LOCUS       NM_025809               4539 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus C-type lectin domain family 14, member a (Clec14a),
            mRNA.
ACCESSION   NM_025809
VERSION     NM_025809.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4539)
  AUTHORS   Chen,J., Zhang,X., DeLaughter,D.M., Trembley,M.A., Saifee,S.,
            Xiao,F., Chen,J., Zhou,P., Seidman,C.E., Seidman,J.G. and Pu,W.T.
  TITLE     Molecular and Spatial Signatures of Mouse Embryonic Endothelial
            Cells at Single-Cell Resolution
  JOURNAL   Circ Res 134 (5), 529-546 (2024)
   PUBMED   38348657
REFERENCE   2  (bases 1 to 4539)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4539)
  AUTHORS   Su,Z., Li,Y., Lv,H., Cui,X., Liu,M., Wang,Z., Zhang,Y., Zhen,J.,
            Tang,W., Wang,X. and Yi,F.
  TITLE     CLEC14A protects against podocyte injury in mice with adriamycin
            nephropathy
  JOURNAL   FASEB J 35 (7), e21711 (2021)
   PUBMED   34107098
  REMARK    GeneRIF: CLEC14A protects against podocyte injury in mice with
            adriamycin nephropathy.
REFERENCE   4  (bases 1 to 4539)
  AUTHORS   Sandoval,D.R., Gomez Toledo,A., Painter,C.D., Tota,E.M.,
            Sheikh,M.O., West,A.M.V., Frank,M.M., Wells,L., Xu,D., Bicknell,R.,
            Corbett,K.D. and Esko,J.D.
  TITLE     Proteomics-based screening of the endothelial heparan sulfate
            interactome reveals that C-type lectin 14a (CLEC14A) is a
            heparin-binding protein
  JOURNAL   J Biol Chem 295 (9), 2804-2821 (2020)
   PUBMED   31964714
  REMARK    GeneRIF: Proteomics-based screening of the endothelial heparan
            sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a
            heparin-binding protein.
REFERENCE   5  (bases 1 to 4539)
  AUTHORS   Kim,Y., Lee,S., Zhang,H., Lee,S., Kim,H., Kim,Y., Won,M.H.,
            Kim,Y.M. and Kwon,Y.G.
  TITLE     CLEC14A deficiency exacerbates neuronal loss by increasing
            blood-brain barrier permeability and inflammation
  JOURNAL   J Neuroinflammation 17 (1), 48 (2020)
   PUBMED   32019570
  REMARK    GeneRIF: CLEC14A deficiency exacerbates neuronal loss by increasing
            blood-brain barrier permeability and inflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4539)
  AUTHORS   Ki,M.K., Jeoung,M.H., Choi,J.R., Rho,S.S., Kwon,Y.G., Shim,H.,
            Chung,J., Hong,H.J., Song,B.D. and Lee,S.
  TITLE     Human antibodies targeting the C-type lectin-like domain of the
            tumor endothelial cell marker clec14a regulate angiogenic
            properties in vitro
  JOURNAL   Oncogene 32 (48), 5449-5457 (2013)
   PUBMED   23644659
  REMARK    GeneRIF: clec14a-CTLD may be a key domain in angiogenesis
REFERENCE   7  (bases 1 to 4539)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   8  (bases 1 to 4539)
  AUTHORS   Rho,S.S., Choi,H.J., Min,J.K., Lee,H.W., Park,H., Park,H., Kim,Y.M.
            and Kwon,Y.G.
  TITLE     Clec14a is specifically expressed in endothelial cells and mediates
            cell to cell adhesion
  JOURNAL   Biochem Biophys Res Commun 404 (1), 103-108 (2011)
   PUBMED   21095181
  REMARK    GeneRIF: These findings demonstrate that Clec14a is a novel
            endothelial cells specific protein that appears to play a role in
            cell-cell adhesion and angiogenesis.
REFERENCE   9  (bases 1 to 4539)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 4539)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY233495.1, AK014681.1, CK331838.1, AK033733.1, AK080201.1 and
            BB307353.2.
