LOCUS       NM_020293               1443 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus claudin 9 (Cldn9), mRNA.
ACCESSION   NM_020293
VERSION     NM_020293.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1443)
  AUTHORS   de Lemos,L., Dias,A., Novoa,A. and Mallo,M.
  TITLE     Epha1 is a cell-surface marker for the neuromesodermal competent
            population
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35299237
REFERENCE   3  (bases 1 to 1443)
  AUTHORS   Higashi,A.Y., Higashi,T., Furuse,K., Ozeki,K., Furuse,M. and
            Chiba,H.
  TITLE     Claudin-9 constitutes tight junctions of folliculo-stellate cells
            in the anterior pituitary gland
  JOURNAL   Sci Rep 11 (1), 21642 (2021)
   PUBMED   34737342
  REMARK    GeneRIF: Claudin-9 constitutes tight junctions of
            folliculo-stellate cells in the anterior pituitary gland.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1443)
  AUTHORS   Ramzan,M., Philippe,C., Belyantseva,I.A., Nakano,Y.,
            Fenollar-Ferrer,C., Tona,R., Yousaf,R., Basheer,R., Imtiaz,A.,
            Faridi,R., Munir,Z., Idrees,H., Salman,M., Nambot,S., Vitobello,A.,
            Kartti,S., Zarrik,O., Witmer,P.D., Sobreria,N., Ibrahimi,A.,
            Banfi,B., Moutton,S., Friedman,T.B. and Naz,S.
  TITLE     Variants of human CLDN9 cause mild to profound hearing loss
  JOURNAL   Hum Mutat 42 (10), 1321-1335 (2021)
   PUBMED   34265170
REFERENCE   5  (bases 1 to 1443)
  AUTHORS   Du,T.T., Dewey,J.B., Wagner,E.L., Cui,R., Heo,J., Park,J.J.,
            Francis,S.P., Perez-Reyes,E., Guillot,S.J., Sherman,N.E., Xu,W.,
            Oghalai,J.S., Kachar,B. and Shin,J.B.
  TITLE     LMO7 deficiency reveals the significance of the cuticular plate for
            hearing function
  JOURNAL   Nat Commun 10 (1), 1117 (2019)
   PUBMED   30850599
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1443)
  AUTHORS   Abuazza,G., Becker,A., Williams,S.S., Chakravarty,S., Truong,H.T.,
            Lin,F. and Baum,M.
  TITLE     Claudins 6, 9, and 13 are developmentally expressed renal tight
            junction proteins
  JOURNAL   Am J Physiol Renal Physiol 291 (6), F1132-F1141 (2006)
   PUBMED   16774906
  REMARK    GeneRIF: developmentally expressed claudin isoforms include claudin
            6, claudin 9, and claudin 13
REFERENCE   7  (bases 1 to 1443)
  AUTHORS   Hashizume,A., Ueno,T., Furuse,M., Tsukita,S., Nakanishi,Y. and
            Hieda,Y.
  TITLE     Expression patterns of claudin family of tight junction membrane
            proteins in developing mouse submandibular gland
  JOURNAL   Dev Dyn 231 (2), 425-431 (2004)
   PUBMED   15366020
REFERENCE   8  (bases 1 to 1443)
  AUTHORS   Kitajiri,S.I., Furuse,M., Morita,K., Saishin-Kiuchi,Y., Kido,H.,
            Ito,J. and Tsukita,S.
  TITLE     Expression patterns of claudins, tight junction adhesion molecules,
            in the inner ear
  JOURNAL   Hear Res 187 (1-2), 25-34 (2004)
   PUBMED   14698084
  REMARK    GeneRIF: Claudin-9 is expressed at the variety of epithelial
            tissues in inner ear including Organ of Corti, stria vascularis,
            Reissner's membrane, spiral limbus, vestibular sensory epithelia,
            and dark cell area.
REFERENCE   9  (bases 1 to 1443)
  AUTHORS   Turksen,K. and Troy,T.C.
  TITLE     Permeability barrier dysfunction in transgenic mice overexpressing
            claudin 6
  JOURNAL   Development 129 (7), 1775-1784 (2002)
   PUBMED   11923212
REFERENCE   10 (bases 1 to 1443)
  AUTHORS   Morita,K., Sasaki,H., Fujimoto,K., Furuse,M. and Tsukita,S.
  TITLE     Claudin-11/OSP-based tight junctions of myelin sheaths in brain and
            Sertoli cells in testis
  JOURNAL   J Cell Biol 145 (3), 579-588 (1999)
   PUBMED   10225958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154766.2.
            
            On Aug 6, 2010 this sequence version replaced NM_020293.2.
