LOCUS       NP_034025                257 aa            linear   ROD 30-APR-2024
DEFINITION  cytokine-inducible SH2-containing protein isoform 1 [Mus musculus].
ACCESSION   NP_034025
VERSION     NP_034025.1
DBSOURCE    REFSEQ: accession NM_009895.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 257)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 257)
  AUTHORS   Maymand,S., Lakkavaram,A.L., Naser,W., Rasighaemi,P.,
            Dlugolenski,D., Liongue,C., Stambas,J., de Koning-Ward,T.F. and
            Ward,A.C.
  TITLE     Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in
            the Regulation of Erythropoiesis
  JOURNAL   Biomolecules 13 (10), 1510 (2023)
   PUBMED   37892192
  REMARK    GeneRIF: Role of Cytokine-Inducible SH2 Domain-Containing (CISH)
            Protein in the Regulation of Erythropoiesis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 257)
  AUTHORS   Naser,W., Maymand,S., Dlugolenski,D., Basheer,F. and Ward,A.C.
  TITLE     The Role of Cytokine-Inducible SH2 Domain-Containing Protein (CISH)
            in the Regulation of Basal and Cytokine-Mediated Myelopoiesis
  JOURNAL   Int J Mol Sci 24 (16), 12757 (2023)
   PUBMED   37628937
  REMARK    GeneRIF: The Role of Cytokine-Inducible SH2 Domain-Containing
            Protein (CISH) in the Regulation of Basal and Cytokine-Mediated
            Myelopoiesis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 257)
  AUTHORS   Xiao,F., Deng,J., Jiao,F., Hu,X., Jiang,H., Yuan,F., Chen,S.,
            Niu,Y., Jiang,X. and Guo,F.
  TITLE     Hepatic cytokine-inducible SH2-containing protein (CISH) regulates
            gluconeogenesis via cAMP-responsive element binding protein (CREB)
  JOURNAL   FASEB J 36 (10), e22541 (2022)
   PUBMED   36083102
  REMARK    GeneRIF: Hepatic cytokine-inducible SH2-containing protein (CISH)
            regulates gluconeogenesis via cAMP-responsive element binding
            protein (CREB).
REFERENCE   5  (residues 1 to 257)
  AUTHORS   Bernard,P.L., Delconte,R., Pastor,S., Laletin,V., Costa Da
            Silva,C., Goubard,A., Josselin,E., Castellano,R., Krug,A.,
            Vernerey,J., Devillier,R., Olive,D., Verhoeyen,E., Vivier,E.,
            Huntington,N.D., Nunes,J. and Guittard,G.
  TITLE     Targeting CISH enhances natural cytotoxicity receptor signaling and
            reduces NK cell exhaustion to improve solid tumor immunity
  JOURNAL   J Immunother Cancer 10 (5) (2022)
   PUBMED   35589278
  REMARK    GeneRIF: Targeting CISH enhances natural cytotoxicity receptor
            signaling and reduces NK cell exhaustion to improve solid tumor
            immunity.
REFERENCE   6  (residues 1 to 257)
  AUTHORS   Hilton,D.J., Richardson,R.T., Alexander,W.S., Viney,E.M.,
            Willson,T.A., Sprigg,N.S., Starr,R., Nicholson,S.E., Metcalf,D. and
            Nicola,N.A.
  TITLE     Twenty proteins containing a C-terminal SOCS box form five
            structural classes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 114-119 (1998)
   PUBMED   9419338
REFERENCE   7  (residues 1 to 257)
  AUTHORS   Masuhara,M., Sakamoto,H., Matsumoto,A., Suzuki,R., Yasukawa,H.,
            Mitsui,K., Wakioka,T., Tanimura,S., Sasaki,A., Misawa,H.,
            Yokouchi,M., Ohtsubo,M. and Yoshimura,A.
  TITLE     Cloning and characterization of novel CIS family genes
  JOURNAL   Biochem Biophys Res Commun 239 (2), 439-446 (1997)
   PUBMED   9344848
REFERENCE   8  (residues 1 to 257)
  AUTHORS   Matsumoto,A., Masuhara,M., Mitsui,K., Yokouchi,M., Ohtsubo,M.,
            Misawa,H., Miyajima,A. and Yoshimura,A.
  TITLE     CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5
            pathway and modulates STAT5 activation
  JOURNAL   Blood 89 (9), 3148-3154 (1997)
   PUBMED   9129017
REFERENCE   9  (residues 1 to 257)
  AUTHORS   Uchida,K., Yoshimura,A., Inazawa,J., Yanagisawa,K., Osada,H.,
            Masuda,A., Saito,T., Takahashi,T., Miyajima,A. and Takahashi,T.
  TITLE     Molecular cloning of CISH, chromosome assignment to 3p21.3, and
            analysis of expression in fetal and adult tissues
  JOURNAL   Cytogenet Cell Genet 78 (3-4), 209-212 (1997)
   PUBMED   9465889
REFERENCE   10 (residues 1 to 257)
  AUTHORS   Yoshimura,A., Ohkubo,T., Kiguchi,T., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Hara,T. and Miyajima,A.
  TITLE     A novel cytokine-inducible gene CIS encodes an SH2-containing
            protein that binds to tyrosine-phosphorylated interleukin 3 and
            erythropoietin receptors
  JOURNAL   EMBO J 14 (12), 2816-2826 (1995)
   PUBMED   7796808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672070.12, AK077338.1 and AK086040.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077338.1, AK170554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..257
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.99 cM"
     Protein         1..257
                     /product="cytokine-inducible SH2-containing protein
                     isoform 1"
                     /note="suppressor of cytokine signaling;
                     cytokine-inducible SH2 protein"
                     /calculated_mol_wt=28406
     Region          77..164
                     /region_name="SH2_CIS"
                     /note="Src homology 2 (SH2) domain found in
                     cytokine-inducible SH2-containing protein (CIS); cd10718"
                     /db_xref="CDD:198285"
     Site            order(89,107,109,117,130)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198285"
     Site            order(140,142,163)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198285"
     Region          170..192
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62225.1)"
     Region          217..257
                     /region_name="SOCS_CIS1"
                     /note="SOCS (suppressors of cytokine signaling) box of CIS
                     (cytokine-inducible SH2 protein) 1-like proteins. Together
                     with the SOCS proteins, the CIS/SOCS family of proteins is
                     characterized by the presence of a C-terminal SOCS box and
                     a central SH2 domain; cd03734"
                     /db_xref="CDD:239703"
     Site            order(218..223,229,234,240,245)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239703"
     CDS             1..257
                     /gene="Cish"
                     /gene_synonym="Cis; CIS-1; CIS1; F17; F23; SOCS"
                     /coded_by="NM_009895.4:357..1130"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS40761.1"
                     /db_xref="GeneID:12700"
                     /db_xref="MGI:MGI:103159"
ORIGIN      
        1 mvlcvqgscp llaveqigrr plwaqslelp gpamqplptg afpeevteet pvqaenepkv
       61 ldpegdllci aktfsylres gwywgsitas earqhlqkmp egtflvrdst hpsylftlsv
      121 kttrgptnvr ieyadssfrl dsnclsrpri lafpdvvslv qhyvascaad trsdspdpap
      181 tpalpmskqd apsdsvlpip vatavhlklv qpfvrrssar slqhlcrlvi nrlvadvdcl
      241 plprrmadyl rqypfql
//