            
            On May 14, 2009 this sequence version replaced NM_025809.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               BY233495.1         3-268
            267-306             AK014681.1         213-252
            307-387             CK331838.1         71-151
            388-3385            AK033733.1         65-3062
            3386-3910           AK080201.1         3000-3524
            3911-4539           BB307353.2         62-690
FEATURES             Location/Qualifiers
     source          1..4539
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 25.65 cM"
     gene            1..4539
                     /gene="Clec14a"
                     /gene_synonym="1200003C23Rik"
                     /note="C-type lectin domain family 14, member a"
                     /db_xref="GeneID:66864"
                     /db_xref="MGI:MGI:1914114"
     exon            1..4539
                     /gene="Clec14a"
                     /gene_synonym="1200003C23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1804
                     /gene="Clec14a"
                     /gene_synonym="1200003C23Rik"
                     /codon_start=1
                     /product="C-type lectin domain family 14 member A
                     precursor"
                     /protein_id="NP_080085.3"
                     /db_xref="CCDS:CCDS25930.1"
                     /db_xref="GeneID:66864"
                     /db_xref="MGI:MGI:1914114"
                     /translation="MRPALALCLLCPAFWPRPGNGEHPTADRAACSASGACYSLHHAT
                     FKRRAAEEACSLRGGTLSTVHSGSEFQAVLLLLRAGPGPGGGSKDLLFWVALERSISQ
                     CTQEKEPLRGFSWLHPDSEDSEDSPLPWVEEPQRSCTVRKCAALQATRGVEPAGWKEM
                     RCHLRTDGYLCKYQFEVLCPAPRPGAASNLSFQAPFRLSSSALDFSPPGTEVSAMCPG
                     DLSVSSTCIQEETSAHWDGLFPGTVLCPCSGRYLLAGKCVELPDCLDHLGDFTCECAV
                     GFELGKDGRSCETKVEEQLTLEGTKLPTRNVTATPAGAVTNRTWPGQVYDKPGEMPQV
                     TEILQWGTQSTLPTIQKTPQTKPKVTGTPSGSVVLNYTSSPPVSLTFDTSSTVVFILV
                     SIAVIVLVVLTITVLGLFKLCFHKSRSSRTGKGALDSPGVECDAEATSLHHSSTQCTD
                     IGVKSGTVA"
     regulatory      3445..3450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec14a"
                     /gene_synonym="1200003C23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3468
                     /gene="Clec14a"
                     /gene_synonym="1200003C23Rik"
                     /note="major polyA site"
ORIGIN      
        1 tggttcctgc ccacgatcat cactgcattc tgagatccaa agtccagata agtgtgagca
       61 agaaaagagc ctcacttgat cccggtggca aacttctttt ctcctgctta tctaagcggg
      121 gcattggacc cccttggccc agcgttgagg cgccagctgt gttcctgacc cctgaataaa
      181 tcagggccaa aaagagcctg gcagggctct gggacacatt tcctgtcacg gcctagggaa
      241 agcagttggc caagggagtg ttgtggcgga gttttcagct gttggaggat gagggctcaa
      301 gagaggcgag gggagggcac acatagtggt agaaagggct gtagagggcg gtgactttag
      361 agaaagctcc gtgccctcca gcaaaccaga ggacttggga gcagctgcat gttgagtctc
      421 caggatgagg ccagcgcttg ccctgtgcct cctctgtcct gcgttctggc ctcggccagg
      481 gaatggggag catcccacgg ccgatcgcgc agcttgttcg gcctcggggg cttgctacag
      541 ccttcaccac gctaccttca agagaagggc ggcggaggag gcctgcagcc taaggggcgg
      601 gactctcagc accgtgcact caggctcgga gtttcaagct gtgctcctgc tcttgcgtgc
      661 aggtcccggg cctggcggag gctccaaaga tcttctgttc tgggtggctc tggaacgcag
      721 catctcacag tgcactcagg agaaagagcc tttaaggggt ttctcctggt tgcacccgga
      781 ctcagaagac tcagaggaca gcccactacc gtgggtggaa gagccacaac gttcctgtac
      841 agtgagaaag tgcgctgcgc tccaggccac caggggagtg gagcctgctg gttggaagga
      901 gatgcgctgt catctgcgca ccgatggcta cctatgcaag taccagtttg aggttctgtg
      961 ccctgcacct cgcccaggag ccgcctctaa tttgagtttc caagctccct tccggctgag
     1021 cagctccgcg ctggacttca gccctcctgg gacagaggtg agtgcgatgt gtcctgggga
     1081 cctttctgtt tcgtccacct gcatccagga agagacaagc gcacactggg acgggctttt
     1141 ccctgggaca gtgctctgcc cctgttccgg gaggtacctc cttgctggca agtgtgtgga
     1201 gctccctgac tgtctagatc acttgggaga cttcacctgc gaatgtgcag tgggctttga
     1261 gctggggaag gacggacgtt cttgtgagac caaagttgaa gaacagctaa ccctcgaggg
