LOCUS       NM_001190310             784 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus C-type lectin domain family 4, member b1 (Clec4b1),
            transcript variant 1, mRNA.
ACCESSION   NM_001190310
VERSION     NM_001190310.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 784)
  AUTHORS   Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M,
            Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P,
            Stocker BL, Timmer MSM, Smith DGM, Williams SJ, Bamba T, Miyamoto
            T, Arita M, Appelmelk BJ and Yamasaki S.
  TITLE     Helicobacter pylori metabolites exacerbate gastritis through C-type
            lectin receptors
  JOURNAL   J Exp Med 218 (1) (2021)
   PUBMED   32991669
  REMARK    GeneRIF: Helicobacter pylori metabolites exacerbate gastritis
            through C-type lectin receptors.
REFERENCE   2  (bases 1 to 784)
  AUTHORS   Backdahl L, Aoun M, Norin U and Holmdahl R.
  TITLE     Identification of Clec4b as a novel regulator of bystander
            activation of auto-reactive T cells and autoimmune disease
  JOURNAL   PLoS Genet 16 (6), e1008788 (2020)
   PUBMED   32497089
  REMARK    GeneRIF: Identification of Clec4b as a novel regulator of bystander
            activation of auto-reactive T cells and autoimmune disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 784)
  AUTHORS   Omahdi Z, Horikawa Y, Nagae M, Toyonaga K, Imamura A, Takato K,
            Teramoto T, Ishida H, Kakuta Y and Yamasaki S.
  TITLE     Structural insight into the recognition of pathogen-derived
            phosphoglycolipids by C-type lectin receptor DCAR
  JOURNAL   J Biol Chem 295 (17), 5807-5817 (2020)
   PUBMED   32139512
  REMARK    GeneRIF: Structural insight into the recognition of
            pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR.
REFERENCE   4  (bases 1 to 784)
  AUTHORS   Man JCK, Mohan RA, Boogaard MVD, Hilvering CRE, Jenkins C, Wakker
            V, Bianchi V, Laat W, Barnett P, Boukens BJ and Christoffels VM.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 784)
  AUTHORS   Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita
            YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y,
            Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Matsuzaki G, Yoshikai
            Y, Yano I, Miyamoto T and Yamasaki S.
  TITLE     C-Type Lectin Receptor DCAR Recognizes Mycobacterial
            Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during
            Infection
  JOURNAL   Immunity 45 (6), 1245-1257 (2016)
   PUBMED   27887882
  REMARK    GeneRIF: DCAR is a critical receptor for phosphatidyl-inositol
            mannosides that functions to promote T cell responses against
            mycobacteria
REFERENCE   6  (bases 1 to 784)
  AUTHORS   Kishimoto A, Watanabe M, Terauchi K, Kojima T, Kameda Y, Yamamoto K
            and Matsumoto N.
  TITLE     Ubiquitous versus restricted expression of the two mouse dendritic
            cell C-type lectin receptors, DCIR1 and DCAR2, among myeloid cells
  JOURNAL   Biochem Biophys Res Commun 467 (2), 383-388 (2015)
   PUBMED   26431873
  REMARK    GeneRIF: While DCIR1 was ubiquitously expressed on myeloid cells in
            various immune organs, significant expression of DCAR2 was detected
            only on subpopulations of conventional dendritic cells from bone
            marrow and skin-draining lymph nodes.
REFERENCE   7  (bases 1 to 784)
  AUTHORS   Nakagawa Y, Sakuma T, Nakagata N, Yamasaki S, Takeda N, Ohmuraya M
            and Yamamoto T.
  TITLE     Application of oocyte cryopreservation technology in TALEN-mediated
            mouse genome editing
  JOURNAL   Exp Anim 63 (3), 349-355 (2014)
   PUBMED   25077765
REFERENCE   8  (bases 1 to 784)
  AUTHORS   Flornes LM, Bryceson YT, Spurkland A, Lorentzen JC, Dissen E and
            Fossum S.
  TITLE     Identification of lectin-like receptors expressed by antigen
            presenting cells and neutrophils and their mapping to a novel gene
            complex
  JOURNAL   Immunogenetics 56 (7), 506-517 (2004)
   PUBMED   15368084
REFERENCE   9  (bases 1 to 784)
  AUTHORS   Kanazawa N, Tashiro K, Inaba K and Miyachi Y.
