LOCUS       NM_009131               1970 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus C-type lectin domain family 11, member a (Clec11a),
            mRNA.
ACCESSION   NM_009131
VERSION     NM_009131.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1970)
  AUTHORS   Zhang,J., Cohen,A., Shen,B., Du,L., Tasdogan,A., Zhao,Z.,
            Shane,E.J. and Morrison,S.J.
  TITLE     The effect of parathyroid hormone on osteogenesis is mediated
            partly by osteolectin
  JOURNAL   Proc Natl Acad Sci U S A 118 (25) (2021)
   PUBMED   34140410
  REMARK    GeneRIF: The effect of parathyroid hormone on osteogenesis is
            mediated partly by osteolectin.
REFERENCE   2  (bases 1 to 1970)
  AUTHORS   Angueira,A.R., Sakers,A.P., Holman,C.D., Cheng,L., Arbocco,M.N.,
            Shamsi,F., Lynes,M.D., Shrestha,R., Okada,C., Batmanov,K.,
            Susztak,K., Tseng,Y.H., Liaw,L. and Seale,P.
  TITLE     Defining the lineage of thermogenic perivascular adipose tissue
  JOURNAL   Nat Metab 3 (4), 469-484 (2021)
   PUBMED   33846639
REFERENCE   3  (bases 1 to 1970)
  AUTHORS   Shen,B., Tasdogan,A., Ubellacker,J.M., Zhang,J., Nosyreva,E.D.,
            Du,L., Murphy,M.M., Hu,S., Yi,Y., Kara,N., Liu,X., Guela,S.,
            Jia,Y., Ramesh,V., Embree,C., Mitchell,E.C., Zhao,Y.C., Ju,L.A.,
            Hu,Z., Crane,G.M., Zhao,Z., Syeda,R. and Morrison,S.J.
  TITLE     A mechanosensitive peri-arteriolar niche for osteogenesis and
            lymphopoiesis
  JOURNAL   Nature 591 (7850), 438-444 (2021)
   PUBMED   33627868
REFERENCE   4  (bases 1 to 1970)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   5  (bases 1 to 1970)
  AUTHORS   Wei,H., Xu,Y., Wang,Y., Xu,L., Mo,C., Li,L., Shen,B., Sun,Y.,
            Cheng,P., Yang,L., Pang,Y., Qin,A., Cao,Y., Morrison,S.J. and
            Yue,R.
  TITLE     Identification of Fibroblast Activation Protein as an Osteogenic
            Suppressor and Anti-osteoporosis Drug Target
  JOURNAL   Cell Rep 33 (2), 108252 (2020)
   PUBMED   33053358
REFERENCE   6  (bases 1 to 1970)
  AUTHORS   Mukhopadhyay,P., Greene,R.M., Zacharias,W., Weinrich,M.C.,
            Singh,S., Young,W.W. Jr. and Pisano,M.M.
  TITLE     Developmental gene expression profiling of mammalian, fetal
            orofacial tissue
  JOURNAL   Birth Defects Res A Clin Mol Teratol 70 (12), 912-926 (2004)
   PUBMED   15578713
REFERENCE   7  (bases 1 to 1970)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 1970)
  AUTHORS   Klein,A., Talvani,A., Silva,P.M., Martins,M.A., Wells,T.N.,
            Proudfoot,A., Luckacs,N.W. and Teixeira,M.M.
  TITLE     Stem cell factor-induced leukotriene B4 production cooperates with
            eotaxin to mediate the recruitment of eosinophils during allergic
            pleurisy in mice
  JOURNAL   J Immunol 167 (1), 524-531 (2001)
   PUBMED   11418691
  REMARK    GeneRIF: This protein mediates eosinophil recruitment in a mouse
            model of allergic pleurisy via production of the chemoattractant
            lipid leukotriene B4.
REFERENCE   9  (bases 1 to 1970)
  AUTHORS   Hiraoka,A., Yano Ki,K., Kagami,N., Takeshige,K., Mio,H., Anazawa,H.
            and Sugimoto,S.
  TITLE     Stem cell growth factor: in situ hybridization analysis on the gene
            expression, molecular characterization and in vitro proliferative
            activity of a recombinant preparation on primitive hematopoietic
            progenitor cells
  JOURNAL   Hematol J 2 (5), 307-315 (2001)
   PUBMED   11920266
  REMARK    GeneRIF: In situ hybridization of whole mouse fetuses and their
            tibias demonstrated expression of SCGF mRNA around skeletal
            tissues, particularly in bone marrow cells, proliferating
            chondrocytes, the perichondrium and periosteum.
REFERENCE   10 (bases 1 to 1970)
  AUTHORS   Mio,H., Kagami,N., Yokokawa,S., Kawai,H., Nakagawa,S., Takeuchi,K.,
            Sekine,S. and Hiraoka,A.
  TITLE     Isolation and characterization of a cDNA for human mouse, and rat
            full-length stem cell growth factor, a new member of C-type lectin
            superfamily
  JOURNAL   Biochem Biophys Res Commun 249 (1), 124-130 (1998)
   PUBMED   9705843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY137682.1, BY115987.1, BB850120.1, BE860221.1, AC152939.2,
            AK042963.1 and CD741904.1.
