LOCUS       NM_001007223            2958 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus C-type lectin domain family 3, member a (Clec3a),
            mRNA.
ACCESSION   NM_001007223
VERSION     NM_001007223.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2958)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2958)
  AUTHORS   Lau,D., Elezagic,D., Hermes,G., Morgelin,M., Wohl,A.P., Koch,M.,
            Hartmann,U., Hollriegl,S., Wagener,R., Paulsson,M., Streichert,T.
            and Klatt,A.R.
  TITLE     The cartilage-specific lectin C-type lectin domain family 3 member
            A (CLEC3A) enhances tissue plasminogen activator-mediated
            plasminogen activation
  JOURNAL   J Biol Chem 293 (1), 203-214 (2018)
   PUBMED   29146595
  REMARK    GeneRIF: Authors have determined the structure, tissue
            distribution, and molecular function of the cartilage-specific
            lectin CLEC3A and show that CLEC3A binds to plasminogen and
            participates in tPA-mediated plasminogen activation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151980.3.
            
            On Jan 25, 2023 this sequence version replaced NM_001007223.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC151980.3         120083-120279       c
            198-281             AC151980.3         115280-115363       c
            282-2958            AC151980.3         110152-112828       c
FEATURES             Location/Qualifiers
     source          1..2958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 60.96 cM"
     gene            1..2958
                     /gene="Clec3a"
                     /gene_synonym="1110019O10Rik; Clecsf1; Gm796"
                     /note="C-type lectin domain family 3, member a"
                     /db_xref="GeneID:403395"
                     /db_xref="MGI:MGI:2685642"
     exon            1..197
                     /gene="Clec3a"
                     /gene_synonym="1110019O10Rik; Clecsf1; Gm796"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..673
                     /gene="Clec3a"
                     /gene_synonym="1110019O10Rik; Clecsf1; Gm796"
                     /note="C-type calcium dependent, carbohydrate-recognition
                     domain lectin, superfamily member 1, cartilage-derived"
                     /codon_start=1
                     /product="C-type lectin domain family 3 member A
                     precursor"
                     /protein_id="NP_001007224.1"
                     /db_xref="CCDS:CCDS22690.1"
                     /db_xref="GeneID:403395"
                     /db_xref="MGI:MGI:2685642"
                     /translation="MAKNGLVLCILVVSLLLDQTDGYPSRMKARKHSKRRVKAKDDDL
                     KSQVEKLWREVNALKEMQALQTVCLRGTKVHKKCYLASEGLKHYHEANEDCISKGGTL
                     VVPRNSDEINALRDYGKRSLPGVNDFWLGINDMVTEGKFLDVHGFAVSFLNWDRAQPS
                     GGKRENCVLFSQSAQGKWSDEACRSSKRYICEFIIP"
     exon            198..281
                     /gene="Clec3a"
                     /gene_synonym="1110019O10Rik; Clecsf1; Gm796"
                     /inference="alignment:Splign:2.1.0"
     exon            282..2958
                     /gene="Clec3a"
                     /gene_synonym="1110019O10Rik; Clecsf1; Gm796"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2940..2945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec3a"
                     /gene_synonym="1110019O10Rik; Clecsf1; Gm796"
                     /note="hexamer: AATAAA"
     polyA_site      2958
                     /gene="Clec3a"
                     /gene_synonym="1110019O10Rik; Clecsf1; Gm796"
                     /note="major polyA site"
ORIGIN      
