LOCUS       NM_025854               2702 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus corepressor interacting with RBPJ, 1 (Cir1), mRNA.
ACCESSION   NM_025854 XM_911462
VERSION     NM_025854.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2702)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2702)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2702)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   4  (bases 1 to 2702)
  AUTHORS   Geyer,S.H., Reissig,L., Rose,J., Wilson,R., Prin,F., Szumska,D.,
            Ramirez-Solis,R., Tudor,C., White,J., Mohun,T.J. and Weninger,W.J.
  TITLE     A staging system for correct phenotype interpretation of mouse
            embryos harvested on embryonic day 14 (E14.5)
  JOURNAL   J Anat 230 (5), 710-719 (2017)
   PUBMED   28185240
REFERENCE   5  (bases 1 to 2702)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2702)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 2702)
  AUTHORS   Maita,H., Kitaura,H., Ariga,H. and Iguchi-Ariga,S.M.
  TITLE     CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative
            splicing
  JOURNAL   Exp Cell Res 303 (2), 375-387 (2005)
   PUBMED   15652350
REFERENCE   8  (bases 1 to 2702)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
REFERENCE   9  (bases 1 to 2702)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2702)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954713.11.
            
            On Nov 8, 2022 this sequence version replaced NM_025854.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006260.1, AK131674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AL954713.11        54426-54587         c
            163-257             AL954713.11        52466-52560         c
            258-331             AL954713.11        48864-48937         c
            332-342             AL954713.11        48437-48447         c
            343-407             AL954713.11        48286-48350         c
            408-456             AL954713.11        47899-47947         c
            457-574             AL954713.11        45749-45866         c
            575-681             AL954713.11        29618-29724         c
            682-767             AL954713.11        28347-28432         c
            768-2702            AL954713.11        25110-27044         c
FEATURES             Location/Qualifiers
     source          1..2702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 43.54 cM"
     gene            1..2702
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /note="corepressor interacting with RBPJ, 1"
                     /db_xref="GeneID:66935"
                     /db_xref="MGI:MGI:1914185"
     exon            1..162
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1443
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /note="CBF1 interacting corepressor"
                     /codon_start=1
                     /product="corepressor interacting with RBPJ 1"
                     /protein_id="NP_080130.2"
                     /db_xref="CCDS:CCDS16127.1"
                     /db_xref="GeneID:66935"
                     /db_xref="MGI:MGI:1914185"
                     /translation="MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQ
                     QYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGVKKENKEKEETEGETEYKFEWQKGA
                     PREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDG
                     SGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQDYVASDCEEDPEVEFLKSLTT
                     KQKQKLLRKLDRLEKKKKKKKSDKKKKKLQKSKNKHKKRKNKSPSSSSSSSSSSSSSS
                     SSSSSSSSSSETSDSSSESDNKEKKREKEKRKKKKKTKCSESKSSDCKEDKPKNMLYE
                     ELSSSHSDRGKAQEKLRFPKQESSGENSMWVHSASDRTSRSHRHSPEKKGSDRNRGIR
                     SRSRSRAESSRRSRSRSPYRQKHREVRSRPHRSPSEEQKGRKGTRSHGEGDHRREHVR
                     "
     exon            163..257
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     exon            258..331
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     exon            332..342
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     exon            343..407
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     exon            408..456
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     exon            457..574