            
            Summary: This intronless gene encodes a member of the claudin
            family. Claudins are integral membrane proteins and components of
            tight junction strands. Tight junction strands serve as a physical
            barrier to prevent solutes and water from passing freely through
            the paracellular space between epithelial or endothelial cell
            sheets, and also play critical roles in maintaining cell polarity
            and signal transductions. This gene is developmentally regulated;
            it is expressed in neonate kidney, but disappers by adulthood. It
            is required for the preservation of sensory cells in the hearing
            organ and the gene deficiency is associated with deafness.
            [provided by RefSeq, Aug 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC058186.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1443              AC154766.2         9094-10536
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 11.99 cM"
     gene            1..1443
                     /gene="Cldn9"
                     /gene_synonym="nmf329"
                     /note="claudin 9"
                     /db_xref="GeneID:56863"
                     /db_xref="MGI:MGI:1913100"
     exon            1..1443
                     /gene="Cldn9"
                     /gene_synonym="nmf329"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1031
                     /gene="Cldn9"
                     /gene_synonym="nmf329"
                     /codon_start=1
                     /product="claudin-9"
                     /protein_id="NP_064689.2"
                     /db_xref="CCDS:CCDS28458.1"
                     /db_xref="GeneID:56863"
                     /db_xref="MGI:MGI:1913100"
                     /translation="MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQ
                     VVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVVALLLALLGLLVAITGA
                     QCTTCVEDEGAKARIVLTAGVLLLLSGILVLIPVCWTAHAIIQDFYNPLVAEALKREL
                     GASLYLGWAAAALLMLGGGLLCCTCPPSHFERPRGPRLGYSIPSRSGASGLDKRDYV"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn9"
                     /gene_synonym="nmf329"
                     /note="hexamer: AATAAA"
     polyA_site      1443
                     /gene="Cldn9"
                     /gene_synonym="nmf329"
                     /note="major polyA site"
ORIGIN      
        1 agacgtccca agtggcacct cacggttccc tgttttgaga caagctgtat accagctgag
       61 agaagacttc aaccaagaaa gtacgtgagc agccagcaga gaggaacgcg gttgttccta
      121 gttcatggca gatctggagg ggctgtaatg ggtgaaggct tccaggagga cacaagcaat
      181 acagatgagc gggacctaag gacttcttcg tattcagtga gtaccagatg tgtgagaggc
      241 ccgcagctgt gaggtctggc ctggtctgag atcaacagat ccccctcctg agcagtgaga
      301 cgcacccgaa ctccaacaca gtgctcccaa ccctattgag tgattcaggc caagagctga
      361 gaagacccga ggagcagatg gcttccactg gccttgaact cctcggcatg accctggctg
      421 tgctaggctg gctaggaact ttggtgtcct gtgccctgcc actgtggaag gtgaccgcct
      481 tcatcggcaa cagcatcgtt gtggcccaag tggtatggga ggggctgtgg atgtcctgtg
      541 tggtccagag cactggccag atgcagtgca aagtatacga ctcactgctg gcgctgcccc
      601 aggacctgca ggcagccaga gccctctgtg tcgtggccct cctgctggct ttgctgggcc
      661 tgctggtggc tatcacgggc gcccagtgca ccacgtgtgt ggaggacgaa ggtgccaagg
      721 cccgtatcgt actcaccgca ggggtcctcc tcctcctctc gggcattttg gtgctcatcc
      781 ctgtctgctg gacagcccat gccatcatcc aggattttta taacccactg gttgcggaag
      841 ccctcaagag agaactgggg gcttccctct acctgggctg ggctgccgct gccctgctca
      901 tgctaggggg agggctcctc tgctgtacgt gtcccccgtc acactttgag cgtccccgcg
      961 gccccaggct gggctactcc atcccttccc gttcaggtgc ttcgggactg gataagaggg
     1021 actatgtgtg aggctgaggc ttcttccaga agcttccacc tgcggcttca tgccctgcat
     1081 tgggctacat ccttatatca tcaaatccat gcgcctgcga agctcactta ttggccagga
     1141 cttggctctt aggggatctc agctggtctg gcttgagcta accctctgta gtggttgcaa
     1201 ccttgagaaa gctccagtta ctgggtaccc tgcttatcgc tgcctcccag gattttgctg
     1261 tggtttgctc tcctggactt tcttactctg gaacctggac ctcagcctcc ttgccttcaa
     1321 agtaagatgt ggactgtgac ctaatactga ggctttagct ggtcaagtct agcccaagca
     1381 ccacctgaat ccaagttact cagcccccta ccctacctgt gaataaaagc acattgtaac
     1441 tga
//
