LOCUS       NM_181490               1172 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus claudin 17 (Cldn17), mRNA.
ACCESSION   NM_181490
VERSION     NM_181490.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1172)
  AUTHORS   Adil,M.S., Parvathagiri,V., Verma,A., Liu,F., Rudraraju,M.,
            Narayanan,S.P. and Somanath,P.R.
  TITLE     Claudin-17 Deficiency in Mice Results in Kidney Injury Due to
            Electrolyte Imbalance and Oxidative Stress
  JOURNAL   Cells 11 (11), 1782 (2022)
   PUBMED   35681477
  REMARK    GeneRIF: Claudin-17 Deficiency in Mice Results in Kidney Injury Due
            to Electrolyte Imbalance and Oxidative Stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1172)
  AUTHORS   Higashi,A.Y., Higashi,T., Furuse,K., Ozeki,K., Furuse,M. and
            Chiba,H.
  TITLE     Claudin-9 constitutes tight junctions of folliculo-stellate cells
            in the anterior pituitary gland
  JOURNAL   Sci Rep 11 (1), 21642 (2021)
   PUBMED   34737342
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1172)
  AUTHORS   Krug,S.M., Gunzel,D., Conrad,M.P., Rosenthal,R., Fromm,A.,
            Amasheh,S., Schulzke,J.D. and Fromm,M.
  TITLE     Claudin-17 forms tight junction channels with distinct anion
            selectivity
  JOURNAL   Cell Mol Life Sci 69 (16), 2765-2778 (2012)
   PUBMED   22402829
REFERENCE   4  (bases 1 to 1172)
  AUTHORS   Westmoreland,J.J., Drosos,Y., Kelly,J., Ye,J., Means,A.L.,
            Washington,M.K. and Sosa-Pineda,B.
  TITLE     Dynamic distribution of claudin proteins in pancreatic epithelia
            undergoing morphogenesis or neoplastic transformation
  JOURNAL   Dev Dyn 241 (3), 583-594 (2012)
   PUBMED   22275141
REFERENCE   5  (bases 1 to 1172)
  AUTHORS   Patel,R.M., Myers,L.S., Kurundkar,A.R., Maheshwari,A., Nusrat,A.
            and Lin,P.W.
  TITLE     Probiotic bacteria induce maturation of intestinal claudin 3
            expression and barrier function
  JOURNAL   Am J Pathol 180 (2), 626-635 (2012)
   PUBMED   22155109
  REMARK    Erratum:[Am J Pathol. 2012 Mar;180(3):1324. doi:
            10.1016/j.ajpath.2011.12.010.. PMID: 32455526]
REFERENCE   6  (bases 1 to 1172)
  AUTHORS   Lal-Nag,M. and Morin,P.J.
  TITLE     The claudins
  JOURNAL   Genome Biol 10 (8), 235 (2009)
   PUBMED   19706201
  REMARK    Review article
REFERENCE   7  (bases 1 to 1172)
  AUTHORS   Angelow,S., Ahlstrom,R. and Yu,A.S.
  TITLE     Biology of claudins
  JOURNAL   Am J Physiol Renal Physiol 295 (4), F867-F876 (2008)
   PUBMED   18480174
  REMARK    Review article
REFERENCE   8  (bases 1 to 1172)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK048287.1.
            
            On Apr 5, 2007 this sequence version replaced NM_181490.2.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. This gene is intronless and is clustered with
            the Cldn8 gene on chromosome 16. [provided by RefSeq, Aug 2010].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK048287.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1172              AK048287.1         3-1174
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 51.12 cM"
     gene            1..1172
                     /gene="Cldn17"
                     /note="claudin 17"
                     /db_xref="GeneID:239931"
                     /db_xref="MGI:MGI:2652030"
     exon            1..1172
                     /gene="Cldn17"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..814
                     /gene="Cldn17"
                     /codon_start=1
                     /product="claudin-17"
                     /protein_id="NP_852467.1"
                     /db_xref="CCDS:CCDS28295.1"
                     /db_xref="GeneID:239931"
                     /db_xref="MGI:MGI:2652030"
                     /translation="MAFYPLQIAGLVLGFFGLVGTIGTTLLPQWRVSAFIGSNIIIFE
                     RIWEGLWMNCIQQAMVTLQCKFYNSILALPPVLEAARALMCVAVALALVALIIGICGM
                     KQLQCTGSSERVKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYDPTVHAGQKRE
                     LGGALFLGWATAAVLFIGGGLLCGYCCCNRKERWHRYPVPAYRVPQKDNQRNVTVPRK
                     SSTSYV"
ORIGIN      
        1 gctgatttgg acgaacacat catgggtatc aggagcggag aagaccaggc actcctctag
       61 actagaagac tcctacacat tctgcatctt gactgtcttc cttcccttcc aggctgaagc
      121 agtaggccaa ggaaagacaa tggcttttta tcccttacag atcgctggac tagttcttgg
      181 attcttcggt ttggttggga cgattgggac aacacttctg cctcaatgga gagtgtcagc
      241 tttcatcggc agcaacatta ttatctttga gaggatctgg gaagggcttt ggatgaactg
      301 catccagcaa gctatggtca ccttgcagtg caaattctat aactccatat tggctctccc
      361 tccggtactg gaagcagcgc gtgccctcat gtgtgtggct gtggctcttg ccttggttgc
      421 tctcattatt ggcatctgcg gcatgaaaca gctccagtgc accggctcca gcgagagggt
      481 caaagcctac ttgcttggaa cctcaggggt gctctttatt ctgactggta tcttcgttct
      541 gattccagtg tcctggactg ctaatatcat catcagagat ttctacgacc caaccgttca
      601 tgcagggcag aagcgagaac ttggaggagc actcttcctt ggctgggcaa ccgctgctgt
      661 cctcttcatt ggaggcgggc tgctctgcgg atattgctgc tgcaacagaa aggaacggtg
      721 gcacagatac ccagtccctg cataccgcgt gccacagaag gataaccaaa ggaatgttac
      781 tgtgcctaga aaatcttcca ccagctacgt ctaaggctta cttccaacat cagtccctgg
      841 cttatgctca tgtgttttat aaagtcaccc cagaaactgt gagtacttca ggcagaacta
      901 cttttatagg agatataaat tgagatgaaa gttgtgattt tttcccctga ggtaggaata
      961 taaatgactt atttggacat tgtgattccc tgggtgttat ttgtgctcac tcttgttgaa
     1021 ctcaatattt attctaatgt atatagtaaa atatcaagta tattctcagt ttgggcatgt
     1081 gataatgatt actaaatttt gcttgttatt ataataagaa agtaaaatgt tacattataa
     1141 ttgatataaa taaaacatac ccgttttcaa gc
//
