LOCUS       NM_001038604            3820 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus C-type lectin domain family 5, member a (Clec5a),
            transcript variant 1, mRNA.
ACCESSION   NM_001038604
VERSION     NM_001038604.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3820)
  AUTHORS   Lin,Y.Y., Chang,W.H., Hsieh,S.L. and Cheng,I.H.
  TITLE     The deficient CLEC5A ameliorates the behavioral and pathological
            deficits via the microglial Abeta clearance in Alzheimer's disease
            mouse model
  JOURNAL   J Neuroinflammation 21 (1), 273 (2024)
   PUBMED   39443966
  REMARK    GeneRIF: The deficient CLEC5A ameliorates the behavioral and
            pathological deficits via the microglial Abeta clearance in
            Alzheimer's disease mouse model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3820)
  AUTHORS   Li,Q., Liu,Y., Wang,X., Xie,C., Mei,X., Cao,W., Guan,W., Lin,X.,
            Xie,X., Zhou,C. and Yi,E.
  TITLE     The influence of CLEC5A on early macrophage-mediated inflammation
            in COPD progression
  JOURNAL   Cell Mol Life Sci 81 (1), 330 (2024)
   PUBMED   39097839
  REMARK    GeneRIF: The influence of CLEC5A on early macrophage-mediated
            inflammation in COPD progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3820)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3820)
  AUTHORS   Wang,H.W., Li,H.H., Wu,S.C., Tang,C.K., Yu,H.Y., Chang,Y.C.,
            Sung,P.S., Liu,W.L., Su,M.P., Yu,G.Y., Huang,L.R., Chen,C.H. and
            Hsieh,S.L.
  TITLE     CLEC5A mediates Zika virus-induced testicular damage
  JOURNAL   J Biomed Sci 30 (1), 12 (2023)
   PUBMED   36803804
  REMARK    GeneRIF: CLEC5A mediates Zika virus-induced testicular damage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3820)
  AUTHORS   Sung,P.S., Peng,Y.C., Yang,S.P., Chiu,C.H. and Hsieh,S.L.
  TITLE     CLEC5A is critical in Pseudomonas aeruginosa-induced NET formation
            and acute lung injury
  JOURNAL   JCI Insight 7 (18), e156613 (2022)
   PUBMED   36048544
  REMARK    GeneRIF: CLEC5A is critical in Pseudomonas aeruginosa-induced NET
            formation and acute lung injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3820)
  AUTHORS   Aoki,N., Kimura,Y., Kimura,S., Nagato,T., Azumi,M., Kobayashi,H.,
            Sato,K. and Tateno,M.
  TITLE     Expression and functional role of MDL-1 (CLEC5A) in mouse myeloid
            lineage cells
  JOURNAL   J Leukoc Biol 85 (3), 508-517 (2009)
   PUBMED   19074552
  REMARK    GeneRIF: MDL-1 plays an important role in immune defense as a
            result of an innate immunity, which involves neutrophils and
            macrophages
REFERENCE   7  (bases 1 to 3820)
  AUTHORS   Chen,S.T., Lin,Y.L., Huang,M.T., Wu,M.F., Cheng,S.C., Lei,H.Y.,
            Lee,C.K., Chiou,T.W., Wong,C.H. and Hsieh,S.L.
  TITLE     CLEC5A is critical for dengue-virus-induced lethal disease
  JOURNAL   Nature 453 (7195), 672-676 (2008)
   PUBMED   18496526
REFERENCE   8  (bases 1 to 3820)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 3820)
  AUTHORS   Yim,D., Jie,H.B., Sotiriadis,J., Kim,Y.S. and Kim,Y.B.
  TITLE     Molecular cloning and expression pattern of porcine myeloid
            DAP12-associating lectin-1
  JOURNAL   Cell Immunol 209 (1), 42-48 (2001)
   PUBMED   11414735
REFERENCE   10 (bases 1 to 3820)
  AUTHORS   Bakker,A.B., Baker,E., Sutherland,G.R., Phillips,J.H. and
            Lanier,L.L.
