistant to diet-induced obesity and exhibit
            gastric hemorrhaging and increased susceptibility to torpor
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 298 (6), R1531-R1542 (2010)
   PUBMED   20357015
  REMARK    GeneRIF: Clic5 mutant mice are resistant to diet-induced obesity.
REFERENCE   7  (bases 1 to 5870)
  AUTHORS   Wegner,B., Al-Momany,A., Kulak,S.C., Kozlowski,K., Obeidat,M.,
            Jahroudi,N., Paes,J., Berryman,M. and Ballermann,B.J.
  TITLE     CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli,
            is a determinant of podocyte integrity
  JOURNAL   Am J Physiol Renal Physiol 298 (6), F1492-F1503 (2010)
   PUBMED   20335315
  REMARK    GeneRIF: CLIC5A colocalizes with ezrin and podocalyxin in podocytes
            and is required for the development/maintenance of the proper
            glomerular endothelial cell and podocyte architecture.
REFERENCE   8  (bases 1 to 5870)
  AUTHORS   Li,F., Yin,J., Yue,T., Liu,L. and Zhang,H.
  TITLE     The CLIC5 (chloride intracellular channel 5) involved in C2C12
            myoblasts proliferation and differentiation
  JOURNAL   Cell Biol Int 34 (4), 379-384 (2010)
   PUBMED   20055760
  REMARK    GeneRIF: CLIC5 disrupts proliferation of C2C12 cells and is
            involved in the differentiation of myoblasts by enhancing the
            protein expression level of MyHC, myogenin and desmin.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5870)
  AUTHORS   Brunskill,E.W., Aronow,B.J., Georgas,K., Rumballe,B.,
            Valerius,M.T., Aronow,J., Kaimal,V., Jegga,A.G., Yu,J.,
            Grimmond,S., McMahon,A.P., Patterson,L.T., Little,M.H. and
            Potter,S.S.
  TITLE     Atlas of gene expression in the developing kidney at microanatomic
            resolution
  JOURNAL   Dev Cell 15 (5), 781-791 (2008)
   PUBMED   19000842
  REMARK    Erratum:[Dev Cell. 2009 Mar;16(3):482. Yu, Jing [added]]
REFERENCE   10 (bases 1 to 5870)
  AUTHORS   Gagnon,L.H., Longo-Guess,C.M., Berryman,M., Shin,J.B., Saylor,K.W.,
            Yu,H., Gillespie,P.G. and Johnson,K.R.
  TITLE     The chloride intracellular channel protein CLIC5 is expressed at
            high levels in hair cell stereocilia and is essential for normal
            inner ear function
  JOURNAL   J Neurosci 26 (40), 10188-10198 (2006)
   PUBMED   17021174
  REMARK    GeneRIF: CLIC5 associates with radixin in hair cell stereocilia and
            may help form or stabilize connections between the plasma membrane
            and the filamentous actin core.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116688.14, AK156849.1 and AC153418.1.
