LOCUS       NM_001204229            6238 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus C-type lectin domain family 16, member A (Clec16a),
            transcript variant 2, mRNA.
ACCESSION   NM_001204229
VERSION     NM_001204229.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6238)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6238)
  AUTHORS   Gingerich,M.A., Zhu,J., Chai,B., Vincent,M.P., Xie,N., Sidarala,V.,
            Kotov,N.A., Sahu,D., Klionsky,D.J., Schnell,S. and
            Soleimanpour,S.A.
  TITLE     Reciprocal regulatory balance within the CLEC16A-RNF41 mitophagy
            complex depends on an intrinsically disordered protein region
  JOURNAL   J Biol Chem 299 (4), 103057 (2023)
   PUBMED   36822331
REFERENCE   3  (bases 1 to 6238)
  AUTHORS   Georgiadou,E., Muralidharan,C., Martinez,M., Chabosseau,P.,
            Akalestou,E., Tomas,A., Wern,F.Y.S., Stylianides,T., Wretlind,A.,
            Legido-Quigley,C., Jones,B., Lopez-Noriega,L., Xu,Y., Gu,G.,
            Alsabeeh,N., Cruciani-Guglielmacci,C., Magnan,C., Ibberson,M.,
            Leclerc,I., Ali,Y., Soleimanpour,S.A., Linnemann,A.K.,
            Rodriguez,T.A. and Rutter,G.A.
  TITLE     Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not
            Incretin-Stimulated beta-Cell Connectivity and Insulin Secretion
  JOURNAL   Diabetes 71 (7), 1472-1489 (2022)
   PUBMED   35472764
REFERENCE   4  (bases 1 to 6238)
  AUTHORS   Hain,H.S., Pandey,R., Bakay,M., Strenkowski,B.P., Harrington,D.,
            Romer,M., Motley,W.W., Li,J., Lancaster,E., Roth,L., Grinspan,J.B.,
            Scherer,S.S. and Hakonarson,H.
  TITLE     Inducible knockout of Clec16a in mice results in sensory
            neurodegeneration
  JOURNAL   Sci Rep 11 (1), 9319 (2021)
   PUBMED   33927318
  REMARK    GeneRIF: Inducible knockout of Clec16a in mice results in sensory
            neurodegeneration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6238)
  AUTHORS   Pandey,R., Bakay,M., Strenkowski,B.P., Hain,H.S. and Hakonarson,H.
  TITLE     JAK/STAT inhibitor therapy partially rescues the lipodystrophic
            autoimmune phenotype in Clec16a KO mice
  JOURNAL   Sci Rep 11 (1), 7372 (2021)
   PUBMED   33795715
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6238)
  AUTHORS   Raum,J.C., Soleimanpour,S.A., Groff,D.N., Core,N., Fasano,L.,
            Garratt,A.N., Dai,C., Powers,A.C. and Stoffers,D.A.
  TITLE     Tshz1 Regulates Pancreatic beta-Cell Maturation
  JOURNAL   Diabetes 64 (8), 2905-2914 (2015)
   PUBMED   25918232
REFERENCE   7  (bases 1 to 6238)
  AUTHORS   Fairfield,H., Srivastava,A., Ananda,G., Liu,R., Kircher,M.,
            Lakshminarayana,A., Harris,B.S., Karst,S.Y., Dionne,L.A.,
            Kane,C.C., Curtain,M., Berry,M.L., Ward-Bailey,P.F., Greenstein,I.,
            Byers,C., Czechanski,A., Sharp,J., Palmer,K., Gudis,P., Martin,W.,
            Tadenev,A., Bogdanik,L., Pratt,C.H., Chang,B., Schroeder,D.G.,
            Cox,G.A., Cliften,P., Milbrandt,J., Murray,S., Burgess,R.,
            Bergstrom,D.E., Donahue,L.R., Hamamy,H., Masri,A., Santoni,F.A.,
            Makrythanasis,P., Antonarakis,S.E., Shendure,J. and Reinholdt,L.G.
