LOCUS       NM_145543               2043 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus chloride channel CLIC-like 1 (Clcc1), transcript
            variant 2, mRNA.
ACCESSION   NM_145543
VERSION     NM_145543.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2043)
  AUTHORS   Glass,T.J., Russell,J.A., Fisher,E.H., Ostadi,M., Aori,N., Yu,Y.E.
            and Connor,N.P.
  TITLE     Altered tongue muscle contractile properties coincide with altered
            swallow function in the adult Ts65Dn mouse model of down syndrome
  JOURNAL   Front Neurol 15, 1384572 (2024)
   PUBMED   38585362
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2043)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2043)
  AUTHORS   Guo,L., Mao,Q., He,J., Liu,X., Piao,X., Luo,L., Hao,X., Yu,H.,
            Song,Q., Xiao,B., Fan,D., Gao,Z. and Jia,Y.
  TITLE     Disruption of ER ion homeostasis maintained by an ER anion channel
            CLCC1 contributes to ALS-like pathologies
  JOURNAL   Cell Res 33 (7), 497-515 (2023)
   PUBMED   37142673
  REMARK    GeneRIF: Disruption of ER ion homeostasis maintained by an ER anion
            channel CLCC1 contributes to ALS-like pathologies.
REFERENCE   4  (bases 1 to 2043)
  AUTHORS   Myles,I.A., Castillo,C.R., Barbian,K.D., Kanakabandi,K.,
            Virtaneva,K., Fitzmeyer,E., Paneru,M., Otaizo-Carrasquero,F.,
            Myers,T.G., Markowitz,T.E., Moore,I.N., Liu,X., Ferrer,M.,
            Sakamachi,Y., Garantziotis,S., Swamydas,M., Lionakis,M.S.,
            Anderson,E.D., Earland,N.J., Ganesan,S., Sun,A.A.,
            Bergerson,J.R.E., Silverman,R.A., Petersen,M., Martens,C.A. and
            Datta,S.K.
  TITLE     Therapeutic responses to Roseomonas mucosa in atopic dermatitis may
            involve lipid-mediated TNF-related epithelial repair
  JOURNAL   Sci Transl Med 12 (560) (2020)
   PUBMED   32908007
REFERENCE   5  (bases 1 to 2043)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2043)
  AUTHORS   Lone,A.G. and Bankhead,T.
  TITLE     The Borrelia burgdorferi VlsE Lipoprotein Prevents Antibody Binding
            to an Arthritis-Related Surface Antigen
  JOURNAL   Cell Rep 30 (11), 3663-3670 (2020)
   PUBMED   32187539
REFERENCE   7  (bases 1 to 2043)
  AUTHORS   Li,L., Jiao,X., D'Atri,I., Ono,F., Nelson,R., Chan,C.C., Nakaya,N.,
            Ma,Z., Ma,Y., Cai,X., Zhang,L., Lin,S., Hameed,A., Chioza,B.A.,
            Hardy,H., Arno,G., Hull,S., Khan,M.I., Fasham,J., Harlalka,G.V.,
            Michaelides,M., Moore,A.T., Coban Akdemir,Z.H., Jhangiani,S.,
            Lupski,J.R., Cremers,F.P.M., Qamar,R., Salman,A., Chilton,J.,
            Self,J., Ayyagari,R., Kabir,F., Naeem,M.A., Ali,M., Akram,J.,
            Sieving,P.A., Riazuddin,S., Baple,E.L., Riazuddin,S.A., Crosby,A.H.
            and Hejtmancik,J.F.
  TITLE     Mutation in the intracellular chloride channel CLCC1 associated
            with autosomal recessive retinitis pigmentosa
  JOURNAL   PLoS Genet 14 (8), e1007504 (2018)
   PUBMED   30157172
  REMARK    GeneRIF: Clcc1+/- KO mice showed decreased electroretinogram and
            photoreceptor number. Intracellular chloride transport by CLCC1 is
            a critical process in maintaining retinal integrity, and CLCC1 is
            crucial for survival and function of retinal cells.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2043)
  AUTHORS   Jia,Y., Jucius,T.J., Cook,S.A. and Ackerman,S.L.
  TITLE     Loss of Clcc1 results in ER stress, misfolded protein accumulation,
            and neurodegeneration
  JOURNAL   J Neurosci 35 (7), 3001-3009 (2015)
   PUBMED   25698737
  REMARK    GeneRIF: This study demonistrated that Loss of Clcc1 results in ER
            stress, misfolded protein accumulation, and neurodegeneration.
REFERENCE   9  (bases 1 to 2043)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB848444.1, AL671917.8 and CF723950.1.