            
            On Jan 21, 2006 this sequence version replaced NM_172621.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156849.1, AK046522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC116688.14        76534-76850
            318-1296            AK156849.1         159-1137
            1297-5870           AC153418.1         185360-189933       c
FEATURES             Location/Qualifiers
     source          1..5870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 20.53 cM"
     gene            1..5870
                     /gene="Clic5"
                     /gene_synonym="5730531E12Rik; B330005L24; Gm322; jbg;
                     nmf318"
                     /note="chloride intracellular channel 5"
                     /db_xref="GeneID:224796"
                     /db_xref="MGI:MGI:1917912"
     exon            1..390
                     /gene="Clic5"
                     /gene_synonym="5730531E12Rik; B330005L24; Gm322; jbg;
                     nmf318"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1083
                     /gene="Clic5"
                     /gene_synonym="5730531E12Rik; B330005L24; Gm322; jbg;
                     nmf318"
                     /note="glutaredoxin-like oxidoreductase CLIC5"
                     /codon_start=1
                     /product="chloride intracellular channel protein 5"
                     /protein_id="NP_766209.1"
                     /db_xref="CCDS:CCDS28804.1"
                     /db_xref="GeneID:224796"
                     /db_xref="MGI:MGI:1917912"
                     /translation="MTDSATTNGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWL
                     KGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYP
                     KLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALRKLDDYLNSPLPEEI
                     DTNTHGDEKGSQRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYL
                     KNAYARDEFTNTCAADSEIELAYADVARRLSRS"
     exon            391..500
                     /gene="Clic5"
                     /gene_synonym="5730531E12Rik; B330005L24; Gm322; jbg;
                     nmf318"
                     /inference="alignment:Splign:2.1.0"
     exon            501..626
                     /gene="Clic5"
                     /gene_synonym="5730531E12Rik; B330005L24; Gm322; jbg;
                     nmf318"
                     /inference="alignment:Splign:2.1.0"
     exon            627..733
                     /gene="Clic5"
                     /gene_synonym="5730531E12Rik; B330005L24; Gm322; jbg;
                     nmf318"
                     /inference="alignment:Splign:2.1.0"
     exon            734..915
                     /gene="Clic5"
                     /gene_synonym="5730531E12Rik; B330005L24; Gm322; jbg;
                     nmf318"
                     /inference="alignment:Splign:2.1.0"
     exon            916..5870
                     /gene="Clic5"
                     /gene_synonym="5730531E12Rik; B330005L24; Gm322; jbg;
                     nmf318"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatcgctg acagtctcgg atcctgtgac acctcccagc agtcaggcac ttgttgctct
       61 tgggacctgt tgtcaatccc ttagctcgct tttcctttta gccccctgct ggctcttgga
      121 gtcctctctt tccgcgtgac acctgggact ctgatctctc aggcatcgct gtccttgctt
      181 ggagaaattg atgagaaact ggtagtctta aaaaaagaaa acattaaaca ccgtgcaaaa
      241 gagaggcccc cgctgtgagc aggagcctga agtgctgcag aggtggcgcc tctccggccc
      301 gggaccgtgg tccggggcgc caacggcatg acggactcag cgacaactaa tggggacgac