  TITLE     Exome sequencing reveals pathogenic mutations in 91 strains of mice
            with Mendelian disorders
  JOURNAL   Genome Res 25 (7), 948-957 (2015)
   PUBMED   25917818
REFERENCE   8  (bases 1 to 6238)
  AUTHORS   Li,J., Jorgensen,S.F., Maggadottir,S.M., Bakay,M., Warnatz,K.,
            Glessner,J., Pandey,R., Salzer,U., Schmidt,R.E., Perez,E.,
            Resnick,E., Goldacker,S., Buchta,M., Witte,T., Padyukov,L.,
            Videm,V., Folseraas,T., Atschekzei,F., Elder,J.T., Nair,R.P.,
            Winkelmann,J., Gieger,C., Nothen,M.M., Buning,C., Brand,S.,
            Sullivan,K.E., Orange,J.S., Fevang,B., Schreiber,S., Lieb,W.,
            Aukrust,P., Chapel,H., Cunningham-Rundles,C., Franke,A.,
            Karlsen,T.H., Grimbacher,B., Hakonarson,H., Hammarstrom,L. and
            Ellinghaus,E.
  TITLE     Association of CLEC16A with human common variable immunodeficiency
            disorder and role in murine B cells
  JOURNAL   Nat Commun 6, 6804 (2015)
   PUBMED   25891430
  REMARK    GeneRIF: CLEC16A associations in common variable immunodeficiency
            disorder represent the first robust evidence of non-HLA
            associations in this immunodeficiency condition.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6238)
  AUTHORS   Soleimanpour,S.A., Gupta,A., Bakay,M., Ferrari,A.M., Groff,D.N.,
            Fadista,J., Spruce,L.A., Kushner,J.A., Groop,L., Seeholzer,S.H.,
            Kaufman,B.A., Hakonarson,H. and Stoffers,D.A.
  TITLE     The diabetes susceptibility gene Clec16a regulates mitophagy
  JOURNAL   Cell 157 (7), 1577-1590 (2014)
   PUBMED   24949970
  REMARK    GeneRIF: Islets from mice with pancreas-specific deletion of
            Clec16a have abnormal mitochondria with reduced oxygen consumption
            and ATP concentration, both of which are required for normal beta
            cell function, Clec16a controls beta cell function and prevents
            diabetes by controlling mitophagy.
REFERENCE   10 (bases 1 to 6238)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122352.4, AC154430.3 and CT010583.8.
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, but maintains the reading frame, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156927.1, SRR10223971.15695.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC122352.4         141230-141533
            305-433             AC122352.4         155912-156040
            434-567             AC122352.4         159028-159161
            568-716             AC122352.4         164273-164421
            717-822             AC122352.4         167385-167490
            823-946             AC122352.4         169191-169314
            947-1121            AC122352.4         172393-172567
            1122-1175           AC122352.4         173779-173832
            1176-1289           AC122352.4         176820-176933
            1290-1473           AC122352.4         191693-191876
            1474-1606           AC154430.3         53614-53746
            1607-1707           AC154430.3         57111-57211
            1708-1830           AC154430.3         69990-70112
            1831-1940           AC154430.3         72656-72765
            1941-1985           AC154430.3         73368-73412
            1986-2036           AC154430.3         77857-77907
            2037-2165           AC154430.3         81398-81526
            2166-2286           AC154430.3         87372-87492