  TITLE     Dendritic cell immunoactivating receptor, a novel C-type lectin
            immunoreceptor, acts as an activating receptor through association
            with Fc receptor gamma chain
  JOURNAL   J Biol Chem 278 (35), 32645-32652 (2003)
   PUBMED   12777403
  REMARK    GeneRIF: identifed a novel C-type lectin receptor, dendritic cell
            immunoactivating receptor (DCAR), whose extracellular lectin domain
            is highly homologous to that of dendritic cell immunoreceptor(DCIR)
            [DCAR]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124337.15.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY365134.1, AY230259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC124337.15        128862-129022
            162-251             AC124337.15        129511-129600
            252-350             AC124337.15        144839-144937
            351-508             AC124337.15        147337-147494
            509-621             AC124337.15        148556-148668
            622-784             AC124337.15        150293-150455
FEATURES             Location/Qualifiers
     source          1..784
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 58.13 cM"
     gene            1..784
                     /gene="Clec4b1"
                     /gene_synonym="1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2;
                     DCARbeta"
                     /note="C-type lectin domain family 4, member b1"
                     /db_xref="GeneID:69810"
                     /db_xref="MGI:MGI:1917060"
     exon            1..161
                     /gene="Clec4b1"
                     /gene_synonym="1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2;
                     DCARbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..766
                     /gene="Clec4b1"
                     /gene_synonym="1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2;
                     DCARbeta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dendritic cell immunoactivating receptor; antigen
                     presenting cell lectin-like receptor A2"
                     /codon_start=1
                     /product="C-type lectin domain family 4, member b1 isoform
                     1"
                     /protein_id="NP_001177239.1"
                     /db_xref="CCDS:CCDS51893.1"
                     /db_xref="GeneID:69810"
                     /db_xref="MGI:MGI:1917060"
                     /translation="MVQERQLQGKAVSWSLRLWSAAVISILLLSTCFIASCVVTYQFS
                     MDKPNRRLSELDRYHSLTCFSEGNMVSDKVWSCCPKDWKLFGSHCYLVPTVFSSASWN
                     KSEENCSRMGAHLVVIHSQEEQDFITGILDIHAAYFIGLWDTGHRQWQWVDQTPYEES
                     VTFWHNGEPSSDNEKCVTVYYRRNIGWGWNDISCNLKQKSVCQMKKINL"
     exon            162..251
                     /gene="Clec4b1"
                     /gene_synonym="1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2;
                     DCARbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            252..350
                     /gene="Clec4b1"
                     /gene_synonym="1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2;
                     DCARbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            351..508
                     /gene="Clec4b1"
                     /gene_synonym="1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2;
                     DCARbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            509..621
                     /gene="Clec4b1"
                     /gene_synonym="1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2;
                     DCARbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            622..784
                     /gene="Clec4b1"
                     /gene_synonym="1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2;
                     DCARbeta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctatctct gtggtattta gctcagagca tgaggaggtt gactgagttc tggcctgttt
       61 gaaagaagca agtccctgag tcatatcttc aagagtcaga tacaagaaac cattgacctg
      121 cacatagacc tcaataatgg ttcaggaaag acagctacaa gggaaggcag tctcctggtc
      181 cctgagactc tggtcagctg ctgtgatttc tatcttactc ctcagcacct gtttcattgc
      241 gagctgtgtg gtcacttacc agtttagtat ggacaagcca aatagaagac tatctgaact
      301 tgacaggtac cattcattga cctgcttcag tgaagggaat atggtgtcag acaaagtctg
      361 gagctgttgc ccaaaggatt ggaagctatt tggttcccac tgctacttgg ttcccacagt
      421 tttttcatca gcatcttgga acaagagtga ggagaactgc tcccgcatgg gtgctcatct
      481 agtggtgatc catagccagg aggagcagga tttcatcact gggatcttgg acattcatgc
      541 tgcttatttt atagggttgt gggatacagg ccatcggcaa tggcaatggg ttgatcagac
      601 accatatgaa gaaagtgtca cattctggca caatggtgag cccagcagtg acaatgaaaa
      661 atgtgttaca gtatattacc gtcggaatat tggatggggc tggaatgata tctcttgcaa
      721 tcttaaacag aagtcagttt gtcagatgaa gaaaataaac ttatgaatca ctcattcttc
      781 atgg
//
