LOCUS       NM_025902               2885 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus CDGSH iron sulfur domain 2 (Cisd2), mRNA.
ACCESSION   NM_025902 NM_026903
VERSION     NM_025902.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2885)
  AUTHORS   Choi,U.Y., Choi,Y.J., Lee,S.A. and Yoo,J.S.
  TITLE     Cisd2 deficiency impairs neutrophil function by regulating calcium
            homeostasis via Calnexin and SERCA
  JOURNAL   BMB Rep 57 (5), 256-261 (2024)
   PUBMED   38627949
  REMARK    GeneRIF: Cisd2 deficiency impairs neutrophil function by regulating
            calcium homeostasis via Calnexin and SERCA.
REFERENCE   2  (bases 1 to 2885)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2885)
  AUTHORS   Yeh,C.H., Shen,Z.Q., Lin,C.C., Lu,C.K. and Tsai,T.F.
  TITLE     Rejuvenation: Turning Back Time by Enhancing CISD2
  JOURNAL   Int J Mol Sci 23 (22), 14014 (2022)
   PUBMED   36430496
  REMARK    GeneRIF: Rejuvenation: Turning Back Time by Enhancing CISD2.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2885)
  AUTHORS   Yeh,C.H., Shen,Z.Q., Wang,T.W., Kao,C.H., Teng,Y.C., Yeh,T.K.,
            Lu,C.K. and Tsai,T.F.
  TITLE     Hesperetin promotes longevity and delays aging via activation of
            Cisd2 in naturally aged mice
  JOURNAL   J Biomed Sci 29 (1), 53 (2022)
   PUBMED   35871686
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2885)
  AUTHORS   Karmi,O., Rowland,L., King,S.D., Manrique-Acevedo,C.,
            Cabantchik,I.Z., Nechushtai,R. and Mittler,R.
  TITLE     The [2Fe-2S] protein CISD2 plays a key role in preventing iron
            accumulation in cardiomyocytes
  JOURNAL   FEBS Lett 596 (6), 747-761 (2022)
   PUBMED   34997963
  REMARK    GeneRIF: The [2Fe-2S] protein CISD2 plays a key role in preventing
            iron accumulation in cardiomyocytes.
REFERENCE   6  (bases 1 to 2885)
  AUTHORS   Wu,C.Y., Chen,Y.F., Wang,C.H., Kao,C.H., Zhuang,H.W., Chen,C.C.,
            Chen,L.K., Kirby,R., Wei,Y.H., Tsai,S.F. and Tsai,T.F.
  TITLE     A persistent level of Cisd2 extends healthy lifespan and delays
            aging in mice
  JOURNAL   Hum Mol Genet 21 (18), 3956-3968 (2012)
   PUBMED   22661501
REFERENCE   7  (bases 1 to 2885)
  AUTHORS   Chang,N.C., Nguyen,M., Bourdon,J., Risse,P.A., Martin,J.,
            Danialou,G., Rizzuto,R., Petrof,B.J. and Shore,G.C.
  TITLE     Bcl-2-associated autophagy regulator Naf-1 required for maintenance
            of skeletal muscle
  JOURNAL   Hum Mol Genet 21 (10), 2277-2287 (2012)
   PUBMED   22343142
  REMARK    GeneRIF: NAF-1, a BCL-2-associated autophagy regulator, is required
            for homeostatic maintenance of skeletal muscle
REFERENCE   8  (bases 1 to 2885)
  AUTHORS   Chen,Y.F., Wu,C.Y., Kirby,R., Kao,C.H. and Tsai,T.F.
  TITLE     A role for the CISD2 gene in lifespan control and human disease
  JOURNAL   Ann N Y Acad Sci 1201, 58-64 (2010)
   PUBMED   20649540
  REMARK    GeneRIF: CISD2 has a role in lifespan control and disease [review]
            Review article
REFERENCE   9  (bases 1 to 2885)
  AUTHORS   Chen,Y.F., Kao,C.H., Chen,Y.T., Wang,C.H., Wu,C.Y., Tsai,C.Y.,
            Liu,F.C., Yang,C.W., Wei,Y.H., Hsu,M.T., Tsai,S.F. and Tsai,T.F.
