LOCUS       NM_020257               2319 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C-type lectin domain family 2, member i (Clec2i),
            transcript variant 2, mRNA.
ACCESSION   NM_020257
VERSION     NM_020257.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2319)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2319)
  AUTHORS   Cao,M., Ma,L., Yan,C., Wang,H., Ran,M., Chen,Y., Wang,X., Liang,X.,
            Chai,L. and Li,X.
  TITLE     Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated IL-6
            production by blocking Dap12-Syk interaction in macrophage
  JOURNAL   Front Immunol 13, 984520 (2022)
   PUBMED   36300111
  REMARK    GeneRIF: Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated
            IL-6 production by blocking Dap12-Syk interaction in macrophage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2319)
  AUTHORS   Lou,Q., Zhang,W., Liu,G. and Ma,Y.
  TITLE     The C-type lectin OCILRP2 costimulates EL4 T cell activation via
            the DAP12-Raf-MAP kinase pathway
  JOURNAL   PLoS One 9 (11), e113218 (2014)
   PUBMED   25411776
  REMARK    GeneRIF: Data show OCILRP2 binding to DAP12 resulting in Raf-MAP
            kinase pathways activation and T-cell activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2319)
  AUTHORS   Chai,L., Wu,S., Liu,G., Wang,Z., Tian,W. and Ma,Y.
  TITLE     OCILRP2 signaling synergizes with LPS to induce the maturation and
            differentiation of murine dendritic cells
  JOURNAL   Biochem Biophys Res Commun 446 (4), 836-842 (2014)
   PUBMED   24631687
  REMARK    GeneRIF: OCILRP2 is a regulator of dendritic cells maturation and
            differentiation following TLR4 activation.
REFERENCE   5  (bases 1 to 2319)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2319)
  AUTHORS   Tian,W., Feng,B. and Liou,H.C.
  TITLE     Silencing OCILRP2 leads to intrinsic defects in T cells in response
            to antigenic stimulation
  JOURNAL   Cell Immunol 235 (1), 72-84 (2005)
   PUBMED   16143319
  REMARK    GeneRIF: May facilitate lipid rafts and immunological synapse
            formation during T cell interaction with antigen presenting cells.
REFERENCE   7  (bases 1 to 2319)
  AUTHORS   Tian,W., Nunez,R., Cheng,S., Ding,Y., Tumang,J., Lyddane,C.,
            Roman,C. and Liou,H.C.
  TITLE     C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T
            cell proliferation and IL-2 production
  JOURNAL   Cell Immunol 234 (1), 39-53 (2005)
   PUBMED   15963483
  REMARK    GeneRIF: studies reveal a unique functional interaction between two
            C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T
            cell costimulation and suggest a role for C-type lectins in
            maintaining T cell response or memory in vivo
REFERENCE   8  (bases 1 to 2319)
  AUTHORS   Iizuka,K., Naidenko,O.V., Plougastel,B.F., Fremont,D.H. and
            Yokoyama,W.M.
  TITLE     Genetically linked C-type lectin-related ligands for the NKRP1
            family of natural killer cell receptors
  JOURNAL   Nat Immunol 4 (8), 801-807 (2003)
   PUBMED   12858173
  REMARK    GeneRIF: mouse Nkrp1d and Nkrp1f bind specific C-type
            lectin-related (Clr) molecules. Nkrp1d mediated inhibition when
            recognizing Clrb, a molecule expressed in dendritic cells and
            macrophages. Nkrp1 and Clr are intertwined in a genetically
            conserved NKC region.
REFERENCE   9  (bases 1 to 2319)
  AUTHORS   Zhou,H., Kartsogiannis,V., Quinn,J.M., Ly,C., Gange,C., Elliott,J.,
            Ng,K.W. and Gillespie,M.T.
  TITLE     Osteoclast inhibitory lectin, a family of new osteoclast inhibitors
  JOURNAL   J Biol Chem 277 (50), 48808-48815 (2002)
   PUBMED   12374791
REFERENCE   10 (bases 1 to 2319)
  AUTHORS   Plougastel,B., Dubbelde,C. and Yokoyama,W.M.
  TITLE     Cloning of Clr, a new family of lectin-like genes localized between
            mouse Nkrp1a and Cd69
  JOURNAL   Immunogenetics 53 (3), 209-214 (2001)
   PUBMED   11398965
  REMARK    GeneRIF: Identification of a novel family of genes, named Clr,
            encoding C-type lectin-like molecules, which maps in the natural
            killer (NK) gene complex (NKC) on mouse Chromosome 6.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102693.9, AY137345.1, AK041724.1, AA175075.1 and BE686253.1.
