LOCUS       NM_013885               4065 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus chloride intracellular channel 4 (Clic4), mRNA.
ACCESSION   NM_013885
VERSION     NM_013885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Chen,R., Pan,C., Mao,X., Zhang,Y., Chen,G., Xu,M., Nivar,J.,
            Tao,Y., Cao,H. and Li,J.
  TITLE     Chloride intracellular channel 4 blockade improves cognition in
            mice with Alzheimer's disease: CLIC4 protein expression and tau
            protein hyperphosphorylation
  JOURNAL   Int J Biol Macromol 278 (Pt 4), 134972 (2024)
   PUBMED   39181373
  REMARK    GeneRIF: Chloride intracellular channel 4 blockade improves
            cognition in mice with Alzheimer's disease: CLIC4 protein
            expression and tau protein hyperphosphorylation.
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Kleinjan,M.L., Mao,Y., Naiche,L.A., Joshi,J.C., Gupta,A.,
            Jesse,J.J., Shaye,D.D., Mehta,D. and Kitajewski,J.
  TITLE     CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1
            Signaling via RhoA
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (8), 1441-1454 (2023)
   PUBMED   37317855
  REMARK    GeneRIF: CLIC4 Regulates Endothelial Barrier Control by Mediating
            PAR1 Signaling via RhoA.
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   Al Khamici,H., Sanchez,V.C., Yan,H., Cataisson,C.,
            Michalowski,A.M., Yang,H.H., Li,L., Lee,M.P., Huang,J. and
            Yuspa,S.H.
  TITLE     The oxidoreductase CLIC4 is required to maintain mitochondrial
            function and resistance to exogenous oxidants in breast cancer
            cells
  JOURNAL   J Biol Chem 298 (9), 102275 (2022)
   PUBMED   35863434
  REMARK    GeneRIF: The oxidoreductase CLIC4 is required to maintain
            mitochondrial function and resistance to exogenous oxidants in
            breast cancer cells.
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Chuang,J.Z., Yang,N., Nakajima,N., Otsu,W., Fu,C., Yang,H.H.,
            Lee,M.P., Akbar,A.F., Badea,T.C., Guo,Z., Nuruzzaman,A., Hsu,K.S.,
            Dunaief,J.L. and Sung,C.H.
  TITLE     Retinal pigment epithelium-specific CLIC4 mutant is a mouse model
            of dry age-related macular degeneration
  JOURNAL   Nat Commun 13 (1), 374 (2022)
   PUBMED   35042858
  REMARK    GeneRIF: Retinal pigment epithelium-specific CLIC4 mutant is a
            mouse model of dry age-related macular degeneration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   Bogenpohl,J.W., Weston,R.M., Foreman,T.N., Kitchen,K.E. and
            Miles,M.F.
  TITLE     Chloride intracellular channel 4 (CLIC4) expression profile in the
            mouse medial prefrontal cortex and its regulation by ethanol
  JOURNAL   Alcohol Clin Exp Res 46 (1), 29-39 (2022)
   PUBMED   34839533
  REMARK    GeneRIF: Chloride intracellular channel 4 (CLIC4) expression
            profile in the mouse medial prefrontal cortex and its regulation by
            ethanol.
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Arnould,T., Mercy,L., Houbion,A., Vankoningsloo,S., Renard,P.,
            Pascal,T., Ninane,N., Demazy,C. and Raes,M.
  TITLE     mtCLIC is up-regulated and maintains a mitochondrial membrane
            potential in mtDNA-depleted L929 cells
  JOURNAL   FASEB J 17 (14), 2145-2147 (2003)
   PUBMED   12958156
  REMARK    GeneRIF: mtCLIC is involved in mitochondrial membrane potential
            generation in mitochondrial DNA-depleted cells.
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4065)
  AUTHORS   Fernandez-Salas,E., Suh,K.S., Speransky,V.V., Bowers,W.L.,
            Levy,J.M., Adams,T., Pathak,K.R., Edwards,L.E., Hayes,D.D.,
            Cheng,C., Steven,A.C., Weinberg,W.C. and Yuspa,S.H.
  TITLE     mtCLIC/CLIC4, an organellular chloride channel protein, is
            increased by DNA damage and participates in the apoptotic response
            to p53
  JOURNAL   Mol Cell Biol 22 (11), 3610-3620 (2002)
   PUBMED   11997498
  REMARK    GeneRIF: mtCLIC/CLIC4, an organellular chloride channel protein, is
            increased by DNA damage and participates in the apoptotic response
            to p53.
REFERENCE   9  (bases 1 to 4065)
  AUTHORS   Fernandez-Salas,E., Sagar,M., Cheng,C., Yuspa,S.H. and
            Weinberg,W.C.
  TITLE     p53 and tumor necrosis factor alpha regulate the expression of a
            mitochondrial chloride channel protein
  JOURNAL   J Biol Chem 274 (51), 36488-36497 (1999)
   PUBMED   10593946
REFERENCE   10 (bases 1 to 4065)
  AUTHORS   Gordon,H.M., Kucera,G., Salvo,R. and Boss,J.M.