  TITLE     Cisd2 deficiency drives premature aging and causes
            mitochondria-mediated defects in mice
  JOURNAL   Genes Dev 23 (10), 1183-1194 (2009)
   PUBMED   19451219
  REMARK    GeneRIF: Cisd2 deficiency in mice causes mitochondrial breakdown
            and dysfunction accompanied by autophagic cell death, and these
            precede nerve and muscle degeneration; together, they lead to a
            panel of phenotypic features suggestive of premature aging
REFERENCE   10 (bases 1 to 2885)
  AUTHORS   Wiley,S.E., Murphy,A.N., Ross,S.A., van der Geer,P. and Dixon,J.E.
  TITLE     MitoNEET is an iron-containing outer mitochondrial membrane protein
            that regulates oxidative capacity
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5318-5323 (2007)
   PUBMED   17376863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156618.5 and BE944243.1.
            
            On Nov 13, 2008 this sequence version replaced NM_025902.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058279.1, AM162549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AC156618.5         114896-115070       c
            176-390             AC156618.5         102648-102862       c
            391-2640            AC156618.5         98278-100527        c
            2641-2885           BE944243.1         1-245               c
FEATURES             Location/Qualifiers
     source          1..2885
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 62.55 cM"
     gene            1..2885
                     /gene="Cisd2"
                     /gene_synonym="1500009M05Rik; 1500026J14Rik;
                     1500031D15Rik; B630006A20Rik; Miner1; Naf-1; Noxp70; Zcd2"
                     /note="CDGSH iron sulfur domain 2"
                     /db_xref="GeneID:67006"
                     /db_xref="MGI:MGI:1914256"
     exon            1..175
                     /gene="Cisd2"
                     /gene_synonym="1500009M05Rik; 1500026J14Rik;
                     1500031D15Rik; B630006A20Rik; Miner1; Naf-1; Noxp70; Zcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            176..390
                     /gene="Cisd2"
                     /gene_synonym="1500009M05Rik; 1500026J14Rik;
                     1500031D15Rik; B630006A20Rik; Miner1; Naf-1; Noxp70; Zcd2"
                     /inference="alignment:Splign:2.1.0"
     exon            391..2869
                     /gene="Cisd2"
                     /gene_synonym="1500009M05Rik; 1500026J14Rik;
                     1500031D15Rik; B630006A20Rik; Miner1; Naf-1; Noxp70; Zcd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      798..803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cisd2"
                     /gene_synonym="1500009M05Rik; 1500026J14Rik;
                     1500031D15Rik; B630006A20Rik; Miner1; Naf-1; Noxp70; Zcd2"
                     /note="hexamer: AATACA"
     polyA_site      820
                     /gene="Cisd2"
                     /gene_synonym="1500009M05Rik; 1500026J14Rik;
                     1500031D15Rik; B630006A20Rik; Miner1; Naf-1; Noxp70; Zcd2"
                     /note="major polyA site"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cisd2"
                     /gene_synonym="1500009M05Rik; 1500026J14Rik;
                     1500031D15Rik; B630006A20Rik; Miner1; Naf-1; Noxp70; Zcd2"
                     /note="hexamer: ATTAAA"
     polyA_site      2867
                     /gene="Cisd2"
                     /gene_synonym="1500009M05Rik; 1500026J14Rik;
                     1500031D15Rik; B630006A20Rik; Miner1; Naf-1; Noxp70; Zcd2"
                     /note="major polyA site"
ORIGIN      
