LOCUS       NM_017474               2935 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus chloride channel accessory 1 (Clca1), mRNA.
ACCESSION   NM_017474 XM_978159
VERSION     NM_017474.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2935)
  AUTHORS   Gaur,P., Rajendran,Y., Srivastava,B., Markandey,M.,
            Fishbain-Yoskovitz,V., Mohapatra,G., Suhail,A., Chaudhary,S.,
            Tyagi,S., Yadav,S.C., Pandey,A.K., Merbl,Y., Bajaj,A., Ahuja,V. and
            Srikanth,C.
  TITLE     Rab7-dependent regulation of goblet cell protein CLCA1 modulates
            gastrointestinal homeostasis
  JOURNAL   Elife 12, 89776 (2024)
   PUBMED   38593125
  REMARK    GeneRIF: Rab7-dependent regulation of goblet cell protein CLCA1
            modulates gastrointestinal homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2935)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2935)
  AUTHORS   Lv,X., Zheng,L., Zhang,T., Wang,W., Chen,Y., Li,J., Cai,Z., Guo,X.
            and Song,L.
  TITLE     CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute
            respiratory distress syndrome
  JOURNAL   Exp Lung Res 50 (1), 85-95 (2024)
   PUBMED   38597420
  REMARK    GeneRIF: CLCA1 exacerbates lung inflammation via p38 MAPK pathway
            in acute respiratory distress syndrome.
REFERENCE   4  (bases 1 to 2935)
  AUTHORS   Zhao,L., Song,W. and Chen,Y.G.
  TITLE     Mesenchymal-epithelial interaction regulates gastrointestinal tract
            development in mouse embryos
  JOURNAL   Cell Rep 40 (2), 111053 (2022)
   PUBMED   35830795
REFERENCE   5  (bases 1 to 2935)
  AUTHORS   Tang,S., Cope,D.I., Vasquez,Y.M. and Monsivais,D.
  TITLE     BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential
            for Receptivity and Early Pregnancy
  JOURNAL   Endocrinology 163 (5) (2022)
   PUBMED   35383354
REFERENCE   6  (bases 1 to 2935)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
REFERENCE   7  (bases 1 to 2935)
  AUTHORS   Leverkoehne,I. and Gruber,A.D.
  TITLE     The murine mCLCA3 (alias gob-5) protein is located in the mucin
            granule membranes of intestinal, respiratory, and uterine goblet
            cells
  JOURNAL   J Histochem Cytochem 50 (6), 829-838 (2002)
   PUBMED   12019299
REFERENCE   8  (bases 1 to 2935)
  AUTHORS   Zhou,Y., Shapiro,M., Dong,Q., Louahed,J., Weiss,C., Wan,S.,
            Chen,Q., Dragwa,C., Savio,D., Huang,M., Fuller,C., Tomer,Y.,
            Nicolaides,N.C., McLane,M. and Levitt,R.C.
  TITLE     A calcium-activated chloride channel blocker inhibits goblet cell
            metaplasia and mucus overproduction
  JOURNAL   Novartis Found Symp 248, 150-65 (2002)
   PUBMED   12568493
  REMARK    GeneRIF: Niflumic acid treatment during natural antigen-exposure,
            where mCLCA3 is greatly up-regulated in the lung, significantly
            reduces airway inflammation, goblet cell metaplasia and mucus
            overproduction in vivo.
REFERENCE   9  (bases 1 to 2935)
  AUTHORS   Leverkoehne,I. and Gruber,A.D.
  TITLE     Assignment of the murine calcium-activated chloride channel genes
            Clca1 and Clca3 (alias gob-5) to chromosome 3 band H2-H3 using
            somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 208-209 (2000)
   PUBMED   10828589
REFERENCE   10 (bases 1 to 2935)
  AUTHORS   Komiya,T., Tanigawa,Y. and Hirohashi,S.
  TITLE     Cloning and identification of the gene gob-5, which is expressed in
            intestinal goblet cells in mice
  JOURNAL   Biochem Biophys Res Commun 255 (2), 347-351 (1999)
   PUBMED   10049711
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033560.1 and AK008659.2.
