LOCUS       NM_028412               2893 bp    mRNA    linear   ROD 21-AUG-2023
DEFINITION  Mus musculus CDKN1A interacting zinc finger protein 1 (Ciz1),
            transcript variant 1, mRNA.
ACCESSION   NM_028412
VERSION     NM_028412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2893)
  AUTHORS   Dobbs OG, Wilson RHC, Newling K, Ainscough JF and Coverley D.
  TITLE     Epigenetic instability caused by absence of CIZ1 drives
            transformation during quiescence cycles
  JOURNAL   BMC Biol 21 (1), 175 (2023)
   PUBMED   37580709
  REMARK    GeneRIF: Epigenetic instability caused by absence of CIZ1 drives
            transformation during quiescence cycles.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2893)
  AUTHORS   Sofi S, Williamson L, Turvey GL, Scoynes C, Hirst C, Godwin J,
            Brockdorff N, Ainscough J and Coverley D.
  TITLE     Prion-like domains drive CIZ1 assembly formation at the inactive X
            chromosome
  JOURNAL   J Cell Biol 221 (4) (2022)
   PUBMED   35289833
  REMARK    GeneRIF: Prion-like domains drive CIZ1 assembly formation at the
            inactive X chromosome.
REFERENCE   3  (bases 1 to 2893)
  AUTHORS   Rodermund L, Coker H, Oldenkamp R, Wei G, Bowness J, Rajkumar B,
            Nesterova T, Susano Pinto DM, Schermelleh L and Brockdorff N.
  TITLE     Time-resolved structured illumination microscopy reveals key
            principles of Xist RNA spreading
  JOURNAL   Science 372 (6547) (2021)
   PUBMED   34112668
  REMARK    GeneRIF: Time-resolved structured illumination microscopy reveals
            key principles of Xist RNA spreading.
REFERENCE   4  (bases 1 to 2893)
  AUTHORS   Stewart ER, Turner RML, Newling K, Ridings-Figueroa R, Scott V,
            Ashton PD, Ainscough JFX and Coverley D.
  TITLE     Maintenance of epigenetic landscape requires CIZ1 and is corrupted
            in differentiated fibroblasts in long-term culture
  JOURNAL   Nat Commun 10 (1), 460 (2019)
   PUBMED   30692537
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2893)
  AUTHORS   Xiao J, Khan MM, Vemula S, Tian J and LeDoux MS.
  TITLE     Consequences of Cre-mediated deletion of Ciz1 exon 5 in mice
  JOURNAL   FEBS Lett 592 (18), 3101-3110 (2018)
   PUBMED   30098009
  REMARK    GeneRIF: CDKN1A interacting zinc finger protein 1 (Ciz1) knockout
            mice (Ciz1(DeltaE5/DeltaE5) ) lose residues encoded by exon 5 but
            may gain function from novel amino acid sequences.
REFERENCE   6  (bases 1 to 2893)
  AUTHORS   Copeland NA, Sercombe HE, Ainscough JF and Coverley D.
  TITLE     Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA
            replication in vitro
  JOURNAL   J Cell Sci 123 (Pt 7), 1108-1115 (2010)
   PUBMED   20215406
REFERENCE   7  (bases 1 to 2893)
  AUTHORS   Hakim O, John S, Ling JQ, Biddie SC, Hoffman AR and Hager GL.
  TITLE     Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long
            range interactions
  JOURNAL   J Biol Chem 284 (10), 6048-6052 (2009)
   PUBMED   19124469
  REMARK    GeneRIF: glucocorticoid-responsive elements proximal to the Lcn2
            promoter apparently functions to regulate both the Lcn2 gene and
            the distal Ciz1 gene.
REFERENCE   8  (bases 1 to 2893)
  AUTHORS   Rahman F, Ainscough JF, Copeland N and Coverley D.
  TITLE     Cancer-associated missplicing of exon 4 influences the subnuclear
            distribution of the DNA replication factor CIZ1
  JOURNAL   Hum Mutat 28 (10), 993-1004 (2007)
   PUBMED   17508423
  REMARK    GeneRIF: conditional exclusion of exon 4 influences the spatial
            distribution of the Ciz1 protein within the nucleus, showing that
            CIZ1 alternative splicing could influence organized patterns of DNA
            replication
REFERENCE   9  (bases 1 to 2893)
  AUTHORS   Ainscough JF, Rahman FA, Sercombe H, Sedo A, Gerlach B and Coverley
            D.
  TITLE     C-terminal domains deliver the DNA replication factor Ciz1 to the
            nuclear matrix
  JOURNAL   J Cell Sci 120 (Pt 1), 115-124 (2007)
   PUBMED   17182902
  REMARK    GeneRIF: Ciz1 is composed of two functionally distinct domains: an
            N-terminal replication domain and a C-terminal nuclear matrix
            anchor
REFERENCE   10 (bases 1 to 2893)
  AUTHORS   Coverley D, Marr J and Ainscough J.
