LOCUS       NM_171826               2194 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus claudin domain containing 1 (Cldnd1), transcript
            variant 1, mRNA.
ACCESSION   NM_171826
VERSION     NM_171826.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2194)
  AUTHORS   Ohnishi,M., Ochiai,H., Matsuoka,K., Akagi,M., Nakayama,Y.,
            Shima,A., Uda,A., Matsuoka,H., Kamishikiryo,J., Michihara,A. and
            Inoue,A.
  TITLE     Claudin domain containing 1 contributing to endothelial cell
            adhesion decreases in presence of cerebellar hemorrhage
  JOURNAL   J Neurosci Res 95 (10), 2051-2058 (2017)
   PUBMED   28244141
  REMARK    GeneRIF: suggest that the transient decrease of CLDND1 after
            cerebellar hemorrhage is responsible for low-molecular-weight
            selective vascular hyperpermeability
REFERENCE   2  (bases 1 to 2194)
  AUTHORS   Mineta,K., Yamamoto,Y., Yamazaki,Y., Tanaka,H., Tada,Y., Saito,K.,
            Tamura,A., Igarashi,M., Endo,T., Takeuchi,K. and Tsukita,S.
  TITLE     Predicted expansion of the claudin multigene family
  JOURNAL   FEBS Lett 585 (4), 606-612 (2011)
   PUBMED   21276448
REFERENCE   3  (bases 1 to 2194)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   4  (bases 1 to 2194)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY122667.1, CA750661.1, BC055695.1 and AV368951.1.
            
            On Nov 14, 2011 this sequence version replaced NM_171826.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3304593.1, CA750661.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               BY122667.1         2-162
            162-948             CA750661.1         5-791
            949-2187            BC055695.1         706-1944
            2188-2194           AV368951.1         242-248
FEATURES             Location/Qualifiers
     source          1..2194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.83 cM"
     gene            1..2194
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="claudin domain containing 1"
                     /db_xref="GeneID:224250"
                     /db_xref="MGI:MGI:2447860"
     exon            1..175
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     exon            176..226
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     exon            227..536
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1006
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     claudin domain-containing protein 1; claudin 25"
                     /codon_start=1
                     /product="claudin domain-containing protein 1 isoform 1"
                     /protein_id="NP_741968.1"
                     /db_xref="CCDS:CCDS28234.1"
                     /db_xref="GeneID:224250"
                     /db_xref="MGI:MGI:2447860"
                     /translation="MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPIQENSS
                     DSNKIAWEDFLGDEADEKTYNDVLFRYNGSLGLWRRCITIPKNTHWYAPPERTESFDV
                     VTKCMSFTLNEQFMEKYVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLC
                     ACICRSLYPTLATGILHLLAGLCTLGSVSCYVAGIELLHQKVELPKDVSGEFGWSFCL
                     ACVSAPLQFMAAALFIWAAHTNRKEYTLMKAYRVA"
     exon            537..647
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     exon            648..785
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     exon            786..2194
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2167..2172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="hexamer: AATAAA"
     polyA_site      2187
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="major polyA site"
ORIGIN      
        1 aaggcccctc ggcccagggc cgctttggcc cggcctgggg tggaggtgga ggcggaggcg
       61 cgggagttat ggagggggcg ggctctgcag ggaagtacgt cagaggaggc gcggggagag
      121 tagggtgctg tggtcggagc tggagggcga agccggtgga gtgagaggat gggcgtatgc
      181 aggtgataga ctagagaaca agacttctgt ctccgtagca tcttggagca gtctgaatgc
      241 cagaatggat aaccgttttg ctactgcgtt tgtgattgct tgtgtgctta gtctgatttc
      301 caccatctac atggcggcct ccataggcac ggacttctgg tatgagtatc gaagtcccat
      361 tcaagagaat tcaagtgact cgaataaaat cgcctgggaa gatttcctcg gtgacgaggc
      421 ggatgagaag acttacaacg atgttctgtt ccgatacaac ggcagcttgg ggctgtggag
      481 acggtgcatc accataccca aaaacactca ctggtatgcg ccaccggaaa ggacagagtc
      541 atttgatgtg gttaccaaat gcatgagttt cacactaaac gagcagttca tggagaagta
      601 tgtggacccc ggcaaccaca atagcggcat cgacctgctt cgcacctacc tgtggcgctg
      661 ccagttcctt ttacccttcg tcagcttggg cttgatgtgc tttggggcgt tgattggcct
      721 ctgtgcctgt atctgccgca gcctgtatcc caccctcgcc actggcattc tccatctcct
      781 tgcaggtctg tgcacactgg gctccgtgag ttgctatgtt gccggcattg aactcttaca
      841 tcagaaagta gagctgccca aggatgtatc tggagaattt ggatggtcct tctgcctggc
      901 ctgcgtctcg gctcccttac agttcatggc ggccgctctc ttcatctggg ctgcccacac
      961 caaccggaaa gagtacacct taatgaaggc ttatcgtgtg gcatgaaggg aggctgcctg
     1021 cttaatgatt aatatttttc atacattttt tttaactatt gaggttttcc cttgtcttcc
     1081 tctcagtcgt ctttaatttt tatttttgtg gatatgccat tgtattctaa aagccccttt
     1141 tatttatata cagtgccact aaataccatt taaaatgtgt gtggttttca ctgagtgact
     1201 tagtcttttt ttaccacact gatctaggtt cagagttcag acagaaagaa ctgtagagat
     1261 gtgacccaag tttgtaaaag aatattagca gtggcaaatt gacccaaaac agggtctgct
     1321 aacgtctgct cagtccagta gtgcagtaac tatgaaacta gaaatgaatt tctgtatgat
     1381 atctgttatc actgtcagac ttcatcttta ctttcctgtt gttgctagca gaaccagcgt
     1441 tcctcaagat gtgtgcacat aaaattggga aatgagctaa catgtgtccc taaactttgg
     1501 tacattactt tatttgaggt gaaatatggc agctgtttat actgtgattg tctacaagaa
     1561 aaaaaaaagt gaaaaatgat gtttacttga aattgtgctt ttaatttcac ttcagtgagg
     1621 aaagttgact aattgtacta cactatacct gtttgttttt tttttaaact gaaactcatc
     1681 aggattttca gtgccaccaa accattgtgg atttttgctg ctcccctccc ccctcccccc
     1741 cacaccaggc ttattaaaga gtactttctt tttaacagag tgagagaaga gtcacagcca
     1801 attcctcaac ttctttgttc tagctgagta ctatatggga ggtcctacca atatcgaccc
     1861 cccagaactg ggggtactac caccacaaga tctaaagctg tagctgccac ctactaacct
     1921 ccatttatgg gtctttattt cttgtggtga aatgatgtgc ctttccttgc ccaaatccct
     1981 tcctggtgtg tatcaacatt acttaatgtc ttctaattca gtcatttttt tataatatgt
     2041 cttctgtaaa cattgaactt aaaaatctta tttatttact ccattattgt agcatttcac
     2101 agattcaaaa aagtgtaact cagtaatttc ttaccaaatc ctaaatctgt cttttttaaa
     2161 aaaataaata aaaaagagaa tcatgtagag tgtc
//