        1 aagatgtggc ttcacagcct ccctgctccc tagctgcccc agagttgcag accaagtggc
       61 cagcctggcc tgtcccagag ccatggcaaa gaacggactt gtcctttgta tcctggtggt
      121 cagcttactc ctggaccaga ccgacggcta cccatctcga atgaaagcca ggaaacacag
      181 caaacgccgc gtgaaagcaa aggatgacga cctgaaatct caagttgaaa agctgtggcg
      241 ggaagtcaac gccttgaagg agatgcaagc tctgcagaca gtctgtctcc gaggcaccaa
      301 agttcataag aagtgctacc ttgcttcaga aggcctcaag cattaccacg aagccaacga
      361 agactgcatt tccaagggag ggaccctggt tgtccccagg aattccgacg aaatcaatgc
      421 ccttcgagac tatggtaaga ggagtctgcc aggtgtcaat gacttttggc taggcataaa
      481 tgacatggtc acagaaggca agttcctcga tgtccacgga ttcgctgtct ccttcctcaa
      541 ctgggaccgt gcccagccaa gtggtggcaa gcgggaaaac tgtgtcctgt tctcccagtc
      601 agctcagggg aaatggagcg acgaagcctg tcgcagtagc aagcgataca tatgtgagtt
      661 tatcatccca taagaagccc ctcctccata tcctcccaag tcagactggt cagccatgat
      721 aaataagctc gtaggccccc tcagtaaact cggattacat ttattcattg cagcatcaca
      781 atgccaggat tggtagtcat aggtatgcag agacagacca tgtttctacc atagctcctt
      841 gtaatattac tcttcgcatg acaaagggga tcagaaaata atgacccaga catggtaaga
      901 aagggacttc tgataatggg cagtcaaatt gtctcccact cttcttgttc ctctcatgtg
      961 aatagacctg acctacttaa aaaaaatcac ctgattcttc aagacagaaa agtttggaat
     1021 atttctcttt aaaatttagt catgatagga atacaatttt gagaaatgtg tcattggttg
     1081 attttctgga tatgtgaaca ttatagtata ccctacatgg atgaaccctg atgttgtagg
     1141 ggcaaaactc caggtggcct ctagatgccc taaagacatg tagtagacac acgctgcatg
     1201 aagctttggc tggcaaaaca tggcaggctt tcatagtata gttcacgaag tacatagtaa
     1261 aacaacagtt ggaaacacag ccgagtaaac tctctttcca tccctttaat aagacagctg
     1321 acacagacat gtgtgaaaca agtgaggtgt atttagcttg taattttatt ggtgtgaggt
     1381 cgggttaagc tgcctcagtg aagtggccaa aggcaagggt ggcggatcac ggcaagaaca
     1441 agtagtcaca tctctctgca gagcaatcct aggatgatca tggtctcctt tcaaagtggt
     1501 gtctccaaat tatccaagga catcctagat ggctgcacct gcttaaggca cacagtgctt
     1561 ttcaaacttg ccacaccagg gtccttggtg gggacagaag caatcaaact accttcagcc
     1621 atagtgtctg ataaacatat aaaccaacaa cacagtgtcg cttgttattg ctgtcaaggg
     1681 tcgtgagctg tgcttagtca ctgcgttcaa ctttaggact cgtggtgtgc tacgtttgta
     1741 tttaacactg ccaccaagaa catgcataaa atttgctaca ggagtagcaa ccaacaacgt
     1801 ctctaggcaa cagaaaattt tcatctccat tactggctta tgggaccacc atcaaatatg
     1861 cagtttgtta gggtcaaaat attgtgtagt gtgtggatac atttggttga cgagaatgcc
     1921 ccaagtcaga gattccaggg tgctatacag tctgtaagtt ttctagcacg atgtttaatt
     1981 tcctccaccc tcttagccta tggtccttgc tttcagttgc tggccacatc ccctggtggg
     2041 atgtggatct tctttgccac atcagagcag ggatgactga caagattctc atctaactcc
     2101 tccaattccc caactctagc tttcttcaag gttcccagtc gaaaccccac cccacccccc
     2161 actccctgag tcagcatata tttgatcatt tctcctctcg gtattctata atagcttcta
     2221 gccagtgagc aacagtaagg caggagaaga gcagcagatg gtgagaacaa agaaaccaga
     2281 gaaaaaaggt agcagggctt tggggattgc acttcagttg gtagggagct tgtctagcag
     2341 gcaggaagac ctgggttcgc aggaatggga cacttaagct tacaatccca gtgctgggga
     2401 ggtggaggta agaagatcag gggttcaagg tcatgctcta ccaactgaac tgcaaggcta
     2461 aaggctacat gagaccctat ctagacaaca aggacgaaag aaaaatgtct ctttccttca
     2521 cgcgtgtatc cttacagtct ccttttatat atgatagcaa tagtttttac tttctttacg
     2581 tgtatatgtc ttcaattatc attatgtatt tcaatctatg aagggcaatt tgtcattaga
     2641 agctgaaagt tagacttaaa taatactatt tgagagtaac acacgtgtgc aattttttat
     2701 tctaacgatg ctatacccat taaattgcct aactagattt tataaaaata acttcattgc
     2761 ttaaacacag gagcatacat ttaaggctta ggggaaatgg gttttgtaga aataaacaat
     2821 tctgaataca ttctgtcctt caaataaata tcttttctct tttgtgaata atgtcctgct
     2881 cccaagagct aaattacata tgcctggaat caaattttag gtttgttttt tcattgcaca
     2941 ataaagctcc aaatctga
//
