LOCUS       NM_177686               2222 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus C-type lectin domain family 12, member a (Clec12a),
            mRNA.
ACCESSION   NM_177686
VERSION     NM_177686.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2222)
  AUTHORS   Malamud,M., Whitehead,L., McIntosh,A., Colella,F., Roelofs,A.J.,
            Kusakabe,T., Dambuza,I.M., Phillips-Brookes,A., Salazar,F.,
            Perez,F., Shoesmith,R., Zakrzewski,P., Sey,E.A., Rodrigues,C.,
            Morvay,P.L., Redelinghuys,P., Bedekovic,T., Fernandes,M.J.G.,
            Almizraq,R., Branch,D.R., Amulic,B., Harvey,J., Stewart,D.,
            Yuecel,R., Reid,D.M., McConnachie,A., Pickering,M.C., Botto,M.,
            Iliev,I.D., McInnes,I.B., De Bari,C., Willment,J.A. and Brown,G.D.
  TITLE     Recognition and control of neutrophil extracellular trap formation
            by MICL
  JOURNAL   Nature 633 (8029), 442-450 (2024)
   PUBMED   39143217
  REMARK    GeneRIF: Recognition and control of neutrophil extracellular trap
            formation by MICL.
REFERENCE   2  (bases 1 to 2222)
  AUTHORS   Nishimura,N., Tomiyasu,N., Torigoe,S., Mizuno,S., Fukano,H.,
            Ishikawa,E., Katano,H., Hoshino,Y., Matsuo,K., Takahashi,M.,
            Izumi,Y., Bamba,T., Akashi,K. and Yamasaki,S.
  TITLE     Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to
            suppress host immune responses
  JOURNAL   Tuberculosis (Edinb) 138, 102294 (2023)
   PUBMED   36542980
  REMARK    GeneRIF: Mycobacterial mycolic acids trigger inhibitory receptor
            Clec12A to suppress host immune responses.
REFERENCE   3  (bases 1 to 2222)
  AUTHORS   Vitry,J., Pare,G., Murru,A., Charest-Morin,X., Maaroufi,H.,
            McLeish,K.R., Naccache,P.H. and Fernandes,M.J.
  TITLE     Regulation of the Expression, Oligomerisation and Signaling of the
            Inhibitory Receptor CLEC12A by Cysteine Residues in the Stalk
            Region
  JOURNAL   Int J Mol Sci 22 (19), 10207 (2021)
   PUBMED   34638548
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2222)
  AUTHORS   Li,K., Neumann,K., Duhan,V., Namineni,S., Hansen,A.L., Wartewig,T.,
            Kurgyis,Z., Holm,C.K., Heikenwalder,M., Lang,K.S. and Ruland,J.
  TITLE     The uric acid crystal receptor Clec12A potentiates type I
            interferon responses
  JOURNAL   Proc Natl Acad Sci U S A 116 (37), 18544-18549 (2019)
   PUBMED   31451663
  REMARK    GeneRIF: Study observed that the uric acid crystal receptor Clec12A
            functions as a positive modulator of the IFN-I response, which
            amplifies nucleic acid-sensing pattern recognition receptors
            signals through the TBK1-IRF3 axis. Clec12a-/- mice exhibit
            increased susceptibility to acute lymphocytic choriomeningitis
            virus (LCMV) infection and improved virus clearance during chronic
            LCMV infection in vivo.
REFERENCE   5  (bases 1 to 2222)
  AUTHORS   Raulf,M.K., Johannssen,T., Matthiesen,S., Neumann,K.,
            Hachenberg,S., Mayer-Lambertz,S., Steinbeis,F., Hegermann,J.,
            Seeberger,P.H., Baumgartner,W., Strube,C., Ruland,J. and
            Lepenies,B.
  TITLE     The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin
            and Contributes to Cerebral Malaria Development
  JOURNAL   Cell Rep 28 (1), 30-38 (2019)
   PUBMED   31269448
  REMARK    GeneRIF: The C-type Lectin Receptor CLEC12A Recognizes Plasmodial
            Hemozoin and Contributes to Cerebral Malaria Development.
REFERENCE   6  (bases 1 to 2222)
  AUTHORS   Lahoud,M.H., Proietto,A.I., Ahmet,F., Kitsoulis,S., Eidsmo,L.,
            Wu,L., Sathe,P., Pietersz,S., Chang,H.W., Walker,I.D.,
            Maraskovsky,E., Braley,H., Lew,A.M., Wright,M.D., Heath,W.R.,
            Shortman,K. and Caminschi,I.
