LOCUS       NM_175526               3268 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus C-type lectin domain family 1, member a (Clec1a),
            transcript variant 1, mRNA.
ACCESSION   NM_175526
VERSION     NM_175526.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3268)
  AUTHORS   Makusheva,Y., Chung,S.H., Akitsu,A., Maeda,N., Maruhashi,T.,
            Ye,X.Q., Kaifu,T., Saijo,S., Sun,H., Han,W., Tang,C. and Iwakura,Y.
  TITLE     The C-type lectin receptor Clec1A plays an important role in the
            development of experimental autoimmune encephalomyelitis by
            enhancing antigen presenting ability of dendritic cells and
            inducing inflammatory cytokine IL-17
  JOURNAL   Exp Anim 71 (3), 288-304 (2022)
   PUBMED   35135958
  REMARK    GeneRIF: The C-type lectin receptor Clec1A plays an important role
            in the development of experimental autoimmune encephalomyelitis by
            enhancing antigen presenting ability of dendritic cells and
            inducing inflammatory cytokine IL-17.
REFERENCE   2  (bases 1 to 3268)
  AUTHORS   Tone,K., Stappers,M.H.T., Hatinguais,R., Dambuza,I.M., Salazar,F.,
            Wallace,C., Yuecel,R., Morvay,P.L., Kuwano,K., Willment,J.A. and
            Brown,G.D.
  TITLE     MelLec Exacerbates the Pathogenesis of Aspergillus
            fumigatus-Induced Allergic Inflammation in Mice
  JOURNAL   Front Immunol 12, 675702 (2021)
   PUBMED   34122436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3268)
  AUTHORS   Stappers,M.H.T., Clark,A.E., Aimanianda,V., Bidula,S., Reid,D.M.,
            Asamaphan,P., Hardison,S.E., Dambuza,I.M., Valsecchi,I.,
            Kerscher,B., Plato,A., Wallace,C.A., Yuecel,R., Hebecker,B., da
            Gloria Teixeira Sousa,M., Cunha,C., Liu,Y., Feizi,T.,
            Brakhage,A.A., Kwon-Chung,K.J., Gow,N.A.R., Zanda,M., Piras,M.,
            Zanato,C., Jaeger,M., Netea,M.G., van de Veerdonk,F.L.,
            Lacerda,J.F., Campos,A., Carvalho,A., Willment,J.A., Latge,J.P. and
            Brown,G.D.
  TITLE     Recognition of DHN-melanin by a C-type lectin receptor is required
            for immunity to Aspergillus
  JOURNAL   Nature 555 (7696), 382-386 (2018)
   PUBMED   29489751
REFERENCE   4  (bases 1 to 3268)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX512526.1, AK049608.1 and AC138620.4.
            
            On Mar 21, 2009 this sequence version replaced NM_175526.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031121.1, BC052840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               BX512526.1         1-254
            255-1653            AK049608.1         2-1400
            1654-3268           AC138620.4         157442-159056       c
FEATURES             Location/Qualifiers
     source          1..3268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.32 cM"
     gene            1..3268
                     /gene="Clec1a"
                     /gene_synonym="5930406N14Rik"
                     /note="C-type lectin domain family 1, member a"
                     /db_xref="GeneID:243653"
                     /db_xref="MGI:MGI:2444151"
     exon            1..397
                     /gene="Clec1a"
                     /gene_synonym="5930406N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            398..496
                     /gene="Clec1a"
                     /gene_synonym="5930406N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            497..673
                     /gene="Clec1a"
                     /gene_synonym="5930406N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            674..825
                     /gene="Clec1a"
                     /gene_synonym="5930406N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            826..944
                     /gene="Clec1a"
                     /gene_synonym="5930406N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            945..3268
                     /gene="Clec1a"
                     /gene_synonym="5930406N14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3243..3248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec1a"
                     /gene_synonym="5930406N14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3266
