LOCUS       NM_001309637            2150 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus C-type lectin domain family 7, member a (Clec7a),
            transcript variant 2, mRNA.
ACCESSION   NM_001309637
VERSION     NM_001309637.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2150)
  AUTHORS   Murphy,B., Miyamoto,T., Manning,B.S., Mirji,G., Ugolini,A.,
            Kannan,T., Hamada,K., Zhu,Y.P., Claiborne,D.T., Huang,L., Zhang,R.,
            Nefedova,Y., Kossenkov,A., Veglia,F., Shinde,R. and Zhang,N.
  TITLE     Myeloid activation clears ascites and reveals IL27-dependent
            regression of metastatic ovarian cancer
  JOURNAL   J Exp Med 221 (12) (2024)
   PUBMED   39570374
REFERENCE   2  (bases 1 to 2150)
  AUTHORS   Zheng,H.N., Zhi,Y.R., Su,Y.S., Jiang,J.Y., Zhang,H.Z., Cao,F.,
            Wang,Y., Chi,Y. and Zhang,Y.
  TITLE     Dectin-1 induces TRPV1 sensitization and contributes to visceral
            hypersensitivity of irritable bowel syndrome in male mice
  JOURNAL   Eur J Pain 28 (10), 1811-1826 (2024)
   PUBMED   38953581
  REMARK    GeneRIF: Dectin-1 induces TRPV1 sensitization and contributes to
            visceral hypersensitivity of irritable bowel syndrome in male mice.
REFERENCE   3  (bases 1 to 2150)
  AUTHORS   Guibo,L., Chunxu,D., Biao,C., Zhaolei,H., Wenwen,L., Xiangnan,J.,
            Wentao,P., Hongmin,C., Yonghua,L. and Guoqiang,Z.
  TITLE     Dectin-1 participates in the immune-inflammatory response to mouse
            Aspergillus fumigatus keratitis by modulating macrophage
            polarization
  JOURNAL   Front Immunol 15, 1431633 (2024)
   PUBMED   39478855
  REMARK    GeneRIF: Dectin-1 participates in the immune-inflammatory response
            to mouse Aspergillus fumigatus keratitis by modulating macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2150)
  AUTHORS   Torigoe,S., Lowman,D.W., Sugiki,T., Williams,D.L. and Yamasaki,S.
  TITLE     Self-recognition through Dectin-1 exacerbates liver inflammation
  JOURNAL   Genes Cells 29 (4), 316-327 (2024)
   PUBMED   38385597
  REMARK    GeneRIF: Self-recognition through Dectin-1 exacerbates liver
            inflammation.
REFERENCE   5  (bases 1 to 2150)
  AUTHORS   Cai,R., Gong,X., Li,X., Jiang,Y., Deng,S., Tang,J., Ge,H., Wu,C.,
            Tang,H., Wang,G., Xie,L., Chen,X., Hu,X. and Feng,J.
  TITLE     Dectin-1 aggravates neutrophil inflammation through
            caspase-11/4-mediated macrophage pyroptosis in asthma
  JOURNAL   Respir Res 25 (1), 119 (2024)
   PUBMED   38459541
  REMARK    GeneRIF: Dectin-1 aggravates neutrophil inflammation through
            caspase-11/4-mediated macrophage pyroptosis in asthma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2150)
  AUTHORS   Brown,G.D., Taylor,P.R., Reid,D.M., Willment,J.A., Williams,D.L.,
            Martinez-Pomares,L., Wong,S.Y. and Gordon,S.
  TITLE     Dectin-1 is a major beta-glucan receptor on macrophages
  JOURNAL   J Exp Med 196 (3), 407-412 (2002)
   PUBMED   12163569
REFERENCE   7  (bases 1 to 2150)
  AUTHORS   Brown,G.D. and Gordon,S.
  TITLE     Immune recognition. A new receptor for beta-glucans
  JOURNAL   Nature 413 (6851), 36-37 (2001)
   PUBMED   11544516
REFERENCE   8  (bases 1 to 2150)
  AUTHORS   Yokota,K., Takashima,A., Bergstresser,P.R. and Ariizumi,K.
  TITLE     Identification of a human homologue of the dendritic
            cell-associated C-type lectin-1, dectin-1
  JOURNAL   Gene 272 (1-2), 51-60 (2001)
   PUBMED   11470510
REFERENCE   9  (bases 1 to 2150)
  AUTHORS   Hermanz-Falcon,P., Arce,I., Roda-Navarro,P. and Fernandez-Ruiz,E.
  TITLE     Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene
            expressed on dendritic cells
  JOURNAL   Immunogenetics 53 (4), 288-295 (2001)
   PUBMED   11491532
  REMARK    Erratum:[Immunogenetics 2001 Aug;53(6):518]
REFERENCE   10 (bases 1 to 2150)
  AUTHORS   Ariizumi,K., Shen,G.L., Shikano,S., Xu,S., Ritter,R. 3rd,
            Kumamoto,T., Edelbaum,D., Morita,A., Bergstresser,P.R. and
            Takashima,A.
  TITLE     Identification of a novel, dendritic cell-associated molecule,
            dectin-1, by subtractive cDNA cloning
  JOURNAL   J Biol Chem 275 (26), 20157-20167 (2000)
   PUBMED   10779524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138620.4, BY750022.1 and AA240643.1.
