LOCUS       NM_009899               3899 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus chloride channel accessory 3A1 (Clca3a1), transcript
            variant 1, mRNA.
ACCESSION   NM_009899
VERSION     NM_009899.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3899)
  AUTHORS   Drake,K.A., Chaney,C., Patel,M., Das,A., Bittencourt,J., Cohn,M.
            and Carroll,T.J.
  TITLE     Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal
            Myofibroblasts in the Developing Mouse Kidney
  JOURNAL   J Am Soc Nephrol 33 (9), 1694-1707 (2022)
   PUBMED   35918150
  REMARK    Erratum:[J Am Soc Nephrol. 2023 Mar 1;34(3):515-516. doi:
            10.1681/ASN.0000000000000056.. PMID: 36857501]
REFERENCE   2  (bases 1 to 3899)
  AUTHORS   England,A.R., Chaney,C.P., Das,A., Patel,M., Malewska,A.,
            Armendariz,D., Hon,G.C., Strand,D.W., Drake,K.A. and Carroll,T.J.
  TITLE     Identification and characterization of cellular heterogeneity
            within the developing renal interstitium
  JOURNAL   Development 147 (15) (2020)
   PUBMED   32586976
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3899)
  AUTHORS   Lin,C.X., Lv,X.F., Yuan,F., Li,X.Y., Ma,M.M., Liu,C.Z., Zhou,J.G.,
            Wang,G.L. and Guan,Y.Y.
  TITLE     Ca2+/Calmodulin-Dependent Protein Kinase II gamma-Dependent
            Serine727 Phosphorylation Is Required for TMEM16A Ca2+-Activated
            Cl- Channel Regulation in Cerebrovascular Cells
  JOURNAL   Circ J 82 (3), 903-913 (2018)
   PUBMED   29081444
  REMARK    GeneRIF: Serine 727 phosphorylation in TMEM16A by CaMKIIgamma
            provides a new mechanism for regulating TMEM16A CaCC activity and
            Ang II-induced BASMC proliferation.
REFERENCE   4  (bases 1 to 3899)
  AUTHORS   Sun,Y., Birnbaumer,L. and Singh,B.B.
  TITLE     TRPC1 regulates calcium-activated chloride channels in salivary
            gland cells
  JOURNAL   J Cell Physiol 230 (11), 2848-2856 (2015)
   PUBMED   25899321
  REMARK    GeneRIF: Together the data suggests that Ca(2+) entry via the TRPC1
            channels is essential for the activation of CaCC
REFERENCE   5  (bases 1 to 3899)
  AUTHORS   Rajagopal,M., Kathpalia,P.P., Widdicombe,J.H. and Pao,A.C.
  TITLE     Differential effects of extracellular ATP on chloride transport in
            cortical collecting duct cells
  JOURNAL   Am J Physiol Renal Physiol 303 (4), F483-F491 (2012)
   PUBMED   22647633
REFERENCE   6  (bases 1 to 3899)
  AUTHORS   Elble,R.C. and Pauli,B.U.
  TITLE     Tumor suppression by a proapoptotic calcium-activated chloride
            channel in mammary epithelium
  JOURNAL   J Biol Chem 276 (44), 40510-40517 (2001)
   PUBMED   11483609
REFERENCE   7  (bases 1 to 3899)
  AUTHORS   Leverkoehne,I. and Gruber,A.D.
  TITLE     Assignment of the murine calcium-activated chloride channel genes
            Clca1 and Clca3 (alias gob-5) to chromosome 3 band H2-H3 using
            somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 208-209 (2000)
   PUBMED   10828589
REFERENCE   8  (bases 1 to 3899)
  AUTHORS   Romio,L., Musante,L., Cinti,R., Seri,M., Moran,O., Zegarra-Moran,O.
            and Galietta,L.J.
  TITLE     Characterization of a murine gene homologous to the bovine CaCC
            chloride channel
  JOURNAL   Gene 228 (1-2), 181-188 (1999)
   PUBMED   10072771
REFERENCE   9  (bases 1 to 3899)
  AUTHORS   Gandhi,R., Elble,R.C., Gruber,A.D., Schreur,K.D., Ji,H.L.,
            Fuller,C.M. and Pauli,B.U.
