LOCUS       NM_139148               3306 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus chloride channel accessory 3B (Clca3b), mRNA.
ACCESSION   NM_139148 XM_978080
VERSION     NM_139148.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3306)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3306)
  AUTHORS   Spach,K.M., Noubade,R., McElvany,B., Hickey,W.F., Blankenhorn,E.P.
            and Teuscher,C.
  TITLE     A single nucleotide polymorphism in Tyk2 controls susceptibility to
            experimental allergic encephalomyelitis
  JOURNAL   J Immunol 182 (12), 7776-7783 (2009)
   PUBMED   19494301
REFERENCE   3  (bases 1 to 3306)
  AUTHORS   Piirsoo,M., Meijer,D. and Timmusk,T.
  TITLE     Expression analysis of the CLCA gene family in mouse and human with
            emphasis on the nervous system
  JOURNAL   BMC Dev Biol 9, 10 (2009)
   PUBMED   19210762
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3306)
  AUTHORS   Huan,C., Greene,K.S., Shui,B., Spizz,G., Sun,H., Doran,R.M.,
            Fisher,P.J., Roberson,M.S., Elble,R.C. and Kotlikoff,M.I.
  TITLE     mCLCA4 ER processing and secretion requires luminal sorting motifs
  JOURNAL   Am J Physiol Cell Physiol 295 (1), C279-C287 (2008)
   PUBMED   18495813
  REMARK    GeneRIF: The 125-kDa mCLCA4 gene product is cleaved to 90- and
            40-kDa fragments, and the NH(2)- and COOH-terminal fragments are
            secreted, where they are found in cell media and associated with
            the plasma membrane.
REFERENCE   5  (bases 1 to 3306)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   6  (bases 1 to 3306)
  AUTHORS   Patel,A.C., Morton,J.D., Kim,E.Y., Alevy,Y., Swanson,S., Tucker,J.,
            Huang,G., Agapov,E., Phillips,T.E., Fuentes,M.E., Iglesias,A.,
            Aud,D., Allard,J.D., Dabbagh,K., Peltz,G. and Holtzman,M.J.
  TITLE     Genetic segregation of airway disease traits despite redundancy of
            calcium-activated chloride channel family members
  JOURNAL   Physiol Genomics 25 (3), 502-513 (2006)
   PUBMED   16569774
REFERENCE   7  (bases 1 to 3306)
  AUTHORS   Elble,R.C., Ji,G., Nehrke,K., DeBiasio,J., Kingsley,P.D.,
            Kotlikoff,M.I. and Pauli,B.U.
  TITLE     Molecular and functional characterization of a murine
            calcium-activated chloride channel expressed in smooth muscle
  JOURNAL   J Biol Chem 277 (21), 18586-18591 (2002)
   PUBMED   11896056
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY008277.1 and
            AC137128.17.
            
            On Nov 27, 2007 this sequence version replaced NM_139148.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2660              AY008277.1         1-2660
            2661-3306           AC137128.17        75969-76614
FEATURES             Location/Qualifiers
     source          1..3306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 69.14 cM"
     gene            1..3306
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /note="chloride channel accessory 3B"
                     /db_xref="GeneID:229927"
                     /db_xref="MGI:MGI:2181989"
     exon            1..176
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..3152
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /note="calcium-activated chloride channel CLCA4; chloride
                     channel calcium activated 4; chloride channel calcium
                     activated 3B"
                     /codon_start=1
                     /product="chloride channel accessory 3B precursor"
                     /protein_id="NP_631887.2"