      361 agggaccccg agatcgagct cttcgtgaag gctgggatcg acggggaaag cattggcaac
      421 tgtcccttct ctcagcgtct cttcatgatc ctctggctga aaggagtcgt gttcaatgtc
      481 accaccgtgg atctgaaaag aaagccagcc gatctacaca acctggctcc tggcacgcac
      541 ccgcccttcc tgaccttcaa tggggatgtg aagacagatg tcaacaagat tgaagagttc
      601 ctggaggaga ccctaacccc cgagaagtac cccaaactgg ctgcaaaaca ccgggaatct
      661 aacaccgcgg gcatcgacat cttctccaag ttctcagcct acatcaaaaa caccaaacaa
      721 cagaacaatg ctgcccttga gagaggcttg acaaaggcgc tgaggaagct ggatgactac
      781 ctaaacagcc ctctgccaga ggagattgac accaacaccc acggggacga gaaggggtcc
      841 cagcgcaagt tcctggatgg ggatgagctg accctggccg actgcaatct gctgcccaag
      901 ctgcatgtgg tcaagattgt ggctaagaag taccgaaact atgacatccc agctgagatg
      961 acaggcttgt ggcgatacct caagaatgcc tatgcacggg acgagttcac caacacctgt
     1021 gcagctgaca gtgagatcga gttggcctac gcagatgtcg ccaggcgcct cagccgatcg
     1081 tgagcttggc tgtctggccc aatttctgct gcagaagaat tctacttctc ccaatggctt
     1141 tcagctctac agactcttct tccccattgc cttggggaaa cataaaaaaa aattaggcca
     1201 catcttactg gcacccctga actcaactcc agccttctac cttctaagat cagtgccatc
     1261 cttctgcctt gccctgcagg agcctggcaa gcagaggaca cggtggcaga ttttttttcc
     1321 acctgctggt ctgatctagg gtcagtgtat ctggggtcag tgaatctggg gtcagtttgc
     1381 agagctctca tgggattgtc accgttccct tctgccaata tcataatgct ttctcagatg
     1441 cgctaacaac ttgaaatgcc agcttctctc tcccctcgtt cctcagcaaa tgcaaggtga
     1501 tggacagata catcatcgtc agggagagat ctatgccttg attggggaga cagtggttgg
     1561 ggggactcag ctgggtgtgg ctctagcaaa acagttccag atgctcacta tttctgacag
     1621 tgggccagat ggagacaccc ccaacacaca atatacccca gttttctggt gcaatatgat
     1681 tacatcctgg ccagcactga cccaagtttt cctcctgtct ccattttgcc acaaaggcag
     1741 tcgatttata actctaaacc aaggtgaccc agatagggag agacttctgg gaagcaatat
     1801 tgatgccaaa aggcccaaac agggtctaca gccacagggg tcactggctg aagagtagtc
     1861 gtccactgga gatcacatga gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1921 gtgtgtgtgt gactgtgttc ttcagtgggt agctttgggt ttgagcaagc gaaggaagtg
     1981 gagggatggg aggaaataaa gttctatttg agtttgacat agcctagaaa acttttagag
     2041 cagtcttctc tctcattatc taaatcttgg attggtgtta cggcacccct accaactgta
     2101 gagcagactc caacatcagc caaaaatgtc ttccaggctc ttcatagtca cttgcagatg
     2161 tgggttgcca cctgcctgtg ccctggctcc cagtttcttc agcctcagcc tctgatgaaa
     2221 gagaaagtct attaatgaat ggtgtgatcg tgggctacct taggaagaaa gcccatgggt
     2281 ctttctgact gggaagccac aacttgaatt tggaaattat ggactgcctt gggcttgggt
     2341 tcattttcct gtcagcaggc tcatctatca gattttcaag gaagagaaaa ctttttaaaa
     2401 atttctttat aaactaatat ttctctcttt agtaattctc cttgagtttt acctacaact
     2461 ctcacagggt gtgaccatga gaacctaggc tgattaggaa ctatgacaaa tcaatcactc
     2521 attagctctt cctctaccag tgagctagtg agtgcctaga agaaatccat caccaggacc
     2581 tcaactccaa caatcccgct tctgtgtcac tgacagtgga ggcgaggctc ctgagggccg
     2641 gtaaggccct ggtcttggct cattgctcgg gagggtggag cagcacagat cctttccata
     2701 gaaatacaac atggtttaac ccaagcagtc actgagccct cctgcctcta gggatctcca
     2761 aagcaaagag tgaccattga tccaaggagg gaggaagcag gaggtctccc tagcccactg
     2821 gggaagagga ctctgcctgc tagaagttta taaacctgaa ggggctttga agaggcaaaa
     2881 tgagccgatt catttccatc gctacaggaa cctttccacg ggctctccat aagctacccc
     2941 tggggatgtt taaaagtgta gcactgctga gggaacagca cttttttctt cagggaagag
     3001 ccctcaatgg gcctctcggg gaagcagaac ttccggaacc atccggaagg ccgtttaatt
     3061 aaaagaaaac catgctgttc tccgggatcc ttcctagaat ttacaagcag gcagggtgaa
