LOCUS       NM_053109               1214 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus C-type lectin domain family 2, member d (Clec2d),
            mRNA.
ACCESSION   NM_053109
VERSION     NM_053109.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1214)
  AUTHORS   Li,F., Wang,H., Li,Y.Q., Gu,Y. and Jia,X.M.
  TITLE     C-type lectin receptor 2d forms homodimers and heterodimers with
            TLR2 to negatively regulate IRF5-mediated antifungal immunity
  JOURNAL   Nat Commun 14 (1), 6718 (2023)
   PUBMED   37872182
  REMARK    GeneRIF: C-type lectin receptor 2d forms homodimers and
            heterodimers with TLR2 to negatively regulate IRF5-mediated
            antifungal immunity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1214)
  AUTHORS   Li,Y.N., Wang,Z.W., Li,F., Zhou,L.H., Jiang,Y.S., Yu,Y., Ma,H.H.,
            Zhu,L.P., Qu,J.M. and Jia,X.M.
  TITLE     Inhibition of myeloid-derived suppressor cell arginase-1 production
            enhances T-cell-based immunotherapy against Cryptococcus neoformans
            infection
  JOURNAL   Nat Commun 13 (1), 4074 (2022)
   PUBMED   35835754
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1214)
  AUTHORS   Christians,A., Weiss,A.C., Martens,H., Klopf,M.G., Hennies,I.,
            Haffner,D., Kispert,A. and Weber,R.G.
  TITLE     Inflammation-like changes in the urothelium of Lifr-deficient mice
            and LIFR-haploinsufficient humans with urinary tract anomalies
  JOURNAL   Hum Mol Genet 29 (7), 1192-1204 (2020)
   PUBMED   32179912
REFERENCE   4  (bases 1 to 1214)
  AUTHORS   Karagianni,P., Moulos,P., Schmidt,D., Odom,D.T. and Talianidis,I.
  TITLE     Bookmarking by Non-pioneer Transcription Factors during Liver
            Development Establishes Competence for Future Gene Activation
  JOURNAL   Cell Rep 30 (5), 1319-1328 (2020)
   PUBMED   32023452
REFERENCE   5  (bases 1 to 1214)
  AUTHORS   Lai,J.J., Cruz,F.M. and Rock,K.L.
  TITLE     Immune Sensing of Cell Death through Recognition of Histone
            Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and
            Tissue Injury
  JOURNAL   Immunity 52 (1), 123-135 (2020)
   PUBMED   31859049
REFERENCE   6  (bases 1 to 1214)
  AUTHORS   Carlyle,J.R., Jamieson,A.M., Gasser,S., Clingan,C.S., Arase,H. and
            Raulet,D.H.
  TITLE     Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural
            killer cell receptors
  JOURNAL   Proc Natl Acad Sci U S A 101 (10), 3527-3532 (2004)
   PUBMED   14990792
  REMARK    GeneRIF: cloning and characterization of a cognate ligand, Ocil,
            for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b
            is displayed at high levels on nearly all hematopoietic cells, in a
            pattern that is similar to that of class I MHC molecules.
REFERENCE   7  (bases 1 to 1214)
  AUTHORS   Iizuka,K., Naidenko,O.V., Plougastel,B.F., Fremont,D.H. and
            Yokoyama,W.M.
  TITLE     Genetically linked C-type lectin-related ligands for the NKRP1
            family of natural killer cell receptors
  JOURNAL   Nat Immunol 4 (8), 801-807 (2003)
   PUBMED   12858173
  REMARK    GeneRIF: Mouse Nkrp1d and Nkrp1f bind specific C-type
            lectin-related (Clr) molecules. Nkrp1d mediated inhibition when
            recognizing Clrb, a molecule expressed in dendritic cells and
            macrophages. Nkrp1 and Clr are intertwined in a genetically
            conserved NKC region.
REFERENCE   8  (bases 1 to 1214)
  AUTHORS   Zhou,H., Kartsogiannis,V., Quinn,J.M., Ly,C., Gange,C., Elliott,J.,
            Ng,K.W. and Gillespie,M.T.
  TITLE     Osteoclast inhibitory lectin, a family of new osteoclast inhibitors
  JOURNAL   J Biol Chem 277 (50), 48808-48815 (2002)
   PUBMED   12374791
REFERENCE   9  (bases 1 to 1214)
  AUTHORS   Zhou,H., Kartsogiannis,V., Hu,Y.S., Elliott,J., Quinn,J.M.,
            McKinstry,W.J., Gillespie,M.T. and Ng,K.W.
  TITLE     A novel osteoblast-derived C-type lectin that inhibits osteoclast
            formation
  JOURNAL   J Biol Chem 276 (18), 14916-14923 (2001)
   PUBMED   11278931
REFERENCE   10 (bases 1 to 1214)
  AUTHORS   Plougastel,B., Dubbelde,C. and Yokoyama,W.M.
  TITLE     Cloning of Clr, a new family of lectin-like genes localized between
            mouse Nkrp1a and Cd69
  JOURNAL   Immunogenetics 53 (3), 209-214 (2001)
   PUBMED   11398965
  REMARK    GeneRIF: Identification of a novel family of genes, named Clr,
            encoding C-type lectin-like molecules, which maps in the natural
            killer (NK) gene complex (NKC) on mouse Chromosome 6.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY320031.1 and AW987086.1.