  TITLE     Molecular and functional characterization of a calcium-sensitive
            chloride channel from mouse lung
  JOURNAL   J Biol Chem 273 (48), 32096-32101 (1998)
   PUBMED   9822685
REFERENCE   10 (bases 1 to 3899)
  AUTHORS   Stewart,A.D. and Stewart,J.
  TITLE     Studies on syndrome of diabetes insipidus associated with
            oligosyndactyly in mice
  JOURNAL   Am J Physiol 217 (4), 1191-1198 (1969)
   PUBMED   4309975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137128.17, AK161805.1 and AK137904.1.
            
            On Feb 10, 2015 this sequence version replaced NM_009899.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF052746.1, AF047838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC137128.17        138260-138497
            239-3289            AK161805.1         3-3053
            3290-3899           AK137904.1         2254-2863
FEATURES             Location/Qualifiers
     source          1..3899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 69.06 cM"
     gene            1..3899
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /note="chloride channel accessory 3A1"
                     /db_xref="GeneID:12722"
                     /db_xref="MGI:MGI:1316732"
     exon            1..414
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2964
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /note="chloride channel calcium activated 1; chloride
                     channel calcium activated 3A1; calcium-activated chloride
                     channel regulator 3A-1"
                     /codon_start=1
                     /product="calcium-activated chloride channel regulator
                     3A-1 precursor"
                     /protein_id="NP_034029.2"
                     /db_xref="CCDS:CCDS17886.1"
                     /db_xref="GeneID:12722"
                     /db_xref="MGI:MGI:1316732"
                     /translation="MVPGLQVLLFLTLHLLQNTESSMVHLNSNGYEGVVIAINPSVPE
                     DERLIPSIKEMVTQASTYLFEASQGRVYFRNISILVPMTWKSKPEYLMPKRESYDKAD
                     VIVADPHLQHGDDPYTLQYGQCGDRGQYIHFTPNFLLTDNLRIYGPRGRVFVHEWAHL
                     RWGVFDEYNVDQPFYMSRKNTIEATRCSTRITGTNVVHNCERGNCVTRACRRDSKTRL
                     YEPKCTFIPDKIQTAGASIMFMQNLNSVVEFCTEKNHNAEAPNLQNKMCNRRSTWDVI
                     KTSADFQNAPPMRGTEAPPPPTFSLLKSRRRVVCLVLDKSGSMDKEDRLIRMNQAAEL
                     YLTQIVEKESMVGLVTFDSAAHIQNYLIKITSSSDYQKITANLPQQASGGTSICHGLQ
                     AGFQAITSSDQSTSGSEIVLLTDGEDNGIRSCFEAVSRSGAIIHTIALGPSAARELET
                     LSDMTGGLRFYANKDLNSLIDAFSRISSTSGSVSQQALQLESKAFDVRAGAWINGTVP
                     LDSTVGNDTFFVITWMVKKPEIILQDPKGKKYTTSDFQDDKLNIRSARLQIPGTAETG
                     TWTYSITGTKSQLITMTVTTRARSPTMEPLLATAHMSQSTAQYPSRMIVYARVSQGFL
                     PVLGANVTALIEAEHGHQVTLELWDNGAGADTVKNDGIYTRYFTDYHGNGRYSLKVRV
                     QAQRNKTRLSLRQKNKSLYIPGYVENGKIVLNPPRPDVQEEAIEATVEDFNRVTSGGS
                     FTVSGAPPDGDHARVFPPSKVTDLEAEFIGDYIHLTWTAPGKVLDNGRAHRYIIRMSQ
                     HPLDLQEDFNNATLVNASSLIPKEAGSKETFKFKPETFKIANGIQLYIAIQADNEASL
                     TSEVSNIAQAVKLTSLEDSISALGDDISAISMTIWGLTVIFNSILN"
     exon            415..555
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..703
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..812