     3121 ctcacgcagc tcacacccct attttccaaa ggtgggctgg tgttaaagat atgaagacta
     3181 gcgtgcatgc tgaggggcct cagaggaagg ggaagaattt tcctcatgtg atgctctgag
     3241 cccagcaatc ggcatgtctt ttaaaaacaa acttcccaag ccgagtcgat gttgtttcta
     3301 gacggttctc ctatggttga gttagtttca catacatcac aatatttagg caatgttgga
     3361 tgctatagga tcaatcagaa cccctttaaa gagaggcacg attgtaaatg ggaggctttc
     3421 ctcagtactt taatgcagat gtaactttaa tgttatcaaa taactataat gagactaacc
     3481 aatgtcttag gacacaatta tcatagtatg taaaaaaaat agcaataaag tcaatgatga
     3541 ttacctaccc caccccctcc aaggagagtt ttctctggag gctctagttt ctttggacct
     3601 tggtcttaac cttgatatgt atatggttta ccatctgcag tcaccctgtg ttgaggttcc
     3661 aagtcccagc tcagaccatg tggaagggtt tgtagtgtgg actctacctg cagaaattct
     3721 ggataagagc tattccggta aatgccagtc ccccaggaag catttggatg tcagagaaaa
     3781 ggaagctatg ttgacagagc tattgtgtat tcttttctca ccttggattg tcacatgaca
     3841 atcttgtatg tatgaaacgt taagtgcaaa gcaagacaga cagacggggt ctgactcaaa
     3901 attactgagc tgagtgtacc tacctattta aaactgccca cttcttaggt tgatccagac
     3961 agaagacatt cttaggttga tccagagaga agatgttatt aactatccac aataagatag
     4021 aaagtgaatt gtttgcttgt ttagaaatat aatttcatat tctcctgaaa aaaaagaaaa
     4081 tgtcctggta agttcaggat cacagtcatg tgtctatctc acagtttaaa tgaggggtct
     4141 aggtagccta ctggaaccaa acaaatcagt tgcaaagtag gaaatggtca ctcagtttat
     4201 ttaggcagtc gatcccaaac tagttctagc ttcctggtag gtggcaatgt ccccactggt
     4261 cccctctagt gttggtggga acaaataggc tctctttttt tttcttcaaa accaaactgt
     4321 tccaaaagtg aagtttgggg cagaacctgc tggtaccttc ttgtgaggtt cttatgaggt
     4381 gaaacaagaa cagtgactag aggggtggac attctgcaga caggtagtcc taagcaggtt
     4441 agaaccatca tggaatgaaa catgcctggc acagagagac gttgctgttg acaagttctg
     4501 gggaccttcc aggcccaggt aaattgtatt atgagggaag tcaaggcaga agccgtgtgt
     4561 ccatctaata aaagttcacc atcgctaaaa gagtttgcat ctacaatcaa atccttctag
     4621 aagcagtagg tgtctggtcg gtaggtactt ctggggtttc tgtccattct tccatggtct
     4681 aggagttagc tcagctgcaa gatgaggcag gatactaatg tggctttgct gggaaacatg
     4741 aaacactaac tcatgattga aactaaattc agtgattctc aaggataacc ttttgagatc
     4801 tacatgtttc tatcatccat attcatatac attatatcta tatatgatat tacaaagaac
     4861 ctttagaaag ggtgaaggaa agaagtgtgc tcatgaggcc tcagactctg gtgttgggag
     4921 aagatttgtg atcttgtctt tggccttggg gcccttctac aaataagcca atgactttgt
     4981 atccactgct ctttatcatt caaactaaca gcttgtgcct gaattataag tgtattttat
     5041 tttccctcta ccaatatttc cctcccagcc ttgctgcaag ctacattcat ctcattatta
     5101 tgaatgagta taaatcaaac tgcccaatct tatttaatgt tgtttcagga tatagatcta
     5161 ttgttcatta tcaccacatg caccagcaaa aataaagaaa atgttattcc aatataaggt
     5221 ttgacttaaa ccgtactttc aataaaatca atctagtgtt tggtaaaaac agttttgaag
     5281 acatggtatt tttgtatata gctagagatg tcacaacatc aactgtgaat atatttatag
     5341 gagatagaag ggtaggatca agcttggtta tagagtgttt gcttaacata cgtgaaaccc
     5401 tgggtcagat ctctagcact gcatcaacca agcatggtag caaacactgg taattccagc
     5461 acaagggagc tgaagtcagg aagaccaagg tcagctgcat agcaaactgg aggctggtct
     5521 gagaccctgt ctcaaaacaa gtaaaatatt cagctgatac ttgaatttct cccccctcca
     5581 cccaagtcac ctagtttttt tttttaattt tattttataa gctgaggagt taactgattg
     5641 gcaattctaa tacattgtat gtagggacac tccaaatgat ggtaacatat tttttgagac
     5701 ctttagcttg ggtgagaaca gaccttgctt tcaagcctta ctcaatgtac cacgcctttg
     5761 actacatacc aagtcaagtg ttttctactt atccttgagc cagctgtaaa tgcatttcct
     5821 ggtcttgatt ggtattgact gattcaaata aagttggttt attttcaaat
//