  TITLE     The C-type lectin Clec12A present on mouse and human dendritic
            cells can serve as a target for antigen delivery and enhancement of
            antibody responses
  JOURNAL   J Immunol 182 (12), 7587-7594 (2009)
   PUBMED   19494282
  REMARK    GeneRIF: Anti-Clec12A mAb alone produced only moderate responses,
            but these were amplified by coinjecting only small amounts of LPS
            as a dendritic cell activation agent
REFERENCE   7  (bases 1 to 2222)
  AUTHORS   Pyz,E., Huysamen,C., Marshall,A.S., Gordon,S., Taylor,P.R. and
            Brown,G.D.
  TITLE     Characterisation of murine MICL (CLEC12A) and evidence for an
            endogenous ligand
  JOURNAL   Eur J Immunol 38 (4), 1157-1163 (2008)
   PUBMED   18350551
  REMARK    GeneRIF: mMICL recognises an endogenous ligand in a variety of
            murine tissues, suggesting that the receptor plays a role in
            homeostasis
REFERENCE   8  (bases 1 to 2222)
  AUTHORS   van Rhenen,A., van Dongen,G.A., Kelder,A., Rombouts,E.J.,
            Feller,N., Moshaver,B., Stigter-van Walsum,M., Zweegman,S.,
            Ossenkoppele,G.J. and Jan Schuurhuis,G.
  TITLE     The novel AML stem cell associated antigen CLL-1 aids in
            discrimination between normal and leukemic stem cells
  JOURNAL   Blood 110 (7), 2659-2666 (2007)
   PUBMED   17609428
  REMARK    GeneRIF: CLL-1 expression is also present on the CD34(+)CD38(-)
            stem- cell compartment in acute myeloid leukemia
REFERENCE   9  (bases 1 to 2222)
  AUTHORS   Han,Y., Zhang,M., Li,N., Chen,T., Zhang,Y., Wan,T. and Cao,X.
  TITLE     KLRL1, a novel killer cell lectinlike receptor, inhibits natural
            killer cell cytotoxicity
  JOURNAL   Blood 104 (9), 2858-2866 (2004)
   PUBMED   15238421
  REMARK    GeneRIF: the molecular cloning, tissue distribution, and functional
            characterization of a novel NK cell receptor, KLRL1, from human and
            mouse dendritic cells [KLRL1]
REFERENCE   10 (bases 1 to 2222)
  AUTHORS   Marshall,A.S., Willment,J.A., Lin,H.H., Williams,D.L., Gordon,S.
            and Brown,G.D.
  TITLE     Identification and characterization of a novel human myeloid
            inhibitory C-type lectin-like receptor (MICL) that is predominantly
            expressed on granulocytes and monocytes
  JOURNAL   J Biol Chem 279 (15), 14792-14802 (2004)
   PUBMED   14739280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB850261.1, AK084335.1 and AC138620.4.
            
            On Feb 18, 2011 this sequence version replaced NM_177686.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084335.1, BC094904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BB850261.1         2-43
            43-1164             AK084335.1         1-1122
            1165-2028           AK084335.1         1124-1987
            2029-2029           AC138620.4         95868-95868
            2030-2222           AK084335.1         1989-2181
FEATURES             Location/Qualifiers
     source          1..2222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.26 cM"
     gene            1..2222
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /note="C-type lectin domain family 12, member a"
                     /db_xref="GeneID:232413"
                     /db_xref="MGI:MGI:3040968"
     exon            1..268
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..981
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /note="myeloid inhibitory C-type lectin-like receptor;
                     C-type lectin-like molecule 1; killer cell C-type
                     lectin-like receptor L1"
                     /codon_start=1
                     /product="C-type lectin domain family 12 member A"
                     /protein_id="NP_808354.1"
                     /db_xref="CCDS:CCDS20584.1"
                     /db_xref="GeneID:232413"
                     /db_xref="MGI:MGI:3040968"
                     /translation="MSEEIVYANLKIQDPDKKEETQKSDKCGGKVSADASHSQQKTVL
                     ILILLCLLLFIGMGVLGGIFYTTLATEMIKSNQLQRAKEELQENVSLQLKHNLNSSKK
