LOCUS       NM_010819               1336 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus C-type lectin domain family 4, member d (Clec4d),
            transcript variant 1, mRNA.
ACCESSION   NM_010819
VERSION     NM_010819.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1336)
  AUTHORS   Muraosa,Y., Hino,Y., Takatsuka,S., Watanabe,A., Sakaida,E.,
            Saijo,S., Miyazaki,Y., Yamasaki,S. and Kamei,K.
  TITLE     Fungal chitin-binding glycoprotein induces Dectin-2-mediated
            allergic airway inflammation synergistically with chitin
  JOURNAL   PLoS Pathog 20 (1), e1011878 (2024)
   PUBMED   38170734
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1336)
  AUTHORS   Guerrero-Juarez,C.F., Schilf,P., Li,J., Zappia,M.P., Bao,L.,
            Patel,P.M., Gieseler-Tillmann,J., Murthy,S., Cole,C., Sverdlov,M.,
            Frolov,M.V., Hashimoto,T., Ishii,N., Rulicke,T., Bieber,K.,
            Ludwig,R.J., Sadik,C.D. and Amber,K.T.
  TITLE     C-type lectin receptor expression is a hallmark of neutrophils
            infiltrating the skin in epidermolysis bullosa acquisita
  JOURNAL   Front Immunol 14, 1266359 (2023)
   PUBMED   37799716
  REMARK    GeneRIF: C-type lectin receptor expression is a hallmark of
            neutrophils infiltrating the skin in epidermolysis bullosa
            acquisita.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1336)
  AUTHORS   Shimamura,M., Kamijo,S.I. and Illarionov,P.
  TITLE     C-type lectin Mincle-dependent and -independent activation of
            invariant NKT cells by exposure to Helicobacter pylori
            alpha-cholesteryl glucosides
  JOURNAL   FEBS J 290 (1), 134-147 (2023)
   PUBMED   35920835
  REMARK    GeneRIF: C-type lectin Mincle-dependent and -independent activation
            of invariant NKT cells by exposure to Helicobacter pylori
            alpha-cholesteryl glucosides.
REFERENCE   4  (bases 1 to 1336)
  AUTHORS   Zhang,Z., Chen,Y., Yin,Y., Chen,Y., Chen,Q., Bing,Z., Zheng,Y.,
            Hou,Y., Shen,S., Chen,Y. and Wang,T.
  TITLE     Candida tropicalis induces NLRP3 inflammasome activation via
            glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling
            pathway in myeloid-derived suppressor cells to promote colorectal
            carcinogenesis
  JOURNAL   Int Immunopharmacol 113 (Pt B), 109430 (2022)
   PUBMED   36384075
REFERENCE   5  (bases 1 to 1336)
  AUTHORS   Li,D., Lu,L., Kong,W., Xia,X., Pan,Y., Li,J., Wang,J., Wang,T.,
            Liang,J., Dou,H. and Hou,Y.
  TITLE     C-type lectin receptor Dectin3 deficiency balances the accumulation
            and function of FoxO1-mediated LOX-1+ M-MDSCs in relieving
            lupus-like symptoms
  JOURNAL   Cell Death Dis 12 (9), 829 (2021)
   PUBMED   34480018
  REMARK    GeneRIF: C-type lectin receptor Dectin3 deficiency balances the
            accumulation and function of FoxO1-mediated LOX-1(+) M-MDSCs in
            relieving lupus-like symptoms.
            Erratum:[Cell Death Dis. 2023 Apr 25;14(4):291. doi:
            10.1038/s41419-023-05809-w.. PMID: 37185572]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1336)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   7  (bases 1 to 1336)
  AUTHORS   Flornes,L.M., Bryceson,Y.T., Spurkland,A., Lorentzen,J.C.,
            Dissen,E. and Fossum,S.
  TITLE     Identification of lectin-like receptors expressed by antigen
            presenting cells and neutrophils and their mapping to a novel gene
            complex
  JOURNAL   Immunogenetics 56 (7), 506-517 (2004)
   PUBMED   15368084
REFERENCE   8  (bases 1 to 1336)
  AUTHORS   Arce,I., Martinez-Munoz,L., Roda-Navarro,P. and Fernandez-Ruiz,E.
  TITLE     The human C-type lectin CLECSF8 is a novel monocyte/macrophage
            endocytic receptor
  JOURNAL   Eur J Immunol 34 (1), 210-220 (2004)
   PUBMED   14971047
REFERENCE   9  (bases 1 to 1336)
  AUTHORS   Balch,S.G., Greaves,D.R., Gordon,S. and McKnight,A.J.
  TITLE     Organization of the mouse macrophage C-type lectin (Mcl) gene and
            identification of a subgroup of related lectin molecules
  JOURNAL   Eur J Immunogenet 29 (1), 61-64 (2002)
   PUBMED   11841491
  REMARK    GeneRIF: The genomic organization of the MCL gene and the sequence
            of the promoter region were determined
REFERENCE   10 (bases 1 to 1336)
  AUTHORS   Balch,S.G., McKnight,A.J., Seldin,M.F. and Gordon,S.
