LOCUS       NM_007708               6898 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus citron (Cit), mRNA.
ACCESSION   NM_007708
VERSION     NM_007708.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6898)
  AUTHORS   Naher,S., Iemura,K., Miyashita,S., Hoshino,M., Tanaka,K., Niwa,S.,
            Tsai,J.W., Kikkawa,T. and Osumi,N.
  TITLE     Kinesin-like motor protein KIF23 maintains neural stem and
            progenitor cell pools in the developing cortex
  JOURNAL   EMBO J 44 (2), 331-355 (2025)
   PUBMED   39632980
REFERENCE   2  (bases 1 to 6898)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6898)
  AUTHORS   Boda,E., Lorenzati,M., Parolisi,R., Harding,B., Pallavicini,G.,
            Bonfanti,L., Moccia,A., Bielas,S., Di Cunto,F. and Buffo,A.
  TITLE     Molecular and functional heterogeneity in dorsal and ventral
            oligodendrocyte progenitor cells of the mouse forebrain in response
            to DNA damage
  JOURNAL   Nat Commun 13 (1), 2331 (2022)
   PUBMED   35484145
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6898)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6898)
  AUTHORS   Little,J.N., McNeely,K.C., Michel,N., Bott,C.J., Lettieri,K.S.,
            Hecht,M.R., Martin,S.A. and Dwyer,N.D.
  TITLE     Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell
            Abscission and Results in p53-Dependent Apoptosis in Developing
            Cortex
  JOURNAL   J Neurosci 41 (15), 3344-3365 (2021)
   PUBMED   33622776
REFERENCE   6  (bases 1 to 6898)
  AUTHORS   Shiraishi,Y., Mizutani,A., Bito,H., Fujisawa,K., Narumiya,S.,
            Mikoshiba,K. and Furuichi,T.
  TITLE     Cupidin, an isoform of Homer/Vesl, interacts with the actin
            cytoskeleton and activated rho family small GTPases and is
            expressed in developing mouse cerebellar granule cells
  JOURNAL   J Neurosci 19 (19), 8389-8400 (1999)
   PUBMED   10493740
REFERENCE   7  (bases 1 to 6898)
  AUTHORS   Furuyashiki,T., Fujisawa,K., Fujita,A., Madaule,P., Uchino,S.,
            Mishina,M., Bito,H. and Narumiya,S.
  TITLE     Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic
            synapses in the thalamus
  JOURNAL   J Neurosci 19 (1), 109-118 (1999)
   PUBMED   9870943
REFERENCE   8  (bases 1 to 6898)
  AUTHORS   Di Cunto,F., Calautti,E., Hsiao,J., Ong,L., Topley,G., Turco,E. and
            Dotto,G.P.
  TITLE     Citron rho-interacting kinase, a novel tissue-specific ser/thr
            kinase encompassing the Rho-Rac-binding protein Citron
  JOURNAL   J Biol Chem 273 (45), 29706-29711 (1998)
   PUBMED   9792683
REFERENCE   9  (bases 1 to 6898)
  AUTHORS   Madaule,P., Eda,M., Watanabe,N., Fujisawa,K., Matsuoka,T., Bito,H.,
            Ishizaki,T. and Narumiya,S.
  TITLE     Role of citron kinase as a target of the small GTPase Rho in
            cytokinesis
  JOURNAL   Nature 394 (6692), 491-494 (1998)
   PUBMED   9697773
REFERENCE   10 (bases 1 to 6898)
  AUTHORS   Madaule,P., Furuyashiki,T., Reid,T., Ishizaki,T., Watanabe,G.,
            Morii,N. and Narumiya,S.
  TITLE     A novel partner for the GTP-bound forms of rho and rac
  JOURNAL   FEBS Lett 377 (2), 243-248 (1995)
   PUBMED   8543060
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162461.6 and AC115795.11.