            
            On Jul 10, 2009 this sequence version replaced NM_009131.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002001.1, AB009245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               BY137682.1         2-209
            209-349             BY115987.1         175-315
            350-461             BB850120.1         321-432
            462-486             BE860221.1         1-25
            487-487             AC152939.2         64626-64626         c
            488-671             BE860221.1         27-210
            672-1952            AK042963.1         141-1421
            1953-1970           CD741904.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.83 cM"
     gene            1..1970
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /note="C-type lectin domain family 11, member a"
                     /db_xref="GeneID:20256"
                     /db_xref="MGI:MGI:1298219"
     exon            1..341
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1181
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /note="stem cell growth factor; osteolectin; lymphocyte
                     secreted C-type lectin"
                     /codon_start=1
                     /product="C-type lectin domain family 11 member A
                     precursor"
                     /protein_id="NP_033157.1"
                     /db_xref="CCDS:CCDS21203.1"
                     /db_xref="GeneID:20256"
                     /db_xref="MGI:MGI:1298219"
                     /translation="MQAAWLLGALVVPQLLSFGHGARGPGREWEGGWGGALEEERERE
                     SQMLKNLQEALGLPTGVGNEDNLAENPEDKEVWETTETQGEEEEEEITTAPSSSPNPF
                     PSPSPTPEDTVTYILGRLASLDAGLHQLHVRLHVLDTRVVELTQGLRQLRDAASDTRD
                     SVQALKEVQDRAEQEHGRLEGCLKGLRLGHKCFLLSRDFETQAAAQARCKARGGSLAQ
                     PADRQQMDALSRYLRAALAPYNWPVWLGVHDRRSEGLYLFENGQRVSFFAWHRAFSLE
                     SGAQPSAATHPLSPDQPNGGVLENCVAQASDDGSWWDHDCERRLYFVCEFPF"
     exon            342..543
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /inference="alignment:Splign:2.1.0"
     exon            544..735
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1956
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1450..1455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /note="hexamer: CATAAA"
     polyA_site      1468
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /note="major polyA site"
     regulatory      1935..1940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /note="hexamer: AATAAA"
     polyA_site      1956
                     /gene="Clec11a"
                     /gene_synonym="Clecsf3; Scgf"
                     /note="major polyA site"
ORIGIN      
        1 aagagaagct gaggagatca aaagttgaga cagagcagat caggagggaa ggcagaagag
       61 aaagcctggc agaaagaagg tccaaggggc ttgtgagctg cccaccagac tgggacactt
      121 gctaggtcta tacagcagtc ctacccctgg cattctgacc tctctactat ttgggtgctg
      181 ggaagcccag ctggatgcag gcagcctggc tcttgggggc cctagtggtc cctcagcttt
      241 tgagttttgg tcatggagcc cgaggtcctg ggagggagtg ggagggaggc tggggaggtg
      301 ccctggagga ggagagagag cgggagtcac agatgttgaa gaatctccag gaggccctag
      361 ggctgcccac tggggtggga aatgaggata atcttgctga aaaccctgaa gacaaagagg
      421 tctgggagac cacagagact caaggggaag aagaggaaga ggaaatcacc acagcacctt
      481 cttctagtcc caaccctttc cccagccctt ctcccacacc agaggacact gtcacttaca
      541 tcttgggccg cttggccagc ctcgatgcag gcctacacca attgcacgtc cgtctgcacg
      601 ttttggacac ccgtgtggtt gagctgaccc aggggctgcg gcagctgcgg gatgctgcga
      661 gtgacacccg cgactcagtg caagccctga aggaggtcca ggaccgtgct gagcaggagc
      721 acggccgctt ggagggctgc ctgaagggcc tgcgccttgg ccacaagtgc ttcctgctct
      781 cgcgagactt cgagacccag gcggcggcgc aggcgcggtg caaggcgcga ggtgggagct
      841 tagcacagcc tgcggaccgc cagcaaatgg atgcgctaag ccggtactta cgcgccgctc
      901 tcgcccccta caactggccg gtgtggctgg gagtgcacga tcggcgctcc gaggggctct
      961 accttttcga gaacggccag cgcgtgtctt tcttcgcctg gcaccgcgca ttcagcctgg
     1021 agtccggcgc ccagcctagt gcggcaacac atccactcag cccggatcag cccaatggcg
     1081 gcgtcctgga gaactgcgtg gcccaggcct cagacgacgg ttcttggtgg gaccatgact
     1141 gtgagcggcg cctctacttc gtctgcgagt tccccttcta gagaaccggt ctctgcccag
     1201 gagctctagt gcacattttg caccgtacac cgcgcaccct attgttaggg gcctgggagt
     1261 cgctcagaga ttaagcgtga ccatgaatac attttaatca gaagaggttt tttattttag
     1321 atactggcac ccagactgat tggggccagg tgtgctcctg agattgcttc caagatgcat
     1381 tatcagccca gggattttaa aggcaaaccc cacaagattg catgtagcct gcttacatgt
     1441 aggccggagc ataaaaattt aacatatatg tcttgaagtt gtcctagtca tcctttgagc
     1501 agaggaagca agattagtta caaaaacaga aatcgcagtt agtcttacaa ctaaatttgc
     1561 taggacagca aattttacaa ggccaatcaa tttcagaata gtcttcaata tctgggagaa
     1621 tgaggaagta gatggactgt tagtgtacag cccacacaag ctaggggctt tcgtctgagg
     1681 catattttgc tttggttttt caagcagtga gtctaaactt ttaaatgtaa tattaaccac
     1741 catacgtaca atgtgcattc cgcaccctga actccacccc gtgcatcttc cactctgcac
     1801 tctatagtgc accctgcatc ttgagccctc cttgggccag aactgccgcc aatcccggct
     1861 ggtcccccag ccccagactt ctccatgtcc ccacctgtct ttgaaacttc aaggtctcaa
     1921 ataggcccag tgccaataaa tccttttaaa atataaaaaa aaaaaaaaaa
//