  TITLE     Tumor necrosis factor induces genes involved in inflammation,
            cellular and tissue repair, and metabolism in murine fibroblasts
  JOURNAL   J Immunol 148 (12), 4021-4027 (1992)
   PUBMED   1602141
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL627078.10
            and AL669936.12.
            
            On Nov 17, 2006 this sequence version replaced NM_013885.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF102578.1, AK169376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AL627078.10        22075-22317         c
            244-353             AL669936.12        47584-47693         c
            354-479             AL669936.12        34746-34871         c
            480-586             AL669936.12        32186-32292         c
            587-768             AL669936.12        27230-27411         c
            769-4065            AL669936.12        22691-25987         c
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.19 cM"
     gene            1..4065
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /note="chloride intracellular channel 4"
                     /db_xref="GeneID:29876"
                     /db_xref="MGI:MGI:1352754"
     exon            1..243
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..933
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /note="mc3s5/mtCLIC; chloride intracellular channel 4
                     (mitochondrial); glutaredoxin-like oxidoreductase CLIC4"
                     /codon_start=1
                     /product="chloride intracellular channel protein 4"
                     /protein_id="NP_038913.1"
                     /db_xref="CCDS:CCDS18783.1"
                     /db_xref="GeneID:29876"
                     /db_xref="MGI:MGI:1352754"
                     /translation="MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMI
                     LWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPP
                     KYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLP
                     DEIDENSMEDIKFSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIW
                     RYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK"
     exon            244..353
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /inference="alignment:Splign:2.1.0"
     exon            354..479
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /inference="alignment:Splign:2.1.0"
     exon            480..586
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /inference="alignment:Splign:2.1.0"
     exon            587..768
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /inference="alignment:Splign:2.1.0"
     exon            769..4065
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2572..2577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /note="hexamer: AATAAA"
     polyA_site      2593
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
     regulatory      4042..4047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /note="hexamer: AATAAA"
     regulatory      4046..4051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /note="hexamer: AATATA"
     polyA_site      4060
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
     polyA_site      4065
                     /gene="Clic4"
                     /gene_synonym="D0Jmb3; mc3s5; mtCLIC; TU-74"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcgagg cgtgaggcgg tgctgaggat ctgaggccac gggcagccag acgccgggac
       61 tgtccagcga acgagcaagc cagcgagtga gcgagcggcg ggaacccgca gccacagcag
      121 ccccggagcc acagccgcag ccgccgtccg cggagcccag cccaaccggc catggcgctg
      181 tcgatgcccc tgaacgggct gaaggaggag gacaaagagc ccctcatcga gctcttcgtc
      241 aaggccggaa gtgatggtga aagcattgga aactgcccct tttcacagag gctcttcatg
      301 atcctttggc tcaaaggagt cgtgttcagt gtcacaaccg ttgacctgaa aaggaaacct
      361 gcagatctac agaacttggc tcctgggacc cacccgccat ttataacctt caacagcgaa
      421 gtcaagacgg atgtgaataa gattgaggaa tttctcgaag aagtcttgtg cccacccaag
      481 tacctaaagc tttcaccaaa gcacccagag tcgaacactg ctggaatgga catctttgcc
      541 aaattctctg cttacatcaa gaactcaaga ccagaggcta atgaagcgct ggagaggggg
      601 ctcttgaaaa cgctgcagaa actggatgag tacctcaact ctcccctccc cgacgaaatc
      661 gacgagaaca gcatggagga catcaaattt tccacacgtc ggtttctgga cggcgatgag