            
            On Feb 18, 2011 this sequence version replaced NM_053109.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY320031.1, AF321553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1209              AY320031.1         1-1209
            1210-1214           AW987086.1         2-6                 c
FEATURES             Location/Qualifiers
     source          1..1214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.16 cM"
     gene            1..1214
                     /gene="Clec2d"
                     /gene_synonym="Clr-b; Clrb; Ocil"
                     /note="C-type lectin domain family 2, member d"
                     /db_xref="GeneID:93694"
                     /db_xref="MGI:MGI:2135589"
     exon            1..133
                     /gene="Clec2d"
                     /gene_synonym="Clr-b; Clrb; Ocil"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..690
                     /gene="Clec2d"
                     /gene_synonym="Clr-b; Clrb; Ocil"
                     /note="osteoclast inhibitory lectin; C-type lectin-domain
                     family 2 member D; C-type lectin-related protein B;
                     lectin-like transmembrane protein; C lectin-related
                     protein B"
                     /codon_start=1
                     /product="C-type lectin domain family 2 member D"
                     /protein_id="NP_444339.1"
                     /db_xref="CCDS:CCDS20581.1"
                     /db_xref="GeneID:93694"
                     /db_xref="MGI:MGI:2135589"
                     /translation="MCVTKASLPMLSPTGSPQEVEVGKILQGKRHGTISPESCAKLYC
                     YYGVIMVLTVAVIALSVALSATKTEQIPVNKTYAACPQNWIGVENKCFYFSEYPSNWT
                     FAQAFCMAQEAQLARFDNQDELNFLMRYKANFDSWIGLHRESSEHPWKWTDNTEYNNT
                     IPIRGEERFAYLNNNGISSTRIYSLRMWICSKLNSYSLHCQTPFFPS"
     exon            134..259
                     /gene="Clec2d"
                     /gene_synonym="Clr-b; Clrb; Ocil"
                     /inference="alignment:Splign:2.1.0"
     exon            260..438
                     /gene="Clec2d"
                     /gene_synonym="Clr-b; Clrb; Ocil"
                     /inference="alignment:Splign:2.1.0"
     exon            439..545
                     /gene="Clec2d"
                     /gene_synonym="Clr-b; Clrb; Ocil"
                     /inference="alignment:Splign:2.1.0"
     exon            546..1214
                     /gene="Clec2d"
                     /gene_synonym="Clr-b; Clrb; Ocil"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1195..1200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec2d"
                     /gene_synonym="Clr-b; Clrb; Ocil"
                     /note="hexamer: AATAAA"
     polyA_site      1207
                     /gene="Clec2d"
                     /gene_synonym="Clr-b; Clrb; Ocil"
                     /note="major polyA site"
ORIGIN      
        1 cgtatttgtg cctctcagct ttcaagtttc aatcctgtag tggaaactca gctcctcagc
       61 tctgagatgt gtgtcacaaa ggcttcccta cctatgctta gtcccacagg cagcccgcag
      121 gaggtagaag tgggtaaaat tctccaagga aaaaggcacg gaaccatctc ccctgagtct
      181 tgtgctaagc tttactgcta ctatggagtg atcatggtcc tcactgtagc tgtaattgct
      241 ctttctgttg ctttgtcagc aacaaagaca gaacagatcc cagtcaacaa gacctatgct
      301 gcttgcccgc aaaactggat tggagttgaa aataaatgtt tttatttttc tgaataccca
      361 agtaactgga cattcgccca ggccttctgc atggcacaag aggcccaact agctcggttt
      421 gacaaccagg atgagctgaa tttcctaatg agatacaagg cgaattttga ttcctggatt
      481 ggcctgcaca gagagtcgtc agagcaccct tggaagtgga cagacaacac tgagtataac
      541 aacacgattc ccatccgggg agaggaaaga tttgcctacc tgaacaacaa cgggatcagc
      601 agtaccagga tctattcact tcggatgtgg atctgtagca agctcaacag ctatagcctc
      661 cactgccaaa ctcctttttt tccttcctag catttaccaa gagacgcttt ttagcctgtt
      721 atctgtgggt gctactcttt cccctatggt cccaaagtgc tatcaaacca gatagagaat
      781 atttcttaac atcagaaatg aaaaccatca tttcatttca tgcagagatt gttcagtggt
      841 taaaatcact gactactctt ccgaaggtcc tgagttcaca tctgagcaac cacatggtgg
      901 ctcacaaaca tccgtaatga gatcttctga ggtgtatgaa aacagctaca ctgtacttta
      961 tactctgcaa tttaaagcat gagggacata ggagagttag ctaccccaca ctgatgagtc
     1021 ccaaaaagga cgaaataaca ggctaaaaag cctctcttga actcttcatc ctttcttctc
     1081 cctcttggtc tttttaaaga ccaggtcgct gaggagaaag agatggagaa atgggggaag
     1141 ggaaggggag agggacatga ttgggggagg ggaggggagg gaaattaata aaaaaataaa
     1201 accaaaatac taca
//