            
            On Feb 6, 2007 this sequence version replaced NM_007708.2.
            
            Sequence Note: This sequence has been modified as follows: removed
            39 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-811               AC162461.6         133888-134698
            812-953             AC162461.6         139384-139525
            954-1129            AC162461.6         147430-147605
            1130-1231           AC162461.6         151190-151291
            1232-1374           AC162461.6         162084-162226
            1375-1465           AC162461.6         164121-164211
            1466-1669           AC162461.6         173098-173301
            1670-1823           AC162461.6         174886-175039
            1824-2007           AC162461.6         196870-197053
            2008-2113           AC162461.6         213626-213731
            2114-2257           AC162461.6         214691-214834
            2258-2377           AC162461.6         216068-216187
            2378-2548           AC162461.6         221630-221800
            2549-2599           AC162461.6         222053-222103
            2600-2653           AC162461.6         222811-222864
            2654-2794           AC162461.6         224961-225101
            2795-2920           AC162461.6         226911-227036
            2921-3016           AC162461.6         230069-230164
            3017-3133           AC115795.11        24931-25047
            3134-3243           AC115795.11        25976-26085
            3244-3418           AC115795.11        27053-27227
            3419-3616           AC115795.11        31598-31795
            3617-3670           AC115795.11        40290-40343
            3671-3868           AC115795.11        47034-47231
            3869-4062           AC115795.11        48110-48303
            4063-4198           AC115795.11        50389-50524
            4199-4303           AC115795.11        52874-52978
            4304-4444           AC115795.11        58501-58641
            4445-4552           AC115795.11        58908-59015
            4553-4670           AC115795.11        60841-60958
            4671-4835           AC115795.11        61229-61393
            4836-4973           AC115795.11        63938-64075
            4974-5154           AC115795.11        64551-64731
            5155-5246           AC115795.11        64865-64956
            5247-5351           AC115795.11        65705-65809
            5352-5521           AC115795.11        66040-66209
            5522-5602           AC115795.11        67302-67382
            5603-5738           AC115795.11        67544-67679
            5739-5878           AC115795.11        69474-69613
            5879-5971           AC115795.11        71757-71849
            5972-6080           AC115795.11        73134-73242
            6081-6209           AC115795.11        73358-73486
            6210-6290           AC115795.11        74539-74619
            6291-6369           AC115795.11        76638-76716
            6370-6549           AC115795.11        76820-76999
            6550-6859           AC115795.11        84928-85237
            6860-6898           AC115795.11        85451-85489
FEATURES             Location/Qualifiers
     source          1..6898
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.1 cM"
     gene            1..6898
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /note="citron"
                     /db_xref="GeneID:12704"
                     /db_xref="MGI:MGI:105313"
     exon            1..811
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     CDS             716..6883
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /EC_number="2.7.11.1"
                     /note="citron-N; rho-interacting, serine/threonine-protein
