LOCUS       NM_019952               1664 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus cardiotrophin-like cytokine factor 1 (Clcf1),
            transcript variant 1, mRNA.
ACCESSION   NM_019952
VERSION     NM_019952.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1664)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1664)
  AUTHORS   Yuan,Y., Li,K., Ye,X., Wen,S., Zhang,Y., Teng,F., Zhou,X., Deng,Y.,
            Yang,X., Wang,W., Lin,J., Luo,S., Zhang,P., Shi,G. and Zhang,H.
  TITLE     CLCF1 inhibits energy expenditure via suppressing brown fat
            thermogenesis
  JOURNAL   Proc Natl Acad Sci U S A 121 (3), e2310711121 (2024)
   PUBMED   38190531
  REMARK    GeneRIF: CLCF1 inhibits energy expenditure via suppressing brown
            fat thermogenesis.
REFERENCE   3  (bases 1 to 1664)
  AUTHORS   Liu,T., Wang,Q., Zhou,L., Zhang,P., Mi,L., Qiu,X., Chen,Z.,
            Kuang,H., Li,S. and Lin,J.D.
  TITLE     Intrahepatic paracrine signaling by cardiotrophin-like cytokine
            factor 1 ameliorates diet-induced NASH in mice
  JOURNAL   Hepatology 78 (5), 1478-1491 (2023)
   PUBMED   35950514
  REMARK    GeneRIF: Intrahepatic paracrine signaling by cardiotrophin-like
            cytokine factor 1 ameliorates diet-induced NASH in mice.
REFERENCE   4  (bases 1 to 1664)
  AUTHORS   Ding,M., Xu,H.Y., Zhou,W.Y., Xia,Y.F., Li,B.Y., Shi,Y.J., Dou,X.,
            Yang,Q.Q., Qian,S.W., Tang,Y., Pan,D.N., Liu,Y. and Tang,Q.Q.
  TITLE     CLCF1 signaling restrains thermogenesis and disrupts metabolic
            homeostasis by inhibiting mitochondrial biogenesis in brown
            adipocytes
  JOURNAL   Proc Natl Acad Sci U S A 120 (33), e2305717120 (2023)
   PUBMED   37549287
  REMARK    GeneRIF: CLCF1 signaling restrains thermogenesis and disrupts
            metabolic homeostasis by inhibiting mitochondrial biogenesis in
            brown adipocytes.
REFERENCE   5  (bases 1 to 1664)
  AUTHORS   Pasquin,S., Tormo,A., Moreau,J., Laplante,V., Sharma,M.,
            Gauchat,J.F. and Rafei,M.
  TITLE     Cardiotrophin-Like Cytokine Factor 1 Exhibits a Myeloid-Biased
            Hematopoietic-Stimulating Function
  JOURNAL   Front Immunol 10, 2133 (2019)
   PUBMED   31552057
  REMARK    GeneRIF: Cardiotrophin-Like Cytokine Factor 1 Exhibits a
            Myeloid-Biased Hematopoietic-Stimulating Function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1664)
  AUTHORS   Vlotides,G., Zitzmann,K., Hengge,S., Engelhardt,D., Stalla,G.K. and
            Auernhammer,C.J.
  TITLE     Expression of novel neurotrophin-1/B-cell stimulating factor-3
            (NNT-1/BSF-3) in murine pituitary folliculostellate TtT/GF cells:
            pituitary adenylate cyclase-activating polypeptide and vasoactive
            intestinal peptide-induced stimulation of NNT-1/BSF-3 is mediated
            by protein kinase A, protein kinase C, and
            extracellular-signal-regulated kinase1/2 pathways
  JOURNAL   Endocrinology 145 (2), 716-727 (2004)
   PUBMED   14605001
  REMARK    GeneRIF: neurotrophin-1/B-cell stimulating factor 3(NNT-1/BSF-3) is
            expressed in pituitary folliculostellate TtT/GF cells and induced
            by PKC-, PKA-, and ERK1/2-dependent mechanisms
REFERENCE   7  (bases 1 to 1664)
  AUTHORS   Forger,N.G., Prevette,D., deLapeyriere,O., de Bovis,B., Wang,S.,
            Bartlett,P. and Oppenheim,R.W.
  TITLE     Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential
            trophic factor for lumbar and facial motoneurons in vivo
  JOURNAL   J Neurosci 23 (26), 8854-8858 (2003)
   PUBMED   14523086
REFERENCE   8  (bases 1 to 1664)
  AUTHORS   Senaldi,G., Stolina,M., Guo,J., Faggioni,R., McCabe,S.,
            Kaufman,S.A., Van,G., Xu,W., Fletcher,F.A., Boone,T., Chang,M.S.,
            Sarmiento,U. and Cattley,R.C.
  TITLE     Regulatory effects of novel neurotrophin-1/b cell-stimulating
            factor-3 (cardiotrophin-like cytokine) on B cell function
  JOURNAL   J Immunol 168 (11), 5690-5698 (2002)
   PUBMED   12023368
REFERENCE   9  (bases 1 to 1664)
  AUTHORS   Uemura,A., Takizawa,T., Ochiai,W., Yanagisawa,M., Nakashima,K. and
            Taga,T.
  TITLE     Cardiotrophin-like cytokine induces astrocyte differentiation of
            fetal neuroepithelial cells via activation of STAT3
  JOURNAL   Cytokine 18 (1), 1-7 (2002)
   PUBMED   12090754
  REMARK    GeneRIF: CLC plays a role in astrocyte differentiation via STAT3
            activation within the developing brain
REFERENCE   10 (bases 1 to 1664)
  AUTHORS   Senaldi,G., Varnum,B.C., Sarmiento,U., Starnes,C., Lile,J.,
            Scully,S., Guo,J., Elliott,G., McNinch,J., Shaklee,C.L.,
            Freeman,D., Manu,F., Simonet,W.S., Boone,T. and Chang,M.S.