      721 atgacattag cagactgtaa cctgctgccc aagctccaca ttgtcaaggt ggtggccaaa
      781 aaataccgca actttgatat tcctaaagga atgacaggca tctggaggta cctgacaaac
      841 gcctacagca gggacgagtt caccaacacc tgtcccagcg acaaggaggt ggaaatcgcg
      901 tacagcgatg tcgccaagag acttaccaag tagacagcac tttcgagaga gatgccttcc
      961 gatcccccga gaatccgctt tcctaacaga ctgctccgcc tcctaaagta gaagtgtatt
     1021 ttgcatgaac acacagttac tcaagactag gagtaaggct agacagagta ggcctctcca
     1081 gtacacactc ctgagcagta ttattctaaa ctcctctacc cagcccacct accctaccct
     1141 gccctgccca tctgctgccc tccagtttgg aggcacttcg ccacaagcgt gtcacccaag
     1201 aggcagtttg ctgtcactct ggagccccga ccatcacgtc ccttcactgt gtagatggca
     1261 gaacttgagg tgctatgttc caccattaga aaagtcgcct gcgacatcag tggaccccat
     1321 gttgctgtgt gcatggtata ggaacattta tgtactgggg gagttgtaat attgtgtaag
     1381 gagtctggaa ggattactac tgtgtcagac gtgctgtttc agagtagtct gttctggagt
     1441 gtctgagtga gaaggccact tctgtagaga cactggtttc taggtagaca tttaattttg
     1501 actaaaatgt gtcatttgta taaattgtaa catccgatag atactacata gaaaatgaag
     1561 gactgagggg ttaggaaggc attttcaaaa tgacaagaga aggttgggtg gggtctctgt
     1621 ctatcttgcc tgctgtgagg gtatcaccca ggcccactta tccatctaca gcgagtagta
     1681 tggcggcctt ccttgtaaca ggctttttct tttctctctt cgtggtgctt gggatggaac
     1741 ccagggcttt gtttaggcct gacaaggctc tgcccctgag ctgtgccaag cccacctccc
     1801 tctgtgtaca aagctccttt cttgggtgac caacatcttc ctgtctttga gcaaccaagg
     1861 ccagcatgcg agccacccag aagttaatta aaccaggttc atcgggagtt tgctgaaatg
     1921 ttaagcatac tctgttctag agagggagtg aagaaggggc catcttaaac tcccgtgagg
     1981 cccaggcctc gtgctcctgc cccacctcca tgtgcatcag actgggtgag aggtccttca
     2041 cttgtcttgg gataaattgt agttgtctta gtgagtgtgt atttccacag ttttgcctca
     2101 tgtcagtccc cacgcggaag gatagccttc tgtgttcttc ttgcctttgt tttgagacag
     2161 gatgttactc tgaaaccctg gttggcctgg aacctgatag gtgaccaagc cagcctcaaa
     2221 ctcgtggcag ccctcttgca tttgcctcct gaattggagc taggattcag cctgcaccac
     2281 cacggctggc ttgttttctc atctctaaaa acaaagtcta agctaaaagt tgtttgcagt
     2341 ctaacaaagg ggaatgagct ttgtaaaacc agaggcccct cccgcccaga caaaatggcc
     2401 tttctcagta gtactccaga gcctgctgtg actttgtgta ctgtgctaca ttttttttta
     2461 gtgatctttt taaaaacatg ttcaagaaat gctctttctt aaagtcgtct cactccacag
     2521 ttcgctgctt taaagtggcc atgctttccc ctacgctgtg ctgacactta aaataaatgc
     2581 cagctttatg gaaccattct gactcatggc agctcccttt gaaaacttac caatacttca
     2641 cctagcacgg gggtcaggga gagcttgaca gtggtccccg tggctcaggg agatgccgtg
     2701 gccacagctt tcaccccatt gctaatcagg gtgtgagcac cctttatatg caaactgggt
     2761 ggtggtctgt ctggttccag tgggaggtac catctcttct cctttgagaa atgcccctgc
     2821 agtgtctccg tgggtggggt ggggttgagc tttgacgatt ccagagaaga ggtctctgtt
     2881 cttctgtgag gggccaagcg agggctcctg ggtcagagct gtactcacag cagagggtgt
     2941 gcagacaggc cttagtgggt gtgaggtgcc cacgattggg tgtttattct ctttggcttc
     3001 ctaaattgcc tcttggttgc tcttgccgtc tctggatatc caaggaaagt ctgtctaggt
     3061 tttggcaagg gtagaattgt tttcctttat agagagacac agttttgtca aggaagtgaa
     3121 aacggattcg agattggcag atggacagaa gctttaaaaa ggaagagccc acagcaagca
     3181 ctctgaccct gagccgagat catggcttac agtcttgaaa tgtgaactgt gatgtctcca
     3241 tgcggctgat gcaggccatg ggccgacatc tacagagtgg ctcctccctc gctcttgctt
     3301 agcctccgat ctgtataagc cctccacctt ggagccggga ttttgagtgg agtctgccta
     3361 ttttccagtg gatactaaga aactattaaa cagtgggaag cctggctgtt ttaagtaccg
     3421 tcgcttcctt tttgatatag atacagactt tgaatacaat gcagtttcct cagtaacatt
     3481 agctttcgta gcagtttata ccataagatg ttctgactgg tttgtacact aggtgggtca
     3541 gctagtagaa tttaggcatt tatacttttc ctgagttata ctcccagaac ctcctcagag
     3601 ttgcatgtag atagcattta tttctgcata tttaaaaaaa aaaaaaccca tttaggaaat
     3661 atctacaaag aagaaatgaa aaatagtaat tattttttca tgaagatttt ggtccacacc
     3721 tcattgagtt gtaatggatt ctccagtttc ttgagttggc aataatcaac atttggtttg
     3781 gagagcgagc atgagagagc gtttgttagt gaaactcaca gacttctaaa agttcattgc
     3841 tacagttatc aaagtggggg aaactaaaat taccttatca aggaaaaaat attaagtcac
     3901 aagccatata catttagctc ccaagccata atgccgaaca gctttggagt atcgtacaga
     3961 aagctcatta caaaatgctt gcgttttctt ttctctggaa catcaacacc agtgtattgc
     4021 tggcagctat tgtattaaaa aaataaatat attttcacta tcaaa
//
