LOCUS       NM_029465               1239 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus C-type lectin domain family 4, member g (Clec4g),
            mRNA.
ACCESSION   NM_029465 XM_110691
VERSION     NM_029465.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Yang,Z., Li,Q., Wang,X., Jiang,X., Zhao,D., Lin,X., He,F. and
            Tang,L.
  TITLE     C-type lectin receptor LSECtin-mediated apoptotic cell clearance by
            macrophages directs intestinal repair in experimental colitis
  JOURNAL   Proc Natl Acad Sci U S A 115 (43), 11054-11059 (2018)
   PUBMED   30301800
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Yang,J., Wang,H., Wang,M., Liu,B., Xu,H., Xu,F., Zhao,D., Hu,B.,
            Zhao,N., Wang,J., Liu,D., Tang,L. and He,F.
  TITLE     Involvement of LSECtin in the hepatic natural killer cell response
  JOURNAL   Biochem Biophys Res Commun 476 (1), 49-55 (2016)
   PUBMED   27184407
  REMARK    GeneRIF: This study shows that C-type lectin LSECtin, a member of
            the DC-SIGN family, is a novel liver regulator for natural killer
            cells (NK cells). LSECtin could bind to NK cells in a
            carbohydrate-dependent manner and could regulate the number of
            hepatic NK cells.
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Kizuka,Y., Kitazume,S., Sato,K. and Taniguchi,N.
  TITLE     Clec4g (LSECtin) interacts with BACE1 and suppresses Abeta
            generation
  JOURNAL   FEBS Lett 589 (13), 1418-1422 (2015)
   PUBMED   25957769
  REMARK    GeneRIF: Data show that C-type lectin-like domain family 4, member
            g (Clec4g) suppresses beta-Site amyloid precursor protein cleaving
            enzyme-1 (BACE1)-mediated amyloid-beta (Abeta) peptides generation.
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Xu,F., Liu,J., Liu,D., Liu,B., Wang,M., Hu,Z., Du,X., Tang,L. and
            He,F.
  TITLE     LSECtin expressed on melanoma cells promotes tumor progression by
            inhibiting antitumor T-cell responses
  JOURNAL   Cancer Res 74 (13), 3418-3428 (2014)
   PUBMED   24769443
  REMARK    GeneRIF: When expressed in B16 melanoma cells, LSECtin promoted
            tumor growth, whereas its blockade slowed tumor growth in either
            wild-type or LSECtin-deficient mice.
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Zhao,D., Zhang,M., Wang,M., Liu,B., Wang,X., Yang,J., He,F. and
            Tang,L.
  TITLE     Up-regulation of Cbl-b is associated with LSECtin-mediated
            inhibition of different CD4+ T-cell subsets
  JOURNAL   Immunobiology 218 (4), 602-608 (2013)
   PUBMED   22884358
  REMARK    GeneRIF: LSECtin-mediated signaling up-regulates the threshold of
            CD4(+) T cell activation via tuning the expression of Cbl-b.
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Orr,S.L., Le,D., Long,J.M., Sobieszczuk,P., Ma,B., Tian,H.,
            Fang,X., Paulson,J.C., Marth,J.D. and Varki,N.
  TITLE     A phenotype survey of 36 mutant mouse strains with gene-targeted
            defects in glycosyltransferases or glycan-binding proteins
  JOURNAL   Glycobiology 23 (3), 363-380 (2013)
   PUBMED   23118208
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Pipirou,Z., Powlesland,A.S., Steffen,I., Pohlmann,S., Taylor,M.E.
            and Drickamer,K.
  TITLE     Mouse LSECtin as a model for a human Ebola virus receptor
  JOURNAL   Glycobiology 21 (6), 806-812 (2011)
   PUBMED   21257728
  REMARK    GeneRIF: The studies provide a basis for using mouse LSECtin, and
            knockout mice lacking this receptor, to model the biological
            properties of the human receptor.
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Tang,L., Yang,J., Liu,W., Tang,X., Chen,J., Zhao,D., Wang,M.,
            Xu,F., Lu,Y., Liu,B., Sun,Q., Zhang,L. and He,F.
  TITLE     Liver sinusoidal endothelial cell lectin, LSECtin, negatively
            regulates hepatic T-cell immune response
  JOURNAL   Gastroenterology 137 (4), 1498-508 (2009)
   PUBMED   19632227
  REMARK    GeneRIF: Liver sinusoidal endothelial cell lectin, LSECtin,
            negatively regulates hepatic T-cell immune response.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079992.1 and AI449163.1.
            
            On Apr 28, 2009 this sequence version replaced NM_029465.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087963.1, AK079992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1017              AK079992.1         2-1018
            1018-1239           AI449163.1         1-222               c
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..1239
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /note="C-type lectin domain family 4, member g"
                     /db_xref="GeneID:75863"
                     /db_xref="MGI:MGI:1923113"
     exon            1..61
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            62..172
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            173..226
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            227..289
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            290..394
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            395..484
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            485..633
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            634..749
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1235
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1211..1216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1231
                     /gene="Clec4g"
                     /gene_synonym="4930572L20Rik"
                     /note="major polyA site"
ORIGIN      
        1 accaccatga acactggtga atacaacaag ctgggcagtg caattgaaga ggtctccaga
       61 gggcaattgg gacgttggga gtgctacaaa caaagacttt tcttcctggt cttggctctg
      121 ctggtggcca cagttctatg ggctctcatt ctgagcaccc tactgtccag tgcctccagc
      181 aagctcaggg tgctgctcag ccaccaggac ctgctgagga caaatgcctc agagcagaag
      241 atgacgttga gttccctgaa ggatgatatc ggagcctgca ggaattgctg ctccgtgaca
      301 aaagcgcagt tgcaaaccac actggcggag tttaaggaca tacaagcaaa gttgatggag
      361 caggagagca tcctgaaaga actgcaagag cgtgtgaccc aggacttggc taaagcaagc
      421 agagaccgtg agaacatccg cagtgagctg ttccaggcac tggaagctgt caagcgccag
      481 aacagctcct gtgagcagtg cccaccatca tggctaccct tccaaggttc ctgctactat
      541 ttctctgaga cacaggccac atgggataca gcacaaagct actgtggagg ccagggtgcc
      601 catctggtga ttgtcagagg cctgaacgag cagggcttcc tgagtcagca cacacgtggc
      661 cggggctatt ggttgggtct gagggcagtt cgccacctca acaagattca aggctaccgg
      721 tgggtagatg gagcctcact caacttcagc cactggaact ctggagagcc caatgattcc
      781 agaggacatg aggactgtat catgatgctg cactcggggc tgtggaatga tgcaccatgt
      841 accaatgaga gagatggctg gatctgtgag aagaggagca gttgctacta agcctagcgc
      901 ccattgcctc ggggtgaatc agaagggtgg ctcctattcc ttgagcccac taccaaggct
      961 gtttttccta atgcaccatt aataagagcc actcagcctg accagtgcat gctttagtga
     1021 ccccagctct aactcacaag acagtttaaa ccttccatct aacctgtcag tctcaaaatc
     1081 actgctctaa accctgatgg tctgatccac tgcctgtttc ctagacacag tgttggagtt
     1141 gttccatctt cctgcatccc cctattttac cctctgactt ggagatttct tcacacacag
     1201 agagagcatc aataaatgtt tgaaaaagta acctaaaaa
//
