LOCUS       NM_019948               2519 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus C-type lectin domain family 4, member e (Clec4e),
            mRNA.
ACCESSION   NM_019948
VERSION     NM_019948.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Linnemann,L., Antwi-Ekwuruke,J., Gnanapragassam,V., Bang,C.,
            Ruhlemann,M., Ruland,J., Hartmann,W., Heepmann,L., Dorken,S.,
            Yunus,S.M., Viebrock,B., Schlosser,A., Lepenies,B. and Breloer,M.
  TITLE     The C-type lectin receptor MINCLE interferes with eosinophil
            function and protective intestinal immunity in Strongyloides
            ratti-infected mice
  JOURNAL   Mucosal Immunol (2024) In press
   PUBMED   39581231
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Rungelrath,V., Ahmed,M., Hicks,L., Miller,S.M., Ryter,K.T.,
            Montgomery,K., Ettenger,G., Riffey,A., Abdelwahab,W.M., Khader,S.A.
            and Evans,J.T.
  TITLE     Vaccination with Mincle agonist UM-1098 and mycobacterial antigens
            induces protective Th1 and Th17 responses
  JOURNAL   NPJ Vaccines 9 (1), 100 (2024)
   PUBMED   38844494
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Wang,C., Zhang,Y., Shen,A., Tang,T., Li,N., Xu,C., Liu,B. and Lv,L.
  TITLE     Mincle receptor in macrophage and neutrophil contributes to the
            unresolved inflammation during the transition from acute kidney
            injury to chronic kidney disease
  JOURNAL   Front Immunol 15, 1385696 (2024)
   PUBMED   38770013
  REMARK    GeneRIF: Mincle receptor in macrophage and neutrophil contributes
            to the unresolved inflammation during the transition from acute
            kidney injury to chronic kidney disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   Muraosa,Y., Hino,Y., Takatsuka,S., Watanabe,A., Sakaida,E.,
            Saijo,S., Miyazaki,Y., Yamasaki,S. and Kamei,K.
  TITLE     Fungal chitin-binding glycoprotein induces Dectin-2-mediated
            allergic airway inflammation synergistically with chitin
  JOURNAL   PLoS Pathog 20 (1), e1011878 (2024)
   PUBMED   38170734
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Guerrero-Juarez,C.F., Schilf,P., Li,J., Zappia,M.P., Bao,L.,
            Patel,P.M., Gieseler-Tillmann,J., Murthy,S., Cole,C., Sverdlov,M.,
            Frolov,M.V., Hashimoto,T., Ishii,N., Rulicke,T., Bieber,K.,
            Ludwig,R.J., Sadik,C.D. and Amber,K.T.
  TITLE     C-type lectin receptor expression is a hallmark of neutrophils
            infiltrating the skin in epidermolysis bullosa acquisita
  JOURNAL   Front Immunol 14, 1266359 (2023)
   PUBMED   37799716
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2519)
  AUTHORS   Yamasaki,S., Matsumoto,M., Takeuchi,O., Matsuzawa,T., Ishikawa,E.,
            Sakuma,M., Tateno,H., Uno,J., Hirabayashi,J., Mikami,Y., Takeda,K.,
            Akira,S. and Saito,T.
  TITLE     C-type lectin Mincle is an activating receptor for pathogenic
            fungus, Malassezia
  JOURNAL   Proc Natl Acad Sci U S A 106 (6), 1897-1902 (2009)
   PUBMED   19171887
  REMARK    GeneRIF: Mincle may recognize specific geometry of alpha-mannosyl
            residues on Malassezia species and use this to distinguish them
            from other fungi.
REFERENCE   7  (bases 1 to 2519)
  AUTHORS   Yamasaki,S., Ishikawa,E., Sakuma,M., Hara,H., Ogata,K. and Saito,T.
  TITLE     Mincle is an ITAM-coupled activating receptor that senses damaged
            cells
  JOURNAL   Nat Immunol 9 (10), 1179-1188 (2008)
   PUBMED   18776906
  REMARK    GeneRIF: Mincle is a receptor that senses nonhomeostatic cell death
            and thereby induces the production of inflammatory cytokines to
            drive the infiltration of neutrophils into damaged tissue.
REFERENCE   8  (bases 1 to 2519)
  AUTHORS   Wells,C.A., Salvage-Jones,J.A., Li,X., Hitchens,K., Butcher,S.,
            Murray,R.Z., Beckhouse,A.G., Lo,Y.L., Manzanero,S., Cobbold,C.,
            Schroder,K., Ma,B., Orr,S., Stewart,L., Lebus,D., Sobieszczuk,P.,
            Hume,D.A., Stow,J., Blanchard,H. and Ashman,R.B.
  TITLE     The macrophage-inducible C-type lectin, mincle, is an essential
            component of the innate immune response to Candida albicans
  JOURNAL   J Immunol 180 (11), 7404-7413 (2008)
   PUBMED   18490740
  REMARK    GeneRIF: findings show that Mincle plays a novel and nonredundant
            role in the induction of inflammatory signaling in response to C.
            albicans infection
REFERENCE   9  (bases 1 to 2519)
  AUTHORS   Flornes,L.M., Bryceson,Y.T., Spurkland,A., Lorentzen,J.C.,
            Dissen,E. and Fossum,S.
  TITLE     Identification of lectin-like receptors expressed by antigen
            presenting cells and neutrophils and their mapping to a novel gene
            complex
  JOURNAL   Immunogenetics 56 (7), 506-517 (2004)
   PUBMED   15368084
REFERENCE   10 (bases 1 to 2519)
  AUTHORS   Matsumoto,M., Tanaka,T., Kaisho,T., Sanjo,H., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Akira,S.
