LOCUS       NM_016751               2400 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus C-type lectin domain family 4, member f (Clec4f),
            mRNA.
ACCESSION   NM_016751
VERSION     NM_016751.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2400)
  AUTHORS   De Ponti,F.F., Bujko,A., Liu,Z., Collins,P.J., Schuermans,S.,
            Maueroder,C., Amstelveen,S., Thone,T., Martens,L., McKendrick,J.G.,
            Louwe,P.A., Sanchez Cruz,A., Saelens,W., Matchett,K.P.,
            Waller,K.J., Zwicker,C., Buglar-Lamb,A., Vanneste,B.,
            Parmentier,F., Binte Abdul Latib,M., Remmerie,A., Kertesz,L.,
            Kremer,A., Verbeke,J., Ipsen,D.H., Pfister,D.R., Liu,Z.,
            Guilliams,M., Henderson,N.C., Ravichandran,K., Marques,P.E. and
            Scott,C.L.
  TITLE     Spatially restricted and ontogenically distinct hepatic macrophages
            are required for tissue repair
  JOURNAL   Immunity 58 (2), 362-380 (2025)
   PUBMED   39862865
REFERENCE   2  (bases 1 to 2400)
  AUTHORS   Wohner,M., Brechtelsbauer,S., Friedrich,N., Vorsatz,C., Bulang,J.,
            Liang,C., Schorr,L., Beschin,A., Guilliams,M., Ravetch,J.,
            Nimmerjahn,F. and Biburger,M.
  TITLE     Tissue niche occupancy determines the contribution of fetal- versus
            bone-marrow-derived macrophages to IgG effector functions
  JOURNAL   Cell Rep 43 (2), 113757 (2024)
   PUBMED   38354088
REFERENCE   3  (bases 1 to 2400)
  AUTHORS   Hu,J., Nieminen,A.L., Weemhoff,J.L., Jaeschke,H., Murphy,L.G.,
            Dent,J.A. and Lemasters,J.J.
  TITLE     The mitochondrial calcium uniporter mediates mitochondrial Fe2+
            uptake and hepatotoxicity after acetaminophen
  JOURNAL   Toxicol Appl Pharmacol 479, 116722 (2023)
   PUBMED   37848124
REFERENCE   4  (bases 1 to 2400)
  AUTHORS   Thomas,S.K., Wattenberg,M.M., Choi-Bose,S., Uhlik,M., Harrison,B.,
            Coho,H., Cassella,C.R., Stone,M.L., Patel,D., Markowitz,K.,
            Delman,D., Chisamore,M., Drees,J., Bose,N. and Beatty,G.L.
  TITLE     Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis
            to the liver in mice
  JOURNAL   Nat Commun 14 (1), 6330 (2023)
   PUBMED   37816712
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2400)
  AUTHORS   Peiseler,M., Araujo David,B., Zindel,J., Surewaard,B.G.J.,
            Lee,W.Y., Heymann,F., Nusse,Y., Castanheira,F.V.S., Shim,R.,
            Guillot,A., Bruneau,A., Atif,J., Perciani,C., Ohland,C., Ganguli
            Mukherjee,P., Niehrs,A., Thuenauer,R., Altfeld,M., Amrein,M.,
            Liu,Z., Gordon,P.M.K., McCoy,K., Deniset,J., MacParland,S.,
            Ginhoux,F., Tacke,F. and Kubes,P.
  TITLE     Kupffer cell-like syncytia replenish resident macrophage function
            in the fibrotic liver
  JOURNAL   Science 381 (6662), eabq5202 (2023)
   PUBMED   37676943
REFERENCE   6  (bases 1 to 2400)
  AUTHORS   Taylor,M.E., Snelling,T., Smith,D.F. and Drickamer,K.
  TITLE     Absence of a human ortholog of rodent Kupffer cell
            galactose-binding receptor encoded by the CLEC4f gene
  JOURNAL   Glycobiology 29 (4), 332-345 (2019)
   PUBMED   30590594
  REMARK    GeneRIF: The CLEC4f protein is expressed in spleen in non-human
            primates and the close evolutionary relationship of the CLEC4f
            protein to langerin (CD207) suggest that it may function in the
            immune system, possibly as a pathogen receptor.
REFERENCE   7  (bases 1 to 2400)
  AUTHORS   Scott,C.L., T'Jonck,W., Martens,L., Todorov,H., Sichien,D.,
            Soen,B., Bonnardel,J., De Prijck,S., Vandamme,N., Cannoodt,R.,
            Saelens,W., Vanneste,B., Toussaint,W., De Bleser,P., Takahashi,N.,
            Vandenabeele,P., Henri,S., Pridans,C., Hume,D.A., Lambrecht,B.N.,
            De Baetselier,P., Milling,S.W.F., Van Ginderachter,J.A.,
            Malissen,B., Berx,G., Beschin,A., Saeys,Y. and Guilliams,M.