  TITLE     Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the
            IL-6 family
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11458-11463 (1999)
   PUBMED   10500198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140073.4.
            
            On Jan 13, 2022 this sequence version replaced NM_019952.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166421.1, SRR7345562.3703414.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC140073.4         208884-208959       c
            77-243              AC140073.4         203040-203206       c
            244-1664            AC140073.4         199890-201310       c
FEATURES             Location/Qualifiers
     source          1..1664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.91 cM"
     gene            1..1664
                     /gene="Clcf1"
                     /gene_synonym="BSF-3; Bsf3; CLC; NNT-1"
                     /note="cardiotrophin-like cytokine factor 1"
                     /db_xref="GeneID:56708"
                     /db_xref="MGI:MGI:1930088"
     exon            1..76
                     /gene="Clcf1"
                     /gene_synonym="BSF-3; Bsf3; CLC; NNT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..738
                     /gene="Clcf1"
                     /gene_synonym="BSF-3; Bsf3; CLC; NNT-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; B-cell stimulating factor 3;
                     neurotrophin-1/B-cell stimulating factor-3; novel
                     neurotrophin-1"
                     /codon_start=1
                     /product="cardiotrophin-like cytokine factor 1 isoform 1
                     precursor"
                     /protein_id="NP_064336.1"
                     /db_xref="CCDS:CCDS29423.1"
                     /db_xref="GeneID:56708"
                     /db_xref="MGI:MGI:1930088"
                     /translation="MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTY
                     DLTRYLEHQLRSLAGTYLNYLGPPFNEPDFNPPRLGAETLPRATVNLEVWRSLNDRLR
                     LTQNYEAYSHLLCYLRGLNRQAATAELRRSLAHFCTSLQGLLGSIAGVMATLGYPLPQ
                     PLPGTEPAWAPGPAHSDFLQKMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAASVTL
                     HLEAHGF"
     exon            77..243
                     /gene="Clcf1"
                     /gene_synonym="BSF-3; Bsf3; CLC; NNT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..1664
                     /gene="Clcf1"
                     /gene_synonym="BSF-3; Bsf3; CLC; NNT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1644..1649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clcf1"
                     /gene_synonym="BSF-3; Bsf3; CLC; NNT-1"
                     /note="hexamer: AATAAA"
     polyA_site      1664
                     /gene="Clcf1"
                     /gene_synonym="BSF-3; Bsf3; CLC; NNT-1"
                     /note="major polyA site"
ORIGIN      
        1 ctcccactcc gccagcctct gggagaggag ccgcgcccgg ccggcccggc ccccagcccc
       61 atggacctcc gagcagggga ctcgtggggg atgttagctt gcctatgcac ggtgctgtgg
      121 cacctccctg cagtgccagc tcttaatcgc acaggagatc caggccctgg cccctccatc
      181 cagaaaacct atgacctcac ccgctacctg gagcatcaac tccgcagctt agctgggacc
      241 tacctgaact acctggggcc ccctttcaac gagcctgact tcaatcctcc tcgactgggg
      301 gcagaaactc tgcccagggc cacggtcaac ttggaagtgt ggcgaagcct caatgacagg
      361 ctgcggctga cccagaacta tgaggcgtac agtcacctcc tgtgttactt gcgtggcctc
      421 aaccgtcagg ctgccacagc tgaactccga cgtagcctgg cccacttctg taccagcctc
      481 cagggcctgc tgggcagcat tgcaggtgtc atggcgacgc ttggctaccc actgccccag
      541 cctctgccag ggactgagcc agcctgggcc cctggccctg cccacagtga cttcctccag
      601 aagatggatg acttctggct gctgaaggag ctgcagacct ggctatggcg ttcagccaag
      661 gacttcaacc ggcttaagaa gaagatgcag cctccagcag cttcagtcac cctgcacttg
      721 gaggcccatg gtttctgacc tctgaccctt aacccccaca cctccaggcc cagtcagctg
      781 tgcttccatt gtggggtgaa aaatcctgta taccaacatt tgttgagcca ggaaccagac
      841 catgggagct ctgccctcct cagccttgga tggggagtgt aactcaataa gccctctagc
      901 tcagaaagtc ctagggtctg gggaaatcgt acagtgggca tcgaggcgat gcctgaggaa
      961 gtggaatggc tctccctgcc tcctgctctc tgcctgccac ttgccagtac tcactcagtc
     1021 cctcatgtgg catttgcaga agcacccttg gagggtatgg gtgggggcca ctgtagcatg
     1081 tgcctttctg ggataaggcc ccttggcttc cctccctctc cttggatggg tgttgctccc
     1141 ctaccccaat aactacatat ccagttcagg aaacaaagtg accagtccta agaagagtgt
     1201 tacagtaaat ggaggggggt agggtttatg ctggaggtgg cctagacacc acaagatgta
     1261 attctaaaag agaagggcag ggacagacca gacccagcag tcaccaagac agttggtggc
     1321 acagggtgga aaacaaaagc catgttgagc attagtacct tgctttgaat tttcttgcca
     1381 gcatcttggt gcctcctctc tgcccccttt cccagggtat ctgtggttgc ctgggctggg
     1441 gagggcagcc atagccatag ccacagggtt tcctgaaagt ttacattgca gtagcattgt
     1501 ggggtgaggg ggatggctcc cccaggctct atccccagcc ccacccactc atgactctaa
     1561 gtttgttgta ttaatattta tttatttgga gatgttattt attagatgat atttattgca
     1621 gaatttctat tcttgtatta acaaataaaa tgctttcccc agaa
//