            2287-2438           AC154430.3         131091-131242
            2439-2643           AC154430.3         133997-134201
            2644-2814           AC154430.3         137231-137401
            2815-2973           AC154430.3         174272-174430
            2974-6238           CT010583.8         31242-34506
FEATURES             Location/Qualifiers
     source          1..6238
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 5.68 cM"
     gene            1..6238
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /note="C-type lectin domain family 16, member A"
                     /db_xref="GeneID:74374"
                     /db_xref="MGI:MGI:1921624"
     exon            1..304
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            305..433
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            434..567
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            568..716
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            717..822
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            823..946
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1121
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1175
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1289
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1473
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1606
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1707
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1830
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1940
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..1985
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2036
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2165
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2286
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2438
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2643
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2814
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2973
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..6238
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6216..6221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /note="hexamer: AATAAA"
     polyA_site      6233
                     /gene="Clec16a"
                     /gene_synonym="4932416N17Rik; curt; mKIAA0350"
                     /note="major polyA site"
ORIGIN      
        1 atttcccaga tttcctcgcg gcggcggccg taaagcgcgg cggtcgaacg gccggttccg
       61 gctgaatgtc agtgcggggc tttgggctgg ggagcaaggt gcttggcagt ctctccaccg
      121 cccccgccgc cgctggctgg gcttgagatg tcgccgcgga caccgggccg ctgggcggct
      181 cggacatgaa accgtgaggc aggcgacagg gctggtctgc ggacatgttt ggacgctcac
      241 ggagctgggt gggcgggggc cacagcaagt cctcccgcaa catccactcc ttggaccacc
      301 tgaagtacct gtaccatgtt ttaacaaaaa acaccactgt cacagaacaa aatcggaacc
      361 tgctcgtgga gaccatccgt tccatcactg agatcctgat ttggggcgat caaaatgaca
      421 gctctgtgtt tgacttcttc ctggagaaga atatgtttgt tttcttcttg aacattctgc
      481 ggcagaaatc aggccgttat gtgtgtgtgc agctgctaca gaccttgaac attctctttg
      541 agaacatcag ccacgagaca tcgctctatt atttgctgtc taataactat gtaaactcga
      601 tcattgtcca taaatttgac ttttccgacg aggagatcat ggcgtattac atatcgttcc
      661 tgaaaacgct ttcattaaag ctcaacaacc acactgtcca tttcttttac aatgagcaca
      721 ccaatgactt tgccctgtac acagaagcca tcaagttctt caatcatccc gaaagcatgg
      781 ttcgaattgc cgtgagaacc atcactttga atgtctacaa agtggataac caggccatgc
