LOCUS       NM_181549               1832 bp    mRNA    linear   ROD 18-OCT-2024
DEFINITION  Mus musculus C-type lectin domain family 18, member A (Clec18a),
            transcript variant 1, mRNA.
ACCESSION   NM_181549
VERSION     NM_181549.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1832)
  AUTHORS   Huang,Y.L., Huang,M.T., Sung,P.S., Chou,T.Y., Yang,R.B., Yang,A.S.,
            Yu,C.M., Hsu,Y.W., Chang,W.C. and Hsieh,S.L.
  TITLE     Endosomal TLR3 co-receptor CLEC18A enhances host immune response to
            viral infection
  JOURNAL   Commun Biol 4 (1), 229 (2021)
   PUBMED   33603190
  REMARK    GeneRIF: Endosomal TLR3 co-receptor CLEC18A enhances host immune
            response to viral infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1832)
  AUTHORS   Gerber,S.D., Amann,R., Wyder,S. and Trueb,B.
  TITLE     Comparison of the gene expression profiles from normal and Fgfrl1
            deficient mouse kidneys reveals downstream targets of Fgfrl1
            signaling
  JOURNAL   PLoS One 7 (3), e33457 (2012)
   PUBMED   22432025
REFERENCE   3  (bases 1 to 1832)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 1832)
  AUTHORS   Burgdorf,S., Lukacs-Kornek,V. and Kurts,C.
  TITLE     The mannose receptor mediates uptake of soluble but not of
            cell-associated antigen for cross-presentation
  JOURNAL   J Immunol 176 (11), 6770-6776 (2006)
   PUBMED   16709836
  REMARK    GeneRIF: Dendritic cells use the mannose receptor for endocytosis
            of a particular antigen type (soluble ovalbumin) intended for
            cross-presentation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093451.25.
            
            On Mar 24, 2022 this sequence version replaced NM_181549.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.638784.1,
                                           SRR17784644.1355843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC093451.25        121997-122215       c
            220-311             AC093451.25        121334-121425       c
            312-554             AC093451.25        119242-119484       c
            555-652             AC093451.25        116520-116617       c
            653-774             AC093451.25        115910-116031       c
            775-882             AC093451.25        115642-115749       c
            883-975             AC093451.25        114143-114235       c
            976-1082            AC093451.25        113116-113222       c
            1083-1212           AC093451.25        112480-112609       c
            1213-1309           AC093451.25        112083-112179       c
            1310-1401           AC093451.25        111179-111270       c
            1402-1832           AC093451.25        109991-110421       c
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.93 cM"
     gene            1..1832
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /note="C-type lectin domain family 18, member A"
                     /db_xref="GeneID:353287"
                     /db_xref="MGI:MGI:2672935"
     exon            1..219
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1439
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /note="isoforn 1 precursor is encoded by transcript
                     variant 1; mannose receptor-like protein"
                     /codon_start=1
                     /product="C-type lectin domain family 18 member A isoforn
                     1 precursor"
                     /protein_id="NP_853527.2"
                     /db_xref="GeneID:353287"
                     /db_xref="MGI:MGI:2672935"
                     /translation="MIQPEPSLWLGSQSRWLGLLLLLLSLLGITWTEVQPPQPKQDPT
                     LQALSRKESFLILTAHNRLRSRVHPPAANMQRMDWSESLAQLAEARAALCVTSVTPNL