                     /db_xref="CCDS:CCDS51086.1"
                     /db_xref="GeneID:229927"
                     /db_xref="MGI:MGI:2181989"
                     /translation="MVPGLQVLLFLTLHLLQNTESSMVHLNSNGYEGVVIAINPSVPE
                     DERLIPSIKEMVTQASTYLFEATERRFYFRNVSILVPITWKSKTEYLTPKQESYDQAD
                     VIVADPHLQHGDDPYTLQYGQCGDRGQYIHFTPNFLLTDNLGIYGPRGRVFVHEWAHL
                     RWGVFDEYNMDRPFYMSRKNTVEATRCSTDITGTSVVRECQGGSCVSRRCRRDAKTGM
                     QEAKCTFIPNKSQTARGSIMFMQSLDSVVEFCTEKTHNVEAPNLQNKMCNLRSTWDVI
                     KASADFQNASPMTGTEAPPLPTFSLLKSRQRVVCLVLDKSGSMRLGSPITRLTLMNQA
                     AELYLIQIIEKESLVGLVTFDSTATIQTNLIRIINDSSYLAISTKLPQYPNGGTSICN
                     GLKKGFEAITSSDQSTSGSEIVLLTDGEDNRISSCFQEVKHSGAIIHTIALGPSAARE
                     LETLSDMTGGLRFYAKEDVNGLIDAFSGISSKSGSISQQALQLESKAFNVGAGAWINS
                     TVPVDSTVGNDTFFVITWTVRKPEIILQDPKGKNYTTSDFQEDKLNIFSVRLRIPGIA
                     ETGTWTYSLLNKGATSQLLTVTVTTRARSPTTLPVIATAHMSQSTAQYPSRMIVYARV
                     SQGFLPVLGANVTAVIEAESGNQVTLELWDNGAGADTLKNDGIYSRYFTDFHGNGRYS
                     LKVNAQARKNMAKLNLKQKNKSLYIPGYVENDQIVLNPPRPEIPEATEATVEDFSRLT
                     SGGSFTVSGAPPDGDHARVFPPSKVTDLEAEFIGDHIHLTWTAPGKVLDKGRAYRYVI
                     RMSGHSLALQEDFSNSTLVNTSSVMPKEAGSKETFKFKPETFKIENGTQVYIAIQADN
                     EARLSSEVSNIAQAVKFIPPQVYLTPSTPPGLSTPSTPPGLSTPSTPPGLSTPSTPPG
                     LSTPSTPPGLSTPSTPPGLSTPSTPPGLSTPSTPPGLSTPSTPPGLSTPSTPPGLSTP
                     STPPGLSTPSTPPGLSTPSTPPGLSTPSTPPGLSTPSTPPGLSTPSTPPGLGTKVSVP
                     SLTVFVLVATLFIF"
     exon            177..317
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            318..465
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            466..574
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            575..752
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..980
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1214
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1392
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1493
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1718
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1989
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2157
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2394
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..3306
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3279..3284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /note="hexamer: ATTAAA"
     regulatory      3285..3290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /note="hexamer: ATTATA"
     polyA_site      3300
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
     polyA_site      3306
                     /gene="Clca3b"
                     /gene_synonym="Clca4"
                     /note="major polyA site"
ORIGIN      
        1 actggagcag tgcgaccatg gtgccagggc tgcaggtcct tctgttcctc accctgcatc
       61 tcctgcagaa cacagagagc tccatggtgc atctcaacag caatggatat gagggtgtgg
      121 tcattgccat taaccccagt gtgccggagg acgaaaggct catcccaagc ataaaggaaa
      181 tggtaactca agcctccact tacctgtttg aagccacaga aagaagattt tatttcagaa
      241 acgtgagcat tttagttccc ataacctgga agtcaaaaac tgagtactta acaccaaaac
      301 aagaatcata tgaccaagca gacgtcatag ttgccgatcc tcacctgcaa catggagacg
      361 acccctacac ccttcagtac ggacagtgtg gggacagagg acagtacata cacttcactc
      421 caaacttcct actcactgat aacttgggta tctacggacc ccgaggcaga gtctttgtcc
      481 atgagtgggc ccatctccgg tggggagtat ttgatgagta taacatggac cggcctttct
