LOCUS       NM_001160098            1035 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus claudin 10 (Cldn10), transcript variant a_v3, mRNA.
ACCESSION   NM_001160098
VERSION     NM_001160098.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1035)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1035)
  AUTHORS   Brideau,G., Cheval,L., Griveau,C., Ling,W.E., Lievre,L.,
            Crambert,G., Muller,D., Brocic,J., Cherchame,E., Houillier,P. and
            Prot-Bertoye,C.
  TITLE     Claudin-10 Expression and the Gene Expression Pattern of Thick
            Ascending Limb Cells
  JOURNAL   Int J Mol Sci 25 (7), 4008 (2024)
   PUBMED   38612818
  REMARK    GeneRIF: Claudin-10 Expression and the Gene Expression Pattern of
            Thick Ascending Limb Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1035)
  AUTHORS   Aure,M.H., Symonds,J.M., Villapudua,C.U., Dodge,J.T., Werner,S.,
            Knosp,W.M. and Hoffman,M.P.
  TITLE     FGFR2 is essential for salivary gland duct homeostasis and
            MAPK-dependent seromucous acinar cell differentiation
  JOURNAL   Nat Commun 14 (1), 6485 (2023)
   PUBMED   37838739
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1035)
  AUTHORS   Winningham,A.H. and Camper,S.A.
  TITLE     Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling
  JOURNAL   Endocrinology 164 (3) (2023)
   PUBMED   36683433
REFERENCE   5  (bases 1 to 1035)
  AUTHORS   Quintanova,C., Himmerkus,N., Svendsen,S.L., von Schwerdtner,O.,
            Merkel,C., Pinckert,L., Mutig,K., Breiderhoff,T., Muller,D.,
            Gunzel,D. and Bleich,M.
  TITLE     Unrecognized role of claudin-10b in basolateral membrane infoldings
            of the thick ascending limb
  JOURNAL   Ann N Y Acad Sci 1517 (1), 266-278 (2022)
   PUBMED   35996827
  REMARK    GeneRIF: Unrecognized role of claudin-10b in basolateral membrane
            infoldings of the thick ascending limb.
REFERENCE   6  (bases 1 to 1035)
  AUTHORS   Kitajiri,S.I., Furuse,M., Morita,K., Saishin-Kiuchi,Y., Kido,H.,
            Ito,J. and Tsukita,S.
  TITLE     Expression patterns of claudins, tight junction adhesion molecules,
            in the inner ear
  JOURNAL   Hear Res 187 (1-2), 25-34 (2004)
   PUBMED   14698084
  REMARK    GeneRIF: Claudin-10 is expressed at the variety of epithelial
            tissues in the coclea of inner ear including Organ of Corti, stria
            vascularis, Reissner's membrane, and spiral limbus.
REFERENCE   7  (bases 1 to 1035)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   8  (bases 1 to 1035)
  AUTHORS   Turksen,K. and Troy,T.C.
  TITLE     Permeability barrier dysfunction in transgenic mice overexpressing
            claudin 6
  JOURNAL   Development 129 (7), 1775-1784 (2002)
   PUBMED   11923212
REFERENCE   9  (bases 1 to 1035)
  AUTHORS   Niimi,T., Nagashima,K., Ward,J.M., Minoo,P., Zimonjic,D.B.,
            Popescu,N.C. and Kimura,S.
  TITLE     claudin-18, a novel downstream target gene for the T/EBP/NKX2.1
            homeodomain transcription factor, encodes lung- and
            stomach-specific isoforms through alternative splicing
  JOURNAL   Mol Cell Biol 21 (21), 7380-7390 (2001)
   PUBMED   11585919
REFERENCE   10 (bases 1 to 1035)
  AUTHORS   Morita,K., Sasaki,H., Fujimoto,K., Furuse,M. and Tsukita,S.
  TITLE     Claudin-11/OSP-based tight junctions of myelin sheaths in brain and
            Sertoli cells in testis
  JOURNAL   J Cell Biol 145 (3), 579-588 (1999)
   PUBMED   10225958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA467408.1, CA481582.1 and
            AI851016.1.
