LOCUS       NM_027562               2466 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C-type lectin domain family 2, member g (Clec2g),
            transcript variant 1, mRNA.
ACCESSION   NM_027562 XM_984444
VERSION     NM_027562.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2466)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2466)
  AUTHORS   Maruyama,S., Kono,H., Furuya,S., Shimizu,H., Saito,R., Shoda,K.,
            Akaike,H., Hosomura,N., Kawaguchi,Y., Amemiya,H., Kawaida,H.,
            Sudo,M., Inoue,S., Shirai,T., Suzuki-Inoue,K. and Ichikawa,D.
  TITLE     Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic Liver
            Injury in Mice
  JOURNAL   Am J Pathol 190 (9), 1833-1842 (2020)
   PUBMED   32473917
  REMARK    GeneRIF: Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic
            Liver Injury in Mice.
REFERENCE   3  (bases 1 to 2466)
  AUTHORS   Lowe,K.L., Navarro-Nunez,L., Benezech,C., Nayar,S., Kingston,B.L.,
            Nieswandt,B., Barone,F., Watson,S.P., Buckley,C.D. and Desanti,G.E.
  TITLE     The expression of mouse CLEC-2 on leucocyte subsets varies
            according to their anatomical location and inflammatory state
  JOURNAL   Eur J Immunol 45 (9), 2484-2493 (2015)
   PUBMED   26173808
  REMARK    GeneRIF: Both circulating B lymphocytes and CD11b-high Gr-1-high
            myeloid cells lose CLEC-2 following entry into secondary lymphoid
            organs.
REFERENCE   4  (bases 1 to 2466)
  AUTHORS   Navarro-Nunez,L., Pollitt,A.Y., Lowe,K., Latif,A., Nash,G.B. and
            Watson,S.P.
  TITLE     Platelet adhesion to podoplanin under flow is mediated by the
            receptor CLEC-2 and stabilised by Src/Syk-dependent platelet
            signalling
  JOURNAL   Thromb Haemost 113 (5), 1109-1120 (2015)
   PUBMED   25694214
  REMARK    GeneRIF: CLEC-2 is an adhesive receptor that supports platelet
            arrest to podoplanin under venous shear. Src/Syk-dependent
            signalling stabilises platelet adhesion to podoplanin.
REFERENCE   5  (bases 1 to 2466)
  AUTHORS   Chen,P., Belanger,S., Aguilar,O.A., Zhang,Q., St-Laurent,A.,
            Rahim,M.M., Makrigiannis,A.P. and Carlyle,J.R.
  TITLE     Analysis of the mouse 129-strain Nkrp1-Clr gene cluster reveals
            conservation of genomic organization and functional receptor-ligand
            interactions despite significant allelic polymorphism
  JOURNAL   Immunogenetics 63 (10), 627-640 (2011)
   PUBMED   21667046
REFERENCE   6  (bases 1 to 2466)
  AUTHORS   Carlyle,J.R., Mesci,A., Ljutic,B., Belanger,S., Tai,L.H.,
            Rousselle,E., Troke,A.D., Proteau,M.F. and Makrigiannis,A.P.
  TITLE     Molecular and genetic basis for strain-dependent NK1.1
            alloreactivity of mouse NK cells
  JOURNAL   J Immunol 176 (12), 7511-7524 (2006)
   PUBMED   16751398
REFERENCE   7  (bases 1 to 2466)
  AUTHORS   Katsu,Y. and Iguchi,T.
  TITLE     Tissue-specific expression of Clec2g in mice
  JOURNAL   Eur J Cell Biol 85 (5), 345-354 (2006)
   PUBMED   16460835
  REMARK    GeneRIF: Data suggest that DDV10 is the long form of Clec2 g
            (Clec2g-L), and DDV10/Clec2g-L may play a role in the
            stratification and/or cornification of epithelial cells during
            differentiation.
REFERENCE   8  (bases 1 to 2466)
  AUTHORS   Katsu,Y., Lubahn,D.B. and Iguchi,T.
  TITLE     Expression of a novel C-type lectin in the mouse vagina
  JOURNAL   Endocrinology 144 (6), 2597-2605 (2003)
   PUBMED   12746323
REFERENCE   9  (bases 1 to 2466)
  AUTHORS   Zhou,H., Kartsogiannis,V., Quinn,J.M., Ly,C., Gange,C., Elliott,J.,
            Ng,K.W. and Gillespie,M.T.
