LOCUS       NM_001085500             761 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus CDGSH iron sulfur domain 3 (Cisd3), transcript variant
            2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001085500 XM_126589 XM_895143 XM_914586 XM_923326
VERSION     NM_001085500.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 761)
  AUTHORS   Jiang,H., Fang,Y., Wang,Y., Li,T., Lin,H., Lin,J., Pan,T., Liu,Q.,
            Lv,J., Chen,D. and Chen,Y.
  TITLE     FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice
            via activation of CISD3
  JOURNAL   Int Immunopharmacol 116, 109762 (2023)
   PUBMED   36702076
  REMARK    GeneRIF: FGF4 improves hepatocytes ferroptosis in autoimmune
            hepatitis mice via activation of CISD3.
REFERENCE   2  (bases 1 to 761)
  AUTHORS   Wiley,S.E., Murphy,A.N., Ross,S.A., van der Geer,P. and Dixon,J.E.
  TITLE     MitoNEET is an iron-containing outer mitochondrial membrane protein
            that regulates oxidative capacity
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5318-5323 (2007)
   PUBMED   17376863
REFERENCE   3  (bases 1 to 761)
  AUTHORS   Kleiter,N., Artner,I., Gmachl,N., Ghaffari-Tabrizi,N. and
            Kratochwil,K.
  TITLE     Mutagenic transgene insertion into a region of high gene density
            and multiple linkage disruptions on mouse chromosome 11
  JOURNAL   Cytogenet Genome Res 97 (1-2), 100-105 (2002)
   PUBMED   12438746
REFERENCE   4  (bases 1 to 761)
  AUTHORS   Tetsu,O., Kanno,R., Isono,K., Taniguchi,M. and Kanno,M.
  TITLE     Cloning and characterization of two transcripts generated from the
            mel-13 gene positioned adjacent to the mammalian Polycomb
            group-related gene mel-18
  JOURNAL   Biochim Biophys Acta 1305 (3), 109-112 (1996)
   PUBMED   8597592
REFERENCE   5  (bases 1 to 761)
  AUTHORS   Caton,A.J., Swartzentruber,J.R., Kuhl,A.L., Carding,S.R. and
            Stark,S.E.
  TITLE     Activation and negative selection of functionally distinct subsets
            of antibody-secreting cells by influenza hemagglutinin as a viral
            and a neo-self antigen
  JOURNAL   J Exp Med 183 (1), 13-26 (1996)
   PUBMED   8551216
REFERENCE   6  (bases 1 to 761)
  AUTHORS   Haupt,Y., Barri,G. and Adams,J.M.
  TITLE     Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral
            insertion locus
  JOURNAL   Mol Biol Rep 17 (1), 17-20 (1992)
   PUBMED   1287475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA987107.1, BC056217.1 and AI414532.1.
            
            On Jun 8, 2018 this sequence version replaced NM_001085500.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA987107.1, AV000569.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AA987107.1         1-40
            41-757              BC056217.1         17-733
            758-761             AI414532.1         9-12                c
FEATURES             Location/Qualifiers
     source          1..761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.06 cM"
     gene            1..761
                     /gene="Cisd3"
                     /gene_synonym="Mel-13; Mel13"
                     /note="CDGSH iron sulfur domain 3"
                     /db_xref="GeneID:217149"
                     /db_xref="MGI:MGI:101788"
     exon            1..283
                     /gene="Cisd3"
                     /gene_synonym="Mel-13; Mel13"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..583
                     /gene="Cisd3"
                     /gene_synonym="Mel-13; Mel13"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; melanoma nuclear protein 13; CDGSH iron-sulfur
                     domain-containing protein 3, mitochondrial"
                     /codon_start=1
                     /product="CDGSH iron-sulfur domain-containing protein 3,
                     mitochondrial isoform 2 precursor"
                     /protein_id="NP_001078969.2"
                     /db_xref="CCDS:CCDS48896.1"
                     /db_xref="GeneID:217149"
                     /db_xref="MGI:MGI:101788"
                     /translation="MGFRRLSFPTDFIFLFPNHICLPALSKPYQRREISSWLARWFPK
                     DPAKPVVAQKTPIRLELVAGKTYRWCVCGRSKNQPFCDGSHFFQRTGLSPLKFKAQET
                     RTVALCTCKATQRPPYCDGTHKSEQVQKAEVGSPL"
     exon            284..403
                     /gene="Cisd3"
                     /gene_synonym="Mel-13; Mel13"
                     /inference="alignment:Splign:2.1.0"
     exon            404..761
                     /gene="Cisd3"
                     /gene_synonym="Mel-13; Mel13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      732..737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cisd3"
                     /gene_synonym="Mel-13; Mel13"
                     /note="hexamer: AATAAA"
     polyA_site      761
                     /gene="Cisd3"
                     /gene_synonym="Mel-13; Mel13"
                     /note="major polyA site"
ORIGIN      
        1 cccctcggcc gcgcgtcccc acagggcagt ctttccggag ggagctcccg agtagatgcc
       61 aagatccgca gcgcctcttc tttgaacctt ttcccaacca ttaaaaaaaa aaaaaaaaaa
      121 aaaaaaaaag gtcccacgct cctttgactt gtggtctttc ccttccctga tgggcttccg
      181 gcgtctctcc ttccccactg attttatttt tctgtttcca aatcatatct gcctgcctgc
      241 cttgtcgaag ccgtatcaga ggcgggaaat ctcttcttgg ctggcccgat ggttccccaa
      301 agacccagcc aagccagtgg tggcacagaa gacacccatc agattggagc tggttgccgg
      361 gaaaacctac aggtggtgtg tatgtggccg aagcaagaat cagcccttct gtgatggctc
      421 ccacttcttc cagcgtactg gcctttctcc actcaagttc aaggcccaag agacacgcac
      481 agtggcccta tgtacctgca aggccactca gcggccccct tactgtgacg gtacccacaa
      541 gagtgagcag gtacagaaag cagaagtagg ttccccactc tgagggggta ctgtgactcc
      601 aggcagtaat gctgagccac acatggaagg gaacctccaa ggaccccatc ttgttagcaa
      661 ttgtaccctg aaaaacctgt attctcctgt tgggcagctg agagccaggt ccagcatccg
      721 gtaaagctgt caataaacac tgaggcctgc cctctaacta a
//