  TITLE     Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor
            involved in the activation of myeloid cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9792-9796 (1999)
   PUBMED   10449773
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BY205833.1,
            CN670295.1, AK137482.1 and AK036697.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104364.1, AA186015.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY205833.1         17-54
            39-552              CN670295.1         1-514
            553-3163            AK137482.1         479-3089
            3164-3820           AK036697.1         3062-3718
FEATURES             Location/Qualifiers
     source          1..3820
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.82 cM"
     gene            1..3820
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /note="C-type lectin domain family 5, member a"
                     /db_xref="GeneID:23845"
                     /db_xref="MGI:MGI:1345151"
     exon            1..159
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..258
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..752
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     C-type (calcium dependent, carbohydrate-recognition
                     domain) lectin, superfamily member 5; type II
                     transmembrane protein MDL-1; C-type lectin superfamily
                     member 5; myeloid DAP12-associating lectin 1"
                     /codon_start=1
                     /product="C-type lectin domain family 5 member A isoform
                     1"
                     /protein_id="NP_001033693.1"
                     /db_xref="CCDS:CCDS20036.1"
                     /db_xref="GeneID:23845"
                     /db_xref="MGI:MGI:1345151"
                     /translation="MNWHMIISGLIVVVIKVVGMTFFLLYFPQVFGKSNDGFVPTESY
                     GTTSVQNVSQIFGRNDESTMPTRSYGTVCPRNWDFHQGKCFFFSFSESPWKDSMDYCA
                     TQGSTLAIVNTPEKLKYLQDIAGIENYFIGLVRQPGEKKWRWINNSVFNGNVTNQDQN
                     FDCVTIGLTKTYDAASCEVSYRWICEMNAK"
     exon            259..333
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..393
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..530
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..637
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..3820
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /note="hexamer: AATAAA"
     polyA_site      1855
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /note="major polyA site"
     regulatory      1936..1941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
                     /note="hexamer: ATTAAA"
     polyA_site      1960
                     /gene="Clec5a"
                     /gene_synonym="Clecsf5; Ly100; MDL-1; Mdl1"
ORIGIN      
        1 tttgcttgga gatgctgcta aaacagagag gctgtgaaca aggacattac cgagcaggag
       61 catacattca gaagacaagg agccctgctc gctgcaccga atatcttatc aaaaagactc
      121 ctatctgtat gccaacccag acttccagaa agagatcaga tccctgaatc cccatcatca
      181 tgaactggca catgatcatc tcggggctta tcgtagtagt gatcaaagtt gttggaatga
      241 ccttttttct gctgtatttc ccacaggttt ttggcaaaag taatgatggc ttcgtcccca
      301 cggagagcta cggaaccact agtgtgcaga atgtctcaca gatctttggg agaaatgacg
      361 aaagtaccat gcctacaagg agctatggaa cagtctgtcc cagaaactgg gattttcacc
      421 aaggaaaatg ctttttcttc tccttctccg aatcaccttg gaaagacagc atggattatt
      481 gtgcaacaca aggatccaca ctggcaattg tcaacactcc agagaaactg aagtatcttc
      541 aggacatagc tggtattgag aattacttta ttggtttggt acgtcagcct ggagagaaaa
      601 agtggcgctg gatcaacaac tctgtgttca atggcaatgt taccaatcag gaccagaact
      661 tcgactgtgt cactataggt ctgacgaaga catatgatgc tgcatcatgt gaagtcagct
      721 atcgctggat ctgcgaaatg aatgccaaat gatcatagat ctctacaaga gtgaattttt
