LOCUS       NM_020001               1245 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus C-type lectin domain family 4, member n (Clec4n),
            transcript variant 1, mRNA.
ACCESSION   NM_020001
VERSION     NM_020001.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Kanj,A.N., Guiance,I.R., Kottom,T.J., Schaefbauer,K.J.,
            Choudhury,M., Limper,A.H. and Skalski,J.H.
  TITLE     The intestinal commensal fungus Wallemia mellicola enhances asthma
            in mice through Dectin-2
  JOURNAL   Med Mycol 62 (2) (2024)
   PUBMED   38331424
  REMARK    GeneRIF: The intestinal commensal fungus Wallemia mellicola
            enhances asthma in mice through Dectin-2.
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Muraosa,Y., Hino,Y., Takatsuka,S., Watanabe,A., Sakaida,E.,
            Saijo,S., Miyazaki,Y., Yamasaki,S. and Kamei,K.
  TITLE     Fungal chitin-binding glycoprotein induces Dectin-2-mediated
            allergic airway inflammation synergistically with chitin
  JOURNAL   PLoS Pathog 20 (1), e1011878 (2024)
   PUBMED   38170734
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Fujita,M., Miyazawa,T., Uchida,K., Uchida,N., Haji,S., Yano,S.,
            Iwahashi,N., Hatayama,T., Katsuhara,S., Nakamura,S., Takeichi,Y.,
            Yokomoto-Umakoshi,M., Miyachi,Y., Sakamoto,R., Iwakura,Y. and
            Ogawa,Y.
  TITLE     Dectin-2 Deficiency Promotes Proinflammatory Cytokine Release From
            Macrophages and Impairs Insulin Secretion
  JOURNAL   Endocrinology 165 (1) (2023)
   PUBMED   38038367
  REMARK    GeneRIF: Dectin-2 Deficiency Promotes Proinflammatory Cytokine
            Release From Macrophages and Impairs Insulin Secretion.
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   Cardoso-Miguel,M.R.D., Burgel,P.H., de Castro,R.J.A., Marina,C.L.,
            de Oliveira,S.A., Albuquerque,P., Silva-Pereira,I., Bocca,A.L. and
            Tavares,A.H.
  TITLE     Dectin-2 is critical for phagocyte function and resistance to
            Paracoccidioides brasiliensis in mice
  JOURNAL   Med Mycol 61 (11) (2023)
   PUBMED   37960963
  REMARK    GeneRIF: Dectin-2 is critical for phagocyte function and resistance
            to Paracoccidioides brasiliensis in mice.
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Guerrero-Juarez,C.F., Schilf,P., Li,J., Zappia,M.P., Bao,L.,
            Patel,P.M., Gieseler-Tillmann,J., Murthy,S., Cole,C., Sverdlov,M.,
            Frolov,M.V., Hashimoto,T., Ishii,N., Rulicke,T., Bieber,K.,
            Ludwig,R.J., Sadik,C.D. and Amber,K.T.
  TITLE     C-type lectin receptor expression is a hallmark of neutrophils
            infiltrating the skin in epidermolysis bullosa acquisita
  JOURNAL   Front Immunol 14, 1266359 (2023)
   PUBMED   37799716
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   Bonkobara,M., Zukas,P.K., Shikano,S., Nakamura,S., Cruz,P.D. Jr.
            and Ariizumi,K.
  TITLE     Epidermal Langerhans cell-targeted gene expression by a dectin-2
            promoter
  JOURNAL   J Immunol 167 (12), 6893-6900 (2001)
   PUBMED   11739507
REFERENCE   7  (bases 1 to 1245)
  AUTHORS   Brown,M.G., Scalzo,A.A., Stone,L.R., Clark,P.Y., Du,Y., Palanca,B.
            and Yokoyama,W.M.
  TITLE     Natural killer gene complex (Nkc) allelic variability in inbred
            mice: evidence for Nkc haplotypes
  JOURNAL   Immunogenetics 53 (7), 584-591 (2001)
   PUBMED   11685471
REFERENCE   8  (bases 1 to 1245)
  AUTHORS   Carnaud,C., Gombert,J., Donnars,O., Garchon,H. and Herbelin,A.
  TITLE     Protection against diabetes and improved NK/NKT cell performance in
            NOD.NK1.1 mice congenic at the NK complex
  JOURNAL   J Immunol 166 (4), 2404-2411 (2001)
   PUBMED   11160299
REFERENCE   9  (bases 1 to 1245)
  AUTHORS   Ariizumi,K., Shen,G.L., Shikano,S., Ritter,R. 3rd, Zukas,P.,
            Edelbaum,D., Morita,A. and Takashima,A.
