LOCUS       NM_019985               1170 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus C-type lectin domain family 1, member b (Clec1b),
            transcript variant 1, mRNA.
ACCESSION   NM_019985
VERSION     NM_019985.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1170)
  AUTHORS   Yamazaki,E., Ikeda,K., Urata,R., Ueno,D., Katayama,A., Ito,F.,
            Ikegaya,H. and Matoba,S.
  TITLE     Endothelial CLEC-1b plays a protective role against cancer
            hematogenous metastasis
  JOURNAL   Biochem Biophys Res Commun 708, 149819 (2024)
   PUBMED   38531221
  REMARK    GeneRIF: Endothelial CLEC-1b plays a protective role against cancer
            hematogenous metastasis.
REFERENCE   2  (bases 1 to 1170)
  AUTHORS   Sheng,M., Sun,R., Fu,J. and Lu,G.
  TITLE     The podoplanin-CLEC-2 interaction promotes platelet-mediated
            melanoma pulmonary metastasis
  JOURNAL   BMC Cancer 24 (1), 399 (2024)
   PUBMED   38561690
  REMARK    GeneRIF: The podoplanin-CLEC-2 interaction promotes
            platelet-mediated melanoma pulmonary metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1170)
  AUTHORS   Bourne,J.H., Smith,C.W., Jooss,N.J., Di,Y., Brown,H.C.,
            Montague,S.J., Thomas,M.R., Poulter,N.S., Rayes,J. and Watson,S.P.
  TITLE     CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood
            at Arterial Shear
  JOURNAL   Thromb Haemost 122 (12), 1988-2000 (2022)
   PUBMED   35817083
  REMARK    GeneRIF: CLEC-2 Supports Platelet Aggregation in Mouse but not
            Human Blood at Arterial Shear.
REFERENCE   4  (bases 1 to 1170)
  AUTHORS   Shao,B., Hoover,C., Shi,H., Kondo,Y., Lee,R.H., Chen,J., Shan,X.,
            Song,J., McDaniel,J.M., Zhou,M., McGee,S., Vanhoorelbeke,K.,
            Bergmeier,W., Lopez,J.A., George,J.N. and Xia,L.
  TITLE     Deletion of platelet CLEC-2 decreases GPIbalpha-mediated integrin
            alphaIIbbeta3 activation and decreases thrombosis in TTP
  JOURNAL   Blood 139 (16), 2523-2533 (2022)
   PUBMED   35157766
REFERENCE   5  (bases 1 to 1170)
  AUTHORS   Kumode,T., Tanaka,H., Esipinoza,J.L., Rai,S., Taniguchi,Y.,
            Fujiwara,R., Sano,K., Serizawa,K., Iwata,Y., Morita,Y. and
            Matsumura,I.
  TITLE     C-type lectin-like receptor 2 specifies a functionally distinct
            subpopulation within phenotypically defined hematopoietic stem cell
            population that contribute to emergent megakaryopoiesis
  JOURNAL   Int J Hematol 115 (3), 310-321 (2022)
   PUBMED   35106701
  REMARK    GeneRIF: C-type lectin-like receptor 2 specifies a functionally
            distinct subpopulation within phenotypically defined hematopoietic
            stem cell population that contribute to emergent megakaryopoiesis.
REFERENCE   6  (bases 1 to 1170)
  AUTHORS   Xie,J., Wu,T., Guo,L., Ruan,Y., Zhou,L., Zhu,H., Yun,X., Hong,Y.,
            Jiang,J., Wen,Y. and Gu,J.
  TITLE     Molecular characterization of two novel isoforms and a soluble form
            of mouse CLEC-2
  JOURNAL   Biochem Biophys Res Commun 371 (2), 180-184 (2008)
   PUBMED   18361921
  REMARK    GeneRIF: Two novel splicing variants of mCLEC-2 derived from
            omission of exon 2 and 2/4, respectively, were indentified in
            mouse.
REFERENCE   7  (bases 1 to 1170)
  AUTHORS   Suzuki-Inoue,K., Kato,Y., Inoue,O., Kaneko,M.K., Mishima,K.,
            Yatomi,Y., Yamazaki,Y., Narimatsu,H. and Ozaki,Y.
  TITLE     Involvement of the snake toxin receptor CLEC-2, in
            podoplanin-mediated platelet activation, by cancer cells
  JOURNAL   J Biol Chem 282 (36), 25993-26001 (2007)
   PUBMED   17616532
  REMARK    GeneRIF: CLEC-2 is a physiological target protein of podoplanin and
            imply that it is involved in podoplanin-induced platelet
            aggregation, tumor metastasis
REFERENCE   8  (bases 1 to 1170)
  AUTHORS   Suzuki-Inoue,K., Fuller,G.L., Garcia,A., Eble,J.A., Pohlmann,S.,
            Inoue,O., Gartner,T.K., Hughan,S.C., Pearce,A.C., Laing,G.D.,
            Theakston,R.D., Schweighoffer,E., Zitzmann,N., Morita,T.,
            Tybulewicz,V.L., Ozaki,Y. and Watson,S.P.
