LOCUS       NM_007705               1275 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus cold inducible RNA binding protein (Cirbp), transcript
            variant 1, mRNA.
ACCESSION   NM_007705 XM_986308
VERSION     NM_007705.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1275)
  AUTHORS   Zhou,M., Aziz,M., Li,J., Jha,A., Ma,G., Murao,A. and Wang,P.
  TITLE     BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance
  JOURNAL   Front Immunol 15, 1426682 (2024)
   PUBMED   38938563
  REMARK    GeneRIF: BMAL2 promotes eCIRP-induced macrophage endotoxin
            tolerance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1275)
  AUTHORS   Shimizu,J., Murao,A., Lee,Y., Aziz,M. and Wang,P.
  TITLE     Extracellular CIRP promotes Kupffer cell inflammatory polarization
            in sepsis
  JOURNAL   Front Immunol 15, 1411930 (2024)
   PUBMED   38881891
  REMARK    GeneRIF: Extracellular CIRP promotes Kupffer cell inflammatory
            polarization in sepsis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1275)
  AUTHORS   Wu,Z., Liu,X., Huang,W., Chen,J., Li,S., Chao,J., Xie,J., Liu,L.,
            Yang,Y., Wu,X. and Qiu,H.
  TITLE     CIRP increases Foxp3+ regulatory T cells and inhibits development
            of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of
            sepsis
  JOURNAL   Int Immunopharmacol 132, 111924 (2024)
   PUBMED   38531201
  REMARK    GeneRIF: CIRP increases Foxp3[+] regulatory T cells and inhibits
            development of Th17 cells by enhancing TLR4-IL-2 signaling in the
            late phase of sepsis.
REFERENCE   4  (bases 1 to 1275)
  AUTHORS   Huang,J., Zhu,Y., Liu,Y., Zhang,R., Zhang,Z., Liu,J., Zhang,Z.,
            Liang,Y. and Ma,B.
  TITLE     The cold-inducible RNA-binding protein-Thioredoxin 1 pathway
            ameliorates mitochondrial dysfunction and mitochondrial
            dynamin-related protein 1 level in the hippocampus of aged mice
            with perioperative neurocognitive dysfunction
  JOURNAL   CNS Neurosci Ther 30 (3), e14433 (2024)
   PUBMED   37641878
  REMARK    GeneRIF: The cold-inducible RNA-binding protein-Thioredoxin 1
            pathway ameliorates mitochondrial dysfunction and mitochondrial
            dynamin-related protein 1 level in the hippocampus of aged mice
            with perioperative neurocognitive dysfunction.
REFERENCE   5  (bases 1 to 1275)
  AUTHORS   Akama,Y., Murao,A., Aziz,M. and Wang,P.
  TITLE     Extracellular CIRP induces CD4CD8alphaalpha intraepithelial
            lymphocyte cytotoxicity in sepsis
  JOURNAL   Mol Med 30 (1), 17 (2024)
   PUBMED   38302880
  REMARK    GeneRIF: Extracellular CIRP induces CD4CD8alphaalpha
            intraepithelial lymphocyte cytotoxicity in sepsis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1275)
  AUTHORS   Matsumoto,K., Aoki,K., Dohmae,N., Takio,K. and Tsujimoto,M.
  TITLE     CIRP2, a major cytoplasmic RNA-binding protein in Xenopus oocytes
  JOURNAL   Nucleic Acids Res 28 (23), 4689-4697 (2000)
   PUBMED   11095679
REFERENCE   7  (bases 1 to 1275)
  AUTHORS   Puttagunta,R., Gordon,L.A., Meyer,G.E., Kapfhamer,D.,
            Lamerdin,J.E., Kantheti,P., Portman,K.M., Chung,W.K., Jenne,D.E.,
            Olsen,A.S. and Burmeister,M.
  TITLE     Comparative maps of human 19p13.3 and mouse chromosome 10 allow
            identification of sequences at evolutionary breakpoints
  JOURNAL   Genome Res 10 (9), 1369-1380 (2000)
   PUBMED   10984455
REFERENCE   8  (bases 1 to 1275)
  AUTHORS   Nishiyama,H., Xue,J.H., Sato,T., Fukuyama,H., Mizuno,N.,
            Houtani,T., Sugimoto,T. and Fujita,J.
  TITLE     Diurnal change of the cold-inducible RNA-binding protein (Cirp)
            expression in mouse brain
  JOURNAL   Biochem Biophys Res Commun 245 (2), 534-538 (1998)
   PUBMED   9571190
REFERENCE   9  (bases 1 to 1275)
  AUTHORS   Nishiyama,H., Higashitsuji,H., Yokoi,H., Itoh,K., Danno,S.,
            Matsuda,T. and Fujita,J.