                     kinase 21; citron kinase"
                     /codon_start=1
                     /product="citron Rho-interacting kinase"
                     /protein_id="NP_031734.3"
                     /db_xref="CCDS:CCDS19597.1"
                     /db_xref="GeneID:12704"
                     /db_xref="MGI:MGI:105313"
                     /translation="MLKFKYGVRNPPEASASEPIASRASRLNLFFQGKPPLMTQQQMS
                     ALSREGMLDALFALFEECSQPALMKMKHVSSFVQKYSDTIAELRELQPSARDFEVRSL
                     VGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQL
                     QYAFQDKNNLYLVMEYQPGGDLLSLLNRYEDQLDESMIQFYLAELILAVHSVHQMGYV
                     HRDIKPENILIDRTGHIKLVDFGSAAKMNSNKVDAKLPIGTPDYMAPEVLTVMNEDRR
                     GTYGLDCDWWSVGVVAYEMVYGKTPFTEGTSARTFNNIMNFQRFLKFPDDPKVSSELL
                     DLLQSLLCVQKERLKFEGLCCHPFFARTDWNNIRNSPPPFVPTLKSDDDTSNFDEPEK
                     NSWVSSSVCQLSPSGFSGEELPFVGFSYSKALGYLGRSESVVSSLDSPAKVSSMEKKL
                     LIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLAT
                     YITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLM
                     MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKPEVGEYS
                     KLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS
                     EGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEK
                     HREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKG
                     KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ
                     KFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELK
                     RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDE
                     IQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRS
                     EVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWR
                     SVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQ
                     ALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM
                     DLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTK
                     LIDFLQAKMDQPAKKKKVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA
                     HRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRR
                     LKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPAT
                     CGLPAEYATHFTEAFCRDKMNSPGLQSKEPGSSLHLEGWMKVPRNNKRGQQGWDRKYI
                     VLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILK
                     MESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLL
                     KLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHIPGIGAVFQIYIIKDLE
                     KLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDVSPNIFEAVKGCHLFAAGKIENSL
                     CICAAMPSKVVILRYNDNLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQ
                     YTLDEFLDKNDHSLAPAVFASSSNSFPVSIVQANSAGQREEYLLCFHEFGVFVDSYGR
                     RSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAYLEIPNPRYL
                     GPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEQHRVPSTSRSSPNKRGPPTYNEH
                     ITKRVASSPAPPEGPSHPREPSTPHRYRDREGRTELRRDKSPGRPLEREKSPGRMLST
                     RRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV"
     exon            812..953
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1129
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1231
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1374
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1465
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1669
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1823
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2007
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2113