  TITLE     Osteoclast inhibitory lectin, a family of new osteoclast inhibitors
  JOURNAL   J Biol Chem 277 (50), 48808-48815 (2002)
   PUBMED   12374791
REFERENCE   10 (bases 1 to 2466)
  AUTHORS   Plougastel,B., Dubbelde,C. and Yokoyama,W.M.
  TITLE     Cloning of Clr, a new family of lectin-like genes localized between
            mouse Nkrp1a and Cd69
  JOURNAL   Immunogenetics 53 (3), 209-214 (2001)
   PUBMED   11398965
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014570.1 and AK137753.1.
            
            On Dec 4, 2009 this sequence version replaced NM_027562.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014570.1, BC117543.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849376,
                                           SAMN00849387 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1183              AK014570.1         2-1184
            1184-1727           AK137753.1         1120-1663
            1728-2230           AK014570.1         1730-2232
            2231-2466           AK137753.1         2168-2403
FEATURES             Location/Qualifiers
     source          1..2466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.11 cM"
     gene            1..2466
                     /gene="Clec2g"
                     /gene_synonym="4632413B12Rik; Clr-c; Clr-d; Clrc; Clrd;
                     Clrx; Ddv10; Ocilrp1"
                     /note="C-type lectin domain family 2, member g"
                     /db_xref="GeneID:70809"
                     /db_xref="MGI:MGI:1918059"
     exon            1..102
                     /gene="Clec2g"
                     /gene_synonym="4632413B12Rik; Clr-c; Clr-d; Clrc; Clrd;
                     Clrx; Ddv10; Ocilrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..846
                     /gene="Clec2g"
                     /gene_synonym="4632413B12Rik; Clr-c; Clr-d; Clrc; Clrd;
                     Clrx; Ddv10; Ocilrp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     osteoclast inhibitory lectin related protein; ocil-related
                     protein 1; osteoclast inhibitory lectin-related protein 1;
                     C-type lectin-related protein C"
                     /codon_start=1
                     /product="C-type lectin domain family 2 member G isoform
                     1"
                     /protein_id="NP_081838.1"
                     /db_xref="CCDS:CCDS20578.1"
                     /db_xref="GeneID:70809"
                     /db_xref="MGI:MGI:1918059"
                     /translation="MNITRASLPMLNTTCSCRREKWNFLGRYEGTFDYWIGLHRASSK
                     HPWMWTDNTEYNNMFVYHMNAQCLKKPEEGESSPGTGGVHSYKILQRNSLRAISPESS
                     AKLYCCCGVIMVLTVAVVALSVALPATKTEQILINKTYAACPKNWIGVGNKCFYFSEY
                     TSNWTFAQTFCMAQEAQLARFDNEKELNFLMRYKANFDSWIGLHRESSEHPWKWTDNT
                     EYNNMIPIQGVETCAYLSGNGISSSRHYIPRIWICSKLNNYSLHCPTPVPV"
     exon            103..209
                     /gene="Clec2g"
                     /gene_synonym="4632413B12Rik; Clr-c; Clr-d; Clrc; Clrd;
                     Clrx; Ddv10; Ocilrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..292
                     /gene="Clec2g"
                     /gene_synonym="4632413B12Rik; Clr-c; Clr-d; Clrc; Clrd;
                     Clrx; Ddv10; Ocilrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..418
                     /gene="Clec2g"
                     /gene_synonym="4632413B12Rik; Clr-c; Clr-d; Clrc; Clrd;
                     Clrx; Ddv10; Ocilrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..597
                     /gene="Clec2g"
                     /gene_synonym="4632413B12Rik; Clr-c; Clr-d; Clrc; Clrd;