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..990
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1218
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1443
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1621
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1722
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1947
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2212
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2380
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2620
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..3899
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3239..3244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /note="hexamer: AATAAA"
     regulatory      3261..3266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /note="hexamer: ATTAAA"
     polyA_site      3261
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /note="major polyA site"
     polyA_site      3292
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
     regulatory      3326..3331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /note="hexamer: AATAAA"
     polyA_site      3358
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
     regulatory      3558..3563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /note="hexamer: AATAAA"
     polyA_site      3575
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
     regulatory      3860..3865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
                     /note="hexamer: AATAAA"
     polyA_site      3879
                     /gene="Clca3a1"
                     /gene_synonym="Cacc; Clca1"
ORIGIN      
        1 atgaattcca ctacaccaaa gttcatagct gcagctaagg cagctgtttc tgttcaggcc
       61 gataaggcct atcatacaaa gtatgtatat cctgcctatc atggcaaata gccaaggtct
      121 tctgggaaga atgttcaagg actgcttgtc caggacaggc tgggggggca gggatcacat
      181 tatttcaaat tcccgagcga ggcacacaca taaataccct tctgtgctgc tccttctcac
      241 tggagcagtg cgaacatggt gccagggctg caggtccttc tgttcctcac cctgcatctc
      301 ctgcagaaca cagagagctc catggtgcat ctcaacagca atggatacga gggtgtggtc
      361 attgccatta accccagtgt gccggaggac gaaaggctca tcccaagcat aaaggaaatg
      421 gtaactcaag cctctaccta cctgtttgaa gccagccaag gaagagttta tttcagaaac
      481 ataagcatat tagtcccgat gacctggaag tcaaaacctg agtacttaat gccaaaacga
      541 gaatcgtatg acaaagcaga cgtcatagtt gcggatcctc acctgcaaca tggagacgac
      601 ccctacaccc ttcagtatgg acagtgtggg gacagaggac agtacataca cttcactcca
      661 aacttcctac tcactgataa cttgcgtatc tacggacccc gaggcagagt ctttgtccat
      721 gagtgggccc atctccggtg gggagtattt gatgagtata acgtggacca gcctttctac
      781 atgtctagaa agaacactat agaagcaaca aggtgttcca ccaggatcac tggcaccaat
      841 gtggttcaca actgtgagag aggcaactgt gtcacaaggg cgtgccggcg tgactcgaag
      901 acacggctgt atgaacccaa atgtacattt atcccagaca aaatacagac ggctggggcc
      961 tccataatgt tcatgcaaaa ccttaattct gtggttgaat tttgcacaga aaaaaaccac
     1021 aatgcagaag ccccaaacct acaaaacaaa atgtgcaatc gcagaagcac gtgggatgta
     1081 atcaagacgt ctgctgactt tcagaatgcc cctcccatga gaggaacaga agcccctcct
     1141 ccacctacat tttcactgct caagtccaga aggcgagtgg tgtgcttggt gctggataaa
     1201 tctggaagca tggacaaaga agaccgtctt attcgaatga atcaagcagc agaactgtac
     1261 ttaactcaaa ttgtggaaaa ggagtctatg gttggattag tcacatttga cagcgctgcc