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2257
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2377
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2548
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2599
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2653
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2794
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2920
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3016
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3133
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3243
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3418
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3616
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3670
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3868
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..4062
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            4063..4198
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            4199..4303
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..4444
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            4445..4552
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            4553..4670
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            4671..4835
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            4836..4973
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            4974..5154
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            5155..5246
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            5247..5351
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            5352..5521
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            5522..5602
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            5603..5738
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            5739..5878
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            5879..5971
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            5972..6080
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            6081..6209
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            6210..6290
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            6291..6369
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            6370..6549
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            6550..6859
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
     exon            6860..6898
                     /gene="Cit"
                     /gene_synonym="C030025P15Rik; Cit-k; CRIK; CRIK-SK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacctcaggg ccccttaaag aggacccatt cccctgtaga ccagtctctg tcccctgcaa
       61 gctttacctg cattcttgcc catggcgctt cccattttct gtgtgatctt atctccctca
      121 cttaatctct ctgttcctgt gtcttcattc tatgagctgg actgaggcct tgggtgggaa
      181 agtgggctct gtattctatt ccgtgcctaa cccagcgcct ccttcttgtg tctttctccc
      241 tctctagcct atctggtcag tcaggcaacc gatcttcctc aggatcattg atctctgtac
      301 cctccagggg cagtgaacct tcctttccct gggataatcc tcaaggctca ctgatcaaac
      361 cctttgggct tggttcacag gttaggtcta tgtagctacg cgacatcaga tatttgtgtt
      421 cgtcagggtt ttctagggga aaagagctgg tagaatggaa aagtggagat ttattaggct
      481 gcagtctgct agtccaccaa tggctggtag ttcttttgga aatgatttat ttccatccct
      541 tatgtgtatg agtacctttg gccttcctgt gtctgtgccc catgtgccgt ggaggctggt
      601 cgccacctcc tcatcctgat ctctttaggg agacacgact ctgccaagcc cttcctgcct
      661 tcaatgtcag tacccgcttg actttcccca gtgttccttc ggcgttggcg gagagatgtt
      721 gaagttcaag tatggtgtgc ggaacccgcc ggaggccagt gcctccgagc ccattgccag
      781 tcgggcctcc aggctaaatc tcttcttcca ggggaaaccg cccctcatga ctcaacagca
      841 gatgtctgct ctttcccggg aagggatgct agacgccctc ttcgctctct ttgaagagtg
