LOCUS       NM_175451               2915 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytoskeleton-associated protein 4 (Ckap4), mRNA.
ACCESSION   NM_175451 XM_125808
VERSION     NM_175451.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Xin,Y., He,Q., Liang,H., Zhang,K., Guo,J., Zhong,Q., Chen,D.,
            Li,J., Liu,Y. and Chen,S.
  TITLE     m6A epitranscriptomic modification regulates neural
            progenitor-to-glial cell transition in the retina
  JOURNAL   Elife 11, e79994 (2022)
   PUBMED   36459087
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Zhang,J., Zhou,Y., Guo,J., Li,L., Liu,H., Lu,C., Jiang,Y. and
            Cui,S.
  TITLE     MicroRNA-7a2 is Required for the Development of Pituitary Stem
            Cells
  JOURNAL   Stem Cells Dev 31 (13-14), 357-368 (2022)
   PUBMED   35652338
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Shi,Y., Jin,X., Yang,M., Jia,J., Yao,H., Yuan,W., Wang,K. and
            Rong,S.
  TITLE     CKAP4 contributes to the progression of vascular calcification (VC)
            in chronic kidney disease (CKD) by modulating YAP phosphorylation
            and MMP2 expression
  JOURNAL   Cell Signal 93, 110270 (2022)
   PUBMED   35108641
  REMARK    GeneRIF: CKAP4 contributes to the progression of vascular
            calcification (VC) in chronic kidney disease (CKD) by modulating
            YAP phosphorylation and MMP2 expression.
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Kaji,D.A., Montero,A.M., Patel,R. and Huang,A.H.
  TITLE     Transcriptional profiling of mESC-derived tendon and fibrocartilage
            cell fate switch
  JOURNAL   Nat Commun 12 (1), 4208 (2021)
   PUBMED   34244516
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Osseni,A., Sebastien,M., Sarrault,O., Baudet,M., Coute,Y.,
            Faure,J., Fourest-Lieuvin,A. and Marty,I.
  TITLE     Triadin and CLIMP-63 form a link between triads and microtubules in
            muscle cells
  JOURNAL   J Cell Sci 129 (20), 3744-3755 (2016)
   PUBMED   27562070
  REMARK    GeneRIF: CLIMP-63 (also known as CKAP4), is the partner of triadin,
            is responsible for this association of triads and microtubules.
REFERENCE   7  (bases 1 to 2915)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 2915)
  AUTHORS   Ferone,G., Mollo,M.R., Thomason,H.A., Antonini,D., Zhou,H.,
            Ambrosio,R., De Rosa,L., Salvatore,D., Getsios,S., van Bokhoven,H.,
            Dixon,J. and Missero,C.
  TITLE     p63 control of desmosome gene expression and adhesion is
            compromised in AEC syndrome
  JOURNAL   Hum Mol Genet 22 (3), 531-543 (2013)
   PUBMED   23108156
  REMARK    GeneRIF: p63 positively regulates desmosome adhesion by directly
            controlling the expression of several desmosome genes, including
            Dsp, Dsc3 and Dsg1.
REFERENCE   9  (bases 1 to 2915)
  AUTHORS   Gupta,N., Manevich,Y., Kazi,A.S., Tao,J.Q., Fisher,A.B. and
            Bates,S.R.
  TITLE     Identification and characterization of p63
            (CKAP4/ERGIC-63/CLIMP-63), a surfactant protein A binding protein,
            on type II pneumocytes
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 291 (3), L436-L446 (2006)
   PUBMED   16556726
  REMARK    GeneRIF: Thus p63 closely interacts with SP-A and may play a role
            in the trafficking or the biological function of the surfactant
            protein.
REFERENCE   10 (bases 1 to 2915)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB620334.1, BE647088.1, AK030708.1 and BB033173.1.
