LOCUS       NM_001370892            3891 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus ciliated left-right organizer metallopeptidase
            (Cirop), mRNA.
ACCESSION   NM_001370892 XM_006519864
VERSION     NM_001370892.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3891)
  AUTHORS   Szenker-Ravi,E., Ott,T., Khatoo,M., Moreau de Bellaing,A.,
            Goh,W.X., Chong,Y.L., Beckers,A., Kannesan,D., Louvel,G.,
            Anujan,P., Ravi,V., Bonnard,C., Moutton,S., Schoen,P., Fradin,M.,
            Colin,E., Megarbane,A., Daou,L., Chehab,G., Di Filippo,S.,
            Rooryck,C., Deleuze,J.F., Boland,A., Arribard,N., Eker,R.,
            Tohari,S., Ng,A.Y., Rio,M., Lim,C.T., Eisenhaber,B., Eisenhaber,F.,
            Venkatesh,B., Amiel,J., Crollius,H.R., Gordon,C.T., Gossler,A.,
            Roy,S., Attie-Bitach,T., Blum,M., Bouvagnet,P. and Reversade,B.
  TITLE     Discovery of a genetic module essential for assigning left-right
            asymmetry in humans and ancestral vertebrates
  JOURNAL   Nat Genet 54 (1), 62-72 (2022)
   PUBMED   34903892
  REMARK    Erratum:[Nat Genet. 2022 Jun;54(6):906. doi:
            10.1038/s41588-022-01053-8.. PMID: 35304595]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009512.6.
            
            On Mar 11, 2022 this sequence version replaced NM_001370892.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               CT009512.6         82776-83082
            308-401             CT009512.6         83199-83292
            402-453             CT009512.6         84150-84201
            454-597             CT009512.6         84622-84765
            598-723             CT009512.6         85064-85189
            724-808             CT009512.6         85369-85453
            809-954             CT009512.6         85585-85730
            955-1126            CT009512.6         85820-85991
            1127-1196           CT009512.6         86311-86380
            1197-1293           CT009512.6         86462-86558
            1294-1557           CT009512.6         86647-86910
            1558-1787           CT009512.6         87367-87596
            1788-1967           CT009512.6         87734-87913
            1968-3891           CT009512.6         88640-90563
FEATURES             Location/Qualifiers
     source          1..3891
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..3891
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /note="ciliated left-right organizer metallopeptidase"
                     /db_xref="GeneID:101056084"
                     /db_xref="MGI:MGI:5588935"
     exon            1..307
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2118
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /note="leishmanolysin like peptidase 2"
                     /codon_start=1
                     /product="ciliated left-right organizer metallopeptidase
                     precursor"
                     /protein_id="NP_001357821.1"
                     /db_xref="GeneID:101056084"
                     /db_xref="MGI:MGI:5588935"
                     /translation="MKMWRLLLLGVATGRCLHEETQKSVRLLRPPFSQMPTHFRSSIL
                     PLPGSHEPRPLRIQTYYSRAPVPGEAWDPEGETRALAAVTETTRRIQGILAVLPVQGP
                     LLLSRDPAQYCHAVWGDPDTPNYQRCSILNPGYKGESCLGAKIPDAHLRGYSLWPEHG
                     LPQLIQPDGPGVQNADFLLYVQVAHTSKCHKEPSVIAYAACCQLDSEDRPLAGTIVYC