      901 cagccaaccc gccctgatga agatgaagca cgtgagcagc tttgtccaga agtattccga
      961 caccatagcc gagttgcggg agctgcagcc gtcggcgaga gacttcgaag ttcgaagcct
     1021 tgtgggctgt ggtcacttcg ctgaagtgca ggtggttaga gagaaggcga ccggggacgt
     1081 ctatgccatg aaaatcatga agaagaaggc tttgctggcc caggaacagg tttcattttt
     1141 cgaggaggag aggaacatat tatctcggag cacgagtcct tggatccccc agttacagta
     1201 cgcctttcag gacaaaaata acctttacct ggtcatggaa tatcagcctg gaggggattt
     1261 gctgtcgctt ctgaacagat acgaggacca attagatgag agcatgatcc agttttacct
     1321 tgctgagctg attttggctg tccacagcgt gcaccagatg ggatatgtgc atcgagacat
     1381 caagcccgag aacatcctca tcgaccggac gggacacatc aagctggtgg attttggatc
     1441 agccgctaag atgaattcaa ataaggtgga tgccaaactc cccattggga ccccggatta
     1501 catggctccg gaagtgttga ccgtgatgaa cgaggaccga aggggcacat acggcttgga
     1561 ctgtgactgg tggtctgtcg gagttgttgc ttatgagatg gtttatggga agaccccatt
     1621 cacagaggga acctccgccc ggaccttcaa caacatcatg aacttccagc ggtttttgaa
     1681 gttcccagat gaccccaaag ttagcagtga gctccttgat ctgcttcaga gtctgctgtg
     1741 tgtccagaaa gagagactga agttcgaggg tctctgctgc caccctttct ttgccagaac
     1801 ggactggaac aacatccgta actctcctcc ccccttcgtc cccaccctca agtctgacga
     1861 tgacacctcc aattttgatg aaccagagaa gaattcgtgg gtttcatcct ctgtgtgcca
     1921 gctgagcccc tcgggcttct caggcgaaga gctgccgttt gtgggatttt cgtacagcaa
     1981 ggcactgggg tatcttggta gatctgagtc tgtcgtgtcg agtctggact cccctgccaa
     2041 ggttagctcc atggaaaaga aacttctcat caaaagcaaa gagctccaag actcccagga
     2101 caagtgtcac aagatggagc aggaaatgac ccggttacat cgcagagtgt cagaggtgga
     2161 ggctgtgctt agtcagaagg aggtggagct gaaggcctct gagactcaga gatccctcct
     2221 ggagcaggac cttgctacct acatcacaga atgcagtagc ttaaagcgaa gtttggagca
     2281 agcgcggatg gaggtgtccc aggaggatga caaagctctg cagcttctcc acgacatccg
     2341 agagcagagc cggaagctcc aggagatcaa ggagcaggag taccaggctc aggtggagga
     2401 gatgaggctg atgatgaatc agctggaaga agacctggtg tcagcccgca gacgcagcga
     2461 tctctacgag tctgagctga gggagtctcg gcttgccgcc gaggaattca agcggaaggc
     2521 aaacgaatgt cagcacaaac tgatgaaggc taaggaccaa gggaagcctg aagtgggaga
     2581 atattccaaa ctggagaaga tcaatgctga gcagcagctg aagatccagg agctccagga
     2641 gaagctggag aaggctgtaa aagccagcac agaggccacc gagctcctgc agaatatccg
     2701 ccaggcaaag gagcgagcag agcgggagct agagaagcta cacaaccggg aagactcctc
     2761 cgagggcatc aaaaagaagc tggtggaagc cgaggaacgc cgccactccc tggagaacaa
     2821 ggtaaagaga ctagagacca tggagcgtag agagaacaga ctgaaggatg acatccagac
     2881 aaagtccgaa cagatccagc agatggctga taaaattctg gagctggagg agaaacatcg
     2941 ggaggctcag gtctcagctc aacatctaga agtacacttg aaacagaaag aacagcacta
     3001 cgaggaaaag atcaaggtat tggacaatca gataaagaag gacctggccg acaaggagag
     3061 cctggagaac atgatgcaga gacacgagga ggaggcccac gagaagggca agatcctcag
     3121 cgagcagaag gcgatgatca acgcgatgga ttccaagatc cgatccctgg agcagaggat
     3181 cgtggagctg tcggaagcca acaagcttgc ggcaaacagc agtctcttca cccagaggaa
     3241 catgaaggcc caggaagaga tgatctcaga actcaggcag cagaaatttt acctggagac
     3301 gcaggccgga aagctggagg cccagaaccg aaagctggaa gagcaactgg agaagatcag
     3361 ccaccaagat cacagtgaca agagtcggct gctggagctg gaaacaaggc tgagggaggt
     3421 cagcctggag cacgaggagc agaagctgga gctgaagcgg cagctcacgg agctgcagct
     3481 gtccctgcag gagcgcgagt cccagctgac ggccctgcag gccgcccggg cagcgctgga
     3541 gagccagctc cgccaggcga agacagagct ggaggagaca accgcggaag cggaggagga
     3601 gatccaggcg ctcacggcac atcgagatga gatccagcgc aaattcgatg cccttcgcaa
     3661 cagctgcacg gtcatcaccg acctggagga gcagctgaac cagctcaccg aggacaacgc
     3721 cgagctcaac aaccaaaact tctacctgtc caaacaactc gatgaggctt ccggggccaa
     3781 tgacgagatt gtgcagctgc ggagtgaggt ggaccatctc cgccgtgaga tcacggagcg
     3841 ggagatgcag ctcaccagcc agaagcaaac gatggaggct ctgaagacga catgcaccat
