LOCUS       NM_019500               1475 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus claudin 14 (Cldn14), transcript variant 1, mRNA.
ACCESSION   NM_019500
VERSION     NM_019500.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1475)
  AUTHORS   Mohanty,S., White,J.K., Scheffschick,A., Fischer,B., Pathak,A.,
            Tovi,J., Ostenson,C.G., Aspenstrom,P., Brauner,H. and Brauner,A.
  TITLE     Diabetes compromises tight junction protein claudin 14 in the
            urinary bladder
  JOURNAL   Cell Tissue Res 398 (1), 27-33 (2024)
   PUBMED   39162877
  REMARK    GeneRIF: Diabetes compromises tight junction protein claudin 14 in
            the urinary bladder.
REFERENCE   2  (bases 1 to 1475)
  AUTHORS   Higashi,A.Y., Higashi,T., Furuse,K., Ozeki,K., Furuse,M. and
            Chiba,H.
  TITLE     Claudin-9 constitutes tight junctions of folliculo-stellate cells
            in the anterior pituitary gland
  JOURNAL   Sci Rep 11 (1), 21642 (2021)
   PUBMED   34737342
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1475)
  AUTHORS   Krohs,C., Korber,C., Ebbers,L., Altaf,F., Hollje,G., Hoppe,S.,
            Dorflinger,Y., Prosser,H.M. and Nothwang,H.G.
  TITLE     Loss of miR-183/96 Alters Synaptic Strength via Presynaptic and
            Postsynaptic Mechanisms at a Central Synapse
  JOURNAL   J Neurosci 41 (32), 6796-6811 (2021)
   PUBMED   34193555
REFERENCE   4  (bases 1 to 1475)
  AUTHORS   Frische,S., Alexander,R.T., Ferreira,P., Tan,R.S.G., Wang,W.,
            Svenningsen,P., Skjodt,K. and Dimke,H.
  TITLE     Localization and regulation of claudin-14 in experimental models of
            hypercalcemia
  JOURNAL   Am J Physiol Renal Physiol 320 (1), F74-F86 (2021)
   PUBMED   33283646
  REMARK    GeneRIF: Localization and regulation of claudin-14 in experimental
            models of hypercalcemia.
REFERENCE   5  (bases 1 to 1475)
  AUTHORS   Claussen,M., Schulze,J. and Nothwang,H.G.
  TITLE     Loss of inner hair cell ribbon synapses and auditory nerve fiber
            regression in Cldn14 knockout mice
  JOURNAL   Hear Res 391, 107950 (2020)
   PUBMED   32251970
  REMARK    GeneRIF: Loss of inner hair cell ribbon synapses and auditory nerve
            fiber regression in Cldn14 knockout mice.
REFERENCE   6  (bases 1 to 1475)
  AUTHORS   Elkouby-Naor,L., Abassi,Z., Lagziel,A., Gow,A. and Ben-Yosef,T.
  TITLE     Double gene deletion reveals lack of cooperation between claudin 11
            and claudin 14 tight junction proteins
  JOURNAL   Cell Tissue Res 333 (3), 427-438 (2008)
   PUBMED   18663477
  REMARK    GeneRIF: We generated claudin 11/claudin 14 double-deficient mice,
            which exhibit deafness, neurological deficits, and male sterility.
            Kidney function and ion balance are not significantly affected.
REFERENCE   7  (bases 1 to 1475)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   8  (bases 1 to 1475)
  AUTHORS   Nunes,F.D., Lopez,L.N., Lin,H.W., Davies,C., Azevedo,R.B., Gow,A.
            and Kachar,B.
  TITLE     Distinct subdomain organization and molecular composition of a
            tight junction with adherens junction features
  JOURNAL   J Cell Sci 119 (Pt 23), 4819-4827 (2006)
   PUBMED   17130295
REFERENCE   9  (bases 1 to 1475)
  AUTHORS   Ben-Yosef,T., Belyantseva,I.A., Saunders,T.L., Hughes,E.D.,
            Kawamoto,K., Van Itallie,C.M., Beyer,L.A., Halsey,K., Gardner,D.J.,
            Wilcox,E.R., Rasmussen,J., Anderson,J.M., Dolan,D.F., Forge,A.,
            Raphael,Y., Camper,S.A. and Friedman,T.B.
  TITLE     Claudin 14 knockout mice, a model for autosomal recessive deafness
            DFNB29, are deaf due to cochlear hair cell degeneration
  JOURNAL   Hum Mol Genet 12 (16), 2049-2061 (2003)
   PUBMED   12913076
  REMARK    GeneRIF: To explore the role of claudin 14 in the inner ear and in
            other tissues we created a mouse model by a targeted deletion of
            Cldn14.
REFERENCE   10 (bases 1 to 1475)
  AUTHORS   Wilcox,E.R., Burton,Q.L., Naz,S., Riazuddin,S., Smith,T.N.,
            Ploplis,B., Belyantseva,I., Ben-Yosef,T., Liburd,N.A., Morell,R.J.,
            Kachar,B., Wu,D.K., Griffith,A.J., Riazuddin,S. and Friedman,T.B.