  TITLE     Cloning and characterization of human CIRP (cold-inducible
            RNA-binding protein) cDNA and chromosomal assignment of the gene
  JOURNAL   Gene 204 (1-2), 115-120 (1997)
   PUBMED   9434172
REFERENCE   10 (bases 1 to 1275)
  AUTHORS   Nishiyama,H., Itoh,K., Kaneko,Y., Kishishita,M., Yoshida,O. and
            Fujita,J.
  TITLE     A glycine-rich RNA-binding protein mediating cold-inducible
            suppression of mammalian cell growth
  JOURNAL   J Cell Biol 137 (4), 899-908 (1997)
   PUBMED   9151692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132584.1 and AI841072.1.
            
            On Dec 23, 2017 this sequence version replaced NM_007705.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075699.1, AK014655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1257              AK132584.1         2-1258
            1258-1275           AI841072.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1275
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /note="cold inducible RNA binding protein"
                     /db_xref="GeneID:12696"
                     /db_xref="MGI:MGI:893588"
     exon            1..78
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /inference="alignment:Splign:2.1.0"
     exon            79..187
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..603
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /note="isoform 1 is encoded by transcript variant 1; A18
                     hnRNP; glycine-rich RNA-binding protein CIRP"
                     /codon_start=1
                     /product="cold-inducible RNA-binding protein isoform 1"
                     /protein_id="NP_031731.1"
                     /db_xref="CCDS:CCDS35975.1"
                     /db_xref="GeneID:12696"
                     /db_xref="MGI:MGI:893588"
                     /translation="MASDEGKLFVGGLSFDTNEQALEQVFSKYGQISEVVVVKDRETQ
                     RSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRG
                     FFRGGRSRGRGFSRGGGDRGYGGGRFESRSGGYGGSRDYYASRSQGGSYGYRSSGGSY
                     RDSYDSYATHNE"
     exon            188..294
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /inference="alignment:Splign:2.1.0"
     exon            295..433
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /inference="alignment:Splign:2.1.0"
     exon            434..515
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /inference="alignment:Splign:2.1.0"
     exon            516..586
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1260
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1238..1243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /note="hexamer: ATTAAA"
     polyA_site      1260
                     /gene="Cirbp"
                     /gene_synonym="Cirp"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgcgc cttaggaagc ttgggtgtgt gtggcgcgct gtcttcccgc tcgcgtcagg
       61 gacctgcccg actcagcggc tgccatggca tcagatgaag gcaagctttt cgtgggagga
      121 ctcagcttcg acaccaacga gcaggcgctg gagcaggtct tctccaagta tgggcagatc
      181 tccgaagtgg tggtggtaaa ggacagggag acccagcgat cccgaggctt tgggtttgtc
      241 acctttgaaa atatcgatga cgctaaggac gccatgatgg ctatgaatgg gaagtctgtg
      301 gacgggcggc agatcagagt tgaccaggct ggcaagtctt ctgacaaccg gtcccgagga
      361 taccggggtg gctctgctgg aggccggggc tttttccgtg ggggacgaag ccggggccga
      421 gggttctcca gaggaggagg agaccggggc tatggaggtg gccgctttga gtcccggagt
      481 gggggttatg gaggctccag agactactat gccagccgga gtcagggtgg cagctatggt
      541 tatcggagct cgggagggtc ctacagagac agctatgaca gttatgctac acacaacgag
      601 taaaagccct ccgcgtccag atcgtccttc catggctgta attaagatgg gggagcttcg
      661 ctgatcgttg tgtagtgagc accttgttcc cacttttgta gtcctttccg ttctgacccg
      721 tcagcagcct gcttctgacc caagatggcc tcgtgactag acctgttttt aaggaagcgc
      781 tgtctgtttt taagtattct taaaaacgtt ttggaaagca cttcagattt tactgtttac
      841 catgagccat gggtttttgt tttttctaaa ttgtcgggtt gtgtgggttt tggttactcg
      901 tttttgtttt ttcaggtttt ttggttgtgg cttttctttt tttttctttt tttgtgtggt
      961 cgcccctgaa gtctggcgcc ccacccctcc tgagatggaa tggactcgat ttgagcaagc
     1021 catggccctc cagctcccca gcccggctgc ggagttgcag caggtcctgc ccatcgggca
     1081 catgtctcaa gcccatgggg agcatagcag tccgggaggc tgtggaaatg tttatttata
     1141 ttgtcctttt ttaccgaaga catgcatact ccatcgatgt tgtattcaca gtggctgagg
     1201 aattcttgta cgcagtttct ttggcttcac gaagccgatt aaaagaccgt gtgaaatgaa
     1261 aaaaaaaaaa aaaaa
//