     3901 gctggaggag caggtcctgg acctggaggc cctgaacgac gagctgctgg agaaggagcg
     3961 ccagtgggag gcctggcgga gcgtcctcgg cgacgagaag tcccagttcg agtgtcgagt
     4021 tcgagagcta cagaggatgc tggacaccga gaagcagagc agggctaggg ccgatcagcg
     4081 gatcaccgag tcgcgccagg tggtggagtt ggcggtgaag gaacacaagg ccgagattct
     4141 tgctctgcag caggctctca aggagcagaa gctcaaagcc gagagcctgt cggacaagct
     4201 caacgacctg gagaagaagc acgccatgct ggagatgaac gcccggagct tacagcagaa
     4261 actagagaca gagcgggagc tcaaacagag gcttctggag gagcaagcca aattgcagca
     4321 gcagatggac ctgcagaaga accacatctt cagactgacg caagggctgc aggaggcgct
     4381 ggaccgggcg gatctgctga agacagaaag gagcgacctg gagtaccagc tggaaaacat
     4441 tcaggttctc tactctcacg agaaagtgaa aatggaaggc acaatctctc agcaaaccaa
     4501 actcattgat ttcctgcaag ccaaaatgga ccagcctgct aaaaagaaaa aggttcctct
     4561 gcagtacaat gagctgaagc tagccctgga aaaggagaaa gcccgatgcg cggagctgga
     4621 ggaggccctt cagaagaccc gcatcgaact ccgctctgcg cgggaggaag ctgcccaccg
     4681 caaagccacg gaccacccgc acccgtctac gccagccact gcgaggcagc agatcgccat
     4741 gtctgccatt gtgcggtcgc ccgagcacca gcccagtgcc atgagcctgc ttgccccacc
     4801 atccagccgc agaaaggagt cgtcaactcc agaggaattc agccggcgtc tgaaagagcg
     4861 catgcaccac aacatccctc accggtttaa tgtgggcctg aacatgagag ccaccaagtg
     4921 cgccgtgtgt ctggatactg tgcactttgg acgccaggca tccaaatgcc tcgaatgtca
     4981 agtgatgtgt caccccaaat gctccacctg cttgcccgct acctgtggcc tgccagctga
     5041 atatgccaca cacttcactg aggccttctg ccgggacaaa atgaactccc cggggctcca
     5101 gagcaaggag cctggcagca gcttgcacct ggaagggtgg atgaaagtgc ccagaaataa
     5161 caaacgggga cagcaaggct gggacaggaa gtacattgtt ctggaggggt caaaagtcct
     5221 catctatgac aatgaagcca gagaagctgg acagaggccg gtggaagaat ttgagctgtg
     5281 ccttcctgac ggggacgtat ctattcatgg tgccgttggt gcttcagaac ttgcaaatac
     5341 cgccaaagca gatgtcccat acatcctgaa gatggagtct cacccacaca ccacctgctg
     5401 gcctgggaga accctctact tgctagcacc cagcttcccc gacaagcagc gctgggtcac
     5461 cgccttagaa tctgtcgtcg caggtgggag agtttctagg gaaaaggccg aagccgatgc
     5521 taaattactt ggaaactctc tgctgaaact ggagggcgat gaccggcttg acatgaactg
     5581 caccctgccc ttcagtgacc aggtagtgct ggtgggcacg gaggaaggcc tctacgccct
     5641 gaatgtcttg aaaaactcct taacccacat cccagggatt ggcgcagtct tccaaattta
     5701 catcatcaag gacctggaga agctgctcat gatagcaggg gaagagcggg ctctgtgcct
     5761 ggtggacgtg aagaaggtga agcagtccct ggcgcagtca cacctgcctg cccagcccga
     5821 cgtctccccc aacatattcg aagccgtcaa aggctgccac ttgttcgctg ctggcaagat
     5881 cgagaacagc ctgtgcatct gcgccgctat gccaagcaaa gtcgtcatcc tccgctacaa
     5941 tgacaacctc agcaagtact gcatccgcaa ggagatcgag acctcagagc cctgcagctg
     6001 tatccacttc accaactaca gcatcctcat tgggaccaac aaattctatg agatcgacat
     6061 gaagcagtac acgcttgacg agttcctgga caagaacgac cattccttgg cacctgctgt
     6121 gttcgcctcc tcgtccaaca gcttccctgt ctccattgtg caggcgaaca gcgccgggca
     6181 gcgagaagaa tacctgctgt gcttccacga atttggggtg ttcgtggatt cttacggaag
     6241 acgtagccgc acagatgatc tcaagtggag tcgcttacct ctggccttcg cctacagaga
     6301 accttatctg tttgtgactc acttcaactc cctggaagtc attgagatcc aggccagatc
     6361 ctcactgggg agccctgccc gagcatatct ggaaattcca aaccctcgct acctgggccc
     6421 cgcgatttcc tccggagcga tttacctggc ctcctcatac caggacaagt taagggtcat
     6481 atgctgcaaa ggaaacctcg tgaaggagtc aggcactgag cagcaccggg tgccctccac
     6541 ctcccgcagc agccccaaca agcgaggccc accaacatac aacgagcaca tcaccaaacg
     6601 cgtggcctcc agcccggcgc caccggaagg ccccagccac ccccgagagc caagcacacc
     6661 gcaccgctac cgagacagag agggtcggac agagctgcgc agggacaagt ctccaggccg
     6721 ccctctggag cgggagaagt ccccaggccg aatgctcagc actaggagag agcggtcccc
     6781 agggagactg tttgaagaca gcagcagggg ccggctgcct gcaggagcag tgaggacccc
     6841 actgtcccag gttaacaagg tctgggacca gtcttcagta taagtctcag ccagaaaa
//