            
            On Apr 27, 2010 this sequence version replaced NM_145543.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169803.1, SRR11927936.1870538.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               BB848444.1         2-298
            298-311             AL671917.8         3744-3757
            312-419             AL671917.8         5248-5355
            420-641             AL671917.8         9687-9908
            642-782             AL671917.8         10423-10563
            783-876             AL671917.8         12626-12719
            877-974             AL671917.8         14544-14641
            975-1121            AL671917.8         15005-15151
            1122-1448           AL671917.8         16361-16687
            1449-1604           AL671917.8         18409-18564
            1605-2043           CF723950.1         1-439
FEATURES             Location/Qualifiers
     source          1..2043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 47.49 cM"
     gene            1..2043
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /note="chloride channel CLIC-like 1"
                     /db_xref="GeneID:229725"
                     /db_xref="MGI:MGI:2385186"
     exon            1..68
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            69..209
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            210..311
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            312..419
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            420..641
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            642..782
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            783..876
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            877..974
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1121
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1448
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1742
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..2043
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2021..2026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /note="hexamer: AATAAA"
     polyA_site      2043
                     /gene="Clcc1"
                     /gene_synonym="ERAC1; Mclc"
                     /note="major polyA site"
ORIGIN      
        1 gcacagctgc gggccgagcg agtcgatgag tccgctcggg actccagtcc gagtgcaccg
       61 tgtttgaggc cttattcagg atgctgtgtc ggctgctcct ttgtgaatgt ctgttgctga
      121 taacgggtta tgctcatgat gacgactgga ttgacccaac agatatgctt aactatgacg
      181 ctgcttcagg aacgatgagg aaatctcagg tgaggtctgg aacatcagag aagaaggaag
      241 tgagccctga ctcgtcagaa gccgaggaac tgtcagactg tttgcacaga ctggattctt
      301 taactcacaa ggttgatagt tgtgaaaaga agaaaatgaa agattatgaa agtcaaagta
      361 atcctgtttt caggagatat ctaaataaga ttttaattga agctggcaag cttggactcc
      421 ctgatgagaa caaagtagag atgcgttacg atgctgagat tctcctgagc agacagacac
      481 tgttggagat tcagaagttc ctcagcggag aggagtggaa gcccggagcc ctggacgacg
      541 cactaagtga cattttaatc aattttaagt gccatgattc agaagcatgg aagtggcagt
      601 ttgaagatta ttttggagta gatccatata atgtgtttat ggttctcttg tgtctgctct
      661 gccttgtggt gctggtggct acagagctgt ggacttatgt tcgctggtac acacagatga
      721 aacggatttt catcatcagc tttctcttga gtttagcatg gaattggata tatctgtata
      781 agatggcttt tgctcagcat caggctaaca ttgctgggat ggagcctttc gacaatttat
      841 gtgctaagaa gatggattgg actggaagtc tctgggaatg gtttacaagt tcatggacct
      901 ataaggatga cccatgccaa aagtactatg agctcctaat agtcaaccct atttggttgg
      961 ttccaccaac aaaggctctg gcgattacat tcactaactt tgtaacggaa ccattaaagc
     1021 acattggaaa aggagcaggt gaattcatta aagcgctcat gaaggagatt ccagtgttac
     1081 ttcagattcc ggtgctggcg atcctggcgc tggctgtcct gagcttctgc tatggtgctg
     1141 gaaggtcagt tcctatgctg agacacttcg gtggtcctga cagagaacct ccccgagcac
     1201 ttgagccaga tgacagaaga cgacagaagg gacttgacta tagactccat ggtggagcag
     1261 gtgatgcaga tttctcttac aggggcccag ctggctccat cgagcaaggc ccttatgaca
     1321 aaatgcatgc gagtaagaga gatgctttga gacagagatt tcactctggc aacaagagcc
     1381 ctgaagtgct ccgggcattt gacttacctg acacagaggc acaagaacat ccagaagtgg
     1441 tccccagcca taaatcaccc attatgaaca caaaccttga gactggtgaa ctcccaggag
     1501 aaagcacccc gacagaatac agccagtctg ccaaggatgt ctctggccaa gttcccagcg
     1561 ctggcaaaag ctcacccaca gtggacaagg cccagctgaa gacagactcc gagtgcagcc
     1621 caccaggagg ctgcccaccc agcaaggaag ctgcagtggc agcacacggg actgaacctg
     1681 tcagcagccc atgtggctaa agaacaatgc acagagcaac cacagctcca gccatctttg
     1741 aaatgcccat ttggggatgg aatctacctt gacagctagc aaagcaacct gctgttcttg
     1801 agtgactaca gcaattcagg gaagacttga ttaacacagg tgacgatatc aaggccagtt
     1861 tattgcagaa aagagaagcg gcttgtctca agtgattagt gtgactatct gaggttaaag
     1921 cacattgtaa ctggctttta agaaaagaac agggtaggta gttgttaaag cactttttaa
     1981 aacagaataa ttgttgaatg cttaaccatt gtaaacacaa aataaacact tatttttaca
     2041 tta
//