      541 acatgtctag aaagaacact gtcgaagcaa caaggtgttc caccgacatc actggcacca
      601 gtgtggtccg tgagtgtcag ggaggcagct gtgtgtcgag gagatgtcgt cgagatgcaa
      661 agacaggaat gcaggaagcc aagtgtacat ttatcccaaa caaatcccag actgcgaggg
      721 gctccatcat gttcatgcaa agtctcgatt ctgtggttga attctgcaca gaaaaaaccc
      781 acaatgtaga agctccaaac ctacaaaaca aaatgtgcaa tctcagaagc acgtgggatg
      841 taatcaaggc gtctgctgac tttcagaatg cctctcccat gacaggaaca gaagcccctc
      901 ccctgcctac attttcactg ctcaaatcca gacagcgagt ggtctgcttg gtgctggata
      961 aatctggaag catgcgctta ggaagcccca tcactcgtct gaccctaatg aaccaagcag
     1021 cagagctata cttaattcaa attattgaaa aggaatcctt ggtcggcctg gtgacatttg
     1081 atagcactgc cacaatccaa actaacctaa taaggatcat caatgacagc tcctacctag
     1141 cgatcagcac aaagctgcct caatacccaa atggcggaac ttcaatttgc aacggactca
     1201 aaaaaggatt cgaggcaatt acctccagtg accagagcac ttccggttct gagatcgtat
     1261 tgctaacaga tggggaagat aatagaataa gctcgtgctt tcaggaggtc aaacacagtg
     1321 gagccatcat ccacaccatc gcgctggggc cttctgctgc gcgagaactg gagactctgt
     1381 cagacatgac aggagggctt cgattttatg ccaaggaaga cgtgaatggc ctgattgatg
     1441 ctttcagtgg gatctcatct aaaagtggca gcatctcaca gcaggctctg cagttggaga
     1501 gcaaagcctt caatgtcgga gcaggggcat ggataaacag tacagtacct gtggacagta
     1561 ccgtcggcaa cgacacgttc tttgttatca cctggacagt aagaaagcca gaaatcattc
     1621 ttcaagatcc aaaaggaaaa aactacacca cctccgattt ccaggaagat aagctaaata
     1681 tcttctctgt tcgccttcgg atcccaggca ttgctgagac aggcacttgg acttacagcc
     1741 tcttaaataa gggtgccaca tctcagttgc taacagtgac agtgaccact cgagcaagaa
     1801 gtcccaccac actcccagtc atcgccaccg ctcacatgag tcagagcaca gcccagtacc
     1861 ctagccggat gattgtgtat gcaagggtca gccaagggtt tttgcctgtt ctgggagcca
     1921 atgtcacagc cgtcatagaa gctgagagtg gaaatcaagt caccctggag ctctgggaca
     1981 acggggcagg tgctgacaca ctcaaaaatg acggcatcta ctcaagatat ttcacagact
     2041 tccatggaaa tggcagatac agcttaaaag tcaatgccca ggcaagaaag aacatggcta
     2101 aactaaatct gaaacaaaag aataagtctc tctatatacc tggctacgtt gaaaatgatc
     2161 aaattgtact gaatccaccc agaccggaaa tcccagaagc cacagaagct acagtggaag
     2221 acttcagcag actaacctct ggaggatcgt ttactgtgtc tggagcgccc cctgatggcg
     2281 atcacgctcg tgtgtttcca ccaagtaaag tcacagacct ggaggctgag tttataggtg
     2341 atcatattca ccttacatgg acggcccctg gcaaggtcct cgataaggga agagcatata
     2401 gatacgtcat caggatgagt gggcattctc tggctctcca agaagatttt agcaactcta
     2461 ctttagtgaa tacttccagt gtaatgccta aagaggctgg ctcaaaagaa acatttaaat
     2521 tcaaaccaga aacttttaaa atagaaaatg gcacccaagt ctacattgca atccaggctg
     2581 acaatgaagc ccgtctctcc tctgaggtct ccaacattgc acaggctgtg aagtttattc
     2641 ctccacaagt ttatttgaca cccagcaccc ctcctggtct gagtaccccc agcacccctc
     2701 ctggtctgag tacccccagc acccctcctg gtctgagtac ccccagcacc cctcctggtc
     2761 tgagtacccc cagcacccct cctggtctga gtacccccag cacccctcct ggtctgagta
     2821 cccccagcac ccctcctggt ctgagtaccc ccagcacccc tcctggtctg agtaccccca
     2881 gcacccctcc tggtctgagt acccccagca cccctcctgg tctgagtacc cccagcaccc
     2941 ctcctggtct gagtaccccc agcacccctc ctggtctgag tacccccagc acccctcctg
     3001 gtctgagtac ccccagcacc cctcctggtc tgagtacccc cagcacccct cctggtctga
     3061 gtacccccag cacccctcct ggtctgggta ccaaagtgtc cgtacccagt ttgacagttt
     3121 ttgtacttgt tgcaacttta ttcatatttt aaactagaaa ttgcagtaga actgaaattc
     3181 aacctttgaa ttcaaattta ctctcctcat tgtctactct acaactcctt gtaacataaa
     3241 cgtgaacatt caatactgta aatttcctat ttgcgtctat taaaattata agttgctata
     3301 tataaa
//