                     GQHLRSPTLSHDDIVMATLHELLHALGFSGQLFKMWRDCPSGLSARENCSTRKQVTRR
                     DERGQLLLTTPAVSHSLAKHLGVPGTLQGAPLEEKGSLSSHWESRLLQGSIMTATFHG
                     AQHTRLDPVTLAAFEDSGWYQVNHSAAEELLWGQGSGPDFGLVSTCRTGSSDFFCTGS
                     GLGCHYLHLDKGSCDSDSTLEGCRIYKPLAKGSECWKEENGLHTRAENPHGEIYHRHS
                     RCFLANLTSQVLSKHTSQPSTAPDLEDPTGCCYLHQCTHKGAYEVQVEGSPWIPCLPG
                     KAVQIPGYDGLLYCPQGRLCLRDEGARAATSQPMSFTTQDLLSQLSLRLTGTPGHSLG
                     KGQREELAEVVLQALVMRAGTSRCYFHSPTITTSLVFTVSMWKSPGCHGPSVAMLHRT
                     LTLTLQMKPLQVHHGEAIFTTDYSKLWTSLDHNPSMTELLLSTGFCLLVLILVGALGT
                     LAYQKRAMLQVAPSTT"
     exon            308..401
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..453
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..597
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..723
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..808
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..954
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1126
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1196
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1293
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1557
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1787
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1967
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..3891
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /note="major polyA site"
     regulatory      3862..3867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /note="hexamer: AATAAA"
     polyA_site      3891
                     /gene="Cirop"
                     /gene_synonym="Gm29776; Lmln2"
                     /note="major polyA site"
ORIGIN      
        1 agaaggctga ggagacacgg aatgaagatg tggcggctac tcctccttgg ggtggccaca
       61 ggcagatgtc tgcatgagga gacccagaag tctgtgcgcc ttcttaggcc tcctttctcc
      121 caaatgccca cccacttccg ctcctcaatc cttcctctcc ctggctccca tgagcctcga
      181 ccccttagaa tccaaaccta ctactcaaga gctcctgtgc ccggtgaggc ttgggatcct
      241 gagggggaaa cgcgagccct ggctgccgtg acagagacca ctcgaaggat tcagggcatc
      301 ctagcagttc tcccggtaca aggacctctg ctcctgagtc gagaccctgc acaatactgc
      361 cacgccgtct ggggagaccc agatacccct aactaccaaa ggtgcagcat cttgaaccca
      421 gggtacaaag gagagagttg ccttggagca aagattccag atgcccacct gcgtggttat
      481 tccttgtggc cagagcatgg tctgccccag ctaatccaac cagatggccc cggagtccaa
      541 aatgctgact ttctcctgta tgtgcaggtt gcccacactt ccaagtgtca caaagagccc
      601 tctgtcatag cctatgctgc ctgctgccag ctggactcag aagacaggcc cctcgctggt
      661 accatcgtct actgtggcca acatctcaga agcccaacac tcagccatga tgatattgtc
      721 atggctacac tacatgaact gctgcatgcc ctgggttttt ctggacagct cttcaagatg
      781 tggcgagact gtccatcagg actcagtgct agagagaatt gttctacgag gaaacaggtg
      841 acccggcgag atgaacgggg acaactgctt ctcaccaccc cagctgtcag ccacagccta
      901 gccaaacact tgggggtgcc tgggactttg cagggagctc ctttggaaga aaagggctct
      961 ttgtcttcac actgggaatc cagattactt cagggatcta taatgactgc taccttccat
     1021 ggtgcccagc acactcgact tgacccagta acccttgctg cttttgaaga ttcaggctgg
     1081 taccaggtca accacagtgc cgcagaggaa cttttgtggg gccagggctc tggtccagac
     1141 tttggcctgg tgagcacatg caggactgga tcctcagatt tcttctgcac cggcagtggc
     1201 ctgggctgtc actacttgca cctggacaag ggaagctgtg actctgactc aacactagaa