  TITLE     Cloning of a novel C-type lectin expressed by murine macrophages
  JOURNAL   J Biol Chem 273 (29), 18656-18664 (1998)
   PUBMED   9660840
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124563.4, AK171409.1, AK089500.1 and AI390740.1.
            
            On Jul 10, 2009 this sequence version replaced NM_010819.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089500.1, AK171409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC124563.4         107070-107133
            65-1056             AK171409.1         3-994
            1057-1333           AK089500.1         1048-1324
            1334-1336           AI390740.1         360-362
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 58.33 cM"
     gene            1..1336
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /note="C-type lectin domain family 4, member d"
                     /db_xref="GeneID:17474"
                     /db_xref="MGI:MGI:1298389"
     exon            1..256
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..888
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     macrophage C-type lectin; C-type (calcium dependent,
                     carbohydrate recognition domain) lectin, superfamily
                     member 8; C-type lectin, superfamily member 8;
                     macrophage-restricted C-type lectin; dectin-3;
                     DC-associated C-type lectin 3; dendritic cell-associated
                     C-type lectin 3"
                     /codon_start=1
                     /product="C-type lectin domain family 4 member D isoform
                     1"
                     /protein_id="NP_034949.3"
                     /db_xref="CCDS:CCDS20513.1"
                     /db_xref="GeneID:17474"
                     /db_xref="MGI:MGI:1298389"
                     /translation="MWLEESQMKSKGTRHPQLIPCVFAVVSISFLSACFISTCLVTHH
                     YFLRWTRGSVVKLSDYHTRVTCIREEPQPGATGGTWTCCPVSWRAFQSNCYFPLNDNQ
                     TWHESERNCSGMSSHLVTINTEAEQNFVTQLLDKRFSYFLGLADENVEGQWQWVDKTP
                     FNPHTVFWEKGESNDFMEEDCVVLVHVHEKWVWNDFPCHFEVRRICKLPGITFNWKPS
                     K"
     exon            257..349
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /inference="alignment:Splign:2.1.0"
     exon            350..457
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /inference="alignment:Splign:2.1.0"
     exon            458..609
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /inference="alignment:Splign:2.1.0"
     exon            610..725
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1336
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      952..957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /note="hexamer: AATAAA"
     polyA_site      992
                     /gene="Clec4d"
                     /gene_synonym="Clecsf8; mcl; Mpcl"
                     /note="major polyA site"
ORIGIN      
        1 tttccttttc ctctttgctc cctgtgttct agtacattag aggaaactct gtttttaaga
       61 tttattcttt ttcacttggc tctcttgtac tgaacactta ctgatcttac cagaataaga
      121 cagatgtatt gatgtccaat cttaaatgtt tctgaagaga tacttgtgat ggaaatatac
      181 actctgggca agaagtaaaa agcagactgg aatctcttga cacacataat gtggctggaa
      241 gaatcccaaa tgaaatcaaa aggtacccga catccccaac tgatcccttg cgtcttcgct
      301 gttgtttcca tctcgttcct tagtgcttgc tttatttcaa cttgtttggt gactcatcat
      361 tactttttac gctggacgag aggaagtgtg gtgaaactgt cagactacca cacgagagta
      421 acgtgcatcc gagaggagcc acagcctgga gctacaggag gtacttggac ctgctgtcct
      481 gttagctgga gagccttcca gtctaactgt tactttcctc ttaatgacaa ccagacctgg
      541 catgagagcg agaggaactg ctcagggatg agcagtcatc tggtgaccat caacaccgaa
      601 gcagaacaga attttgtgac ccagcttttg gataaacggt tttcttattt cctgggactt
      661 gctgatgaga atgtggaagg ccaatggcag tgggtggaca agacgccatt taacccacac
      721 acggtattct gggaaaaggg ggaatccaat gactttatgg aagaagactg tgttgtcctt
      781 gttcatgtcc atgaaaaatg ggtctggaat gactttcctt gtcactttga ggtgagaagg
      841 atttgtaaat tacctggaat aacattcaat tggaagccct cgaagtgatc cttgatgagg
      901 atgaagaaga tgaacctatc agacccaggg aaagtgtcct tgcatcatag aaataaagaa
      961 cacactgggt catagaccac tgttaaccat gaggatgttt ttcattattt ttgtttaaat
     1021 ttaattcaat atacatagca taatttgtgc tctctcactc tctctgtctc tctgtgtgtg
     1081 ggggtacaca ctggcatgca cacacatgct aatgcacaca tatgtttaag atagtgaggt
     1141 tttgtgtcct gttttgatag agaaaatgat catcatccta tgggattcag tttttaatca
     1201 ttgtttcctt gatagtattt taagaattta cttttcagtt ggtatgtttt tgttatatat
     1261 ttaatgaatg gattagataa tataatcttt ttgtcatttt tctcctgcct cttaaaatta
     1321 aaacttacag cagaca
//