     1321 cacatccaaa attatctaat aaaaataacg agtagtagtg actaccaaaa gatcaccgca
     1381 aacctccccc aacaggcttc tggtggaact tcaatttgcc atggactcca ggcaggattt
     1441 caggcaatta cctccagtga ccagagcact tccggttctg agatcgtatt gctgacagat
     1501 ggggaagata atggaatacg ttcctgcttt gaggccgtct ctcgcagcgg tgccatcatc
     1561 cacaccatcg ctctggggcc ttcggctgcc cgagaactgg agactctgtc ggacatgaca
     1621 ggagggcttc gtttctatgc caacaaagac ctaaacagcc ttatcgatgc tttcagtaga
     1681 atttcatcta caagtggcag cgtctcccag caggctctgc agttggagag caaagccttc
     1741 gatgtcagag caggggcatg gataaacggt acagtacctc tggacagtac cgtcggcaac
     1801 gacacgttct ttgttatcac ctggatggta aaaaagccag aaatcattct tcaagatcca
     1861 aaaggaaaaa aatatacaac ctcagatttc caagatgata aactaaacat ccggtctgct
     1921 agacttcaaa taccgggcac tgcagagaca ggtacttgga cttacagcat cacgggtacc
     1981 aagtctcagt tgattacaat gacagtgacc actcgagcaa gaagtcccac catggaacca
     2041 ctcctggcta ctgctcacat gagtcagagc acagcccagt accctagccg gatgattgtg
     2101 tacgcacggg tcagccaagg atttttgcct gttctgggag ccaatgtcac agccctcata
     2161 gaagctgaac atggacatca agtcaccttg gagctctggg acaatggggc aggtgctgat
     2221 actgttaaaa atgatggcat ctacacaaga tactttacag attatcatgg aaatggtaga
     2281 tacagcctaa aagtgcgtgt ccaggcacaa agaaacaaaa ccagactgag cttaagacag
     2341 aagaacaagt ctttatatat acctggctat gtggaaaatg gtaaaattgt actgaatcca
     2401 cccagaccag atgtccaaga agaagccata gaagctacag tggaagactt caacagagta
     2461 acctctggag ggtcgtttac tgtgtctgga gcgccccctg atggcgacca cgctcgtgtg
     2521 ttcccaccaa gtaaagtcac agacctggag gctgagttta taggtgatta tattcacctt
     2581 acatggacgg cccctggcaa ggttctcgac aatggaagag cacatagata catcatcaga
     2641 atgagccagc atcctctgga tctccaagaa gattttaaca atgctacttt agtgaatgct
     2701 tccagtctga tacctaaaga agctggctca aaagaaacat ttaaattcaa accagaaact
     2761 tttaaaatag caaatggcat ccagctctac attgcaatcc aggcagacaa tgaagccagt
     2821 ctcacctctg aggtctccaa catcgcacag gctgtcaagc ttacttctct agaagatagt
     2881 atctctgcac tgggtgatga tatttctgca atctctatga caatttgggg gttaactgtg
     2941 atttttaact ctattttaaa ctagaagata gaatggcact aaaatgcaat cctgtacata
     3001 tttgctaagt gttgctttag aatgacttta ctacacactc aaaggctgcc tgtcaacaat
     3061 tgtaatatag aagttcatat tcaaagttga aaatcccgag ttactaacaa cattcttttg
     3121 ctatatgtag atcaagatta acagttcctc attcaatttc ttaattgttc catttactat
     3181 ggaaataaga tatccattct cttttcacag tgtgatgcaa gttcactttg tatatgaaaa
     3241 taaaaaattt gtacaagtcg attaaaggga attattcata tttaatagca aacaatttta
     3301 tagttgaatt atttgtaaga caattaataa agaatgcttc ctgcttatac aactgaaatc
     3361 aagagggact atgaaagtaa tttgtagggc tgaagagatg gctcagtggt taagagcact
     3421 gactgctctt ccagaggtcc tgagttcaat tcccagcaac cacatggtag ctcataacca
     3481 tctgtaatgg gatctgatgc cctcttcttg tgtgtctgaa gacagcaaca gtgtactcat
     3541 acacataaaa attaataaat aaatctttaa aagaatttca tctatatctt caaaagtaat
     3601 ttgtagagaa aaatggtcaa aagaggtcat aaagtcaaat gtcttttgtc attggctgaa
     3661 ggtgttttat cagtacacaa agtgattagc aagaatgtct ttacctatga attgcaggca
     3721 tcacactgag tctggttctg tcctgggacc atcatttgat cttaagagca tcagcaagac
     3781 gtacagttag aattgagatt ttttttttca ctttgtagct cttggatcta gagaaaaact
     3841 tgatatgtag tagacattca ataaatgttt ggtaaataat taatgttttt tttactttc
//