      841 tgcactacat cagagacaaa accgctgtcc cgtacttctc caatttggtc tggttcattg
      901 ggagccatgt gatcgaactt gacaactgtg tgcagacaga tgaggagcac cggaatcggg
      961 ggaaactgag tgacctggtg gctgagcact tggaccacct gcactatctc aacgacatcc
     1021 tgatcatcaa ctgcgagttc ctcaatgacg tactcaccga ccacctgctc aacaggcttt
     1081 tcctgccgct ctacgtgtac tccctggaga accccgacaa gggaggagaa cggccaaaaa
     1141 tcagcctgcc tgtgtccctc tatcttctct cccaggtctt cctcattata catcacgccc
     1201 cgctggtgaa ctctctggct gaagtcattc tgaatggtga tctatctgag acatacacaa
     1261 agcctgcaca ggatgttccc agaagttctg ccaagcccag catccggtgc ttcattaagc
     1321 ccactgagac actcgagcgg tcccttgaga tgaacaagca caagggcaag aagcggatgc
     1381 aaaagagacc caactacaaa aacgttgggg aggaggagga cgaggagaga gggtctgctg
     1441 aagatgccca ggaagacgct gagaagacta aagagattga gatggtgatc atgaagcttg
     1501 gcaagctctc agaggtggcc gctgctggga cctcagtgca ggagcagaac accacagacg
     1561 aggagaagag cgccgccacg aactcagaga atgcacagtg gagcagaccc ttcctggata
     1621 tggtgtacca tgccctggac agccctgacg atgactatca cgccctcttc gtgctctgcc
     1681 tcctgtatgc catgtctcat aacaaaggca tggatcctga aaaactaaaa cgaattcagc
     1741 tcccagtgcc aagtgaagct gagaaaacca cctacaacca tctgctggcc gagaggctca
     1801 tcaggatcat gaacaatgct gctcagccag atggcaggat ccggttggct acactggagc
     1861 tgagctgcct gctcctgaag cagcaagtac tgaccagctc tggctgtgtc atcaaggatg
     1921 tgcacctggc ctgtttggag ggtgcaagag aagagagtgt ccaccttgta cgtcatttct
     1981 ataagggaga agagattttc ttggacatgt ttgaagatga gtacaggagc atgacaataa
     2041 agcccatgaa tgtggagtat ctcatgatgg atgcttccat cctcctgccc ccaacgggca
     2101 ctccactgac tggcattgac tttgtgaagc ggctgccatg tggtgatgtg gagaagacga
     2161 ggcgggccat ccgggtattc ttcatgctgc gttccctgtc actgcagctg cgaggggaac
     2221 ctgagaccca gttgccactg actcgggagg aggacctgat caaaacagat gatgtcttgg
     2281 atctgaataa cagtgacttg attgcatgca cagtcatcac caaggatggt ggtatggtcc
     2341 agcggttcct ggctgtggac atttaccaga tgagcctggt ggagcctgac gtatccagac
     2401 ttggctgggg agtggtcaag tttgctggcc ttctacagga catgcaggtg acaggagtgg
     2461 aggatgacag ccgtgccctg aacatcacca ttcacaagcc tgcctccagc ccgcactcta
     2521 agcccttccc tatcctgcag gccaccttcg tgttctcgga tcatatccgc tgcattattg
     2581 ccaagcagcg cctggccaag ggccgcatcc aggccaggcg catgaagatg cagaggatag
     2641 ccgcccttct ggacctccca atccagccga caacagaagt cctgggattt ggactctgct
     2701 cctcctcctc ctcctcccag cacctgcctt tccgtttcta tgagcagtgc cgcagaggca
     2761 gcagtgaccc gacagtgcaa cgctctgtgt ttgcatccgt agacaaggtg ccaggctttg
     2821 ctgtggccca gtgcataaac cagcatagct ctccatccct gtcatcaccg tcgccaccat
     2881 ttgccagtgg gagccctggt ggcagtggaa gcaccagcca ctgtgactca ggaggctctt
     2941 cctctgcacc ctcagcaacc cagagcccgg cagatgcccc cacgactcca gaacagcctc
     3001 agcctcacct agaccagtca gtgattggga atgaaatgga tgtcaactcc aagcccagca
     3061 agaactcatc ggccaggagc tctgaggggg agacaatgca cctgtcccct agcctccttc
     3121 ccgcccagca gcccaccatc tccttgctct acgaggacac tgctgacaca ctgagtgtcg
     3181 agtcactgac cattgtcccc ccggtcgatc cccacagcct ccgagccctc tctggcatct
     3241 cccagctccc cacactgcct gcagcagata cggagacccc agctgagggt gctgtaaacc
     3301 cagagcctgc ggaacccaca gagcactgag tgcgccagag ctctcccttt gtgtgtgcgg
     3361 cccgctggta gggacccccc atgcattttg tgacagcaag acacactggg agcacccaca
     3421 attctccgtg gccctgaaaa ctgcccctca tacctctccc tacaagacaa ccaccaagca
     3481 ctcatttgct ctgacctctc gctgagcagg ctgggatcct agaaacggcc tcctgtgtag