            
            On Aug 13, 2009 this sequence version replaced NM_017474.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033560.1, AB017156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK033560.1         1-4
            5-2935              AK008659.2         2-2932
FEATURES             Location/Qualifiers
     source          1..2935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 69.26 cM"
     gene            1..2935
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /note="chloride channel accessory 1"
                     /db_xref="GeneID:23844"
                     /db_xref="MGI:MGI:1346342"
     exon            1..193
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2773
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /note="calcium-activated chloride channel regulator 1;
                     chloride channel calcium activated 3; mCLCA3; protein
                     gob-5; calcium-activated chloride channel family member 3;
                     chloride channel calcium activated 2; chloride channel
                     calcium activated 1"
                     /codon_start=1
                     /product="calcium-activated chloride channel regulator 1
                     precursor"
                     /protein_id="NP_059502.1"
                     /db_xref="CCDS:CCDS17889.1"
                     /db_xref="GeneID:23844"
                     /db_xref="MGI:MGI:1346342"
                     /translation="MESLKSPVFLLILHLLEGVLSESLIQLNNNGYEGIVIAIDHDVP
                     EDEALIQHIKDMVTQASPYLFEATGKRFYFKNVAILIPESWKAKPEYTRPKLETFKNA
                     DVLVSTTSPLGNDEPYTEHIGACGEKGIRIHLTPDFLAGKKLTQYGPQDRTFVHEWAH
                     FRWGVFNEYNNDEKFYLSKGKPQAVRCSAAITGKNQVRRCQGGSCITNGKCVIDRVTG
                     LYKDNCVFVPDPHQNEKASIMFNQNINSVVEFCTEKNHNQEAPNDQNQRCNLRSTWEV
                     IQESEDFKQTTPMTAQPPAPTFSLLQIGQRIVCLVLDKSGSMLNDDRLNRMNQASRLF
                     LLQTVEQGSWVGMVTFDSAAYVQSELKQLNSGADRDLLIKHLPTVSAGGTSICSGLRT
                     AFTVIKKKYPTDGSEIVLLTDGEDNTISSCFDLVKQSGAIIHTVALGPAAAKELEQLS
                     KMTGGLQTYSSDQVQNNGLVDAFAALSSGNAAIAQHSIQLESRGVNLQNNQWMNGSVI
                     VDSSVGKDTLFLITWTTHPPTIFIWDPSGVEQNGFILDTTTKVAYLQVPGTAKVGFWK
                     YSIQASSQTLTLTVTSRAASATLPPITVTPVVNKNTGKFPSPVTVYASIRQGASPILR
                     ASVTALIESVNGKTVTLELLDNGAGADATKNDGVYSRFFTAFDANGRYSVKIWALGGV
                     TSDRQRAAPPKNRAMYIDGWIEDGEVRMNPPRPETSYVQDKQLCFSRTSSGGSFVATN
                     VPAAAPIPDLFPPCQITDLKASIQGQNLVNLTWTAPGDDYDHGRASNYIIRMSTSIVD
                     LRDHFNTSLQVNTTGLIPKEASSEEIFEFELGGNTFGNGTDIFIAIQAVDKSNLKSEI
                     SNIARVSVFIPAQEPPIPEDSTPPCPDISINSTIPGIHVLKIMWKWLGEMQVTLGLH"
     exon            194..334
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            335..482
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            483..588
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            589..769
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            770..988
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1216
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1391
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1498
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1714
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1976
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2147
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2384
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2935
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2896..2901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /note="hexamer: ATTAAA"
     regulatory      2915..2920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /note="hexamer: AATACA"
     polyA_site      2923
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
                     /note="major polyA site"