  TITLE     Cloning of a second dendritic cell-associated C-type lectin
            (dectin-2) and its alternatively spliced isoforms
  JOURNAL   J Biol Chem 275 (16), 11957-11963 (2000)
   PUBMED   10766825
REFERENCE   10 (bases 1 to 1245)
  AUTHORS   Fernandes,M.J., Finnegan,A.A., Siracusa,L.D., Brenner,C.,
            Iscove,N.N. and Calabretta,B.
  TITLE     Characterization of a novel receptor that maps near the natural
            killer gene complex: demonstration of carbohydrate binding and
            expression in hematopoietic cells
  JOURNAL   Cancer Res 59 (11), 2709-2717 (1999)
   PUBMED   10363996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164111.4 and AK131697.1.
            
            On Jun 16, 2010 this sequence version replaced NM_020001.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023008.1, AF240357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC164111.4         156852-156865
            15-1240             AK131697.1         2-1227
            1241-1245           AC164111.4         174029-174033
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 58.3 cM"
     gene            1..1245
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /note="C-type lectin domain family 4, member n"
                     /db_xref="GeneID:56620"
                     /db_xref="MGI:MGI:1861231"
     exon            1..201
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..806
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     C-type (calcium dependent, carbohydrate recognition
                     domain) lectin, superfamily member 10; dectin-2; C-type
                     lectin domain family 6 member A; DC-associated C-type
                     lectin 2; C-type lectin superfamily member 10; dendritic
                     cell-associated C-type lectin 2; natural killer complex
                     lectin"
                     /codon_start=1
                     /product="C-type lectin domain family 6 member A isoform
                     1"
                     /protein_id="NP_064385.1"
                     /db_xref="CCDS:CCDS20512.1"
                     /db_xref="GeneID:56620"
                     /db_xref="MGI:MGI:1861231"
                     /translation="MVQERQSQGKGVCWTLRLWSAAVISMLLLSTCFIASCVVTYQFI
                     MDQPSRRLYELHTYHSSLTCFSEGTMVSEKMWGCCPNHWKSFGSSCYLISTKENFWST
                     SEQNCVQMGAHLVVINTEAEQNFITQQLNESLSYFLGLSDPQGNGKWQWIDDTPFSQN
                     VRFWHPHEPNLPEERCVSIVYWNPSKWGWNDVFCDSKHNSICEMKKIYL"
     exon            202..291
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            292..393
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            394..545
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            546..661
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1245
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1224..1229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /note="hexamer: AATAAA"
     polyA_site      1239
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /note="major polyA site"
     polyA_site      1242
                     /gene="Clec4n"
                     /gene_synonym="Clec6a; Clecsf10; Nkcl"
                     /note="major polyA site"
ORIGIN      
        1 agtgcagact ctctgacttc tgggtttgca gcattggccc gctctgtggc atttaactca
       61 agtgtgtgtg gaagttgatt ctgaactctg gcctctttga cagaagccag gtccctgagt
      121 cgtattttgg agacagatgc aagaaacccc tgaccttctg aacatacacc tcaacaatgg
      181 tgcaggaaag acaatcccaa gggaagggag tctgctggac cctgagactc tggtcagctg
      241 ctgtgatttc catgttactc ttgagtacct gtttcattgc gagctgtgtg gtgacttacc
      301 aatttattat ggaccagccc agtagaagac tatatgaact tcacacatac cattccagtc
      361 tcacctgctt cagtgaaggg actatggtgt cagaaaaaat gtggggatgc tgcccaaatc
      421 actggaagtc atttggctcc agctgctacc tcatttctac caaggagaac ttctggagca
      481 ccagtgagca gaactgtgtt cagatggggg ctcatctggt ggtgatcaat actgaagcgg
      541 agcagaattt catcacccag cagctgaatg agtcactttc ttacttcctg ggtctttcgg
      601 atccacaagg taatggcaaa tggcaatgga tcgatgatac tcctttcagt caaaatgtca
      661 ggttctggca cccccatgaa cccaatcttc cagaagagcg gtgtgtttca atagtttact
      721 ggaatccttc gaaatggggc tggaatgatg ttttctgtga tagtaaacac aattcaatat
      781 gtgaaatgaa gaagatttac ctatgagtgc ctgttattca ttaatatctt taaagttcag
      841 acctaccaag aagccataac ttcttggcct gtacatctga cagaggccgt tcttttccta
      901 gccactattc tttactcaaa cagaatgagc cctttctcct tctgatggtt agagttttgt
      961 caacttgaca caaactagag tcacctgggg agtaggatct tcagctaagg aattgcctct
     1021 gtcagcttga ccagtcagca tgtctggggg cattttcttg attaatgatt gttgtaagag
     1081 ggtccaggtg gtaagcaaag gtgttaaacc catgaagagc aagccaggga gcatcatcca
     1141 tccatctctg ccctcaggtt tctgccccag ggtcttgccc tggtttcttt ctatgaactg
     1201 ctgttacttg aaagtataag atgaataaac aatttcatcc aagtt
//
