LOCUS       NM_030601               3654 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus chloride channel accessory 3A2 (Clca3a2), mRNA.
ACCESSION   NM_030601
VERSION     NM_030601.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3654)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 3654)
  AUTHORS   Shelton EL, Ector G, Galindo CL, Hooper CW, Brown N, Wilkerson I,
            Pfaltzgraff ER, Paria BC, Cotton RB, Stoller JZ and Reese J.
  TITLE     Transcriptional profiling reveals ductus arteriosus-specific genes
            that regulate vascular tone
  JOURNAL   Physiol Genomics 46 (13), 457-466 (2014)
   PUBMED   24790087
REFERENCE   3  (bases 1 to 3654)
  AUTHORS   Roussa E, Wittschen P, Wolff NA, Torchalski B, Gruber AD and
            Thevenod F.
  TITLE     Cellular distribution and subcellular localization of mCLCA1/2 in
            murine gastrointestinal epithelia
  JOURNAL   J Histochem Cytochem 58 (7), 653-668 (2010)
   PUBMED   20385786
  REMARK    GeneRIF: The apical membrane localization and overall distribution
            pattern of mCLCA2 favor a transmembrane protein implicated in
            transepithelial ion transport and protein secretion.
REFERENCE   4  (bases 1 to 3654)
  AUTHORS   Piirsoo M, Meijer D and Timmusk T.
  TITLE     Expression analysis of the CLCA gene family in mouse and human with
            emphasis on the nervous system
  JOURNAL   BMC Dev Biol 9, 10 (2009)
   PUBMED   19210762
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3654)
  AUTHORS   Patel S, Xi ZF, Seo EY, McGaughey D and Segre JA.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   6  (bases 1 to 3654)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
REFERENCE   7  (bases 1 to 3654)
  AUTHORS   Leverkoehne I, Horstmeier BA, von Samson-Himmelstjerna G, Scholte
            BJ and Gruber AD.
  TITLE     Real-time RT-PCR quantitation of mCLCA1 and mCLCA2 reveals
            differentially regulated expression in pre- and postnatal murine
            tissues
  JOURNAL   Histochem Cell Biol 118 (1), 11-17 (2002)
   PUBMED   12122442
  REMARK    GeneRIF: Quantitation of mCLCA1 and mCLCA2 in 19 pre- and 44
            postnatal murine tissues reveals differentially regulated
            expression in pre- and postnatal murine tissues
REFERENCE   8  (bases 1 to 3654)
  AUTHORS   Elble RC and Pauli BU.
  TITLE     Tumor suppression by a proapoptotic calcium-activated chloride
            channel in mammary epithelium
  JOURNAL   J Biol Chem 276 (44), 40510-40517 (2001)
   PUBMED   11483609
REFERENCE   9  (bases 1 to 3654)
  AUTHORS   Lee D, Ha S, Kho Y, Kim J, Cho K, Baik M and Choi Y.
  TITLE     Induction of mouse Ca(2+)-sensitive chloride channel 2 gene during
            involution of mammary gland
  JOURNAL   Biochem Biophys Res Commun 264 (3), 933-937 (1999)
   PUBMED   10544033
REFERENCE   10 (bases 1 to 3654)
  AUTHORS   Stewart,A.D. and Stewart,J.
  TITLE     Studies on syndrome of diabetes insipidus associated with
            oligosyndactyly in mice
  JOURNAL   Am J Physiol 217 (4), 1191-1198 (1969)
   PUBMED   4309975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137128.17 and AF115852.1.