            
            On May 17, 2005 this sequence version replaced XM_125808.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030708.1, BC025522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BB620334.1         1-18
            19-112              BE647088.1         1-94
            113-116             BB620334.1         113-116
            117-1821            AK030708.1         1-1705
            1822-2905           AK030708.1         1707-2790
            2906-2915           BB033173.1         239-248
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.52 cM"
     gene            1..2915
                     /gene="Ckap4"
                     /gene_synonym="5630400A09Rik; CLIMP-63; P63"
                     /note="cytoskeleton-associated protein 4"
                     /db_xref="GeneID:216197"
                     /db_xref="MGI:MGI:2444926"
     exon            1..442
                     /gene="Ckap4"
                     /gene_synonym="5630400A09Rik; CLIMP-63; P63"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1750
                     /gene="Ckap4"
                     /gene_synonym="5630400A09Rik; CLIMP-63; P63"
                     /note="63 kDa membrane protein; 63-kDa
                     cytoskeleton-linking membrane protein"
                     /codon_start=1
                     /product="cytoskeleton-associated protein 4"
                     /protein_id="NP_780660.1"
                     /db_xref="CCDS:CCDS24080.1"
                     /db_xref="GeneID:216197"
                     /db_xref="MGI:MGI:2444926"
                     /translation="MPSAKQRGSKGGHGAASPSDKGAHPSGGADDVAKKPPAAPQQPQ
                     PPAPHPPQHPQNQAHRGGHRGRSSAATANASSASCSRRLGRVLNFLFYLSLVAAAAFS
                     GWYVHHVLEEVQQVRRGHQDFSRQRDELGQGLQGVEQKVQSLQATFGTFESLLRNSQH
                     KQDLTEKAVKEGESELNRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEE
                     RLTELTKSINDNIAIFTDVQKRSQKEINEVKMKVASLEESKGDRSQDVKTLKDAVKEV
                     QASMMSRERDIEALKSSLQTMESDVYTEVRELVSLKQEQQAFKQAADSERLALQALTE
                     KLLRSEESSSRLPEDIRRLEEELQQLKVGAHGSEEGAVFKDSKALEELQRQIEGLGAR
                     LQYVEDGVYSMQVASARHTESLESLLSKSQEYEQRLAMLQEHVGNLGSSSDLASTVRS
                     LGETQLALSSDLKELKQSLGELPGTVESLQEQVLSLLSQDQAQAEGLPPQDFLDRLSS
                     LDNLKSSVSQVESDLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFL
                     KVEKIHEKI"
     exon            443..2915
                     /gene="Ckap4"
                     /gene_synonym="5630400A09Rik; CLIMP-63; P63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2885..2890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ckap4"
                     /gene_synonym="5630400A09Rik; CLIMP-63; P63"
                     /note="hexamer: AATAAA"
     polyA_site      2915
                     /gene="Ckap4"
                     /gene_synonym="5630400A09Rik; CLIMP-63; P63"
                     /note="major polyA site"
ORIGIN      
        1 ccgccgagcc gccgccgccg ccatgccctc ggccaaacaa aggggctcca agggcggcca
       61 cggcgccgcg agcccctcgg acaagggcgc ccacccgtcg ggcggcgcgg atgacgtggc
      121 gaagaagccg ccggcggcgc cgcagcagcc gcagcctccc gcgccgcacc cgccgcagca
      181 cccgcagaac caggcgcacc ggggcggcca ccgcggccgg tcctcagccg ccaccgccaa
      241 cgcgtcctcc gcgtcctgct cgcgcaggct tggccgggtg ctcaactttc tcttctacct