            
            On Jan 28, 2019 this sequence version replaced NM_001309637.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The encoded
            isoform (2) is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.84174.1, BE306741.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC138620.4         203538-203543       c
            7-30                BY750022.1         3-26
            31-489              AA240643.1         1-459
            490-573             AC138620.4         196213-196296       c
            574-2150            AC138620.4         192349-193925       c
FEATURES             Location/Qualifiers
     source          1..2150
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.34 cM"
     gene            1..2150
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /note="C-type lectin domain family 7, member a"
                     /db_xref="GeneID:56644"
                     /db_xref="MGI:MGI:1861431"
     exon            1..203
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..700
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     C-type (calcium dependent, carbohydrate recognition
                     domain) lectin, superfamily member 12; dectin-1;
                     DC-associated C-type lectin 1; C-type lectin superfamily
                     member 12; dendritic cell-associated C-type lectin 1;
                     beta-glucan receptor"
                     /codon_start=1
                     /product="C-type lectin domain family 7 member A isoform
                     2"
                     /protein_id="NP_001296566.1"
                     /db_xref="CCDS:CCDS85170.1"
                     /db_xref="GeneID:56644"
                     /db_xref="MGI:MGI:1861431"
                     /translation="MKYHSHIENLDEDGYTQLDFSTQDIHKRPRGSEKGSQAPSSPWR
                     PIAVGLGILCFVVVVVAAVLGALGGFSQPCLPNWIMHGKSCYLFSFSGNSWYGSKRHC
                     SQLGAHLLKIDNSKEFEFIESQTSSHRINAFWIGLSRNQSEGPWFWEDGSAFFPNSFQ
                     VRNTAPQESLLHNCVWIHGSEVYNQICNTSSYSICEKEL"
     exon            204..302
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            303..454
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            455..573
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            574..2150
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2127..2132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /note="hexamer: ATTAAA"
     polyA_site      2150
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /note="major polyA site"
ORIGIN      
        1 aagggctgtt tcagggtttg ggttagtgag cctcatcctg gcagttattt tatagtaaag
       61 aacattcaag tgctctgcct acctagggcc ctgtgaagca atgaaatatc actctcatat
      121 agagaatctg gatgaagatg gatatactca attagacttc agcactcaag acatccataa
      181 aaggcccagg ggatcagaga aaggaagcca ggctccatct tcaccttgga ggcccattgc
      241 agtgggttta ggaatcctgt gctttgtggt agtagtggtt gctgcagtgc tgggtgccct
      301 aggaggtttt tctcagcctt gccttcctaa ttggatcatg catgggaaga gctgttacct
      361 atttagcttc tcaggaaatt cctggtatgg aagtaagaga cactgctccc agctaggtgc
      421 tcatctactg aagatagaca actcaaaaga atttgagttc attgaaagcc aaacatcgtc
      481 tcaccgtatt aatgcatttt ggataggcct ttcccgcaat cagagtgaag ggccatggtt
      541 ctgggaggat ggatcagcat tcttccccaa ctcgtttcaa gtcagaaata cagctcccca
      601 ggaaagctta ctgcacaatt gtgtatggat tcatggatca gaggtctaca accaaatctg
      661 caatacttct tcatacagta tctgtgagaa ggaactgtaa atgtatgtga gaatataaag
      721 atggtgtgtg tgtgtgtgtg tgtgtgtgtg tacatgcaca cacaccacca ccaccaccac
      781 taccaacaac agaacagaac agaacagaac agaacagatt aatattaaaa aacagaaaaa
      841 atgctgggat gctaagagac tttaacctca tttgagaact tggatgaaga agctgagact
      901 tttgtacttg tcatcttcac aaagatggtg gcactatctt ccagttagga agtcactaga
      961 catggagtga gggcagctca acaatacaga gaatatgtga acctgaggta ccctgactca
     1021 aatttcacaa ccacaatgaa acccctacac tatcaggaaa cactgtagag gagtgagact
     1081 gaagacttta aaagccagag aatcagccta cttactgtgg tgttttctag acaggacagg
     1141 gaaagtatat ctaggaaata aaaacaatac aattcagcaa acaaaatctg cataatgaca
     1201 acctcagttg gtatggtatg ttatggtatg gtatgggtgt agaagtttca caaggcccta
     1261 tgaagaacta cagacagtta aataggggga aagctttttc taggatcaag cctactgaac
     1321 cccaagaagt cagcactgaa catatgtaca gatcagtatc attaaatgaa ctagtaagac
     1381 atatacatat atgttaatca aatattggta ccagagtaca cactgtgttt gcatgatttt
     1441 ctcagtatct acagtacacc agacacaggg agaaggcaaa atgaacttct aaattgagaa
     1501 gtgaaaaaaa tgagggaaga gaatcttcac cacaaatagg gattctattt tcacccacat
     1561 gatcattatt aagatggcca tcacccaaac gtcgtgaccc aagctacttc ctcaactaga
     1621 taactcaaag agtctgccca ccttttctga tagcaaatct ggtatctaga tttcactgtt
     1681 tccttatgct gtctggccag cagtatgaca aaggtgctgc cctttcagga agcagtctcc
     1741 ttaaatgctg tagttggaaa gataaatcat atctgatagt gaatatttaa aaagcgccca
     1801 gtcaggataa gtgttttgga acacagaaca tatttcatct ttttatgata cactatcttg
     1861 caattaacaa ccaattctta agtcatttct ttacaaacat atgactggaa tatgactgtt
     1921 tcctagtgtg atctgtcttg ttaacttcta agattgtcca ttaataccac ccttatttcc
     1981 agtgtggact tccaaattgc tggggatctg tttatagctt tctcagacta atcaatatgt
     2041 gggcagaaat tgtgctgagt ccactgaatt gttctcttga aaatgattgg gtttatgtca
     2101 ctttcatctc aattgaaaaa ctgcttatta aagtatcttt ggcctctgaa
//
