LOCUS       NM_010796               1498 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus C-type lectin domain family 10, member A (Clec10a),
            transcript variant 2, mRNA.
ACCESSION   NM_010796
VERSION     NM_010796.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1498)
  AUTHORS   Ward,S.E., Guest,T., Byrne,C., Lopes,P., O'Sullivan,J.M.,
            Doherty,D., O'Connell,D., Gutierrez Llaneza,S., Chion,A.,
            Fazavana,J., Fallon,P.G., Preston,R.J.S., Johnsen,J.M., Pipe,S.W.,
            Turecek,P.L. and O'Donnell,J.S.
  CONSRTM   iPATH Study Group
  TITLE     Macrophage Galactose Lectin Contributes to the Regulation of FVIII
            (Factor VIII) Clearance in Mice-Brief Report
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (4), 540-546 (2023)
   PUBMED   36727518
  REMARK    GeneRIF: Macrophage Galactose Lectin Contributes to the Regulation
            of FVIII (Factor VIII) Clearance in Mice-Brief Report.
REFERENCE   2  (bases 1 to 1498)
  AUTHORS   Kurashina,R., Denda-Nagai,K., Saba,K., Hisai,T., Hara,H. and
            Irimura,T.
  TITLE     Intestinal lamina propria macrophages upregulate interleukin-10
            mRNA in response to signals from commensal bacteria recognized by
            MGL1/CD301a
  JOURNAL   Glycobiology 31 (7), 827-837 (2021)
   PUBMED   33677516
  REMARK    GeneRIF: Intestinal lamina propria macrophages upregulate
            interleukin-10 mRNA in response to signals from commensal bacteria
            recognized by MGL1/CD301a.
REFERENCE   3  (bases 1 to 1498)
  AUTHORS   Naqvi,K.F., Huante,M.B., Saito,T.B., Endsley,M.A., Gelman,B.B. and
            Endsley,J.J.
  TITLE     Novel Role for Macrophage Galactose-Type Lectin-1 to Regulate
            Innate Immunity against Mycobacterium tuberculosis
  JOURNAL   J Immunol 207 (1), 221-233 (2021)
   PUBMED   34183369
REFERENCE   4  (bases 1 to 1498)
  AUTHORS   Raulf,M.K., Lepenies,B. and Strube,C.
  TITLE     Toxocara canis and Toxocara cati Somatic and Excretory-Secretory
            Antigens Are Recognised by C-Type Lectin Receptors
  JOURNAL   Pathogens 10 (3), 321 (2021)
   PUBMED   33803269
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1498)
  AUTHORS   Brooks,P.J., Wang,Y., Magalhaes,M.A., Glogauer,M. and
            McCulloch,C.A.
  TITLE     CD301 mediates fusion in IL-4-driven multinucleated giant cell
            formation
  JOURNAL   J Cell Sci 133 (24) (2020)
   PUBMED   33571108
  REMARK    GeneRIF: CD301 mediates fusion in IL-4-driven multinucleated giant
            cell formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1498)
  AUTHORS   Tsuiji,M., Fujimori,M., Ohashi,Y., Higashi,N., Onami,T.M.,
            Hedrick,S.M. and Irimura,T.
  TITLE     Molecular cloning and characterization of a novel mouse macrophage
            C-type lectin, mMGL2, which has a distinct carbohydrate specificity
            from mMGL1
  JOURNAL   J Biol Chem 277 (32), 28892-28901 (2002)
   PUBMED   12016228
  REMARK    GeneRIF: mMGL1 preferentially binds Lewis X-conjugated soluble
            polyacrylamides
REFERENCE   7  (bases 1 to 1498)
  AUTHORS   Tsuiji,M., Fujimori,M., Seldin,M.F., Taketo,M.M. and Irimura,T.
  TITLE     Genomic structure and chromosomal location of the mouse macrophage
            C-type lectin gene
  JOURNAL   Immunogenetics 50 (1-2), 67-70 (1999)
   PUBMED   10541808
REFERENCE   8  (bases 1 to 1498)
  AUTHORS   Mizuochi,S., Akimoto,Y., Imai,Y., Hirano,H. and Irimura,T.
  TITLE     Immunohistochemical study on a macrophage calcium-type lectin in
            mouse embryos: transient expression in chondroblasts during
            endochondral ossification
  JOURNAL   Glycoconj J 15 (4), 397-404 (1998)
   PUBMED   9613827
REFERENCE   9  (bases 1 to 1498)
  AUTHORS   Sato,M., Kawakami,K., Osawa,T. and Toyoshima,S.