                     /gene="Clec1a"
                     /gene_synonym="5930406N14Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggtctgtaa aaggcggata ttttaataac tgttcacaga ccgcccagcc agaaacacgc
       61 gatttcccct cagccagact aacttggcat tctgaataca ggctcagagg ggaggggccg
      121 ggtctctcca tgcaggaact ggagtcagag gcttcccttg ctgcttgcag ggaaagacta
      181 ttaagaatgc ctctcagtgc ctggtttcct gaggtatctg agggtagaca ggcggcctct
      241 cgagcaatct gagcacatct caccggcatc tctgcaggaa tcaggatgca ggccaaatac
      301 agcagcacaa gggacatgct cgatgatgat gataccacca taagcctgta ttctggaacc
      361 tccactgtca ccagacgtgc agagcccagg cactcagaga atgggacacc ctcttcagtt
      421 tggcgcccag tggccctgac cctgctgacc ttgtgtttgg tgctgctcgt tggcctggca
      481 gccctgggcc ttgtgttttt tcagttctac cagctgtcta atatccagca agacagcatc
      541 actgaaaagg atgaaaagct ggggaacatg tcccgacagc tacagtctct ccaggcccag
      601 aacagaaaac tcattgaaac tctacagcag gtagccgtaa aactgtgccg tgaactttac
      661 aacaaaagtg gaggacatag atgcagtcct tgcccagaaa aatggaagtg gtatggagac
      721 aaatgttacc agttctataa agaaagtaag aactggcaga gttgtgaata cttctgcctg
      781 gctgacaatg ccaccatgct gaagataagc acacaggaag agctggattt tgccatgccc
      841 cagagctact ctgagttttt ctactcttat tggacagggc tctcccgcaa tggcagtggc
      901 aaagcctggc tgtggacaga tgggacacct tactcctttg aactgtttga gattataata
      961 gatcccacca acctaagaaa cagggactgt atgaccatct tcaatggaaa ggcttactct
     1021 aaggactgca aagagctgag gaggtgtgcc tgtgagagga tagcagggag agtggtacct
     1081 ggagagctcc agtaggtgac atgaagcatt ggattgaggg gtcaacaggt cagcttcaac
     1141 caccagcaaa aggactgcca agtgaggcca atgtgaagga cattcaaagc tttgggaaac
     1201 agatgggcag ctgctggggc tggtatgtga gaggttttcc tggttctagc tcagcatcat
     1261 ccaggcctgg gctttagttc ttgtgcacat gttctagaca caaagggtct tattgatgaa
     1321 cctccgacta gccccaggaa gtcatagagt tgtcctcctt gatttacaaa agactttcag
     1381 ttttctccct tctcagggtc tagacgttat cagcctctgt ctcatgtctc ccttactctt
     1441 ggaaaagtga gaaacataag aagatagaag agttgataca aagccacaaa ctagatgagc
     1501 tagtgtccac ataactattg gtcctttaga gtcacagcac ttggaaggag aaggaagaca
     1561 tgagaagttc aaggccagcc tcaggtacat atttgcaggc catcctaggc tacatgagta
     1621 cacctttcaa gtgacagaaa gaaggaacaa aagaacaaga gaaaaaagaa aggaagaatg
     1681 gaagaagaaa tgtgaaaatc aaagtgaaaa gagagaaaag aagaagaaaa catggtgtcc
     1741 tttatcctaa caggcaatcc aagaaaaact agcagaagac cccaaccctg tgctgctcta
     1801 cacacagaca attctttttg cgtccagctc acactttcct aggctcgcaa aagtgacttc
     1861 acctactgtg cctgtggcca gctttccagc tgatacagtt ctcattatgt caaccaccac
     1921 tccatcaatt gtgtctttcc cctaattatg tctcctagga aagagaccgt ctcaattcta
     1981 agctagaatt aatgtccctg tacaccttaa gagactgaag cctagaaaaa acaataacaa
     2041 aacaaacaaa acaacaacaa aatccagaac aacctctgta cagataatag gttgatttct
     2101 tcttccatca tttttgaaca atgtttatac ctttcaggta ctgaatgttt aataataata
     2161 agtgtaaata atgtgaaatg ggtgacgttc tagaatggat ttgtgatttg gtgtaggaga
     2221 ccagcaaagg aatccttttc acaaaatgga aaccatcact ccttaactcc ttgtgcattg
     2281 acaggtggtg agaccactat aaagatattg tttatgagat tacatgagta taagaaagtc
     2341 ttcaagagga tggctttata atattcctaa agtgaaatgt ctgaggcgaa atcatgacgt
     2401 tgaggttggt atgttgacta actggggtgt gggagaagca tggtttctaa acaggcgtgg
     2461 gaggaaatgg agaagctgtg acatctgcac agccagactc ttgactagac atgagcttct
     2521 ctcggtggtg acattccaag ccacaacagg gtctttgtga atagtaccat gccaagtggt
     2581 ttcattggtt agagataaat cagcattagg ggttggtggc accagcaata gatttcacac
     2641 tctaaatttt cagtagtaaa aattggaaaa catccatatc atggtgaaat tacaattaaa
     2701 ttagcacttt gttatgaaaa acaattctct atttattttc ataagactta attttatgac
     2761 tgtcatttat ctaagcattg ctgtgagacc acttgagttt tctttgagat ttccttcatg
     2821 ttcgtttggg gagttcttca atattgaatt ctatgcaggt ttactgggac aagcagatag
     2881 aagtgtattt gtgtttttaa aacttgaggg acttacatct ttcttgtttt ggtttgttta
     2941 ttgagccaat cacctcacat catgtagctt attaaaaagt gggaatattt ataatttccc
     3001 tatgatgtta cttttaaaaa gtgtgaagtt agtctcataa tgtaggttgt aatataaaat
     3061 gtgttgaaaa ttaagaaaat attctaaaga gtttaatgat cattttaatg tagcagaaca
     3121 caagggcagc atctgtagtc attaaagaag aaaggtattc tcaaatattt tccataacta
     3181 acaaaattat aactgtttct tctgtttggt taaattgtct aatataatat ttcaaaatat
     3241 ggaataaaga tcaagtccat cattaagc
//
