LOCUS       NM_033444               1159 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus chloride intracellular channel 1 (Clic1), mRNA.
ACCESSION   NM_033444
VERSION     NM_033444.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Ko,M., Jung,H.Y., Lee,D., Jeon,J., Kim,J., Baek,S., Lee,J.Y.,
            Kim,J.Y. and Kwon,H.J.
  TITLE     Inhibition of chloride intracellular channel protein 1 (CLIC1)
            ameliorates liver fibrosis phenotype by activating the
            Ca2+-dependent Nrf2 pathway
  JOURNAL   Biomed Pharmacother 168, 115776 (2023)
   PUBMED   37924785
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Zapata,R.C., Zhang,D., Yoon,D., Nasamran,C.A., Chilin-Fuentes,D.R.,
            Libster,A., Chaudry,B.S., Lopez-Valencia,M., Ponnalagu,D.,
            Singh,H., Petrascheck,M. and Osborn,O.
  TITLE     Targeting Clic1 for the treatment of obesity: A novel therapeutic
            strategy to reduce food intake and body weight
  JOURNAL   Mol Metab 76, 101794 (2023)
   PUBMED   37604246
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Mao,Y., Kleinjan,M.L., Jilishitz,I., Swaminathan,B., Obinata,H.,
            Komarova,Y.A., Bayless,K.J., Hla,T. and Kitajewski,J.K.
  TITLE     CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to
            facilitate Rac1 and RhoA activity and function
  JOURNAL   Sci Signal 14 (679) (2021)
   PUBMED   33879602
  REMARK    GeneRIF: CLIC1 and CLIC4 mediate endothelial S1P receptor signaling
            to facilitate Rac1 and RhoA activity and function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Chalothorn,D., Zhang,H., Smith,J.E., Edwards,J.C. and Faber,J.E.
  TITLE     Chloride intracellular channel-4 is a determinant of native
            collateral formation in skeletal muscle and brain
  JOURNAL   Circ Res 105 (1), 89-98 (2009)
   PUBMED   19478202
  REMARK    GeneRIF: Ischemia augmented CLIC1 and CLIC4 expression similarly in
            wild-type mice. However, CLIC1 increased 3-fold more in Clic4(-/-)
            mice, suggesting compensation.
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Cui,X.S., Li,X.Y., Shen,X.H., Bae,Y.J., Kang,J.J. and Kim,N.H.
  TITLE     Transcription profile in mouse four-cell, morula, and blastocyst:
            Genes implicated in compaction and blastocoel formation
  JOURNAL   Mol Reprod Dev 74 (2), 133-143 (2007)
   PUBMED   16998848
  REMARK    Review article
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC087117.9.
            
            On Nov 17, 2006 this sequence version replaced NM_033444.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004658.1, AK150382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC087117.9         158860-159103
            245-354             AC087117.9         161052-161161
            355-480             AC087117.9         161398-161523
            481-587             AC087117.9         161650-161756
            588-769             AC087117.9         163844-164025
            770-1159            AC087117.9         166947-167336
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.58 cM"
     gene            1..1159
                     /gene="Clic1"
                     /gene_synonym="Clcp; G6"
                     /note="chloride intracellular channel 1"
                     /db_xref="GeneID:114584"
                     /db_xref="MGI:MGI:2148924"
     exon            1..244
                     /gene="Clic1"
                     /gene_synonym="Clcp; G6"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..931
                     /gene="Clic1"
                     /gene_synonym="Clcp; G6"
                     /EC_number="1.8.5.1"
                     /note="NCC27; nuclear chloride ion channel 27;
                     glutaredoxin-like oxidoreductase CLIC1;
                     glutathione-dependent dehydroascorbate reductase CLIC1"
                     /codon_start=1
                     /product="chloride intracellular channel protein 1"
                     /protein_id="NP_254279.1"
                     /db_xref="CCDS:CCDS28675.1"
                     /db_xref="GeneID:114584"
                     /db_xref="MGI:MGI:2148924"
                     /translation="MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVT
                     TVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAMLCPPRYPKLAALNPE
                     SNTSGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDE
                     GISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREE
                     FASTCPDDEEIELAYEQVARALK"
     exon            245..354
                     /gene="Clic1"
                     /gene_synonym="Clcp; G6"
                     /inference="alignment:Splign:2.1.0"
     exon            355..480
                     /gene="Clic1"
                     /gene_synonym="Clcp; G6"
                     /inference="alignment:Splign:2.1.0"
     exon            481..587
                     /gene="Clic1"
                     /gene_synonym="Clcp; G6"
                     /inference="alignment:Splign:2.1.0"
     exon            588..769
                     /gene="Clic1"
                     /gene_synonym="Clcp; G6"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1159
                     /gene="Clic1"
                     /gene_synonym="Clcp; G6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggagcag ctgggtgtgg ggtgcactgg gcctgtgggg aagccgtgtt ggagcgaact
       61 aaagggtctg atcggacttg ggttgcgccg aagggacagc cctgagtctg gaggagagaa
      121 tcccggaccg tgagacccgc cttcccttgc cccggcccct cccagttccc ccagcgacgg
      181 ctgcttcctg gtccccgacg caaccatggc tgaagaacaa cctcaggtcg aactgttcgt
      241 gaaggctggc agtgatggtg ccaagattgg gaactgcccc ttctcccaga gactgttcat
      301 ggtgctctgg ctcaagggag tcaccttcaa cgttaccact gtggacacca agagacggac
      361 agagactgta cagaagctct gccccggtgg gcagctgccg ttcttgctct atggcaccga
      421 agtgcacaca gacaccaaca agatcgagga attcctggag gccatgctgt gccctcccag
      481 gtacccaaag ctggctgccc tgaaccctga gtccaacacc tcgggactgg acatatttgc
      541 aaagttttct gcctacatca agaactcaaa cccagccctc aatgacaacc tagagaaggg
      601 actcctgaaa gccctgaagg ttctagacaa ttacctgaca tcccccctcc cagaagaagt
      661 ggatgaaacc agcgccgaag atgagggcat ctctcagagg aagtttctgg acggcaatga
      721 gctcaccctg gctgactgca acctgctgcc aaagcttcac atagtacagg tggtgtgcaa
      781 aaagtacaga ggcttcacca tcccagaggc attccgtgga gtgcatcggt acttgagcaa
      841 cgcttatgcc cgggaagaat ttgcctccac ctgtccagat gatgaagaga tagagctagc
      901 ctatgagcaa gtggccaggg ctctcaaatg agcacttttt aaagggtcct tcacccactc
      961 tgtgctctcc acagaggctt cggggggctt ccacgttgct gcataatgga cacactccga
     1021 aattgccagt gggcaggaaa tccggggcac ttgtggggtg gggctgtggg ataaggcaaa
     1081 ggatagtgga caagggtaag atttttattt tgggatgggg tgggtaggac aacgcatttc
     1141 agtaataaaa tacagaatg
//
