LOCUS       NM_001005860            1107 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C-type lectin domain family 4, member a4 (Clec4a4),
            mRNA.
ACCESSION   NM_001005860
VERSION     NM_001005860.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1107)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1107)
  AUTHORS   Bellini,R., Moregola,A., Nour,J., Uboldi,P., Bonacina,F. and
            Norata,G.D.
  TITLE     Dendritic cell immunoreceptor 2 (DCIR2) deficiency decreases
            hepatic conventional dendritic cell content but not the progression
            of diet-induced obesity
  JOURNAL   Immun Inflamm Dis 11 (10), e1024 (2023)
   PUBMED   37904682
  REMARK    GeneRIF: Dendritic cell immunoreceptor 2 (DCIR2) deficiency
            decreases hepatic conventional dendritic cell content but not the
            progression of diet-induced obesity.
REFERENCE   3  (bases 1 to 1107)
  AUTHORS   Uto,T., Fukaya,T., Mitoma,S., Nishikawa,Y., Tominaga,M.,
            Choijookhuu,N., Hishikawa,Y. and Sato,K.
  TITLE     Clec4A4 Acts as a Negative Immune Checkpoint Regulator to Suppress
            Antitumor Immunity
  JOURNAL   Cancer Immunol Res 11 (9), 1266-1279 (2023)
   PUBMED   37432112
REFERENCE   4  (bases 1 to 1107)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   5  (bases 1 to 1107)
  AUTHORS   Uto,T., Fukaya,T., Takagi,H., Arimura,K., Nakamura,T., Kojima,N.,
            Malissen,B. and Sato,K.
  TITLE     Clec4A4 is a regulatory receptor for dendritic cells that impairs
            inflammation and T-cell immunity
  JOURNAL   Nat Commun 7, 11273 (2016)
   PUBMED   27068492
  REMARK    GeneRIF: These findings highlight roles of Clec4A4 in regulation of
            the function of CD8alpha(-) conventional dendritic cells for
            control of the magnitude and quality of immune response.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1107)
  AUTHORS   Price,J.D., Hotta-Iwamura,C., Zhao,Y., Beauchamp,N.M. and
            Tarbell,K.V.
  TITLE     DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and
            Inhibit Diabetes
  JOURNAL   Diabetes 64 (10), 3521-3531 (2015)
   PUBMED   26070317
  REMARK    GeneRIF: This study showed that DCIR2(+) DCs are capable of
            inducing antigen-specific tolerance in the face of ongoing
            autoimmunity; Zbtb32 is a suppressive transcription factor that
            controls T cell-mediated autoimmunity.
REFERENCE   7  (bases 1 to 1107)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1107)
  AUTHORS   Nagae,M., Yamanaka,K., Hanashima,S., Ikeda,A., Morita-Matsumoto,K.,
            Satoh,T., Matsumoto,N., Yamamoto,K. and Yamaguchi,Y.
  TITLE     Recognition of bisecting N-acetylglucosamine: structural basis for
            asymmetric interaction with the mouse lectin dendritic cell
            inhibitory receptor 2
  JOURNAL   J Biol Chem 288 (47), 33598-33610 (2013)
   PUBMED   24108122
  REMARK    GeneRIF: the unique binding mode of mDCIR2 for bisecting
            GlcNAc-containing glycans, a mode that contrasts sharply with that
            of other immune C-type lectin receptors such as DC-SIGN.
REFERENCE   9  (bases 1 to 1107)
  AUTHORS   Flornes,L.M., Bryceson,Y.T., Spurkland,A., Lorentzen,J.C.,
            Dissen,E. and Fossum,S.
  TITLE     Identification of lectin-like receptors expressed by antigen
            presenting cells and neutrophils and their mapping to a novel gene
            complex
  JOURNAL   Immunogenetics 56 (7), 506-517 (2004)
   PUBMED   15368084
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY397673.1 and BX524711.1.
