LOCUS       NM_027709               1523 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus C-type lectin domain family 12, member B (Clec12b),
            transcript variant 2, mRNA.
ACCESSION   NM_027709 XM_132881 XM_917847
VERSION     NM_027709.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1523)
  AUTHORS   Kottom,T.J., Carmona,E.M., Schaefbauer,K. and Limper,A.H.
  TITLE     CLEC4A and CLEC12B C-type lectin receptors mediate interactions
            with Pneumocystis cell wall components
  JOURNAL   J Med Microbiol 72 (6) (2023)
   PUBMED   37294293
  REMARK    GeneRIF: CLEC4A and CLEC12B C-type lectin receptors mediate
            interactions with Pneumocystis cell wall components.
REFERENCE   2  (bases 1 to 1523)
  AUTHORS   Iijima,A., Kanemaru,K., Wang,Y., Nabekura,T., Nakamura,Y.,
            Fujisawa,Y., Mori,D., Ohmuraya,M., Yamasaki,S., Tahara-Hanaoka,S.
            and Shibuya,A.
  TITLE     Selective expression of a C-type lectin receptor, Clec12b, on skin
            mast cells
  JOURNAL   Biochem Biophys Res Commun 561, 101-105 (2021)
   PUBMED   34020140
  REMARK    GeneRIF: Selective expression of a C-type lectin receptor, Clec12b,
            on skin mast cells.
            Erratum:[Biochem Biophys Res Commun. 2021 Sep 3;568:193-194. doi:
            10.1016/j.bbrc.2021.07.009.. PMID: 34246465]
REFERENCE   3  (bases 1 to 1523)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016908.1 and AV319772.1.
            
            On Feb 18, 2011 this sequence version replaced NM_027709.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016908.1, SRR5189685.167670.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1521              AK016908.1         2-1522
            1522-1523           AV319772.1         232-233
FEATURES             Location/Qualifiers
     source          1..1523
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.28 cM"
     gene            1..1523
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /note="C-type lectin domain family 12, member B"
                     /db_xref="GeneID:71183"
                     /db_xref="MGI:MGI:1918433"
     exon            1..104
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..841
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /note="macrophage antigen h"
                     /codon_start=1
                     /product="C-type lectin domain family 12 member B"
                     /protein_id="NP_081985.1"
                     /db_xref="CCDS:CCDS51922.1"
                     /db_xref="GeneID:71183"
                     /db_xref="MGI:MGI:1918433"
                     /translation="MSDEVTYATLMLQDSARVRGNRDGNNLRKEGHPAQSSLWRGAAL
                     SLMTLCLVLVTGLVTLATMFLQVSNDINSDSEKLSQLQKSIHPQQDNLSESLNSSRKS
                     LTEESLQSQISALLERQEQMATKLCKEFLIHASDHKCNPCPKTWQWYGNSCYYFSINE
                     EKSWSDSRKDCIDKNATLVKIDSTEERDLLQSQLSLTFSFFWLGLSWNSSGRNWLWED
                     GSFPPPTLLSDKELASFNGSRECAYFERGNIYTSRCRAEIPWICEKRASLVKIEDLD"
     exon            105..203
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            204..419
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            420..574
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..690
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1523
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1085..1090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1107
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /note="major polyA site"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1523
                     /gene="Clec12b"
                     /gene_synonym="4933425B16Rik"
ORIGIN      
        1 actttctcct aggatgtctg atgaagtgac ctatgcgaca ctgatgcttc aggactctgc
       61 aagagtgagg gggaatcggg atggaaataa cctaagaaaa gaaggacacc cagctcaatc
      121 ctcactttgg cgaggcgctg ccttgagttt gatgaccctc tgtttggtgc tggtaacagg
      181 actggtgacc ttggcaacta tgtttttgca ggtgtctaat gacattaact ctgattcaga
      241 gaagttgagt cagcttcaga aaagcatcca tccacagcag gacaatctgt ctgaatcact
      301 gaacagctcc agaaagagtc tgacggagga gtctctccag tcccagatct ctgccctact
      361 ggagaggcag gagcagatgg ctaccaaact ctgcaaggaa ttcctcatcc acgcttctga
      421 ccataaatgc aacccttgtc ccaagacatg gcaatggtat ggaaacagtt gctactattt
      481 ctcaatcaat gaagagaaat cctggagtga tagcagaaag gactgtatag acaagaatgc
      541 cactctggtg aagattgaca gcaccgaaga aagggatctc cttcagtcac agctgtccct
      601 cacattttct ttcttttggc tgggattgtc ctggaactca tctggcagaa actggctgtg
      661 ggaggatggt tcattccccc ctccaaccct gcttagtgac aaggagcttg cgagtttcaa
      721 tggatccaga gagtgtgctt attttgaaag agggaatatt tacacttctc gctgtcgtgc
      781 tgaaatccct tggatttgtg agaagagagc ctccctggtg aagattgaag atttggatta
      841 atctgactct tccagatcta tccagaagta aagacctatt gcaaacccat gcaagaaaga
      901 agaaagctac aatatttgag tcaactaaaa attgactgtg tacttaaaac tattgcacgg
      961 acaaacctgc ttctcagaac gttctcctct tcacgtctga ttccctctga cctgttctga
     1021 ttacttagat cttaaaatga tgtcaagtgc ccaggaaagt acgtgtcttc tcagtctgtc
     1081 tgtcaataaa cattgtttct tgctttattc ttacatgtct acatggatac tgggtgatat
     1141 ttaaatattt accacgagac caacacaggc cacagtttgg gagcaagttc taggagaccc
     1201 ctgctataaa acctgctcaa tcatgtacag gtctgaggga gcccaaggta aaacaacagt
     1261 gctgtgttgt tgaattgaaa atattttagt gttttagaga tcatctgtct aaacccctag
     1321 gtatcagcct ccatgtacag agtaaatttt ctctgtctac ctatgaaact atgtactata
     1381 aactcttata acttatagcc tacatacaat agaatgaaca ctggtcttca tattttatca
     1441 tttatttaaa ctaataacat ccaggttatt gatttggcaa tctgggtatt atcagaataa
     1501 taaagatttt tattctatta cta
//
