LOCUS       NM_016674               3263 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus claudin 1 (Cldn1), mRNA.
ACCESSION   NM_016674 XM_358828
VERSION     NM_016674.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3263)
  AUTHORS   Coren,L., Zaffryar-Eilot,S., Odeh,A., Kaganovsky,A. and Hasson,P.
  TITLE     Fibroblast diversification is an embryonic process dependent on
            muscle contraction
  JOURNAL   Cell Rep 43 (12), 115034 (2024)
   PUBMED   39636726
REFERENCE   2  (bases 1 to 3263)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3263)
  AUTHORS   Zhu,L., Tang,N., Hang,H., Zhou,Y., Dong,J., Yang,Y., Mao,L.,
            Qiu,Y., Fu,X. and Cao,W.
  TITLE     Loss of Claudin-1 incurred by DNMT aberration promotes pancreatic
            cancer progression
  JOURNAL   Cancer Lett 586, 216611 (2024)
   PUBMED   38309617
  REMARK    GeneRIF: Loss of Claudin-1 incurred by DNMT aberration promotes
            pancreatic cancer progression.
REFERENCE   4  (bases 1 to 3263)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3263)
  AUTHORS   Mak,S. and Hammes,A.
  TITLE     Canonical and Non-Canonical Localization of Tight Junction Proteins
            during Early Murine Cranial Development
  JOURNAL   Int J Mol Sci 25 (3), 1426 (2024)
   PUBMED   38338705
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3263)
  AUTHORS   Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A.
            and Tsukita,S.
  TITLE     Ca(2+)-independent cell-adhesion activity of claudins, a family of
            integral membrane proteins localized at tight junctions
  JOURNAL   Curr Biol 9 (18), 1035-1038 (1999)
   PUBMED   10508613
REFERENCE   7  (bases 1 to 3263)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   8  (bases 1 to 3263)
  AUTHORS   Citi,S. and Cordenonsi,M.
  TITLE     Tight junction proteins
  JOURNAL   Biochim Biophys Acta 1448 (1), 1-11 (1998)
   PUBMED   9824655
  REMARK    Review article
REFERENCE   9  (bases 1 to 3263)
  AUTHORS   Furuse,M., Sasaki,H., Fujimoto,K. and Tsukita,S.
  TITLE     A single gene product, claudin-1 or -2, reconstitutes tight
            junction strands and recruits occludin in fibroblasts
  JOURNAL   J Cell Biol 143 (2), 391-401 (1998)
   PUBMED   9786950
REFERENCE   10 (bases 1 to 3263)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK036780.1 and CK626537.1.
            
            On Aug 3, 2010 this sequence version replaced NM_016674.3.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. The knockout mice lacking this gene die soon
            after birth as a consequence of dehydration from trandermal water
            loss, indicating that this gene is indispensable for creating and
            maintaining the epidermal barrier. The protein encoded by this gene
            also has gastric tumor suppressive activity, and is a key factor
            for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008536.1, AK036780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3236              AK036780.1         2-3237
            3237-3263           CK626537.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..3263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.0 cM"
     gene            1..3263
                     /gene="Cldn1"
                     /note="claudin 1"
                     /db_xref="GeneID:12737"
                     /db_xref="MGI:MGI:1276109"
     exon            1..436
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..849
                     /gene="Cldn1"
                     /codon_start=1
                     /product="claudin-1"
                     /protein_id="NP_057883.1"
                     /db_xref="CCDS:CCDS28087.1"
                     /db_xref="GeneID:12737"
                     /db_xref="MGI:MGI:1276109"
                     /translation="MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQ
                     AIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGM
                     KCMRCLEDDEVQKMWMAVIGGIIFLISGLATLVATAWYGNRIVQEFYDPLTPINARYE
                     FGQALFTGWAAASLCLLGGVLLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV"
     exon            437..601
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..686
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..3242
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3218..3223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn1"