        1 ccgcgagccc gccggccgct tccgctctca cgcaagcgca gcagccgggc agcggacgcc
       61 gccggcggca ggatggtcct ggacagcgtg gcccgcatcg tgaaggtgca gctgcccgcc
      121 tacctcaagc agctcccggt ccccgacagc atcaccgggt tcgcccgcct cacagtttca
      181 gactggctcc gcctactgcc cttcctcggg gtacttgcgc ttctgggcta cctcgcagtg
      241 cgcccattct tcccaaagaa gaagcaacag aaggatagct tgatcaatct taagatacaa
      301 aaggaaaatc ccaaggtggt gaatgagata aacattgaag atctgtgtct caccaaagca
      361 gcttattgta ggtgctggcg gtccaagacg tttcctgcct gtgatggatc ccataataag
      421 cataatgaat tgacaggcga taacgtgggt cctctcatcc tgaagaagaa agaagtatag
      481 cagtggccat ttgagatgaa actctgacag agtgtttcca tgtgtgttgt gcatagaaaa
      541 gtctttggaa gttttaactc tcagtactgg ttgaataatt atttctgcca gttattttct
      601 tgctacacta ctgcttatat ttggtacttt atatagtcag tcatttctat agaaatcaga
      661 tggtcaagtc tcattctgaa attaagttta atgtgtcttt caacaataaa gtcagcactt
      721 cagattttaa ttaattggga atttaaagtt tgactgtggg ccaaaagtta tttctttgta
      781 tatcagtatt tcaacagaat acatagtttt aaaaaaatta tcctttgttc tgttaaatgt
      841 atctttatat tgtcttgttt tgctcatttg aagtcatttg ccattttttt ggccttttgt
      901 ggaactctgc tgcttttaga agaattatga aaaataattg ccatcaacaa tattttgagg
      961 cagtaaaacc ccttgtttta tagagacttt catcttatta ccatgattat cccaatttct
     1021 aaaaagtaaa tcagatataa aaatttccaa ttagaaacaa ttattttcat cataaaaatg
     1081 gttcacctta caaaagcctt gttgtgtgtg tgagggtgtg agggtgtata tgtgtgtgtg
     1141 agtatgtgtg tgtgtgtgag agagagagag tatgtgtgtg tgtgtgtggt gcttaacttg
     1201 gagactgctg ggtggcaaga gcactcatga actagagttt gaagatcagt tagatattaa
     1261 ataactgaat ttgcattaaa atgatgcata gttcattgct caaaattatg ttttatcttt
     1321 tctgttgtaa attatagaga aacggcaaca ggatattaag ttcttgtatt ctaatggatt
     1381 gaatttgtac atactgagag aaaatatttt gatctttttt aaaagagata actcttgttg
     1441 tattttttta acgtcacaaa atatagatca aacacttgtg ggcataatga cagaaaaaaa
     1501 gtctggaagg accaaggact atgactatga cacagcatgg tccacttgca cggataagga
     1561 cgaggactta gcaaaggttg ctgcttttac tctctatttc tcttcccccc cccccccccc
     1621 cgcaacaaac ctttatatgc tttgctttta attgatcttt tcttaattga ggctttgaat
     1681 agaatcgtca tagcacagtt aagctcttta ggcccgagtg ataagacctg attgattgtc
     1741 taaggatagg gtggagccag cagggcagga agcatcatca caagtggatt agacagaggc
     1801 tgttcgagga gaggaagcca cacacgtgtt acagcaaata ctgaaaaaac caaaacacca
     1861 acagtccttt cacgtctggc tcctaagtga aatgacacgt caagggcaag gtaggctaaa
     1921 taaagaaggt gggctttaag tatgtacttc agttctgccg tgttccccca gaagcagggt
     1981 aaaagcaaga cagttaaatc tggggacact cacctgtctg cctgctggag tagatggacc
     2041 atctctagga tttcttcttt attaaatgag cacacagtat gcctggtacc acatgaattc
     2101 tgtttgttct ctttctttag ctatcctatc tagcagtttg agaaagacta gtgatggcaa
     2161 gctaaaaagg aaaatgatta ccagtcaact tgtcacaaaa ttaagttaca ctgacacagt
     2221 ttgtagtctt agtttgtgta ttgtaaagtg taaataatgt taaaacagac agacatgttt
     2281 tagaaagact tatttcatgt gtatgagtgc ctgtctgcct gtctgtgtgt ctgtctgtgc
     2341 accatgcaca tgcctggtgc ccgaggaagc cagagagaat gttggatccc tggaactgga
     2401 attaacagat agttgtgagc taccatgtga atactgggaa ctgaacctgg tctcctacaa
     2461 gaacatccag tgctattaac aactgagcca tctctctaac cctataaaac ttttaataaa
     2521 agaggttatg attggtttga agtagcaact gaaatgtgga aggaagtatt ccgaaaggca
     2581 gaagtggtac aaagccgtgt ctgctcactc cactcatggt actgaggatg gaacccaggg
     2641 cctcccacac cctggcaaga gcccttcaca ctgagctccg tcttgagttg tatcttttca
     2701 atagcataaa ccattgagac aaaatacaag aaagttttcc atataggttt actggaattt
     2761 ttgaattatt tgtgatttta gcctactatc agaagtctct ttagttttat tttacaagtc
     2821 tcatgtaaga gctattctta aactattaaa gatacaacct actcgttcaa aaaaaaaaaa
     2881 aaaaa
//