     1321 gaccaagttg cccaccagga atgtaacagc cactccagca ggtgctgtga caaacagaac
     1381 atggccaggt caggtctatg acaagccagg agagatgcca caggtcactg agattcttca
     1441 gtggggaaca cagagtactt tacctactat tcaaaagacc ccacaaacca agccaaaagt
     1501 cactggcaca ccatcaggaa gcgtggtcct gaactacaca tcttcgcccc ctgtttctct
     1561 gactttcgac acctcttcca cggtggtctt catacttgtg agcatagcag ttatcgtttt
     1621 ggtcgtcttg accattacag tgctggggct tttcaaactc tgcttccaca aaagccgttc
     1681 ctccaggaca gggaagggag ctttggactc accaggtgtg gaatgtgatg ccgaggctac
     1741 ctctttgcac cacagttcta cacaatgcac tgacattgga gtgaagagtg ggactgtggc
     1801 ctgaaggact gagcttaggt tcttcactgg ctgggtgcgc tcttggatcg ggacacttag
     1861 ggaaacacct caatgctcac atcttgccta gactttttca gtcccaacaa ttggggaaag
     1921 aagaaaattt tcagtgatta ctgtggaagt cctccttccc atacatttta ttttgtgcta
     1981 aatctgaaag agacacttgt tccctgaaag gggaagaggt ggaagctgtg ggctggtatt
     2041 ggaagacagg gtaaaaaatg gcaagagaca ttttcctatt ctctggggga atttgaagaa
     2101 atgcttgaat atttccagta ctgggaacaa ataaataaca ctataatttt ttgaacattt
     2161 cttttcatcc aaaatgggaa gggaatatct atattattca ggctaggaat atattagctt
     2221 gaaattttga ggcaaataat aaaacattgt tgaaaaccta ggctaacata tgtttgactt
     2281 atacaaaggg tgttatttag gaatacacca ttctgaggat agcaactggc tatgagttta
     2341 ctggtaagac acacaagggt acactctgag ctttggggga aaagtcttta tacaccagct
     2401 ccttcagaac tagtgaagtt tccctttatt cttttatcct ttgctttcaa agtcactgtg
     2461 actgtgctct gccataaatc ggaagtgcaa tgttgccagt ttctgactcc agaagcaaat
     2521 tacagttgac caccaatcca agtgtttact gtgtgtcctt gcccaaggaa acaaatgatt
     2581 tgtgtcttcc ttttccaggg tttgtgttct ccagtgtaat gaccttccta ttcaagccac
     2641 cttgtaggca tcaagatgct gatcctcact tccaattaca atgatgttaa ttctcaatta
     2701 aaacgttaat gctacgtatt gatttgaaat cttctgggtg cactaaagcc aaaggaagct
     2761 ttgcttcttc caaggttgct agattcttgt gtcctattta atccatgtgg gtgggggctg
     2821 gggacacttg aatgtcaagc catttctgtt tcttctcaat agattgtgaa tacaatgaca
     2881 atgtgtgtgc atcagggggt tgttacaact gagcaagagt ctttgcaggc aaaactaggg
     2941 gaaattgctt tccacagaat taatagtgta aaaaggaaat aacaaataaa aatataacac
     3001 cttgctatga cttgagatgt tagcatataa taagaaatat cacacattca ggtggtaaat
     3061 aattaaggaa taataataaa aaacaatctg gttgaagcca aagaccttgg agaatatttc
     3121 aggtagatta gagtgctgcg atttttgtaa gtgttgtaaa gttgtgtgaa gagaaacaga
     3181 gaaataaact cactcttggg agaaaatgaa actagaaaat aaacttgagt tatatttttc
     3241 tagaatcatt tttatactct tgattgtact aagagttgat ttaaagttag caaatatcct
     3301 ataataaaat aacctagaaa attaagagag ttcaatatat gaatctgtgt tctaaatata
     3361 aatctatgtg tttaatattg tttcactgaa gaaacaaatt gagagcttgc ttcatatgaa
     3421 tgtggtttta aatagttaca gttaaataaa atcacaaatg aattcaaatt agctgttaag
     3481 attcttcaat ttaaaccaga agctaacaat tacatgggta aatggctccc accaagttcc
     3541 tcatctggtc agctacatat tccagtttta cttgttctta gcattgtagt catcttctcc
     3601 actgtatgtt ctctcagttg tagagacaac tattctagca caatatgtcc tgtttgactt
     3661 tataatttga aatatagcct catctataag tggaatgagc acacacacac atacacatac
     3721 actcaaatgc acatatttat gtacatgcat agctaagtac atgtgtatgt gtgtatacgt
     3781 atatacataa acattttgtt ttagagaagg atgcccttat attagtcttt cagtaaatga
     3841 gagtgtgcat agttatcaca taacatgtaa cagatgacag tgtggttctg gggcccgaaa
     3901 tgccctatgt gaagaaaaaa atcatggtga cccaattact tgaatattgt cccctactat
     3961 agatcagagg agaattaagg aaccttattt gtttatatct taaatcattt cttgacaaac
     4021 cagacaagat agaacttcct ttgatttctg gttgtggtgg tcacctccag aaattgtttc
     4081 aatggcagaa taaggtcagt taagtacagg atctcctgcg tccttttgca ggtaggagta
     4141 atgttcttac tactacctct ctacttctcg cacttcctca acatgtttga ggttcattcc
     4201 tttgagggtt aaagcctttt gctctcacat tcatcactca gtttcctaca cacccatttc
     4261 cttacaatta aacatggagt ctctcctaca gcctttcttt ctacccttca ccctgttatc
     4321 ttacacacta acatctttct gcatgctgca taatgcccat gcacttcagc tcttactctt
     4381 cagacccaat gacctgcact tcattttagc cattcattcc atagctacac aaattaagtt
     4441 gattctgaat ttcttcccca tcccagacct caatgtcaaa tttccatatt caagtgttaa
     4501 aaaacttgtg ctttaataaa tttgtctgtg attagaggc
//