  TITLE     A novel LPS-inducible C-type lectin is a transcriptional target of
            NF-IL6 in macrophages
  JOURNAL   J Immunol 163 (9), 5039-5048 (1999)
   PUBMED   10528209
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124563.4.
            
            On Nov 17, 2006 this sequence version replaced NM_019948.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB024717.1, AK171103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC124563.4         134675-134834       c
            161-256             AC124563.4         133857-133952       c
            257-343             AC124563.4         131395-131481       c
            344-495             AC124563.4         131171-131322       c
            496-611             AC124563.4         130432-130547       c
            612-2519            AC124563.4         126752-128659       c
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 58.35 cM"
     gene            1..2519
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /note="C-type lectin domain family 4, member e"
                     /db_xref="GeneID:56619"
                     /db_xref="MGI:MGI:1861232"
     exon            1..160
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     exon            161..256
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     exon            257..343
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     exon            344..495
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     exon            496..611
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     exon            612..2519
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1620..1625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /note="hexamer: AATAAA"
     polyA_site      1648
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /note="major polyA site"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /note="hexamer: AATACA"
     polyA_site      1734
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /note="major polyA site"
ORIGIN      
        1 cggtctgtta gtcttgaact tttaaaaaga gggccaagga ttcaccattc aagactcact
       61 ttccaggggc tctttctaaa ctgagaagag aaggaaaagg aagaaaggca ggaaaaagga
      121 agaatgaatt caaccaaatc gcctgcatcc caccacacag agagaggatg cttcaaaaac
      181 tcccaagtgc tctcctggac gatagccggg gcctccatcc tgtttctcag tggctgtttc
      241 atcaccagat gtgtcgtaac atatcgcagc tctcaaattt ccgggcagaa cttacagcca
      301 catagaaata ttaaggagct ttcctgctac agtgaggcat caggttcagt caagaattgc
      361 tgtcctttga actggaaaca ttatcaatct agttgttatt ttttctctac gacaaccttg
      421 acctggtcat caagtttaaa gaattgctca gacatggggg ctcacctggt ggttatcgac
      481 acacaggaag agcaggaatt cctttttcgc acaaaaccta aaaggaaaga gttttatatt
      541 ggactgacag accaggtggt ggagggtcag tggcaatggg tggatgatac acctttcaca
      601 gagtccctga gcttctggga tgctggggag cccaacaata tagttttggt ggaggactgt
      661 gccaccataa gggactcttc aaactccagg aagaactgga atgatatacc ctgtttctac
      721 agtatgcctt ggatttgtga gatgccagaa ataagtcctc tggactaagt gcaaggaaat
      781 acaagggaca tggcttacat gcatgaagaa gaacaagagt gaatgtaata acaaccaaaa
      841 tccaacataa gaaaatatct atcaggcatc agaaggactg cacatgtatg tattactggg
      901 acataagtaa aatgacttgt tcccattgct aaaagtccac agcattgtct gatggtcttg
      961 ccataacctg aaagacctct ttttagactg tacagatcaa ttctctaaca aatgcaacaa
     1021 gaagaaaggg attctccttt tcacatctgt cttgcacatc tgtcttgctc atgagaattg
     1081 atatgaagga acaggtagaa agcagatgtc tgtataaaga gactttaatg gtcactatgt
     1141 catcctgttc tttctacatc cttgggtcta gcttatctat ctatcagtac atagatcact
     1201 tctgtgttct ccaacagtga ggaagatgca tctttgagtc tttaaactta cctgccgctt
     1261 gggagaatgg catggccttc agcaaggaca tctccatatg gaaaggccgg tcaaacttca
     1321 gttcctaaca gattgtgatc tagtccactc ttcctggagc cccattttct ctgtgttctc
     1381 ttctataaac tggatttcac ctgtacttgt atctactgcg caagtagaac ctgctcagta
     1441 ggttcaaagt gaaattattt aaaaattcat gttcacattt ttctgtctca ggactgcatt
     1501 tattgcatga tattctgtca atatagacca tgtttcttcc agacaaagcc ctaaaggaac
     1561 cttcagcagc agtcacacat tgtaataaac atgtatcctt gagtaggaaa attaaactaa
     1621 ataaattaat ttgacatatt agcactcatt acgagcactt ctattagact ttctcacaat
     1681 ctgattttga aattgataac cttattttaa atacaaatat atcttacaac cacacatttg
     1741 acttctcttt ttaaaattat ttttgtttga aaattttgtg catttatata attcactttt
     1801 aatgaaccca tccttactct cctcactaca acctgctcct atccacctca ctgattttcc
     1861 ctcccaattt catgtgctcc tctttgtttt aaacccactc tatctgctca gtgcttcctg
     1921 aatgcacttg agtataaggc tttctactgg accatagcct ctcggcaacc acatcccaca
     1981 ctccacctgc tccagcaggc aacaatagcc aattgaccat cctcagctga ggatggaatt
     2041 tcatgagctc catgccattc atgctggaat ttgggttgtt ttatgttacc tttattatat
     2101 tgtgctatct cttctgtatc cctagaatct ctaggagctt catattaaaa gattctgaat
     2161 tccatcaaag ggcacacaaa gaaatcacaa agaccatgtg gtttctgtcc ttgggtttat
     2221 ttgcatggtt cattacactc cttgacttgt atatattgtg acatccctcc atctctagga
     2281 tgaaactgaa gtgatcatga tagataactt ttggatcttt tcacttttct attgctgtga
     2341 tgaaacatga gccaaaacta tcttgggccg ggaaaatttt aatttatctt aacataaatt
     2401 tcctatttag aaattggaca ggtggggaat catccaattg aaactcgaaa aatgtagtgt
     2461 tttgtacatt aggttacaga aaaacaactt tagccacaaa aataaagtaa taaactatt
//