  TITLE     A novel Syk-dependent mechanism of platelet activation by the
            C-type lectin receptor CLEC-2
  JOURNAL   Blood 107 (2), 542-549 (2006)
   PUBMED   16174766
REFERENCE   9  (bases 1 to 1170)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1170)
  AUTHORS   Colonna,M., Samaridis,J. and Angman,L.
  TITLE     Molecular characterization of two novel C-type lectin-like
            receptors, one of which is selectively expressed in human dendritic
            cells
  JOURNAL   Eur J Immunol 30 (2), 697-704 (2000)
   PUBMED   10671229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064054.1 and AC138620.4.
            
            On Feb 23, 2011 this sequence version replaced NM_019985.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064054.1, AK007925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1090              BC064054.1         1-1090
            1091-1170           AC138620.4         136092-136171
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.3 cM"
     gene            1..1170
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /note="C-type lectin domain family 1, member b"
                     /db_xref="GeneID:56760"
                     /db_xref="MGI:MGI:1913287"
     exon            1..382
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1008
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     C-type lectin-like receptor 2"
                     /codon_start=1
                     /product="C-type lectin domain family 1 member B isoform
                     1"
                     /protein_id="NP_064369.1"
                     /db_xref="CCDS:CCDS20586.1"
                     /db_xref="GeneID:56760"
                     /db_xref="MGI:MGI:1913287"
                     /translation="MQDEDGYITLNIKPRKQALSSAEPASSWWRVMALVLLISSMGLV
                     VGLVALGIMSVTQQKYLLAEKENLSATLQQLAKKFCQELIRQSEIKTKSTFEHKCSPC
                     ATKWRYHGDSCYGFFRRNLTWEESKQYCTEQNATLVKTASQSTLDYIAERITSVRWIG
                     LSRQNSKKDWMWEDSSVLRKNGINLSGNTEENMNCAYLHNGKIHPASCKERHYLICER
                     NAGMTRVDQLL"
     exon            383..478
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..604
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..756
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /inference="alignment:Splign:2.1.0"
     exon            757..863
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1170
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1052..1057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /note="hexamer: AATAAA"
     polyA_site      1071
                     /gene="Clec1b"
                     /gene_synonym="1810061I13Rik; Clec-2; Clec2"
                     /note="major polyA site"
ORIGIN      
        1 ctccctcagg acggaacatc ccttcactca gagctgaaga taagagagca ggaaacgagc
       61 cccgcatcta ctctttcacc acaagttatt attatttttg tttttaggtt caagcccacg
      121 tatctctgaa catccaagaa agggcttcct ggaaaacaag acaaagcaaa acaaacccca
      181 agtgtcctgg tgcatatggc cccacaccac cgggagagaa ggagcccaca ctggcaggca
      241 ctgagactct aagggtggac attgggtgag ttctgcagag tcactgagct ctgagctctt
      301 tgctgttcaa ggggagccat gcaggatgaa gatgggtata tcactttaaa catcaagccc
      361 cggaaacaag ctctcagctc agcggaacct gcctcttctt ggtggcgtgt gatggcttta
      421 gttctgctga tctcatccat ggggctggtt gttggactcg tggctctggg gatcatgtcg
      481 gtcacacagc aaaagtatct actggcggag aaggaaaatc tctcagcgac tctgcaacaa
      541 ttggccaaga aattctgcca agagttgatt agacaatcag aaattaagac aaagagcact
      601 tttgagcaca agtgcagccc ctgcgccacg aagtggagat accatggaga tagttgctac
      661 gggttcttca ggcgtaacct aacatgggaa gagagcaagc agtattgcac tgagcagaat
      721 gcaacacttg tgaagactgc cagccagagc accctggact acattgcaga aaggattact
      781 tcagtccgtt ggattggatt atcacgccag aactctaaga aagactggat gtgggaggat
      841 agctcagttc ttcgcaagaa cgggattaat ctttctggga atacagaaga aaacatgaat
      901 tgtgcttatc ttcataatgg aaaaatccat ccagcttcct gtaaagagag acattactta
      961 atatgtgaga gaaatgctgg catgacaaga gtggaccaac tgctttaatg cagaaggatg
     1021 gacaggatgt cagataagtg cttgatcatg caataaaaga tctggacaaa agaactccgc
     1081 attcataaaa ctgcttattt tgtattttta tatcatcctt atatcacagg tctgatcctt
     1141 tctctgtata ttaaaaaaac agcatgtcag
//