     3541 agacgatggc attggccacc tcagaggggt ctggggccct gcccctgatc ctgacagccg
     3601 cagggggcag gacccactgg caccgtcctt tgggcagctc ctttgtcttc cctcccagtg
     3661 tgcacagaag tggacaaggt tactctgggt agaaacctgt ggagaagcaa acctagataa
     3721 gcatctcctc gagctagtta tttctggttt tggcaacaaa tgaagagatt tattttaaaa
     3781 gaatctattt tggaggaggg gcaaaaagaa aaagccctca accataaggc tcggagtctc
     3841 attagaagtg tcagctgtta aggttctctg tccttagaac ttttccatgt ttttattctg
     3901 aagttgtggc tgtcacttcc tctgttttcc tgagtgattc ttctttctct gtccccaact
     3961 ctacaagcct gtggggtgat gatgtctctc cctgaaacac tgaggtactt ctgaacaaga
     4021 tgagagagac ctgagtccgc tcaggtcaca tgggtgagaa ggccaagcct ctgctctcgc
     4081 gtgacctgga tgacgtctgt tccctgctca ggacaccaca cagacgctgc tccgagcagg
     4141 cacgctccct tctctcttca tccaagaaag acccattagc cagtgtccgt gacagaaatc
     4201 aaaggattta aggcacagaa agtcatcctc agatataatc tgcttcccaa gatgcaagtg
     4261 gatgcccaac tggggcccag ctgcaaaaca ggtgaccaaa agcagaatcc caccctcccc
     4321 ctccctcctc cccctccctc ctccccctcc ctcctgcccc accctttgct gcttccacgc
     4381 agtatgaaaa ccccatagtt gtaggcatgt gccagcaagg aacagatctg tgccatcagc
     4441 ccctccctcc tctgaactgg ccagccaggt cactactcca ggctccgtgg cgaggccctc
     4501 tatggcttcc tacagatctg gcctcaccca gtttcagtac ccaccaaagg cgagccacaa
     4561 gggtacccca tacattacca tctgctcatc attagaccct gacactctgc taagctaact
     4621 tccctgcagg ccccaatgct cagttttcca agagaaagca gtgctcccta ggaaggtagt
     4681 ggaacccatg tggactggct tctctggtct ttaaaagtgc tccagtgggc atgctgtcaa
     4741 agacaagatg ttttctaaaa cagaaggctg ggtcaggaag tcaaccaatc ttccttagag
     4801 gcagccactc caaaggccct ggcaaagtag gatgttctag gatgcttagc ccctgggaag
     4861 agaggaaagt gatggccact gggaacaaga gctctgtgga ccccacagcc aaccttgggt
     4921 gttttttgct catttgcagg gaggggtaga caaagaagca ggctagccct gtcttcagca
     4981 caactgtaca ctttgggttt tgaaatgaca attgctaggg tcagcataaa tgttacacaa
     5041 ttcaagtgac tctctaccat gcagtgtggt ctccagagaa aagcctacag ccaccctaac
     5101 ccacataaac aggtcagccc tatccttctg tgactagcct cctctttgca atccggaaat
     5161 tttaaggaag ggaaaagatt gtgcccatgg tgttcagcaa accctgaaag ggcaactgct
     5221 gtgtaaaatt caccaacaat aagcctgttc ccacagctgg ctttaaggtt gctcccagag
     5281 ggttcctgca accaggagcc tagggcatac ctccaagtga gcaaatgtgg acttcctgtg
     5341 agcagaactg tggcccattg ctgatggagg gatggggtcc tggaggaagc aacaggacct
     5401 caggactctg aagaaggaca ctgtctcacc taggtgttgg tggcattggg tacaacccag
     5461 tcttcaggag tactctgcta acttggcaac tgtgctctcc agacagacct aaccagcaag
     5521 aacctactgg gtctctgtag aactgaggga tctaaggtcc agtaggtccc acagctcctg
     5581 acctggaggt cccagagtca gcctccaaaa tcattgctcc catctcccag gccatgcatg
     5641 ccacgtctgc cctggtctcc ctcccttctt caactgcccc agggcagact agcagagctg
     5701 gcctctaacc catcacctca gctttgaccg tcaccatggc aacatgcagt gctgcctcct
     5761 ccctgttgaa gtcttaggca ggtgggacac ttcccacagg tcagactcag tgtggtggtg
     5821 agcgccctct atggtggaag tggtgaagag gcttcacctg ctactctacc caccaaacac
     5881 ttgcattggc aggagtaggc tggctgcatc ctaaggatgg cattggcttt ctctgtggcc
     5941 tctgacgtgc agttgtaaat aaggcatggg taaaccaagt ctgatctttt gtagatgcaa
     6001 taaatatatt tcacacagtc acaatgggca gaaggttaaa tgctccttcc ctccctcaga
     6061 gctgaagctg tgaggaaaaa agagggggag ggggcagaac tgggaaggtc tggccaggga
     6121 agtgcctgct tctgccagca ggactcatgc tttgtgggga ctgaacctga ggggaggaat
     6181 ggaagctaga actttcttgt aatttgaaac ttggcaataa aaagcaaaac caatggcc
//