            
            On Aug 26, 2009 this sequence version replaced NM_030601.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039166.1, AK132498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC137128.17        79743-79752
            11-2774             AF115852.1         2-2765
            2775-3654           AC137128.17        101799-102678
FEATURES             Location/Qualifiers
     source          1..3654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 69.12 cM"
     gene            1..3654
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /note="chloride channel accessory 3A2"
                     /db_xref="GeneID:80797"
                     /db_xref="MGI:MGI:1931471"
     exon            1..184
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2734
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /note="chloride channel calcium activated 2; chloride
                     channel calcium activated 3A2"
                     /codon_start=1
                     /product="chloride channel calcium activated 3A2
                     precursor"
                     /protein_id="NP_085104.1"
                     /db_xref="CCDS:CCDS17887.1"
                     /db_xref="GeneID:80797"
                     /db_xref="MGI:MGI:1931471"
                     /translation="MVPGLQVLLFLTLHLLQNTESSMVHLNSNGYEGVVIAINPSVPE
                     DERLIPSIKEMVTQASTYLFEASQGRVYFRNISILVPMTWKSKSEYLMPKRESYDKAD
                     VIVADPHLQHGDDPYTLQYGQCGDRGQYIHFTPNFLLTDNLRIYGPRGRVFVHEWAHL
                     RWGVFDEYNVDRPFYISRKNTIEATRCSASITGKKVVHECQRGSCVTRACRRDSKTRL
                     YEPKCTFIPDKIQTAGASIMFMQNLNSVVEFCTENNHNAEAPNLQNKMCNRRSTWDVI
                     KASADFQNSPPMRGTEAPPPPTFSLLKSRRRVVCLVLDKSGSMDKEDRLIRMNQAAEL
                     YLTQIVEKESMVGLVTFDSAAHIQNYLIKITSSSDYQKITANLPQQATGGTSICHGLQ
                     AGFQAITSSDQSTSGSEIVLLTDGEDNGISSCFEAVSRSGAIIHTIALGPSAARELET
                     LSDMTGGLRFYANKHVSSLIDAFSRISSTSGSVSQQALQLESKAFNVRAGAWINSTVP
                     VDSTVGNDTFFVITWTVQKPEIILQDPKGKKYITSDFQDDELNIRSARLQIPGTAETG
                     TWTYSITGTKSQLITMTVTTRARSPTMEPLLATAHMSQSTAQYPSRMIVYVRVSQGFL
                     PVLGANVTAIIEAEHGHQVTLELWDNGAGADTVKNDGIYTRYFTDYHGNGRYSLKVRV
                     QARKNKARLSLRQKNKSLYIPGYVENGKIVLNPPRPDVQEEAIEATVEDFNRVTSGGS
                     FTVSGAPPDGDHARVFPPSKVTDLEAEFIGDYIQLTWTAPGKVLDKGRAHRYIIRVSQ
                     HPLGLQEDFNNATLVNASSLIPKEAGSKETFKFKPETFKIANDTQLYIAIQAYNEAGL
                     TSEVSNIAQAVKFTSLEDSISALGADISAISMTVWGLAVIFNSILN"
     exon            185..325
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..473
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..582
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..760
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..988
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1213
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1391
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1492
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1717
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1982
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2150
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2390
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..3654
                     /gene="Clca3a2"
                     /gene_synonym="Clca2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccttctcac tggagcagtg cgaccatggt gccagggctg caggtccttc tgttcctcac
       61 cctgcatctc ctgcagaaca cagagagctc catggtgcat ctcaacagca atggatacga
      121 gggtgtggtc attgccatta accccagtgt gccagaggac gaaaggctca tcccaagcat
      181 aaaggaaatg gtaactcaag cttctaccta cctgtttgaa gccagccaag gaagagttta
      241 tttcaggaac ataagcatat tagtcccgat gacctggaag tcaaaatctg agtacttaat
      301 gccaaaacga gaatcgtacg acaaagcaga cgtcatagtt gcggatcctc acctgcaaca
      361 tggagacgac ccctacaccc ttcagtatgg acagtgtggg gacagaggac agtacataca
      421 cttcactcca aacttcctac tcactgataa cttgcgtatc tatggacccc gaggcagagt
