LOCUS       NM_153197               1328 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C-type lectin domain family 4, member a3 (Clec4a3),
            transcript variant 1, mRNA.
ACCESSION   NM_153197
VERSION     NM_153197.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1328)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1328)
  AUTHORS   Hsu,Y., Okada,R., Nishimura,T., Kawasaki,N., Yamamoto,K. and
            Matsumoto,N.
  TITLE     DCIR3 and DCIR4 are co-expressed on inflammatory and patrolling
            monocytes
  JOURNAL   Biochem Biophys Res Commun 494 (3-4), 440-445 (2017)
   PUBMED   29042196
  REMARK    GeneRIF: The anti- DCIR3 antibody established in this study,
            together with the previously established anti-DCIR1 and anti-DCIR4
            antibodies, would be a valuable tool to investigate biology and
            pathophysiology of monocytes.
REFERENCE   3  (bases 1 to 1328)
  AUTHORS   Flornes,L.M., Bryceson,Y.T., Spurkland,A., Lorentzen,J.C.,
            Dissen,E. and Fossum,S.
  TITLE     Identification of lectin-like receptors expressed by antigen
            presenting cells and neutrophils and their mapping to a novel gene
            complex
  JOURNAL   Immunogenetics 56 (7), 506-517 (2004)
   PUBMED   15368084
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK156040.1 and BC034893.1.
            
            On Feb 24, 2011 this sequence version replaced NM_153197.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156040.1, AK014135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1300              AK156040.1         1-1300
            1301-1328           BC034893.1         1165-1192
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 58.04 cM"
     gene            1..1328
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /note="C-type lectin domain family 4, member a3"
                     /db_xref="GeneID:73149"
                     /db_xref="MGI:MGI:1920399"
     exon            1..306
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..938
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /codon_start=1
                     /product="dendritic cell inhibitory receptor 3"
                     /protein_id="NP_694877.2"
                     /db_xref="CCDS:CCDS20508.1"
                     /db_xref="GeneID:73149"
                     /db_xref="MGI:MGI:1920399"
                     /translation="MFSENIYVNTNFKNKVDSSDIDTDSWPAPQRKNTSQKSCHKFSK
                     VLFTSLIIYFLLLTILFSGALITLFTKYSQLLEEKMIIKELNYTELECTKWASLLEDK
                     VWSCCPKDWKPFGSYCYFTSTDLVASWNESKENCFHMGAHLVVIHSQEEQDFITGILD
                     TGTAYFIGLSNPGDQQWQWIDQTPYDDNTTFWHKGEPSSDNEQCVIINHRQSTGWGWS
                     DIPCSDKQNSICHVKKIYL"
     exon            307..423
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /inference="alignment:Splign:2.1.0"
     exon            424..525
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /inference="alignment:Splign:2.1.0"
     exon            526..680
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /inference="alignment:Splign:2.1.0"
     exon            681..793
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1304
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1279..1284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /note="hexamer: AATAAA"
     polyA_site      1302
                     /gene="Clec4a3"
                     /gene_synonym="3110037K17Rik; Dcir3"
                     /note="major polyA site"
ORIGIN      
        1 ggtatagctg taattctatg attggacgga atgcattttc tgtccgcgat actccctttg
       61 caggccaggg gagtgctgca agctgagggc agctgtctgt tactgcctct catttctagc
      121 tggtgtcagg attatttgct gtcacgtttg tttcttgttc aggagatatt ttaaagacgg
      181 gatgacacac atcttctgag ggcaggggaa actttcatct caacatgttt tcagaaaaca
      241 tttatgttaa cacgaacttc aaaaataaag ttgactcctc agacatcgac acagactctt
      301 ggccagctcc ccaaaggaag aacacgtctc agaaaagttg tcacaaattc tctaaggtcc
      361 tctttacctc actcataatc tatttcctgc tgttgacaat cttattctcc ggtgctctga
      421 tcactttgtt tacaaaatat tctcagcttc ttgaagaaaa aatgattata aaagaactga
      481 actatactga attggagtgt acaaaatggg cttcactctt ggaagacaaa gtctggagct
      541 gttgcccaaa ggattggaag ccgtttggtt cctactgcta cttcacttca actgacttgg
      601 tggcatcttg gaatgagagt aaggagaact gcttccacat gggtgctcat ctggtggtga
      661 tccacagcca ggaagaacag gatttcatca ctgggatcct ggacactggt actgcttatt
      721 ttataggact ttcaaatcca ggtgatcaac aatggcaatg gattgatcag acaccgtacg
      781 atgataatac cacattctgg cacaaaggtg agcctagcag tgacaatgaa cagtgtgtta
      841 taataaatca tcgtcagagt actggatggg gctggagtga tatcccttgc agtgataaac
      901 agaactcaat ttgccatgtg aaaaaaatat acttatgaat cacacattct ccatggccat
      961 gggattgcat tgttatccac cattacgcag acacttggaa agttcttcat gtggaacaga
     1021 gatccacaga attttaggta ggcagccaat ggttatacat atgataatac tggcacatgt
     1081 gtaaacttac ttggtcattg tcattctctt atataatgag aatttttcat gtaccagaga
     1141 ctatatagga gactctgtgc atatgtggaa gcaacaaaca tctctgccca ctctcagatt
     1201 cccaaagtct tattcctttt acccatctct ctctctctct ctctctctgg ctttggcttt
     1261 attgatgtat agttaacaaa taaatcatgt atacttgtgt tacaaaaaaa aaaaaaaaaa
     1321 aaaaaaaa
//