  TITLE     The Transcription Factor ZEB2 Is Required to Maintain the
            Tissue-Specific Identities of Macrophages
  JOURNAL   Immunity 49 (2), 312-325 (2018)
   PUBMED   30076102
REFERENCE   8  (bases 1 to 2400)
  AUTHORS   Scott,C.L., Zheng,F., De Baetselier,P., Martens,L., Saeys,Y., De
            Prijck,S., Lippens,S., Abels,C., Schoonooghe,S., Raes,G.,
            Devoogdt,N., Lambrecht,B.N., Beschin,A. and Guilliams,M.
  TITLE     Bone marrow-derived monocytes give rise to self-renewing and fully
            differentiated Kupffer cells
  JOURNAL   Nat Commun 7, 10321 (2016)
   PUBMED   26813785
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2400)
  AUTHORS   Yang,C.Y., Chen,J.B., Tsai,T.F., Tsai,Y.C., Tsai,C.Y., Liang,P.H.,
            Hsu,T.L., Wu,C.Y., Netea,M.G., Wong,C.H. and Hsieh,S.L.
  TITLE     CLEC4F is an inducible C-type lectin in F4/80-positive cells and is
            involved in alpha-galactosylceramide presentation in liver
  JOURNAL   PLoS One 8 (6), e65070 (2013)
   PUBMED   23762286
  REMARK    GeneRIF: CLEC4F is an inducible C-type lectin in F4/80-positive
            cells and is involved in alpha-galactosylceramide presentation in
            liver.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2400)
  AUTHORS   Kawamoto,S., Matsumoto,Y., Mizuno,K., Okubo,K. and Matsubara,K.
  TITLE     Expression profiles of active genes in human and mouse livers
  JOURNAL   Gene 174 (1), 151-158 (1996)
   PUBMED   8863742
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK040696.1.
            
            On Apr 6, 2007 this sequence version replaced NM_016751.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040696.1, BC013647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2400              AK040696.1         2-2401
FEATURES             Location/Qualifiers
     source          1..2400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..2400
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /note="C-type lectin domain family 4, member f"
                     /db_xref="GeneID:51811"
                     /db_xref="MGI:MGI:1859834"
     exon            1..160
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1731
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /note="C-type (calcium dependent, carbohydrate recognition
                     domain) lectin, superfamily member 13; Kupffer cell c-type
                     lectin receptor; C-type lectin 13; C-type lectin
                     superfamily member 13; kupffer cell receptor"
                     /codon_start=1
                     /product="C-type lectin domain family 4 member F"
                     /protein_id="NP_058031.2"
                     /db_xref="CCDS:CCDS20281.1"
                     /db_xref="GeneID:51811"
                     /db_xref="MGI:MGI:1859834"
                     /translation="MKEAELNRDMARYCTDNQCVSLQPQGLGPKSAALMAPRTLRHVQ
                     VILALMVVTVIFSLLALFVVASQPWRPEWNKEPPSLLLRGSNNSGHDNHSQFVRETEM
                     QVAIQRLRDYEENSSSCHKEVQILKYQMDNVSSLVQLLGSHLEDVNADILQTKDVLKE
                     SGALALETQALRSSLEVASADIHSLRGDLEKANAMTSQTRGLLKSSTENTSAELHVLG
                     RGLEEAQSEIQALRGSLQSANDLSSQTQGFLQHSMDNISAQIQTVRDGMERAGEKMNS
                     LKKELETLTAQTQKANGHLEQTDAQIQGLKAELKSTSSLNSRIEVVNGQMKDASRELQ
                     TLRRDLSDVSALKSNVQMLQSNLQRAKTEMQSLKADLQATKALTAKIQGEQNRLGALQ
                     EAVAAQKQEQKTQNQVLQLIAQNWKYFNGNFYYFSRDKKPWREAEKFCTSQGAHLASV
                     TSQEEQAFLVQTTSSGDHWIGLTDQGTEGIWRWVDGTPFNNAQSKGFWGKNQPDNWRH
                     RNGEREDCVHVRQQWNDMACGSSYPWVCKKSTGWSAARVG"
     exon            161..277
