LOCUS       NM_025415                694 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus CDC28 protein kinase regulatory subunit 2 (Cks2),
            mRNA.
ACCESSION   NM_025415
VERSION     NM_025415.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 694)
  AUTHORS   Ellederova,Z., Del Rincon,S., Koncicka,M., Susor,A., Kubelka,M.,
            Sun,D. and Spruck,C.
  TITLE     CKS1 Germ Line Exclusion Is Essential for the Transition from
            Meiosis to Early Embryonic Development
  JOURNAL   Mol Cell Biol 39 (13), e00590-18 (2019)
   PUBMED   30988159
  REMARK    GeneRIF: Study shows that CKS2 is a crucial regulator of
            maturation-promoting factor (MPF) activity during meiosis and that
            its deletion in oocytes results in delayed MPF activation and
            germinal vesicle breakdown and defective spindle assembly.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 694)
  AUTHORS   Moon,S., Im,S.K., Kim,N., Youn,H., Park,U.H., Kim,J.Y., Kim,A.R.,
            An,S.J., Kim,J.H., Sun,W., Hwang,J.T., Kim,E.J. and Um,S.J.
  TITLE     Asxl1 exerts an antiproliferative effect on mouse lung maturation
            via epigenetic repression of the E2f1-Nmyc axis
  JOURNAL   Cell Death Dis 9 (11), 1118 (2018)
   PUBMED   30389914
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 694)
  AUTHORS   Qi,J., Yu,Y., Akilli Ozturk,O., Holland,J.D., Besser,D.,
            Fritzmann,J., Wulf-Goldenberg,A., Eckert,K., Fichtner,I. and
            Birchmeier,W.
  TITLE     New Wnt/beta-catenin target genes promote experimental metastasis
            and migration of colorectal cancer cells through different signals
  JOURNAL   Gut 65 (10), 1690-1701 (2016)
   PUBMED   26156959
  REMARK    GeneRIF: New direct Wnt/beta-catenin target gene Cks2 , which
            induced epithelial-mesenchymal transition, cell migration and
            experimental metastasis of Colorectal cancer cells was identified.
REFERENCE   4  (bases 1 to 694)
  AUTHORS   Flowers,S., Patel,P.J., Gleicher,S., Amer,K., Himelman,E., Goel,S.
            and Moran,E.
  TITLE     p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase
            promoter during osteoblast differentiation
  JOURNAL   Bone 69, 47-54 (2014)
   PUBMED   25182511
REFERENCE   5  (bases 1 to 694)
  AUTHORS   Lui,J.H., Nowakowski,T.J., Pollen,A.A., Javaherian,A.,
            Kriegstein,A.R. and Oldham,M.C.
  TITLE     Radial glia require PDGFD-PDGFRbeta signalling in human but not
            mouse neocortex
  JOURNAL   Nature 515 (7526), 264-268 (2014)
   PUBMED   25391964
REFERENCE   6  (bases 1 to 694)
  AUTHORS   Lan,Y., Zhang,Y., Wang,J., Lin,C., Ittmann,M.M. and Wang,F.
  TITLE     Aberrant expression of Cks1 and Cks2 contributes to prostate
            tumorigenesis by promoting proliferation and inhibiting programmed
            cell death
  JOURNAL   Int J Cancer 123 (3), 543-551 (2008)
   PUBMED   18498131
  REMARK    GeneRIF: Elevated expression of Cks1 may contribute to prostate
            tumorigenesis by promoting proliferation, anchorage-independent
            growth and migration of the cells, and elevated expression of Cks2
            by protecting cells from undergoing programmed cell death.
REFERENCE   7  (bases 1 to 694)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 694)
  AUTHORS   Ajioka,I., Maeda,T. and Nakajima,K.