      781 acagagctag caaaggagat tagttgtgac tgaaaccagc ccaggaaata tagagcatca
      841 aagactgtgc ccatcttcca taggtggagt tccctattga atcctcaaag tcaatttgtt
      901 actccacaaa catcttcaca tagtaaaact ccctttctga ccaagtattc cctaagacca
      961 cacttcctgt gagaggggac tggattctag ttatctgcag acagagccag gattctggag
     1021 atgaaatcaa tatggaaatg cagtctgttt ctgtagagct gagcctttta actaatcagt
     1081 agggttttgt ctgttgtcag aactgtttga tccttagaga acatgcccac gccactgagg
     1141 agaaactgct cgtggaacag atatgagaac tgttaggaag cactatgggc agaagaatat
     1201 aaacttggct tcacaacatc ccccattcca gaaagcctcc cattcccata caacatcgta
     1261 gaagcagagg tccttctgaa ttggggaagg acctctacag ctcgacttgg tactgaacaa
     1321 atattgaggg aatgaagaaa gttctgaata ggacagagat aaacaaggag gagaaggaaa
     1381 gagataggaa gaaaggagaa gtgggaagga gggggaaaag gaatgatggg caggagaaaa
     1441 agagacagga ggagccagga aaaacactca agctaaattt ttttcaggtt ttggataaaa
     1501 tctattgtga cataaataat atcttttcat tagaagagaa aaggcaaaat tggggacaaa
     1561 tgggcaccat gagagatgaa gcagaggtta atttgatcac aaggaaagaa aggcaggaat
     1621 gaggttgaaa actttttgga taccttggct gttatctcaa gaaggtacaa gctgcataaa
     1681 gtataggaga aaagagatgt gctggttgtt ttaagtagca aaaattaaac tacagagaag
     1741 cctatagaaa gctaaaggaa ttaaaaccat ccaataatca attcattatt ttcaactaat
     1801 agcaatatgt atgtgcatta ctagtcaaaa taaattgtga attctgttat tataatacta
     1861 agttatttta tagtttctag gtttcatatt tcgtgtatta gcagatttat attttaatag
     1921 gacaatgtac ttcctattaa aacctgtttg aagaaggtca tcagaaatga tctagtagat
     1981 actggaatta catttgtacc caatgagcta tgtgttctct gatagtctta atacatcaaa
     2041 gctgggacaa ggtgggcaga atctatggta gggagaagca attgtgttct aaccagaggt
     2101 cagacccata actcagacaa cagaaaggaa atcttggtcc tttttgagaa aggggaactt
     2161 tcattgccac acttcctatc tttggacaga agagttgcag actcctgggg tcaggaaatg
     2221 aggacatcta gtgatttctg tggttgaagt ctgaatctcc cacaagatga gaagttactc
     2281 atgtacaggt tcttaaagaa gcctgcacag gggctggcat gagaaaaaga atattcaggg
     2341 actctgtgta tattgtttca attactaggg aagggactcg tgaagggtaa ataaatgtgg
     2401 cctttgttag ggagcagtga tatgagtttt aagatggaat taataagaca tttgggttgg
     2461 agttttgacc taagttctaa gatactttcc cttacacatc aggcacacta ggtatagtct
     2521 ttatagcttc attagaatat aagtaacatg tccgaaaatt tttgacaacc aggaatagcc
     2581 actaaattac ccatttgaaa tgtacagctc aataggtttg gtacattcac agtagtttac
     2641 agccgtcccc taaaaaagaa atcctgatct acttcccgtc tctacagagt tccttctgct
     2701 ggctgtcata tgaatagaat catacaatgt atgtccttct ttactacttc ctctgcttag
     2761 aataagattt tcaagattca cccatgaatt tcagcatatc gcagtttccc agtctgtatc
     2821 ttgagtgtcc cccgtagatc aaaggctcat tccctaggat tgtgatattg gaatgtggta
     2881 gagcctggaa ctcctggaat tgatttaggt ccctgagagt gtggtctctc tgagggcagt
     2941 actatcctca gccctttcat tttgctccca agccaggagc ggttgtcctc tattgtatgc
     3001 ttttaacata aagtgtggcc aactaattag ggattgaaat ctctaaaacc ttttgataag
     3061 ctatgtatct caggcatgtg ttacagtggt acaaagcttg ttatttgtac atacaatctg
     3121 tatttcattc tatggatgaa tactattcca tttgtttatt ccttcaatgg ctgattggta
     3181 ttttagcttt gtacctgtca actattataa ctcctacaaa catccatttc tcaagcatac
     3241 acctaggagt gagactgcta attcatcttg ttatctgata cattatgtaa agaactttct
     3301 gtcttcaaaa gctactgaac cattgcacct tccatcggga atatgtatgg actctaatat
     3361 ttgccatacc cttgccaata tgcactgtta cctaactgcc ttgctttatg ctaatgtgtt
     3421 cctatggtga ttttgatgtt tatttcatct ccattcttta tcatctttct tgtactttga
     3481 gtaacctctt ctgctgagaa tgatgttttt ctttctattg gacattttaa cttaagatgt
     3541 aaggaaagga tatggttata tcaacacatc ttattttgtt aatagtcttg agctctcagc
     3601 ctctttgtaa aaatctagaa atacctccat aattgtgtct taaggcatgc tgaagatgaa
     3661 actcagcact ttctacatac tacctttcta gcaataagtt atagtgtcct tcctttgttt
     3721 tgtggttttt tttttttttg gtgtgggttt ttttagtaaa ttttattatt aaaaggttgc
     3781 atataaaaaa ctttgcatat aaataaaaac atcacacacc
//