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /inference="alignment:Splign:2.1.0"
     exon            278..358
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /inference="alignment:Splign:2.1.0"
     exon            359..1300
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1452
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1571
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..2400
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1900..1905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="Clec4f"
                     /gene_synonym="Clecsf13; Kclr; KUCR_MOUSE"
                     /note="major polyA site"
ORIGIN      
        1 aggctcccac tgtgtttcag gctctcacta ctgtgggctt gcaggacagg ctttaggaac
       61 cagtggcaag aacggtgcag gaggatgaag gaggccgagc tgaacagaga tatggctaga
      121 tattgcacag acaaccagtg tgtctcccta cagccccaag gactggggcc taagtcagct
      181 gctctcatgg ctcccaggac cctgcggcac gtccaggtca ttctggcatt aatggtggtg
      241 actgtgatct tttctctcct tgctcttttt gtggtggctt cacagccttg gagacctgag
      301 tggaataaag agcctccctc cctcctgctt cggggaagca acaactctgg acacgacaat
      361 cattcccaat ttgtcaggga gacagaaatg caagtggcta tccagaggct tagggactat
      421 gaggagaatt ctagcagctg tcacaaggag gtacagatac tgaagtacca aatggacaat
      481 gttagttctc tggtgcagtt gcttgggagc catctagagg atgtgaatgc tgacatcctg
      541 cagacaaaag atgtgctgaa ggaatctgga gccttggctt tggagaccca ggcgctgaga
      601 agctccttgg aggtggccag tgctgatatc catagtctga gaggagattt ggaaaaggca
      661 aacgctatga cttcccagac ccgaggtctc ttaaagagca gcacagaaaa caccagtgct
      721 gagctccacg tgctgggcag aggcctggag gaagcccagt ctgagatcca ggcgttgagg
      781 ggaagtctgc agagtgcaaa tgacctcagc tcccagaccc agggctttct ccagcacagt
      841 atggacaaca ttagtgctca gatccagacc gtgagagatg gtatggaaag ggctggtgaa
      901 aagatgaact cgttaaagaa agagctggaa acactcactg ctcagactca aaaggcaaat
      961 ggccacctgg agcagacaga tgcccagatc cagggcttaa aagctgagct gaaaagcacc
     1021 agttccttga actcccggat tgaggtggtc aatggccaaa tgaaagatgc cagcagagag
     1081 ttacagaccc tgagaaggga cctgagtgat gtctcagctt tgaagtccaa tgtccagatg
     1141 ctacagagca atcttcagag ggccaagaca gagatgcaga gtttgaaggc agatctgcag
     1201 gcgaccaaag ccctcactgc caagattcag ggggagcaga atcgcctggg ggccctgcag
     1261 gaagctgtgg ctgcacagaa gcaggagcag aagactcaga atcaggttct ccagctgatc
     1321 gcgcagaact ggaagtactt caatggaaac ttttattact tttctcgtga caagaagccg
     1381 tggcgggagg ctgagaagtt ctgtacgtcc cagggagcgc acctggcttc ggtgacctct
     1441 caggaggaac aggcattcct ggtacagact acaagttctg gggaccattg gattgggctc
     1501 actgaccagg gcacagaggg catctggcgc tgggtagatg ggacaccatt caacaatgcc
     1561 cagagcaaag ggttttgggg gaaaaatcag cctgacaact ggagacatag gaacggagag
     1621 cgagaagact gtgttcacgt ccggcagcag tggaacgaca tggcctgtgg atcctcctac
     1681 ccctgggtgt gcaagaagtc cacagggtgg tctgcggcca gagtaggcta gagctgagtc
     1741 tgtccttcct gagactcctt cagccttgat ctcacttcag ggcttcctgt cctgtattgc
     1801 cctgtcgttc tgctatttaa aacatgcttg cctccttctt aaagacaagc cctgcattgg
     1861 agtcccctca gcaccccatg tctgcccaga taagccctca ataaacactc actgaatgga
     1921 cagaaacttg gttcttgaca gtccctgaag ctgccctcac tcccatctct ccatggactg
     1981 tcccctcctt cccttgggtc tttctgtcac tacaggtcca cttttcagtg acagtgcaga
     2041 cagcagctgg ggtttcacag gaactacagg gctttcctaa gtcaccccag gggttccatg
     2101 tgtttcttca tgtgtgtatt tggggccctg tttctctccc ttgtcctgtg ggctggtggt
     2161 ctctgctcca ccctgtcatt catcttgcta atctttccag ggatctcctt tctgctcacc
     2221 ttagggtgag aacctcagga gctctctctt ggtgtctcca tacacaagga atcccattca
     2281 ggtttctgga tctttctctt tttctctttg acttcttcat attcttccct caaactgcaa
     2341 agagcttcct ctcctcgacc tgggtggaat ggcattcctt aataaatagt gtcttcgctg
//