                     IKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMA
                     CSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTD
                     DIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR"
     exon            269..367
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /inference="alignment:Splign:2.1.0"
     exon            368..556
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /inference="alignment:Splign:2.1.0"
     exon            557..708
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /inference="alignment:Splign:2.1.0"
     exon            709..812
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /inference="alignment:Splign:2.1.0"
     exon            813..2222
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1311..1316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /note="hexamer: ATTAAA"
     polyA_site      1335
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /note="major polyA site"
     regulatory      1733..1738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
                     /note="hexamer: AATAAA"
     polyA_site      1754
                     /gene="Clec12a"
                     /gene_synonym="CLL-1; D230024O04; KLRL1; Micl; mKLRL1;
                     mMICL"
ORIGIN      
        1 gtggctcata gacacatatt tgagagtctg gcatagtggt ttttcaaaag gaaatttgag
       61 cttgtgaggt tagccacagt ttacagaggg ttgaaagtct aggtaggctt acttaactgt
      121 cagccctctc acctttttcg aaggacattt tctggagcct tctttgaata ttcatcaatg
      181 tctgaagaaa ttgtttatgc aaatctcaaa atccaggacc ctgataaaaa agaagaaacc
      241 cagaagtctg acaaatgtgg gggaaaagta tccgccgatg cttcccattc acagcaaaaa
      301 acagtcttga ttctgattct tctatgcctt ctgctgttca ttggaatggg ggtcttagga
      361 ggcatctttt atacaacttt ggcaacagaa atgataaaat cgaatcaatt gcaaagggcc
      421 aaggaagaac ttcaggaaaa tgtttcccta cagctgaagc acaatctcaa cagctccaag
      481 aaaatcaaga acctttctgc catgctgcaa agcacagcca cccagctgtg ccgagagctg
      541 tatagcaaag aaccagagca caaatgtaaa ccatgtccaa agggttcaga atggtacaag
      601 gacagctgtt attctcaact caatcagtat ggaacatggc aagagagtgt catggcctgc
      661 tctgctcgga atgccagcct cctgaaggtt aagaacaagg atgtgctgga atttataaag
      721 tacaagaagc tacgctattt ttggcttgca ttgttgccca gaaaagatcg cacacaatat
      781 ccactaagtg agaagatgtt cctctctgaa gagtctgaaa gaagcacaga tgacatagat
      841 aagaagtact gcggatatat agacagggtc aatgtttatt atacatactg cactgatgag
      901 aacaatatca tatgtgaaga gacagccagc aaggtgcagt tggaaagtgt gttgaatggc
      961 ctcccagagg atagcaggta gctactctga gttgcttgtc cctagctgct ctcctgctgt
     1021 gatggtttga atgagaatgg cccccaaggg ctcatttgaa tacttggtcc tctgctggtg
     1081 gaactgtttc agagacacca gaaggtgtga ccttgttaga ggaggttgtg tcattgagag
     1141 tgggctttgc gttttcaaaa gcccatgcca ttcccagtta gttctctatc ttgtgcttgt
     1201 ggattgagct gtgagctcac agctactgct taggaccttg tctgcctgca tgctgctatc
     1261 ctcctcacca caatggtcat ggactctaac cctcccaaac caggagccaa attaaatgct
     1321 tctttttata agtaaccttg gtcaaggtgt ttttgtcaca gcaattgaaa ggttgctaag
     1381 acatctgtca ctcagaagaa ctgtaggcag tgtgcgtctc ctctcacaca aacacagtag
     1441 cagcagtaca actacagtcc tgcctctctg tagtgtttat gtctagattt ctttgtctca
     1501 tttgctgact gccacgatac taagtcatag cttttcacca tgtattttca gcatacaatg
     1561 cgctgaacac aagaccatgc agcctatttc ttctcttttt tttttcccca aagataaacc
     1621 aggcaaattt caacctcaaa gaaaataaag tctggaaaaa tatagaaagc atagtacgat
     1681 aagaacaatt tgtattaaag atgtataaat actttaaaaa gatgtgaggg aaaataaact
     1741 ttgcaattga catagcgaag catttgatga gtactttata ccctgtcgta ataaagctta
     1801 ataaactagg agtagatttc ccaaatacaa tcaagctttg acatgaaata aacagcaagc
     1861 aaatgaacaa aactctgaag tttgaattaa catcatagtt ctagcaagag aaaacatatt
     1921 cctagtttta gaataagata agaatgaacg ttattaaatc acttcattcg tcattattaa
     1981 tacgaagagc agaacaccaa tggatgttaa aaaatgaagc tgggcaaaga tcagaattag
     2041 accaaagctg ggaggacaat agatgggagt atctattgct aacccaccct ggttagtgag
     2101 gccaagtgga ctgaagaaaa taccagagat ccatgtgggg acaccagggg atgccacaca
     2161 tttgggttca ggagtagagc gatcaaagca cttctcattt gtattattaa agcaatcaag
     2221 ac
//