  TITLE     Mutations in the gene encoding tight junction claudin-14 cause
            autosomal recessive deafness DFNB29
  JOURNAL   Cell 104 (1), 165-172 (2001)
   PUBMED   11163249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC165961.2, AC168220.1,
            BE863348.1 and AI851731.1.
            
            On Oct 8, 2009 this sequence version replaced NM_019500.3.
            
            Summary: This gene encodes a member of the claudin family of tight
            junction proteins. The encoded protein is an integral membrane
            protein that may function in maintaining apical membrane
            polarization in tight junctions located between outer hair cells
            and supporting cells. Loss of function of this gene is associated
            with hearing problems. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF314089.2, BC138497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AC165961.2         92817-93129
            314-451             AC168220.1         55748-55885
            452-760             BE863348.1         124-432
            761-1024            AC168220.1         78425-78688
            1025-1475           AI851731.1         1-451               c
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 54.99 cM"
     gene            1..1475
                     /gene="Cldn14"
                     /note="claudin 14"
                     /db_xref="GeneID:56173"
                     /db_xref="MGI:MGI:1860425"
     exon            1..313
                     /gene="Cldn14"
                     /inference="alignment:Splign:2.1.0"
     exon            314..451
                     /gene="Cldn14"
                     /inference="alignment:Splign:2.1.0"
     exon            452..1458
                     /gene="Cldn14"
                     /inference="alignment:Splign:2.1.0"
     CDS             533..1252
                     /gene="Cldn14"
                     /codon_start=1
                     /product="claudin-14"
                     /protein_id="NP_062373.3"
                     /db_xref="CCDS:CCDS28345.1"
                     /db_xref="GeneID:56173"
                     /db_xref="MGI:MGI:1860425"
                     /translation="MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAV
                     SYLKGLWMECVWHSTGIYQCQIYRSLLALPRDLQAARALMVISCLLSGMACACAVVGM
                     KCTRCAKGTPAKTTFAVLGGALFLLAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEI
                     GQALYLGFISSSLSLIGGTLLCLSCQDEAPYRPYPPQSRAGATTTATAPAYRPPAAYK
                     DNRAPSVTSAAHSGYRLNDYV"
     regulatory      1435..1440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn14"
                     /note="hexamer: AATAAA"
     polyA_site      1458
                     /gene="Cldn14"
                     /note="major polyA site"
ORIGIN      
        1 gtcggaatgg catgttctga aagggcagcg ttgatagctg aaactaggtg cgcctcaggc
       61 cggggctgtg ggaagcccga gcatcttggg caccagcaaa gtttctagca gccttgggaa
      121 ggagaggaaa gtcaggtgga tctgattggt gggaaaggtg acctggggaa acttgccctg
      181 tggttcatac aacctgccag gcagaagcag gagccagggg cacctgagca agaaacccca
      241 taagatgttc aagtggagtt ccagacaggc acctggatat agttctggac ccggaggggg
      301 acgcgtcaac actgggctgc atggcccagc gatctggaca aaggccaaga agccaaagac
      361 tgttgaagcc gcagtctcca ctcttctact gacgccagcg accacccagc ccagccaggc
      421 catatggcct cctgcttgcc tgatgtatga ggcttcctgc gggcacctaa ggaccagatc
      481 catccctggg gacctgggca ctgctcagcg cggctagcag gggcccttag ccatggccag
      541 cacagcggtc cagctcctag gcttcctgct tagcttcctg ggcatggtag gaacgctcat
      601 caccaccatc ctgccacact ggcggaggac ggcccatgtg ggcaccaaca tcctgactgc
      661 cgtatcctac ctgaagggac tgtggatgga atgtgtgtgg cacagcacag gcatctacca
      721 gtgtcagatc taccgctcac tgctggcgct gccccgggac ttgcaggccg cccgggcgct
      781 catggtcatc tcctgcctgt tgtcgggcat ggcctgcgcc tgcgcagtag tgggcatgaa
      841 gtgcacacgc tgcgccaaag gcacacccgc caagaccacc tttgcagtgc tggggggcgc
      901 gctcttcctg ctggccggcc tgctgtgcat ggtggccgtg tcctggacca cgaatgacgt
      961 ggtgcagaat ttttataacc cgctgctgcc cagtggcatg aagtttgaaa tcggccaggc
     1021 cctgtacctg ggcttcatct cctcatccct gtctctcatc gggggcaccc tgctctgctt
     1081 atcctgccag gacgaggccc cctacagacc ctacccgccc cagtccaggg ccggagctac
     1141 caccacggct accgcccctg cctaccgccc accagcggcc tacaaggaca accgtgcccc
     1201 ctcggtgacc tcagccgcgc acagtgggta caggctgaat gactacgtgt gagttccttc
     1261 cccgggcttc tgccagggat gctgggcccc aaaggaccaa tgatggatgt gggaaggatg
     1321 cagagagcaa gcccggaaca cagggaagga ggtgctcttc aaagcaaaga cttctaaaaa
     1381 gtgctggttt tttatttatt atatgtattt atgcgggtgg cttaataaga gctcaataaa
     1441 gagtgtcttg gaagcgtgaa aaaaaaaaaa aaaaa
//