                     /note="hexamer: AATAAA"
     polyA_site      3242
                     /gene="Cldn1"
                     /note="major polyA site"
ORIGIN      
        1 ctcagagaac tctgccactt ctcacttcca gactccacca ccgcctaccc ggaccagaag
       61 ccaggagcct cgccccgcag ctgcacagag agcaagggta taggcactaa cttgtttgca
      121 gagaccccat caccttcggg agctcaggtg cgcaccttgc aaactccact ttctgcatct
      181 gccactgagc ccgcgggagc ctcggaaaga gccatggcca acgcggggct gcagctgctg
      241 ggtttcatcc tggcttctct gggatggatc ggctccatcg tcagcactgc cctgccccag
      301 tggaagattt actcctatgc tggggacaac atcgtgaccg ctcaggccat ctacgaggga
      361 ctgtggatgt cctgcgtttc gcaaagcacc gggcagatac agtgcaaagt cttcgactcc
      421 ttgctgaatc tgaacagtac tttgcaggca acccgagcct tgatggtaat tggcatcctg
      481 ctggggctga tcgcaatctt tgtgtccacc attggcatga agtgcatgag gtgcctggaa
      541 gatgatgagg tgcagaagat gtggatggct gtcattgggg gcataatatt tttaatttca
      601 ggtctggcga cattagtggc cacagcatgg tatggaaaca gaattgttca agaattctat
      661 gaccccttga cccccatcaa tgccaggtat gaatttggcc aggccctctt tactggctgg
      721 gccgctgcct ccctctgcct tctgggaggt gtcctacttt cctgctcctg tccccggaaa
      781 acaacctctt acccaacacc acggccttat cccaagccaa caccttctag tgggaaagac
      841 tatgtgtgac agaggcaaag gaagagatct tcctggagca aatacaaaat ggacattgaa
      901 cctaggattg acattaacgc cttagactgt tgatgatggt tatcggaact gtggtagaac
      961 agaaggaagc atatttttat acatccccat ggctatgcag gccttggctg taccttacca
     1021 tcttccctga gcacaggagg gaaggctttt gcctgtgaac tgctgcttcc ctctgagaaa
     1081 tcacactcaa acggggataa ggtgctcctt gcatgtgtat agatatgtac agatacatag
     1141 tttctattaa aaatagacaa gttacaaatc ccttattctc ctcatactgt accagcacac
     1201 tttaaatgac tctacaatat atacaattat gttttgatta aataagcctt tttgatgtat
     1261 tattcctttt tctctatgaa catatgtgat cagtcaaata tcaccccttt gatcagcatt
     1321 tagtaacttt gccataagac cagacttcct tatgaactca gactgtgttc tttttaaccc
     1381 catgtgtctt ctttacatca aaatatttaa tttttttact ctgaaacaca ctttttcaga
     1441 ctgttactct gaggtttgat tctaactccc aaatctaata atgaatttgg agcccacatt
     1501 ttgaagcgta aaaccagtaa gaatcccata gtcctcctgt ttctgagctg tggtgaccaa
     1561 cattctagtc agatgatgtt ttcccgatga cctttctgga cggtctttgc actttggtct
     1621 ggagctgtct tgtttgcttt aaaaatattt gtttccctga gtggctgtgc tgctaaccct
     1681 gttgttgaaa cagttttatt gcctgcattt tttaggtact tattttccat cccagatcct
     1741 gcaaactgtg cttctcctct ccccccaccc cagctgtcta gtttccccac atataattat
     1801 ctgacagttt agctcttttc agataggtgt ggtctgttta tctacacaaa ctgctagact
     1861 tgccagagtg gtaatctagt gacaaatatt ccctaggtag ccgtgaacaa tttacaatct
     1921 ttatacctcg ttttcccatc tgtcaaattg agataattat acttaagcag ctggtagagg
     1981 taatgtgagt attaattagt tgatatgact ctcattcttt gaacatgaaa tatgcctaag
     2041 tagtgttttt ccttgctcaa ttagcagttt tgaagacact gaataagatc tatgcacatg
     2101 ccttcaactg ttctgtatct ctctttgtca tgagttgatt tcctcccatc cagctgtgca
     2161 tggcctcttg ttggtgctgt tttgttttga ccagtgctct taatatactc tcatccatag
     2221 gaaaggccct tcagcagagc aaggttttgt aatacaaagg gtgttgccat tgacattggt
     2281 agacctggat ttgcatcttg gtgctatcac ttaattagtg agcttgggca aaggcacttg
     2341 gttgccctac atgtattgct acatctagac aacgggttca ttaactcttg tcctgcctat
     2401 gttgcatgag tcaagagggg gcacaggcta acatggtttt atattggaaa acatgttact
     2461 ctacaaatta atggcttttg tgtttatttt ttcaaacaac tggaaagaga aaaatgttaa
     2521 gtgagtttca ttccttaaga actctctcaa atgaggagtt cctaaagctt actaagttaa
     2581 actgatctta agtctttaag gcttttggtt gggagtcagt gtttcagcct atggtccaaa
     2641 ctggccaaga gcccctatgt cactcaaaga tccttcttcc tcaacctccc aactgttaag
     2701 atgagaggca tgaacccttc ctactgttac accctagttt cagttgtttg gcctggaact
     2761 tctgttgcta agcaaatgta atggtgaaag tctatgtata ctctaaaagc aaatgaagtg
     2821 ctctttgtga agtgatactt tcaaaattaa atggaagctg acagttatag gagaggttaa
     2881 gaattataat tcatggtaaa accacatgga tgaagttata gacagaatgg agtcttatgt
     2941 gaatttgtac tatgtaagtt ttactatatt tgtgtgtgta aagtaatcat gcaaagatgt
     3001 tttgccacag aatctgtgct taatatgtaa tgtaaatgca tagaaatgat acttgccaaa
     3061 ctacacaaat ctatatattc taaaataatc ccatagaaat cttacatcag aacttaccta
     3121 gttttgatat ttttataccc tactaccaaa gctggaaaga gatcagttga tatctggggg
     3181 ctgcaatggg aatttgtaca aagcactact ctttttcaat aaattgtttt ttaattaata
     3241 aaaaaaaaaa aaaaaaaaaa aaa
//