     polyA_site      2935
                     /gene="Clca1"
                     /gene_synonym="Clca2; Clca3; gob-5; gob5"
ORIGIN      
        1 acccagccct ttccagaggg aaagctgcag gatggaatct ttgaagagtc ctgtcttcct
       61 cttgatcctc caccttctgg aaggagttct gagtgagtcc ctcatccaac tgaacaacaa
      121 cggctatgag ggcatcgtca tcgccataga ccacgacgtg ccggaagatg aagccctcat
      181 tcaacacata aaggacatgg tgactcaggc ctctccatac ctgtttgaag ctacaggaaa
      241 aagattttac ttcaaaaatg ttgccatttt gattcccgag agctggaagg caaagcctga
      301 atatacgagg ccaaaacttg aaaccttcaa aaacgctgat gtccttgtat caacaaccag
      361 ccctctaggc aatgatgagc cctacaccga acatatagga gcatgtggag aaaaggggat
      421 caggattcac ctgactcctg acttcttagc aggaaagaag ctgactcagt atgggccaca
      481 agacaggacc tttgtccatg agtgggctca cttccgatgg ggagtgttta atgaatacaa
      541 caacgacgag aagttctact tatccaaagg aaaaccccaa gcagtgaggt gttcagcagc
      601 cattaccggt aaaaatcaag ttcgtcggtg ccagggaggc agttgtatca ctaacggaaa
      661 gtgtgtaatc gacagagtaa cgggactgta taaagacaat tgtgtatttg taccagatcc
      721 acaccaaaac gagaaggctt ccatcatgtt taaccaaaat atcaattctg tggttgaatt
      781 ctgtacagaa aaaaatcaca atcaagaagc cccaaatgac caaaaccaac gatgcaatct
      841 ccgaagcacg tgggaagtca tccaggaatc tgaggacttc aagcaaacca ctcccatgac
      901 agcccagcca cctgcaccca ccttctcact gctgcaaatt ggacaaagaa ttgtgtgctt
      961 agttcttgat aagtccggga gcatgctgaa cgatgatcgt cttaaccgaa tgaatcaggc
     1021 aagccggctt ttcctgctgc agactgtgga gcagggatcc tgggtcggga tggtgacctt
     1081 tgacagtgct gcctatgtac aaagcgaact caaacagtta aacagtggtg ctgacagaga
     1141 tctgctgatc aagcacttac ccacagtatc tgcaggaggg acatctatat gctctggcct
     1201 tcggacagca tttacagtga taaagaagaa gtatccaact gatggatctg aaattgtgct
     1261 gctgaccgat ggggaggaca acaccattag cagctgcttt gacctggtga agcagagcgg
     1321 ggccatcatc catacagtgg ccctgggacc ggctgccgct aaagagcttg agcagctgtc
     1381 caaaatgaca ggaggcctgc agacatactc ttcggatcag gttcagaaca atggtcttgt
     1441 tgatgctttc gcagcactct cctcaggaaa tgcggcgatc gctcagcact ccatccagct
     1501 ggagagcagg ggagttaatc tccagaataa ccaatggatg aatggctcag tgatcgtgga
     1561 cagctcggtg ggcaaggaca ccttgtttct tatcacctgg acaacgcatc ctcctacaat
     1621 atttatctgg gatcccagcg gagtggaaca aaatggtttt atactagaca caaccactaa
     1681 ggtggcctac ctccaagtcc caggcacggc taaggttggc ttttggaaat acagcattca
     1741 agcgagctca cagactctca ccttgactgt cacctcccgt gcagcaagtg ctacactgcc
     1801 tcctattaca gtgaccccgg tagtgaataa gaacacaggg aaattcccca gccctgtaac
     1861 agtgtatgca agcattcgcc aaggagcctc gcctattctc agggccagcg tcacagcctt
     1921 gattgaatct gtgaatggaa aaacagtaac cctggaatta ctggataacg gagcaggtgc
     1981 cgatgccacc aagaatgatg gtgtctactc aaggtttttt acagcttttg atgcaaatgg
     2041 tagatacagc gttaaaatat gggctctggg aggagtcact tcagacagac agagagcagc
     2101 acctccgaag aacagagcca tgtacataga tggctggatt gaggatggtg aagtaagaat
     2161 gaacccacca cgtcctgaaa ctagttatgt tcaagacaag cagctgtgct tcagcaggac
     2221 atcttcaggg ggatcgtttg tggccaccaa tgtccccgca gcagctccca ttcctgacct
     2281 ctttccaccc tgtcaaatca ctgacctgaa ggccagcatc caagggcaga acctggtgaa
     2341 tctgacgtgg acggctcctg gggatgacta cgaccacggg agagcttcca actacatcat
     2401 ccgaatgagc accagtatcg ttgatctcag ggaccacttc aacacctcac tccaagtgaa
     2461 cactaccggt cttatcccca aagaggccag ctctgaggaa atctttgagt ttgaactggg
     2521 aggcaacact tttggaaatg gcacagatat cttcattgct atccaggctg tggataagtc
     2581 caatctgaaa tcagaaatct ccaacattgc acgggtgtct gtgttcatcc ccgctcagga
     2641 gccgcccatt cccgaagact caactccccc ttgtcctgac atcagcatca acagcaccat
     2701 tcctggcatc cacgtgctga agataatgtg gaagtggcta ggggaaatgc aggtgacact
     2761 aggtttgcac tgaattttca ggcaagaaat caaccagtca ttcctttcac tggagaattt
     2821 tctaaaaatg tactttagac ttcctgtagg gggcggtata gtaacactcg aagctgtaaa
     2881 actgggtctg ggtgcattaa aaattatctg ttcaaataca aaagttttat cactg
//