  TITLE     Identification of ventricular-side-enriched molecules regulated in
            a stage-dependent manner during cerebral cortical development
  JOURNAL   Eur J Neurosci 23 (2), 296-308 (2006)
   PUBMED   16420439
REFERENCE   9  (bases 1 to 694)
  AUTHORS   Spruck,C.H., de Miguel,M.P., Smith,A.P., Ryan,A., Stein,P.,
            Schultz,R.M., Lincoln,A.J., Donovan,P.J. and Reed,S.I.
  TITLE     Requirement of Cks2 for the first metaphase/anaphase transition of
            mammalian meiosis
  JOURNAL   Science 300 (5619), 647-650 (2003)
   PUBMED   12714746
  REMARK    GeneRIF: mice lacking Cks2 were viable but sterile in both sexes;
            Cks2 is required for the first metaphase/anaphase transition of
            meiosis
REFERENCE   10 (bases 1 to 694)
  AUTHORS   Kagami,Y. and Furuichi,T.
  TITLE     Investigation of differentially expressed genes during the
            development of mouse cerebellum
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 39-59 (2001)
   PUBMED   15018818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV661312.1, AK166688.1 and AU016270.1.
            
            On Oct 5, 2007 this sequence version replaced NM_025415.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV661312.1, CB589196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                DV661312.1         1-84
            85-682              AK166688.1         2-599
            683-694             AU016270.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 26.12 cM"
     gene            1..694
                     /gene="Cks2"
                     /gene_synonym="1110038L14Rik; CKSHS2"
                     /note="CDC28 protein kinase regulatory subunit 2"
                     /db_xref="GeneID:66197"
                     /db_xref="MGI:MGI:1913447"
     exon            1..240
                     /gene="Cks2"
                     /gene_synonym="1110038L14Rik; CKSHS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..421
                     /gene="Cks2"
                     /gene_synonym="1110038L14Rik; CKSHS2"
                     /note="CKS-2"
                     /codon_start=1
                     /product="cyclin-dependent kinases regulatory subunit 2"
                     /protein_id="NP_079691.1"
                     /db_xref="CCDS:CCDS36664.1"
                     /db_xref="GeneID:66197"
                     /db_xref="MGI:MGI:1913447"
                     /translation="MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWR
                     RLGVQQSLGWVHYMIHEPEPHILLFRRPLPKEQQK"
     exon            241..368
                     /gene="Cks2"
                     /gene_synonym="1110038L14Rik; CKSHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..694
                     /gene="Cks2"
                     /gene_synonym="1110038L14Rik; CKSHS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      664..669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cks2"
                     /gene_synonym="1110038L14Rik; CKSHS2"
                     /note="putative"
     polyA_site      682
                     /gene="Cks2"
                     /gene_synonym="1110038L14Rik; CKSHS2"
                     /note="putative"
ORIGIN      
        1 ctgcgcggag cgtgattggt tggtggcttc gcccaatcgg cggagggctg tcggattcaa
       61 atccagagcg ttgggcctgc ggtcgttggc ctcattcgag tcgttgcgtc ggccctaggc
      121 ggacgtagag ccccttgcgc ccggtttcct gatcccgctt actcctctgc gcgccggcag
      181 gatggcccac aagcagatct actactcaga caagtacttc gatgagcact acgagtaccg
      241 gcatgtcatg ttacccagag aactctctaa acaagtaccc aaaactcatc tgatgtccga
      301 agaggagtgg aggagacttg gtgtccaaca gagtctagga tgggttcatt acatgattca
      361 tgagccagaa ccgcatattc ttctctttag acgacctctt ccaaaagaac aacaaaaatg
      421 aagtgcagct gggatcatct aatctttttc aaatttaatg tatatgtgta tataaggtag
      481 tattcagtga atacttgaaa agtgtacaaa cctttcatcc atacctgtgc atgcgctgta
      541 ttcttcacag caacagagct cagtcaaatg caactgcaag tagggttgtt ttaagttgtt
      601 caagatagtt tcttgtagtt ttttcttaat ataaatgcct gttttatttt acctgttttg
      661 ttaaataaag tttgtatatt gcatttatat cacc
//