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     exon            575..681
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     exon            682..767
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     exon            768..2702
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2653
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /note="major polyA site"
     regulatory      2668..2673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /note="hexamer: AATAAA"
     regulatory      2682..2687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
                     /note="hexamer: ATTATA"
     polyA_site      2692
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
     polyA_site      2702
                     /gene="Cir1"
                     /gene_synonym="1700023B02Rik; 2810021A19Rik; Cicr; Cir"
ORIGIN      
        1 aaacttgcct agcagttccg gtgaagctcc gggagtttgt ttacgttccg agaagaccta
       61 gcggttggct tctccgactc agacgccaag atggggaagt cattcgccaa tttcatgtgt
      121 aagaaggact tccatcctgc gtccaaatcc aacatcaaga aggtatggat ggcagaacag
      181 aaaatatcgt atgataaaaa gaaacaagaa gaattaatgc aacagtacct taaagagcag
      241 gagtcgtatg ataacagatt gcttatggga gatgaacgtg tgaagaatgg cctgaatttc
      301 atgtacgagg ccccaccagg agttaagaaa gaaaacaaag agaaagaaga aacggaagga
      361 gagaccgagt acaagtttga atggcagaaa ggcgctccga gagaaaaata tgccaaagat
      421 gacatgaaca tcagagatca gccctttggt attcaggttc gaaatgtaag gtgtattaaa
      481 tgtcacaagt ggggccatgt gaacacagat cgagagtgtc ccttgtttgg tctttctggg
      541 atcaatgcaa gttcagttcc tactgatggc tcagggccgt cgatgcaccc ctcggagcta
      601 atagcggaga tgagaaacag tgggtttgca ctgaaacgaa atgtactggg gagaaacttg
      661 accgcaaatg atccatcaca ggactatgtc gcaagtgact gtgaagaaga ccctgaagtt
      721 gagttcttaa agtcgctcac caccaagcag aagcagaagc tcctcaggaa attggataga
      781 cttgaaaaga aaaaaaagaa aaagaaaagt gataagaaaa agaagaagtt acagaagagc
      841 aaaaataaac acaagaaacg taaaaacaaa tccccttcct cttcctcctc ttcctcctct
      901 tcctcctctt cctcctcctc ctcctcctct tcctcttcct cctcctcgga gacatcagat
      961 agcagcagtg agagtgataa caaagaaaag aaaagagaga aagagaagag gaagaagaag
     1021 aagaaaacca aatgttctga aagtaaatcc agtgactgta aggaggacaa gcctaagaac
     1081 atgctttacg aagaactttc cagcagtcac agtgacaggg gaaaagccca ggaaaaatta
     1141 aggtttccaa aacaagagag ttctggggag aatagcatgt gggtccattc tgcttctgac
     1201 cggacatcca gaagccaccg gcacagtcca gagaagaaag ggtctgacag aaatcgggga
     1261 atccgaagtc ggagccgtag ccgggctgag agcagccggc gaagcagaag caggagtcct
     1321 taccgtcaga agcacaggga ggtgaggagc cggccacacc ggagccctag tgaagagcag
     1381 aagggaagaa agggcaccag aagccatggt gaaggtgacc atagaagaga gcacgtgcgc
     1441 tgagcgccca ggagataaag ggagaggcag caggctcaac agagcttcgg agcaaccacc
     1501 tgggcatcaa ggacatcttt agcaagggct aacatacaca ttgttatcta ataaaaaaag
     1561 tcaattcatt ttccatctct gtaaactgtt gtttcaagta ttaaagcact gttgtaccac
     1621 aagcttaagt ttgcagatat ttgcagggaa tttagggtat acaagtagtt tttgttttgt
     1681 tgttgttgtg gtggtggtga tggtggtggt agtggtggtt ttcttgttgg tagttgtttc
     1741 ttctgcctta taccagattt aaaatatgta cgtaattgtg tgattttgtt gttgttttga
     1801 aacaccatta aaacagtgac agaatcttga ataattatca attcaaattt gttattttaa
     1861 gatttgaata tgcttgaagc aaaatgtaat cattgttgaa actgactagg gtgaataaaa
     1921 tactggatat caaaaagcat gtccttaaga ctttaaaagt atgatattta taattggatg
     1981 tcctgttatt tgtctatgtt ggcaaacaaa atcacttcaa acttaacagt tgtgaaaatc
     2041 agaattctgg catgggtctc actaggataa gatgaaggca tgggtagaat gtcttccttc
     2101 agaaaatcca tggtgcccag ttttggtggt tggctccctt ttctaacgaa gagaactccc
     2161 ctgtttccaa gtcctggagt cagtctgaca ctaactgcac cctccttcac ttggtaagga
     2221 ccctgtgagt atagcaggtc cacatttaag accaactgat tatcaacctt aactttgcac
     2281 ctgtaaatgt aacatattca tggcttgggg gagggggcgg gggggggggg ttggaaacat
     2341 gtatatcttg aggggagtgt tattctgtct cctcccacaa tagcctttct ggttgacatt
     2401 gcaaagtttt tcttcaggag gtaaaacata ttacaaagaa ataatgtaaa ctagatattt
     2461 tgtatttaaa ggtgtatgtt gggagtggag ggaacggttt ctctttgaga cagggtcttc
     2521 ccattactat gtagctcttg ctagcctgaa actcactatg tagaccaagc caacatataa
     2581 ggtgttttgt ttttttttaa aaacttagct atacattttg ccatatgttc caaaggatta
     2641 gaagaagaga aaactatgga aattttcaat aaaaaatgca gattatatgc aactaaaact
     2701 tt
//