  TITLE     Ciz1 promotes mammalian DNA replication
  JOURNAL   J Cell Sci 118 (Pt 1), 101-112 (2005)
   PUBMED   15585571
  REMARK    GeneRIF: Ciz1 promotes DNA replication.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808027.14.
            
            On Jan 6, 2022 this sequence version replaced NM_028412.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018483.1, SRR7345562.2228342.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AL808027.14        216429-216649
            222-396             AL808027.14        217156-217330
            397-512             AL808027.14        217570-217685
            513-584             AL808027.14        219154-219225
            585-814             AL808027.14        220654-220883
            815-908             AL808027.14        223383-223476
            909-1011            AL808027.14        223593-223695
            1012-1556           AL808027.14        224215-224759
            1557-1678           AL808027.14        224987-225108
            1679-1876           AL808027.14        225649-225846
            1877-2001           AL808027.14        227693-227817
            2002-2089           AL808027.14        228836-228923
            2090-2203           AL808027.14        229360-229473
            2204-2365           AL808027.14        229617-229778
            2366-2435           AL808027.14        230644-230713
            2436-2557           AL808027.14        230860-230981
            2558-2893           AL808027.14        231315-231650
FEATURES             Location/Qualifiers
     source          1..2893
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..2893
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /note="CDKN1A interacting zinc finger protein 1"
                     /db_xref="GeneID:68379"
                     /db_xref="MGI:MGI:1920234"
     exon            1..221
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            222..396
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..2764
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Cip1-interacting zinc finger protein"
                     /codon_start=1
                     /product="cip1-interacting zinc finger protein isoform 1"
                     /protein_id="NP_082688.1"
                     /db_xref="CCDS:CCDS15911.1"
                     /db_xref="GeneID:68379"
                     /db_xref="MGI:MGI:1920234"
                     /translation="MFNPQLQQQQQLQQQQQQLQQQLQQQQLQQQQQQILQLQQLLQQ
                     SPPQASLSIPVSRGLPQQSSPQQLLSLQGLHSTSLLNGPMLQRALLLQQLQGLDQFAM
                     PPATYDGASLTMPTATLGNLRAFNVTAPSLAAPSLTPPQMVTPNLQQFFPQATRQSLL
                     GPPPVGVPINPSQLNHSGRNTQKQARTPSSTTPNRKDSSSQTVPLEDREDPTEGSEEA
                     TELQMDTCEDQDSLVGPDSMLSEPQVPEPEPFETLEPPAKRCRSSEESTEKGPTGQPQ
                     ARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPEH
                     LAPQQDQVEPQVPSQPPWQLQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVP
                     TQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATEPQLSSHAAEAGSDPDKALP
                     EPVSAQSSEDRSREASAGGLDLGECEKRAGEMLGMWGAGSSLKVTILQSSNSRAFNTT
                     PLTSGPRPGDSTSATPAIASTPSKQSLQFFCYICKASSSSQQEFQDHMSEAQHQQRLG
                     EIQHSSQTCLLSLLPMPRDILEKEAEDPPPKRWCNTCQVYYVGDLIQHRRTQEHKVAK
                     QSLRPFCTICNRYFKTPRKFVEHVKSQGHKDKAQELKTLEKETGSPDEDHFITVDAVG
                     CFESGQEEDEDDDEEEEEEGEIEAEEEFCKQVKPRETSSEQGKGSETYNPNTAYGEDF
                     LVPVMGYVCQICHKFYDSNSELRLSHCKSLAHFENLQKYKAKNPSPPPTRPVSRKCAI
                     NARNALTALFTSSHQPSPQDTVKMPSKVKPGSPGLPPPLRRSTRLKT"
     exon            397..512
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            513..584
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            585..814
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            815..908
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1011
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1556
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1678
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1876
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2001