            
            On Feb 24, 2011 this sequence version replaced NM_001005860.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY397673.1, BC104370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-776               AY397673.1         1-776
            777-1107            BX524711.1         63-393
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 58.07 cM"
     gene            1..1107
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /note="C-type lectin domain family 4, member a4"
                     /db_xref="GeneID:474145"
                     /db_xref="MGI:MGI:3624119"
     CDS             1..711
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /note="dendritic cell inhibitory receptor 2"
                     /codon_start=1
                     /product="C-type lectin domain family 4, member a4"
                     /protein_id="NP_001005860.1"
                     /db_xref="CCDS:CCDS20509.1"
                     /db_xref="GeneID:474145"
                     /db_xref="MGI:MGI:3624119"
                     /translation="MASEITYAEVRITNESDSLDTYSKCPAAPREKPIRDLRKPGSPS
                     LLLTSLMLLLLLLAITFLVAFIIYFQKYSQLLEEKEAAKNIMYKELNCIKNGSLMEDK
                     VWSCCPKDWKPFVSHCYFILNDSKASWNESEEKCSHMGAHLVVIHSQAEQDFITSNLN
                     TSAGYFIGLLDAGQRQWRWIDQTPYNKSATFWHKGEPNQDWERCVIINHKTTGWGWND
                     IPCKDEHNSVCQVKKIYL"
     exon            1..82
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /inference="alignment:Splign:2.1.0"
     exon            83..199
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /inference="alignment:Splign:2.1.0"
     exon            200..301
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /inference="alignment:Splign:2.1.0"
     exon            302..456
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..569
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..1092
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1055..1060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /note="hexamer: ATTAAA"
     polyA_site      1076
                     /gene="Clec4a4"
                     /gene_synonym="Dcir2"
                     /note="major polyA site"
ORIGIN      
        1 atggcttcag aaatcactta tgcagaagtg aggatcacga atgaatccga ctccttggac
       61 acctactcaa aatgtcctgc agctcccaga gagaaaccta tccgtgatct aagaaagcct
      121 ggttccccct cactgcttct tacatccctg atgctacttc tcctgctgct ggcaatcaca
      181 ttcttagttg cttttatcat ttattttcaa aagtactctc aacttcttga agaaaaagaa
      241 gctgcaaaaa atataatgta caaggaattg aactgcataa aaaatggttc actcatggaa
      301 gacaaagtct ggagctgttg cccaaaggat tggaaaccat ttgtttccca ctgctacttc
      361 attttgaatg actcgaaggc atcttggaat gagagtgagg agaagtgctc ccacatgggt
      421 gctcatctgg tggtgatcca cagccaggca gagcaggatt tcatcaccag caacctgaac
      481 acaagtgctg gttattttat aggacttttg gatgctggtc aaagacaatg gcgatggatt
      541 gatcagacac catacaataa gagtgctacg ttctggcaca aaggtgagcc caaccaagat
      601 tgggaacgat gtgttataat aaatcataaa acaactggat ggggctggaa tgatatccct
      661 tgcaaagatg aacacaattc agtttgtcag gtgaagaaaa tatacttatg aatcacacat
      721 tcttcatggg gatttgattt ctttgttagc cgtcataaca tggatacctg ggaagttctc
      781 aaagtggaag agcagctcac agaatttaag gggacagcaa atggttatgc acatgacaca
      841 ctggcccaca tatatccttg ttcatttatc tacttactca gagttaaaat gaagtttcat
      901 tgagaatttt tatgtaccag agaatataca gagtcccttt tgggtacacc tggagctttt
      961 tgccaactcc ccaaggtttc atttactcat gccatattat gatattttct cttggtctat
     1021 ttgtgctttt taatatgtct ttggatttat tgacattaaa ttgagaagta aaattatata
     1081 tatttaagtg tcaaaaaaaa aaaaaaa
//
