LOCUS       NM_029295                667 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus chemokine-like factor (Cklf), transcript variant 1,
            mRNA.
ACCESSION   NM_029295
VERSION     NM_029295.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 667)
  AUTHORS   Wang,H., Ye,J., Peng,Y., Ma,W., Chen,H., Sun,H., Feng,Z., He,W.,
            Li,G., Chu,S., Zhang,Z. and Chen,N.
  TITLE     CKLF induces microglial activation via triggering defective
            mitophagy and mitochondrial dysfunction
  JOURNAL   Autophagy 20 (3), 590-613 (2024)
   PUBMED   37908119
  REMARK    GeneRIF: CKLF induces microglial activation via triggering
            defective mitophagy and mitochondrial dysfunction.
REFERENCE   2  (bases 1 to 667)
  AUTHORS   Li,G., Li,G.Y., Wang,Z.Z., Ji,H.J., Wang,D.M., Hu,J.F., Yuan,Y.H.,
            Liu,G. and Chen,N.H.
  TITLE     The chemokine-like factor 1 induces asthmatic pathological change
            by activating nuclear factor-kappaB signaling pathway
  JOURNAL   Int Immunopharmacol 20 (1), 81-88 (2014)
   PUBMED   24583145
  REMARK    GeneRIF: NF-kappaB signaling pathway was involved in the asthmatic
            change induced by CKLF1, among which CCR4 might play a crucial role
REFERENCE   3  (bases 1 to 667)
  AUTHORS   Lou,Y., Xia,D., Han,W., Wang,Y., Li,X., Li,Y., Rui,M., Ding,P.,
            Song,Q., Zhang,Y. and Ma,D.
  TITLE     Molecular cloning and characterization of rat chemokine-like factor
            1 and 2
  JOURNAL   Gene 307, 125-132 (2003)
   PUBMED   12706894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115718.15, AK046397.1 and BE630757.1.
            
            On Nov 3, 2013 this sequence version replaced NM_029295.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB645023.1, AK046397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC115718.15        2449-2496           c
            49-664              AK046397.1         1-616
            665-667             BE630757.1         1-3                 c
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8"
     gene            1..667
                     /gene="Cklf"
                     /gene_synonym="1700001C14Rik; 1810018M11Rik;
                     A730028G07Rik; C32; CKLF1; Cklf2; CKLF3; CKLF4; CKLF5;
                     Cklf6; HSPC224; UCK-1"
                     /note="chemokine-like factor"
                     /db_xref="GeneID:75458"
                     /db_xref="MGI:MGI:1922708"
     exon            1..235
                     /gene="Cklf"
                     /gene_synonym="1700001C14Rik; 1810018M11Rik;
                     A730028G07Rik; C32; CKLF1; Cklf2; CKLF3; CKLF4; CKLF5;
                     Cklf6; HSPC224; UCK-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..616
                     /gene="Cklf"
                     /gene_synonym="1700001C14Rik; 1810018M11Rik;
                     A730028G07Rik; C32; CKLF1; Cklf2; CKLF3; CKLF4; CKLF5;
                     Cklf6; HSPC224; UCK-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chemokine-like factor 2; chemokine-like factor 4;
                     chemokine-like factor 6"
                     /codon_start=1
                     /product="chemokine-like factor isoform 1"
                     /protein_id="NP_083571.1"
                     /db_xref="CCDS:CCDS40450.1"
                     /db_xref="GeneID:75458"
                     /db_xref="MGI:MGI:1922708"
                     /translation="METPRPVVSRRPFCCTLKCFVKFLRLVVTVTSMIFFIVGQAPEP
                     YIVITGFEVTVIFCFLVLYTCGLDKIMRSFFWPLLDVINSMVTALCMLIVSVLALIPE
                     TSTKTILGGVFGFLTVTCTIADCALMCQKLRFRPRQPYQKKSTNDIDDRE"
     exon            236..394
                     /gene="Cklf"
                     /gene_synonym="1700001C14Rik; 1810018M11Rik;
                     A730028G07Rik; C32; CKLF1; Cklf2; CKLF3; CKLF4; CKLF5;
                     Cklf6; HSPC224; UCK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..490
                     /gene="Cklf"
                     /gene_synonym="1700001C14Rik; 1810018M11Rik;
                     A730028G07Rik; C32; CKLF1; Cklf2; CKLF3; CKLF4; CKLF5;
                     Cklf6; HSPC224; UCK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..667
                     /gene="Cklf"
                     /gene_synonym="1700001C14Rik; 1810018M11Rik;
                     A730028G07Rik; C32; CKLF1; Cklf2; CKLF3; CKLF4; CKLF5;
                     Cklf6; HSPC224; UCK-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      641..646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cklf"
                     /gene_synonym="1700001C14Rik; 1810018M11Rik;
                     A730028G07Rik; C32; CKLF1; Cklf2; CKLF3; CKLF4; CKLF5;
                     Cklf6; HSPC224; UCK-1"
                     /note="hexamer: ATTAAA"
     polyA_site      667
                     /gene="Cklf"
                     /gene_synonym="1700001C14Rik; 1810018M11Rik;
                     A730028G07Rik; C32; CKLF1; Cklf2; CKLF3; CKLF4; CKLF5;
                     Cklf6; HSPC224; UCK-1"
                     /note="major polyA site"
ORIGIN      
        1 gggcggcccg cgctagtgcg caggcgcgcc cggacttggc ctgagcgcgg tgccgcaggc
       61 ccagccccgg cagttgagct ggtggcgcga gtcctggaaa gagccattaa tcgagaaggc
      121 ttgaaagaga ggcgtgactg ttgggtctgt gggcaagatg gagactccac ggccggtcgt
      181 aagccgtcgg cccttctgct gtactctgaa atgctttgtg aagttcctgc ggttggtggt
      241 aactgtgaca tctatgatct ttttcatcgt gggacaagcc cctgaaccat atatcgtcat
      301 cactgggttt gaagtcaccg ttattttctg tttcctagtc ttatacacgt gtggacttga
      361 caagataatg agatctttct tttggccttt gcttgatgtt attaactcaa tggtaacagc
      421 attatgcatg ctcattgtgt ctgtgttggc tctaatacca gaaacctcaa caaagacaat
      481 ccttggaggg gtgtttggtt tcctgacagt aacatgtact attgccgact gtgcccttat
      541 gtgccagaaa cttcggtttc gtccacgtca accttatcag aaaaagtcta ctaatgacat
      601 cgatgacaga gaataatttt gtacttattt tttactactt attaaactaa ttatttatac
      661 atccata
//