                     Clrx; Ddv10; Ocilrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..704
                     /gene="Clec2g"
                     /gene_synonym="4632413B12Rik; Clr-c; Clr-d; Clrc; Clrd;
                     Clrx; Ddv10; Ocilrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..2466
                     /gene="Clec2g"
                     /gene_synonym="4632413B12Rik; Clr-c; Clr-d; Clrc; Clrd;
                     Clrx; Ddv10; Ocilrp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcctatag tggtaactca gcttctcagc tctgagatga acattacaag ggcttcccta
       61 cctatgctca acaccacttg cagctgcagg agggagaagt ggaatttcct agggagatac
      121 gaggggactt ttgactactg gatcggcctg cacagagcgt cgtctaagca cccttggatg
      181 tggacagaca acactgagta taacaacatg tttgtgtatc acatgaatgc tcagtgccta
      241 aagaagccag aagaaggcga aagctccccc ggaactggag gtgtacattc ttataaaatt
      301 ctccaaagaa atagtctcag agccatctcc cctgagtctt ctgctaagct ttactgctgc
      361 tgtggagtga tcatggtcct cactgtagct gtagttgctc tttctgttgc tttgccagca
      421 acaaagacag aacagatcct aatcaacaag acctatgctg cttgcccgaa aaactggatt
      481 ggagttggaa ataaatgttt ttatttttct gaatacacaa gtaactggac attcgcccag
      541 accttctgca tggcacaaga ggcccaacta gctcggtttg acaacgagaa ggagctgaat
      601 ttcctaatga gatacaaggc aaattttgat tcctggattg gactgcacag agagtcgtca
      661 gagcaccctt ggaagtggac agacaacact gagtataaca acatgattcc catccaggga
      721 gtggaaacat gtgcctacct gagcggcaat gggatcagca gttccaggca ctatatacct
      781 cggatatgga tctgtagcaa gcttaacaac tatagcctcc actgcccaac tcctgttcct
      841 gtctagcatt taccaagaga ctcttcctag cctgttatct atgggtgcta ctttttcccc
      901 tatggtccca cagtgctatc aaacgggatt gagaatattt tttaacgtcg caaatgaaaa
      961 ccatcaaggc tggagagatt gctccgtagt taagagactg actgctcttc tgcatgtccc
     1021 gagttcacat ctgagcaacc acatggtgtc ttacaaacat ctgtaatgac atcttatgtc
     1081 ctcttctgtg gtgtgtgaaa acagctacac tatacctaca tatgataaat aagtaaatct
     1141 taaaaaagaa aaagaaaacc accttagaga ggtgcacaca tggaggatta caagaccata
     1201 gatgagtttt aaatagatgt cagcactcat accttaagcc taaagtacaa ctaatgttag
     1261 ggaaccccac ttttatgata ttaaggtttt gtgcagagaa ttcttctttt gaatttatga
     1321 gaccacaaaa atgagtcccc caacatgggt gtaaccttta ataatgaaag cagaatggct
     1381 gggatcctga gaagcatctg taatcccagg taccgaaggg ttgacacagg agggtctcag
     1441 gttcaccagt ggggacggaa agcacaaaaa cactttaata atgataggga agatgagatg
     1501 tctgttgcat cccgtaattt gaagaaacat attatacatg cttttcaaaa attcaaacca
     1561 acatacagaa gaatttttaa aaagtgtgta aaattaagat ttacttttta ctctgcaatt
     1621 taaaaagatg agggacattg gcgaaatgtt tctccacttt aattttaata ttcctatttc
     1681 caattatact gttctaagta taattatact tacttacttt tcctgttcta agtgtactgc
     1741 attttataat caaataccat tttaatttca ctattttatt ccaggagcct tctggcccag
     1801 gccagtgtaa tggtggagtc tatatagaat cactacaaga tagttcatct ttgtggatct
     1861 gcagagatct gcttcaaagg gggagtgttt ctactcagca attgttatat atgtttaaca
     1921 ataacagtaa aagcacatta atagcaggaa tctctcctaa aacgagtcac tcatagcctt
     1981 gcttaatgag ggctcacctg tcacagatta tataataatc tgaggcaggc cacttcagga
     2041 tgatcacctg ctagttatta gcttgtctca ttatgggtcc tgaccatttt tttggattta
     2101 tttcacatca aatgtgagtt aaactcctta ggcatttaat acttaatttt acactagcat
     2161 gtgcattact gagcctttaa aaaaatattg aaaatcttat agattgagct accatgtact
     2221 gatgagtccc aaaagagaaa aaatcatagg ctaaacgcag ctcttggtct cttcatcctt
     2281 tcttctcctt cttggtcttt ttaaagacta tatcaacttg atatgccaag ggggagttga
     2341 tatccatggg aggcctccag gtctttaagg agaaagggat ggagaaatgg aggaagggaa
     2401 ggggagaggg acataggggg agggaggagg gaagggaaat taaaaaaaaa ataaaaccta
     2461 aacact
//