      481 ctttgtccat gagtgggccc atctccggtg gggagtattt gatgagtata acgtggaccg
      541 gcctttctac atttctagaa agaacactat agaagcaaca aggtgctccg ccagcatcac
      601 aggcaagaag gtggtccacg agtgtcagag aggcagctgt gtgacaaggg cgtgccggcg
      661 tgactcgaag acacggctgt atgaacccaa atgtacattt atcccagaca aaatacagac
      721 agctggggcc tccataatgt tcatgcaaaa cctcaattct gtggttgaat tttgcacaga
      781 aaataaccac aatgcagaag ccccaaacct acaaaacaaa atgtgcaatc gcagaagcac
      841 gtgggatgta atcaaggcgt ctgctgactt tcagaattcc cctcccatga gaggaacaga
      901 agcgcctcct ccacctacat tttcattgct caagtccaga aggcgagtgg tgtgcttggt
      961 gctggataaa tctggaagca tggacaaaga agaccgtctt attcgaatga atcaagcagc
     1021 agaactgtac ttaactcaaa ttgtggaaaa ggagtctatg gttggattag tcacatttga
     1081 cagcgctgcc cacatccaaa attatctaat aaaaataacg agtagtagtg actaccaaaa
     1141 gatcaccgca aacctccccc aacaggctac tggtggaact tcaatttgcc atggactcca
     1201 ggcaggattt caggcaatta cctccagtga ccagagcact tccggttctg agatcgtatt
     1261 gctgacagat ggggaagata atggaataag ttcctgcttt gaggccgtct ctcgcagcgg
     1321 tgccatcatc cacaccatcg ctctggggcc ttctgctgcc cgagaactgg agactctgtc
     1381 agacatgaca ggagggcttc gtttctatgc caacaaacat gtaagcagcc ttatcgacgc
     1441 tttcagtagg atttcatcta caagtggcag cgtctcccag caggctctgc agttggagag
     1501 caaagccttc aatgtcagag caggggcatg gataaacagt acagtacctg tggacagtac
     1561 cgtcggcaac gacacgttct ttgttatcac ctggacggta caaaagccag aaatcattct
     1621 tcaagatcca aaaggaaaaa aatatataac ctcagatttc caagatgatg aactaaacat
     1681 ccggtctgct cgacttcaaa taccgggcac tgcagagaca ggtacttgga cttacagcat
     1741 cacgggtacc aagtctcagt tgattacaat gacagtgacc actcgagcaa gaagtcccac
     1801 catggaacca ctcctggcta ccgctcacat gagtcagagc acagcccagt accctagccg
     1861 gatgattgtg tatgtacggg tcagccaagg gtttttgcct gttctaggag ccaatgtcac
     1921 agccatcata gaagctgaac atggacatca agtcaccctg gagctatggg acaatggggc
     1981 aggtgctgat actgttaaaa atgatggcat ctacacaaga tactttacag attatcatgg
     2041 aaatggtaga tacagcctaa aagtgcgtgt ccaggcaaga aaaaacaaag ccagactaag
     2101 cttaagacag aagaacaagt ctttatatat acctggctat gtggaaaatg gtaaaattgt
     2161 actgaatcca cccagaccag atgtccaaga agaagccata gaagctacag tggaggactt
     2221 caacagagta acctctggag ggtcatttac tgtgtctgga gcgccccctg atggcgacca
     2281 tgctcgtgtg ttcccaccaa gtaaagtcac agacctggag gctgagttta taggtgatta
     2341 tattcaactt acatggacgg cccctggcaa ggttctcgat aagggaagag cgcatagata
     2401 catcatcaga gtgagccagc atcctctggg tctccaagaa gattttaaca atgctacttt
     2461 agtgaatgct tccagtctga tacctaaaga ggctggctca aaagaaacat ttaaattcaa
     2521 accagaaact tttaaaatag caaatgacac ccagctctac attgcaatcc aggcatacaa
     2581 tgaagctggt ctcacctctg aggtctccaa cattgcacag gctgtcaagt ttacttctct
     2641 agaagatagt atctctgcac tgggtgctga tatttctgca atctctatga cagtttgggg
     2701 gttagctgtg atttttaact ctattttaaa ctagaagata caatagcact aaaatgcaac
     2761 cctgtatata tttgctgact gttgctttag aatgacttta ctacactcaa aggctgcctg
     2821 tcaacacttg taatatagaa gttcatattc aaagttgaaa atcccgagtt actaacaaca
     2881 ttcttctgct atatgtagat caagattaac agttcctcat tcaatttcct aattgttcca
     2941 tttactatgg aaattagata tccattccct tttcacagtg tgatgcaggt tcactttaca
     3001 aaatattacc aaaataaaat ttgtataagt caattaaagg gaattattct tatataatag
     3061 caaacaattt tatagtagaa ttatttgtaa gacaattaat aaagaatgct acctgctttt
     3121 acaactgaaa tcaagaggga ctatgaaagt aatttgtagg gctgaagaga tggctcagtg
     3181 gttaagagca ctgattgctc ttccagaggt cctgagttca attcccagaa accacatagt
     3241 agctcataac catctgtaat gcgatccaat gtcctcttct ggtgtgtctg aagacagcaa
     3301 ctgtgtattc atacacataa aaataaataa ataaatctca aaaagaattt catctatatc
     3361 atcaaaagga atttgtagag aaaaatggtc aaaagaggtc ataaaatcaa atgattttgt
     3421 cattggctga agttgtttta tcagtacaca aagtgactag caagaatgtc tttacctatg
     3481 aattgcaggc atcacactga gtctggttct gtcctgggac catcatttga tcttaagagc
     3541 atcagcaaga tgtacaatta gaattgagat taatttttca cctttgtagc tcttggatct
     3601 agagaaaaac ttgatatgta gtagatattc aataaatgtt tggtaaataa ttaa
//