      301 ctccctggtg gcggcggccg ccttctcggg ctggtatgtc catcacgtcc tggaggaggt
      361 ccagcaggtc cggcgtggcc accaggactt ctcccgtcag agggatgagc tgggccaggg
      421 cttgcagggc gtcgagcaga aggtccaatc cctgcaagcc acatttggga ctttcgagtc
      481 cctcctgaga aactcccagc ataaacagga tctcacagag aaagccgtga aggaagggga
      541 gagcgagctc aaccgaatta gcgaagttct acagaagttg cagaatgaga ttctcaaaga
      601 tctgtcggac gggatccacg tggtgaagga tgcccgggag cgggacttca cgtccctgga
      661 gaacacagtc gaggagcgcc tgacggagct taccaagtct atcaatgaca acatcgccat
      721 cttcactgat gtccagaaga ggagccagaa ggagatcaat gaggtcaaga tgaaggtggc
      781 ctccctggaa gaatccaagg gggatcgcag tcaggacgtg aaaactctga aggacgccgt
      841 gaaggaggtc caggcctcca tgatgtcgag ggagagggac attgaggccc tgaagagttc
      901 ccttcagacg atggagtccg acgtctacac agaggtgcgg gaactggtga gcctcaagca
      961 ggagcaacag gcgttcaagc aggcggccga ctcagagcgc ctggctctgc aggccctcac
     1021 ggagaagctt ctgcggtccg aggagtcctc ctctcgtctc ccagaggaca tccggagact
     1081 ggaggaagag ctacagcagc tgaaggtcgg ggcccatggg tcagaggaag gtgccgtctt
     1141 caaagactcc aaagccttag aggaactgca gaggcagatt gagggcctgg gtgccaggct
     1201 ccagtatgta gaggacgggg tctactcaat gcaggtggct tctgcacgcc acaccgaaag
     1261 cctggagtcg ctcctgtcca agagccagga gtacgagcaa cgcctggcta tgctgcagga
     1321 gcacgtggga aacctgggct cctcatctga cctggccagc acagtcagga gcctggggga
     1381 gacccagctg gcgctgtcca gcgacttgaa ggagctgaag cagagcctgg gtgagctgcc
     1441 cggtaccgtg gagtcactgc aggagcaagt gctctcactg ctcagccagg accaagccca
     1501 ggccgagggc ttgcctcctc aggacttcct ggacagactg tcctctctag acaacctgaa
     1561 atcctcagtg agccaagtgg agtcagactt gaaaatgctc aggactgccg tggacagttt
     1621 ggtggcctat tccgtcaaaa tcgaaacgaa tgagaataac ttagagtcag ccaagggctt
     1681 gctggatgac ctgcggaacg acctggatag gttgtttctg aaagttgaga agatccatga
     1741 aaagatctaa gtgaactgcg tgtgtgggca cagtttctta cgaccaaaac caaacaaaca
     1801 aaaaaaacaa aacaaaaaaa atcccattgt tttctcccag gtgccctctc atcaccttct
     1861 cgcccctccc ccaccccatg gaaagtagca gataccgact ggacaccgcc ctggttttct
     1921 gtgcccagtt aatttatttg cagttattac cacacacctt tggtttctta agtcctgttt
     1981 ctgcttttgg tttggcttcc tgaaggccca gccagccctg tgcagaaaag gatgtgtctc
     2041 ctgttagaaa gatgacagtg gctttaactg gggattatca ggaagcagat taacctaaaa
     2101 aaagatcctg tcaggcagtc aaatttatag taaaatagaa aaacaacaaa ggacaggtgg
     2161 ggggcacttt ttaaaaaatt ttttaaggaa aattaatttt attggtttgt tgtttttgtt
     2221 tttgtttttt gtttttttat actcctggcc agggttttta gaagctgtct cattcttgtc
     2281 ttccatttag aactggtaaa aactcctaga ggtcagctct gaatgggcga aagaggaccc
     2341 cacatccacc cccaacctgc ctgagagtca ctctcagagg cgtggtctct ctccattccc
     2401 taatccaatc aaacggtaac tatgcaaatt cagtaggtcc tgaaggccca gtgcacttct
     2461 ggtcctggtg acccacctgt gtcatcaggc taggaggggt caccatgtgc gtttggaggg
     2521 ggtgttcttt gggttctgat gtgagagctg tattttccac agaggatttg ggcatcttcc
     2581 cgagagatgt gggccaggtc tttttgtttt atcacagcgt ctctggagag gcctcccttc
     2641 gcctcgcccg gcccccatct gtcagtgagg atcacgtggg ctgcgtttct gtaattgttc
     2701 tccatgtacc cttgcccttt gagatgtatt gtttttgatg gctgccttgc ccttccactc
     2761 cctctcccct ccccccaaaa aaaaggaaag aaaaaaaaaa cagaaaaagc tgaaaagaaa
     2821 accaagattt gttagtttac tgtgaaatga actgtatggc ttctttacag tatttttaat
     2881 tcttaataaa cacttgagct ttgttatgac cttca
//