                     ASTPGHNSHVGWNVQLMPMGSASFVEVVNLWFAEGLQYRHGDAECAHNATCAHYTQLV
                     WATSSQLGCGRQPCFVDQEAMEAFVCAYSPGGNWDINGKTVAPYKKGTWCSLCTARVS
                     GCFKAWDHAGGLCEVPRNPCRMSCRNLGHLNISTCRCHCQPGYTGRYCQVRCSVQCVH
                     GQFRKEECSCICDVGYGGAQCATKVGFPFHTCDLRIDGDCFMVSPEADTYYGAKMKCQ
                     GKGGVLAQIESQKVQDILAFYLGRLETTNEVTDSDFETKNFWIGLTYKAAKDSFRWTT
                     GEHQSFTSFAFGQPDNQGFGNCVEMQASAAFNWNDQRCKTRNRYICQFAQKHYSRWEP
                     GP"
     exon            220..311
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            312..554
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            555..652
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            653..774
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            775..882
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            883..975
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1082
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1212
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1309
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1401
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1832
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1812..1817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /note="hexamer: ATTAAA"
     polyA_site      1832
                     /gene="Clec18a"
                     /gene_synonym="Mrcl"
                     /note="major polyA site"
ORIGIN      
        1 gacttgtgaa tagcttcatg aacacgggga ggctagctgg acagctgaga gaagccatgt
       61 ctgcagcatc cggcaggcca atgattcagc cggagccctc cctgtggctg ggaagccaga
      121 gccgatggct cggtctcttg cttctgctcc tgtctctcct tggcatcaca tggacagagg
      181 ttcaaccacc ccagccaaag caagatccca ctctgcaagc cctgagcagg aaggagagtt
      241 tcttaatcct caccgcacac aaccgactgc gcagccgggt ccaccctcct gcagccaaca
      301 tgcagagaat ggactggagc gagagcctgg ctcagctagc tgaagccagg gcagcccttt
      361 gtgtcacttc agtcacccca aacctggcat ctaccccagg gcacaactca catgtgggct
      421 ggaatgtgca gctaatgccc atgggctcag catcctttgt cgaagtggtc aacctctggt
      481 ttgctgaagg gctgcagtac agacatgggg atgctgagtg tgcccacaat gccacctgtg
      541 cccactacac acaacttgtg tgggctacct ccagccagct gggctgtggg cggcagccat
      601 gctttgtgga ccaggaagcc atggaagcct ttgtctgtgc ctactcccct ggaggcaact
      661 gggatataaa tgggaagaca gtcgcccctt acaagaaagg cacctggtgc tccctctgca
      721 cagccagggt ctcgggctgc ttcaaggcct gggatcacgc aggggggctc tgtgaggttc
      781 ccaggaaccc atgccgcatg agctgccgaa atctcggaca tctcaacatt agcacttgtc
      841 gctgtcactg tcaacctggc tacacaggga ggtactgcca agtgcgctgc agtgtacagt
      901 gtgtgcacgg ccaattccgg aaagaagaat gttcctgtat ctgtgatgtc ggctatgggg
      961 gagcccagtg tgccaccaag gtgggctttc ccttccacac ctgtgacctg aggattgacg
     1021 gagactgctt catggtgtct cctgaggcag acacctacta tggagccaag atgaaatgtc
     1081 agggaaaagg tggggtgcta gcccagatcg agagccagaa agtgcaagac atccttgcct
     1141 tctacctggg ccgcctggag accaccaacg aggtgactga cagtgacttt gagaccaaga
     1201 atttctggat tgggctcacc tacaaggcag ctaaggattc cttccgctgg actactggag
     1261 aacaccagtc cttcaccagt tttgccttcg ggcagcctga caaccagggg tttgggaatt
     1321 gtgtggaaat gcaggcatct gctgccttca actggaatga ccaacgttgt aaaactcgaa
     1381 accgttatat ctgccagttt gctcagaagc actattcccg gtgggagcca gggccctgag
     1441 cctggccaat cagctctcct gccagcccct gaatgcacaa atcagtttgc tggacttctc
     1501 acccgtgtga aacaagtgcc tggctaggac taaatgccca acctcccaag aggtctcaga
     1561 ccttccacaa tgctggacgc tgggtaagat agtagtgtag cccatgggaa acaaatagga
     1621 agtggaacaa gagcctagca tgggaagaga agcgccagca tcctcagcct gcctctgatg
     1681 ggaaagaggg gctcccatgg gttcctaaag caaaagccag agccaggggc cagaagaggc
     1741 tgttctgctc catccagacc aaactccttc gggcagctgg agttttccag actagcggcc
     1801 tttaattcca gattaaatga cattgtgaat ca
//