            
            Summary: This intronless gene encodes a member of the claudin
            family. Claudins are integral membrane proteins and components of
            tight unction strands. Tight junction strands serve as a physical
            barrier to prevent solutes and water from passing freely through
            the paracellular space between epithelial or endothelial cell
            sheets, and also play critical roles in maintaining cell polarity
            and signal transductions. Six alternatively spliced transcript
            variants have been identified, which encode different isoforms with
            distinct electric charge of the first extracellular loop and with
            or without the fourth transmembrane region. These isoforms exhibit
            distinct localization and function in paracellular anion or cation
            permeability. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (a_v3) lacks an alternate in-frame
            segment in the 5' coding region and an alternate in-frame exon in
            the 3' coding region, compared to variant a. The resulting isoform
            (a_i3) lacks an internal segment within the first extracellular
            loop and an internal segment including the entire fourth
            transmembrane region, compared to isoform a. This variant is
            expressed only in kidney and uterus.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               CA467408.1         38-432
            396-687             CA481582.1         404-695
            688-1035            AI851016.1         1-348               c
FEATURES             Location/Qualifiers
     source          1..1035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 62.55 cM"
     gene            1..1035
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
                     /note="claudin 10"
                     /db_xref="GeneID:58187"
                     /db_xref="MGI:MGI:1913101"
     exon            1..443
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..811
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
                     /note="isoform a_i3 is encoded by transcript variant a_v3;
                     claudin-10A; claudin 10B"
                     /codon_start=1
                     /product="claudin-10 isoform a_i3"
                     /protein_id="NP_001153570.1"
                     /db_xref="GeneID:58187"
                     /db_xref="MGI:MGI:1913101"
                     /translation="MSRAQISALVCGVGGFGALVAATTSNEWKVTTRASSVITATWVY
                     QGLWMNCAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDQAKAKIACLAGIV
                     FILSGLCSMTGCSLYANKITTEFFDPLYMEQKMGYTYNGPTSAMSSRTKYQGGEGDFK
                     TTGPSKQFDKNAYV"
     exon            444..605
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
                     /inference="alignment:Splign:2.1.0"
     exon            606..687
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
                     /inference="alignment:Splign:2.1.0"
     exon            688..1021
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      919..924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
                     /note="hexamer: TATAAA"
     polyA_site      939
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
     regulatory      1003..1008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
                     /note="hexamer: AATAAA"
     polyA_site      1021
                     /gene="Cldn10"
                     /gene_synonym="6720456I16Rik; Cldn10a; Cldn10b;
                     D14Ertd728e"
                     /note="major polyA site"
ORIGIN      
        1 aacaagagaa aaaaatatct gcagtaccaa caccttcaag attcctctac aaagttttgg
       61 tatttcagta gggaattaga aagattattc taagctatct ctaagatgcc cttagtgtga
      121 tatactttat tctaatttcc cacacttcaa gccatgagat tatgaagaat tgtcacctac
      181 cctcatgggc tggctttaac attcgtggaa gttttgtcca gtgtctgcat gcctaggcca
      241 ccaaagcctt ctgtgtggac tgtggcagca ggcaaggctg agcgacatgt ccagggcaca
      301 gatctcagct ctggtgtgtg gtgttggagg gtttggtgct ctcgtcgctg ccaccacatc
      361 caacgaatgg aaagtgacca cccgagcgtc gtctgtgatt accgccacct gggtttacca
      421 gggtctgtgg atgaactgcg caggttacat ccaggcatgt agaggactaa tgatcgctgc
      481 ggtcagcctg ggatttttcg gttccatttt tgcactcttt ggaatgaaat gtaccaaagt
      541 cggaggctca gatcaagcca aagctaaaat tgcttgcttg gccgggattg tattcatatt
      601 gtcaggtctg tgttccatga caggctgttc cctgtatgca aacaaaatca caacagaatt
      661 ctttgatcct ctttatatgg agcaaaaaat gggctacaca tacaacggac ccacgtctgc
      721 catgtcttct cggaccaagt atcaaggcgg agaaggagat tttaaaacca caggcccttc
      781 aaaacagttt gataaaaatg cctatgtcta aagagctctg gcaagctgcc tcctgagttt
      841 tgttgtgcaa gagaactgtc ctcacaatag tccttccaag gctctcctgt aattactgct
      901 taagctgttt tttaaaaata taaatttgaa gactgttaat tggatgtaaa tgttcttata
      961 gttatatact aatcattttc tgctgtgcct ttctgtaagg gaaataaaca ggttatttac
     1021 aaaaaaaaaa aaaaa
//