            
            On Jan 25, 2014 this sequence version replaced NM_020257.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon and uses an alternate in-frame splice site, compared to
            variant 1. The encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY137345.1, AF121352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC102693.9         13535-13535         c
            2-1004              AY137345.1         1-1003
            1005-2049           AK041724.1         1720-2764
            2050-2147           AA175075.1         230-327
            2148-2319           BE686253.1         1-172               c
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.1 cM"
     gene            1..2319
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /note="C-type lectin domain family 2, member i"
                     /db_xref="GeneID:93675"
                     /db_xref="MGI:MGI:2136650"
     exon            1..80
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..702
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     osteoclast inhibitory lectin related protein 2;
                     ocil-related protein 2; C-type lectin-related protein G;
                     lymphoid-derived C-type lectin-1; C-type lectin-related
                     protein DCL1"
                     /codon_start=1
                     /product="C-type lectin domain family 2 member I isoform
                     2"
                     /protein_id="NP_064653.1"
                     /db_xref="CCDS:CCDS51920.1"
                     /db_xref="GeneID:93675"
                     /db_xref="MGI:MGI:2136650"
                     /translation="MPDCLETGEKLFVHNMNAQCVQKPEEGNGPLGTGGKIVQGKCFR
                     IISTVSPVKLYCCYGVIMVLTVAVIALSVALSTKKTEQIIINKTYAACSKNWTGVGNK
                     CFYFSGYPRNWTFAQAFCMAQEAQLARFDNEEELIFLKRFKGDFDCWIGLHRESSEHP
                     WKWTNNTEYNNMNPILGVGRYAYLSSDRISSSRSYINRMWICSKLNNYNLHCQTPPV"
     exon            81..151
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..277
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /inference="alignment:Splign:2.1.0"
     exon            278..456
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..563
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..2319
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /note="hexamer: AATAAA"
     polyA_site      2308
                     /gene="Clec2i"
                     /gene_synonym="Clr-g; Clrg; Dcl1; LCL-1; OCILrP2"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgggct cattgcttca gcaagaagat agtggtgcag agcctcccat gccagattgc
       61 ttggagacag gagaaaaact gtttgtacat aacatgaatg cccagtgtgt acagaagcca
      121 gaagagggca atggacccct tggaactgga ggtaaaattg tccaaggaaa atgtttcaga
      181 atcatctcca ctgtgtctcc tgttaaactt tactgctgct atggagtgat catggtcctc
      241 actgtagctg taattgctct ttctgttgct ttgtcaacaa aaaagacaga acagatcata
      301 atcaacaaga cctatgctgc ttgctcaaaa aactggactg gagttggaaa taaatgtttt
      361 tatttttctg gatacccacg taactggaca tttgcccagg ccttctgcat ggcacaagag
      421 gcccaactag ctcggtttga caacgaggag gagctgattt tcctaaagag attcaagggg
      481 gattttgatt gctggattgg cctgcacaga gagtcgtcag agcacccttg gaagtggaca
      541 aacaacactg agtataacaa catgaatccc atcctaggag tgggaagata tgcctacctg
      601 agcagcgata ggatcagcag ttcgaggagc tatataaatc ggatgtggat ctgtagcaag
      661 ctcaacaact ataacctcca ttgccaaact cctcctgtct agcacttacc aagagactct
      721 tcttagcctg ttatctatgg gtgctacttt ttcccctatg gtcccacagt gctatcaaat
      781 gggattgaga atatttttta acatcacaaa tgaaaacaat cgaggctaga gagattgctc
      841 aatagttaag agcactgact gctcttctgc atgttcccag ttcacatctg agcaaccaca
      901 tggtgtctta caaacatctg taatgacatc tcatgtcctc ttctgggatg tgtgaaaaca
      961 ggtacactat acttacatat agtaaataag taaatcttaa aaaagaaaaa gaaaaccatc
     1021 ttagggaggt gcacacatgg aggattacaa gaccatagat gagttttaaa tagatgtcag
     1081 cactcatacc ttaacctaaa gtacaactaa tgttagggaa cccttctttt atgatattaa
     1141 ggttttgtgc agagaattct tcttttgaat ttatgagact acaaaaatga gtccccaacg
     1201 tgaggtgtcc tttaataatg taagcagaat ggctgggata gtgagaagca tctgcaatcc
     1261 caggtaccta agggttgaca caggagggtc tcaggttcac gagtggggac agaaagcaca
     1321 gaaacacttt cataatgata gggaagatga gaatctttct gtagcatccc ataatttgaa
     1381 gaaacatatt atacatgctt ttcaaaaatt caaaccaaca tacagaagaa tttttaaaaa
     1441 gtgtaaaatt aagatttact ttatactctg caatttaaaa gatgagggac attggcaaaa
     1501 tgtttctcca ctttagtttt caatatttcc aattatactg ttctaagtat aattataatt
     1561 acttacttat cctgttctaa gtacaatgca ttttataaac agatgccatt ttaatttcac
     1621 tattttatgc caggagcctt ctggcccggg ccagggtaat ggtggggtct atatagcatc
     1681 actacaagat ccatgtttgt ggatctgcag agatctgctc ctagggggag tgttcctact
     1741 tagcaattgt tatatatgtt taatgataac aggaaaagca cattaatagc aggaatcttt
     1801 cctaaaatga gtcactcata gccttgctta atgagggctc acctgtcaca gattatataa
     1861 taatccgagg caggccactt caggatgatc acctgctaat tattagcttg tctcattatg
     1921 actcttgaca attttattgt atttatttcc catcaaatat gagttaaact ccttaggtat
     1981 ttaatactta attttacact agcatctgca ttatttggtc tttaaaatta ttaaaaatct
     2041 tatagagtta gctactctgt attaatgagt tctaaaaggg aagaatttca ggttaaaagc
     2101 atctcttgat ctcttcatcc tttcttctcc ctcttgttct ttttaaagac tatatcaact
     2161 tgatatgctg tgtggggcgc ggttgatatc tatgggaggc ctccaggtct ttaaggagaa
     2221 agatatggag aaatggagga aggggagagg agagggacat agggggaggg aagagggaag
     2281 ggaaattaat aaaaaaataa aaccaaaacc aaaaccctt
//