  TITLE     Molecular cloning and expression of cDNA encoding a
            galactose/N-acetylgalactosamine-specific lectin on mouse
            tumoricidal macrophages
  JOURNAL   J Biochem 111 (3), 331-336 (1992)
   PUBMED   1587794
REFERENCE   10 (bases 1 to 1498)
  AUTHORS   Oda,S., Sato,M., Toyoshima,S. and Osawa,T.
  TITLE     Purification and characterization of a lectin-like molecule
            specific for galactose/N-acetyl-galactosamine from tumoricidal
            macrophages
  JOURNAL   J Biochem 104 (4), 600-605 (1988)
   PUBMED   3241002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669869.10.
            
            [WARNING] On Feb 5, 2025 this sequence was replaced by NM_010796.4.
            
            On Feb 24, 2011 this sequence version replaced NM_010796.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014811.1, ERR3363658.5372606.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AL669869.10        32065-32258
            195-382             AL669869.10        33259-33446
            383-493             AL669869.10        34028-34138
            494-589             AL669869.10        34571-34666
            590-661             AL669869.10        34750-34821
            662-733             AL669869.10        34901-34972
            734-820             AL669869.10        35178-35264
            821-972             AL669869.10        35368-35519
            973-1079            AL669869.10        35602-35708
            1080-1498           AL669869.10        35860-36278
FEATURES             Location/Qualifiers
     source          1..1498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..1498
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /note="C-type lectin domain family 10, member A"
                     /db_xref="GeneID:17312"
                     /db_xref="MGI:MGI:96975"
     exon            1..194
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            195..382
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..493
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..589
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..661
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..733
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..820
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..972
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1079
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1498
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1478..1483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /note="hexamer: ATTAAA"
     polyA_site      1496
                     /gene="Clec10a"
                     /gene_synonym="CD301a; M-ASGP-BP-1; Mgl; Mgl1"
                     /note="major polyA site"
ORIGIN      
        1 atttatggtt aagacttgaa atcggatgtc ccaaaataca gaccactggg cacaaaaccc
       61 agcaagactc tgtcttgtgt gcttgtggct tctgcttgtc cctcccacac caaccctccg
      121 ggatatagtt ctcaactctg actgagttcc tgcctctggt cactgctgca cagggaagcc
      181 aagacttcac actgttccag gctttacctc attaaagctt ctagcactct ccttggtccc
      241 agatccgtat ctgtctggat cctggtgtct tggtttccgt ccagacagcc ccagaggcct
      301 cgtgtttgtt caagtgtaac aatgatatac gaaaacctcc agaactcaag gatcgaggag
      361 aaaacccaag agcctggtaa agctccttcc cagtccttcc tgtggcgcat cctctcttgg
      421 acccacctcc tcctgttctc cctgggcctc agcctcctgc tgttggtggt cgtctccgtg
      481 attggatccc aaaattccca gttaaggagg gacctaggca ccctgagagc cactttagac
      541 aacaccacct ccaagataaa ggctgaattc cagtccctgg actccagggc tgacagcttc
      601 gaaaaaggga tcagttctct gaaagtggat gtggaggatc acaggcagga actgcaggca
      661 ggccgagact tgagccagaa ggtgacttct ctggagagca cagtggagaa gagggagcag
      721 gctctcaaaa cagatctgtc tgatttaacc gaccatgtgc aacagctgag gaaggacttg
      781 aaggccctga cgtgccagct ggccaacctc aagaacaacg gctcggaagt ggcctgctgc
      841 ccgcttcact ggacggagca tgaaggcagc tgctattggt tctctgagtc tgagaagtcg
      901 tggcctgaag ctgacaagta ctgccggctg gagaattctc acctggtggt ggtcaactcc
      961 ctggaggagc agaattttct acagaatcgc ttagccaatg tggttagttg gatcggccta
     1021 acggaccaaa acgggccctg gcgatgggtg gatgggaccg actttgagaa aggctttaag
     1081 aactgggccc cactgcagcc agataactgg ttcggacacg gactgggagg aggtgaggac
     1141 tgtgcccaca tcactacagg tggtccctgg aatgatgatg tctgccagag aaccttccgc
     1201 tggatctgtg agatgaagct ggccaaggag agctaggagc tctcgccaag taatttattt
     1261 cttcagtggt ttcagctgct caagtctgga gtttggaatc ctcctacccg gtctcaacat
     1321 tactggggac ccccccccgc cccaagaatt ttaaggcaag gagaaaggat tgtgtttgag
     1381 ctgggtagtg tggtgtttgc aagaataagg ttgctgaaat ctgtgatatt ttgtacagtg
     1441 tgcagcttat tgtaggcaac ttttgaatgt aacaaaaatt aaatactttt tgttgatt
//