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2089
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2203
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2365
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2435
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2557
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2893
                     /gene="Ciz1"
                     /gene_synonym="0610038H21Rik; 2900056O04Rik; LSFR1;
                     ZNF356"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcagcccg ggagctccgg agcccgcctt acgagtcagc tcgtggcttt cacggtttcg
       61 gttttcgtgg attgccggga ggtgaggggg agccagtgtg gtgcccgccc cggaagcgac
      121 agtggaggag ggttgggcac cccgggaagg gtggaccgca gggatagcgg ctacttgcag
      181 agagcctacg ggctttgtgg acaggcgagg ccacaggatt accaccatgt tcaacccgca
      241 actccagcag cagcaacagt tgcagcagca gcagcaacag ttgcagcagc agctccagca
      301 gcagcagctc cagcagcagc aacagcagat actgcagctc caacagctgc tgcaacagtc
      361 cccaccacag gcctccttgt ccattcctgt cagccggggc ctcccccagc agtcatcccc
      421 gcaacagctt ctgagtctcc agggcctcca ctcgacctcc ctgctcaatg gccccatgct
      481 gcaaagagct ttgctcctac agcagttgca aggactggac cagtttgcaa tgccaccagc
      541 cacgtatgac ggtgccagcc tcaccatgcc tacggcaaca ctgggtaacc tccgtgcttt
      601 caatgtgaca gccccaagcc tagcagctcc cagccttaca ccaccccaga tggtcacccc
      661 aaatctgcag cagttctttc cccaggctac tcgacagtct ctgctggggc ctcctcctgt
      721 tggggtccca ataaaccctt ctcagctcaa ccactcaggg aggaacaccc agaaacaggc
      781 cagaaccccc tcttccacca cccccaatcg caaggattct tcttctcaga cggtgcctct
      841 ggaagacagg gaagacccca cagaggggtc tgaggaagcc acggagctcc agatggacac
      901 atgtgaagac caagattcac tagtcggtcc agatagcatg ctgagtgagc cccaagtgcc
      961 tgagcctgag ccctttgaga cattggaacc accagccaag aggtgcagga gctcagagga
     1021 gtccaccgag aaaggcccta cagggcagcc acaagcaagg gtccagcctc agacccagat
     1081 gacagcacca aagcagacac agaccccgga tcggctgcct gagccaccag aagtccaaat
     1141 gctgccgcgt atccagccac aggcactgca gatccagacc cagccaaagc tgctgaggca
     1201 ggcacagaca cagacctctc cagagcactt agcgccccag caggatcagg tagagccaca
     1261 ggtaccatca cagcccccat ggcagttgca gccacgggag acagacccac cgaaccaagc
     1321 tcaggcacag acccagcctc agcccctctg gcaggcgcag tcacagaagc aggcccagac
     1381 acaggcacat ccacaggtac ccacccaagc acagtcacag gagcagacat cagagaagac
     1441 ccaggaccag cctcagacct ggccacaggg gtcagtaccc ccaccagaac aagcgtcagg
     1501 tccagcctgt gccacggaac cacagctatc ctctcacgct gcagaagctg ggagtgaccc
     1561 agacaaggcc ttgccagaac cagtaagtgc ccagagcagt gaagacagga gccgggaggc
     1621 gtccgctggt ggcctggatt tgggagaatg tgaaaagaga gcgggagaga tgctggggat
     1681 gtggggggct gggagctccc tgaaggtcac catcctgcag agtagcaaca gccgggcctt
     1741 taacaccaca cccctcacat ctggacctcg ccctggggac tctacctctg ccacccctgc
     1801 cattgccagc acaccctcca agcaaagcct ccagttcttc tgctacatct gcaaggccag
     1861 cagcagcagc cagcaggagt tccaggatca catgtcagag gctcagcacc aacagcggct
     1921 tggggaaata caacactcga gccagacctg cctgctgtcc ctgctgccca tgcctcggga
     1981 catcctggag aaagaagcgg aagatcctcc gcccaaacgc tggtgcaaca cctgccaggt
     2041 gtactacgtg ggagacttga tccagcaccg taggacacag gagcacaagg ttgccaaaca
     2101 atccctgagg cccttctgca ccatatgcaa ccgttacttc aagacccctc gaaagtttgt
     2161 ggagcacgtg aagtcccagg gacacaagga caaggcccaa gagctgaaga cacttgaaaa
     2221 ggagacaggc agcccagatg aggaccactt catcactgtg gacgccgtcg gttgctttga
     2281 gagtggtcaa gaagaggacg aggatgacga cgaggaagaa gaagaagaag gagagattga
     2341 ggctgaggag gaattctgca agcaggtgaa gccgagagaa acatcctcag agcaagggaa
     2401 gggctctgag acgtacaacc ccaacacagc ctatggtgag gatttcctgg tgccagtgat
     2461 gggctatgtc tgtcaaatct gtcacaagtt ctacgacagc aactcagaat tgcggctttc
     2521 tcactgcaag tccctggccc actttgagaa cctgcagaaa tacaaagcca agaacccaag
     2581 ccctcctcct acccggcctg tgagccgcaa gtgtgccatc aacgcccgca acgccctgac
     2641 tgcactgttc acctctagcc accagcccag cccccaggac acagtgaaaa tgcccagcaa
     2701 ggtgaagcct ggatcccccg gactccctcc tccccttcgg cgctcaacac gcctcaaaac
     2761 ctgatagagg gagctctggc cactcagcct gactaaggct cagtctgcta atgcttccta
     2821 ggtatctgtg tagaaatgtt caagtggttg gtgtttttac tcaaaatcca ataaagagtc
     2881 agtagtttgg cta
//