     1261 ggctgccgca tatacaaacc cttagccaaa gggagtgaat gctggaagga agagaatgga
     1321 ctccacacca gagcggagaa cccccacggg gagatctacc ataggcacag tcgctgcttc
     1381 cttgccaacc ttacctccca agtgctctcc aaacacacca gccaaccctc aacagctccg
     1441 gatcttgaag atcccacagg ctgttgctat ttacatcagt gcacccacaa gggagcctac
     1501 gaggtgcaag tggagggatc accgtggatc ccctgccttc cggggaaggc tgttcagatc
     1561 cctggctacg acggtcttct ctactgtccc caaggccggc tgtgtctgag ggatgaaggt
     1621 gccagggctg ccacttctca accgatgagc tttacaaccc aagacctgct atcccagctg
     1681 tctctaaggt taacggggac cccaggccac tctctgggga aaggacagag agaagagctt
     1741 gctgaggtcg ttctgcaggc cctggtgatg agagctggca ctagcaggtg ttatttccac
     1801 agcccgacca tcaccaccag cttggtgttc actgtgagta tgtggaagtc tcctggctgc
     1861 catggacctt ccgttgctat gctacacagg accctgaccc tgaccctaca gatgaagccc
     1921 ctccaagtac accatggaga agccatcttt accacagact acagcaagct gtggacttcc
     1981 ttggaccata acccctctat gactgagcta cttctgtcca ctggattctg ccttctggtg
     2041 ttaattctgg tgggtgcact gggaactttg gcttaccaga aacgggctat gctccaagtg
     2101 gcaccatcta ccacttaacc atcacaagag ctacatggca caagagatca gattaaaata
     2161 aagcagtcat gatgccactc tgccggatgc cagacagcaa gagggctcac tgggtaaagt
     2221 ccttcacctg tgcggattcc caaggagcca cagtatggag aaaaccagct ctgcaagctg
     2281 tcctgacttg tacgtgtgcg ccgtggctca cgggtactca tacactgatg cacatgcagc
     2341 gccatggctc acgggtactc atacactgat gcacatgcag cgccgtggct cacgggcact
     2401 cacacataga tgcacatgca gcgccgtggc tcacgggcac tcatacactg atgcacatgc
     2461 agcgccgtgg ctcacgggca ctcacacata gatgcacatg cagcgccgtg gctcacgggc
     2521 actcatacac tgatgcacat gcagcgccgt ggctcacggg cactcataca ctgatgcaca
     2581 tgcagcgccg tggctcacgg gcactcacac atagatgcac atgcagcgcc gtggctcacg
     2641 ggcactcaca catagatgca catgcagcgc cgtggctcac gggcactcat acactgatgc
     2701 acatgcagcg ccgtggctca cgggcactca cacatagatg cacatgcagc gccgtggctc
     2761 acgggcactc atacactgat gcacatgcag cgccgtggct cacgggcact cacacataga
     2821 tgcacatgca gcgccgtggc tcacgggcac tcatacactg atgcacatgc agcgccgtgg
     2881 ctcacgggca ctcatacact gatgcacatg cagcgccgtg gctcacgggc actcacacat
     2941 agatgcacat gcagcgccgt ggctcacagg cactcataca ctgatgcaca tgcagcgccg
     3001 tggctcacgg gcactcacac atagatgcac atgcagcgcc gtggctcacg ggcactcata
     3061 cactgatgca catgcagcgc cgtggctcac gggcactcat acactgatgc acatgcagcg
     3121 ccgtggctca cgggcactca cacatagatg cacatgcagc gccgtggctc acgggcactc
     3181 atacactgat gcacatgcag cgccgtggct cacgggcact catacactga tgcacatgca
     3241 gtgccgtggc tcacgggcac tcacacatag atgcacatgc agcgccgtgg ctcacgggca
     3301 ctcatacact gatgcacatg cagtgccgtg gctcacgggc actcatacac tgatgcacat
     3361 gcagcgccgt ggctcacggg cactcacaca tagatgcaca tgcagcgccg tggctcacgg
     3421 gcactcatac actgatgcac atgcagcgcc gtggctcacg ggcactcaca catagatgca
     3481 catgcagcgc cgtggctcac gggcactcac acatagatgc acatgcagcg ccgtggctca
     3541 cgggcactca tacactgatg cacatgcagc gccgtggctc acgggcactc acacatagat
     3601 gcacatgcag cgccgtggct cacgggcact cacacataga tgcacatgca gcgccgtggc
     3661 tcacgggcac tcacacatag atgcacatgc acacggtcag agttgctctt atagagaccc
     3721 aagcaccaac actggtggct cacaaccttc cataactgta gttccagggt atccgacatc
     3781 ctagtctgac ctctgtgggc actagcatgt acatggtaca tacacatggc atgcaggccc
     3841 tcacacacac atgtagatat aaataaaaag acatctggat ggaaaaccct a
//
